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Preeclampsia is a serious pregnancy complication, but early identification of women at risk remains difficult due to limited biomarkers. Here, the authors show that cell-free DNA fragmentomics from maternal blood can predict preeclampsia risk early in pregnancy.

Self-healing materials typically suffer from poor mechanical properties due to the inherent trade-off between mechanical robustness and self-healing capability. Here the authors report a composite featuring an aligned array of hydroxyapatite nanowires interwoven with dynamic borate bond networks by a bidirectional freeze-drying method.

The authors developed biodegradable meta-membranes that regulate the skin microenvironment, self-decontaminate, and maintain high air purification efficiency even under humidity were developed, offering a sustainable solution for personal protective equipment.

Neuraminidase activity of NEU1 regulates insulin resistance and glucose tolerance. Here the authors report that NEU1 also inhibits hepatic gluconeogenesis in a non-enzymatic manner by binding SAM68, thereby activating GCN5 transcription.

Background motion profoundly impacts visual perception. Here, the authors show that an inhibitory brainstem pathway, recruited by global background motion, suppresses superior colliculus activity and visual perception mediated by this structure.

Spindle neurons in the human cortex are morphologically distinct. Here, authors show that they also possess distinctive electrophysiological and transcriptomic features, establishing them as a functionally specialized cell type in the human brain.

Molecular devices offer the potential for the scalability and energy efficiency required to develop energy-sustainable AI. Zhang et al. report a single-molecule neuromorphic device that consumes 6.34 aJ per operation and support both short-term to long-term memory, featuring over 10 distinct conductance states.

Nasopharyngeal carcinoma (NPC) screening in southern China uses EBV serology, but its positive predictive value is low. Here, the authors introduce a swab-based E-CpMQ method in high-risk individuals, achieving better specificity.

Despite the global prevalence of SARS-CoV-2 infection, its maternal–fetal interface during the first trimester remains underexplored. Here, the authors combined a cohort of 700+ samples and determine that maternal SARS-CoV-2 infection in the first trimester rarely infects placental tissue but alters immune responses and cellular communication, which may influence pregnancy outcomes.

Treatment failure exists in Induction chemotherapy followed by concurrent chemoradiotherapy (CCRT) for locoregionally advanced nasopharyngeal carcinoma (LA-NPC) patients. Here this group reports a phase 2 randomized trial evaluating the efficacy and safety of adding nimotuzumab, to CCRT on 246 patients with untreated, non-keratinising, stage II–IVA LA-NPC.

A programmable photonic quantum processor, Jiuzhang 4.0, incorporates 1,024 high-efficiency squeezed states into a hybrid spatial–temporal encoded 8,176-mode circuit.

In vivo base editing of a causative mutation that leads to the neurodevelopmental disorder Snijders Blok–Campeau syndrome restores protein dosage and ameliorates molecular and behavioural deficits in a humanized mouse model of the condition.

Mechanistic insights reveal that cathepsin B dependent glycolysis regulates urate transporter expression, contributing to impaired renal uric acid excretion in hyperuricemia

Emerging evidence suggests that organs age at different rates. This study identifies a mechanism by which the naturally hypoxic intervertebral disc ages relatively slowly, via selective autophagy of HIF-1α, and designs a small molecule to export this mechanism across tissues.

The development of Tat clusters has advanced the intracellular delivery of functional antibodies at low concentrations, but the variety of proteins that can be successfully delivered remains limited. Here, the authors report that by reversibly modifying the surface of functional proteins with anionic peptides, various protein cargoes (otherwise difficult to deliver) can be delivered into living cells by synergetic electrostatic interactions with the cationic cell-penetrating peptide clusters TAT₃.

The DAMPE satellite observed a universal charge-dependent spectral softening in primary cosmic rays, and ruled out mass-dependent softening with >99.999% confidence.

Asparagales is the largest monocot order. Here, the authors produce the phylogeny of Asparagales with transcriptomic data from 455 species and investigate the evolution of genes involved with allium flavor biosynthesis.

MoCox6 is an inner mitochondrial membrane regulator of mitophagy in Magnaporthe oryzae, and targeting it with a small molecule, Pan-RAS-IN-1, suppresses fungal virulence and reduces rice blast disease.

DeepDrugDiscovery is an AI-powered screening platform incorporating ADMET and blood–brain barrier penetrability predictions to successfully identify mTOR-independent autophagy enhancers that can cross the blood–brain barrier for Alzheimer’s disease therapy.

Non-reciprocal optical elements usually require the presence of magnetic fields, which makes chip integration difficult. Here, Hua et al. demonstrate a non-magnetic optical isolator with bidirectional injection on a silicon platform utilizing parametric amplification in four-wave mixing.

In semiconductors, an absorbed photon can generate multiple electron-hole pairs, but measurements of this carrier multiplication efficiency in nanocrystals need to correctly account for charged excitons. Xiaoet al.meet this need by measuring energy transfer of biexcitons from nanocrystals to acceptor dyes.

Dong and colleagues report that blockade of T cell-expressed cytotoxic and regulatory T cell molecule results in selective mitigation of immune-related toxicities without affecting antitumor efficacy of immune checkpoint inhibitors.

TRIP6 phosphorylation triggers a signalling cascade that promotes glycolysis in KRAS-mutant colorectal cancer cells. The resulting lactate accumulation drives extracellular lactylation of CD44 on CD8⁺ T cells, thereby compromising their anti-tumour activity.

Colorectal cancer has high recurrence and metastasis rates making treatment difficult. Here, the authors report on peptide modified cell membrane coated cobalt based metal-organic frameworks which degrades and forms, in situ, photothermal materials with H₂S, allowing for immune-photothermal therapy.

The catalytic asymmetric dearomatization (CADA) reaction is a powerful protocol for the assembly of three-dimensional cyclic compounds but phenols have been considered challenging substrates. Here, the authors report the chiral phosphoric acidcatalyzed divergent intermolecular CADA reactions of phenols with azoalkenes to obtain tetrahydroindolone and cyclohexadienone products in good yields with excellent ee values.

A dated phylogeny of 16,585 vascular plant species native to China reveals three major centres of endemism, including a potential new global biodiversity hotspot.

Single-nucleus chromatin and RNA sequencing identifies epigenetic chromatin domains that confer vulnerability to paediatric brain tumours such as ependymomas, providing insight into the development of such tumours despite ‘quiet’ genomes.

Here they show that high blood sugar drives neutrophils to release 4-GBA, a Pad4 byproduct that blocks bone-forming stem cells. A peptide gel that traps 4-GBA restores jawbone healing in rats, rabbits and dogs, suggesting a local, immune-sparing therapy.

CircPBX1 alleviates metabolic memory-associated erectile dysfunction in diabetic rats by sponging miR-195-5p, restoring YAP1/VEGF signaling and endothelial angiogenic function, highlighting a potential therapeutic target for DMED.

Allogeneic stem cell transplantation (alloHSCT) is approved for the treatment of transfusion-dependent thalassemia but remains limited to the use of matched sibling donors. In this multi-centre, phase-4 prospective clinical trial, the authors evaluate the use of alloHSCT with matched unrelated donors and haploidentical relatives.

Slow sulfur redox limits the development of wide-temperature-range Na-S batteries. Here, authors prepare Sn-doped CoNiS multipods catalyst with amorphous–crystalline interfaces that accelerate polysulfides conversion, enabling high-capacity and long-life batteries operated from −20 to 50 °C.