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Pulmonary microbiotacomponents in bronchiectasis patients receive repeated antibiotic exposures, whereas previous studies on the effects ofantibiotic treatment focused on typical pathogens rather than commensals. By integrating experimental evolution withsingle-cell resolution, the authors reveal a multifaceted strategy by which Neisseria subflava, a common airwaycommensal associated with bronchiectasis, exploits antibiotic selection to transition towards pathogenicity.

Organic solar cells (OSCs) rely on morphological optimization for high efficiency. The authors show cyclobutyl-mediated interchain supramolecular interactions among acceptors, suppressing electron-phonon coupling and optimizing acceptor alloy phase morphology in ternary OSCs to achieve efficiencies approaching 21%.

Traditional recycling of polyoxymethylene plastic often leads to significant material loss and toxic emissions. Here, the authors introduce an acidic electrochemical process that efficiently converts plastic waste into valuable chemicals with conversion efficiency approaching 90%.

Authors reconstruct the molecular evolution of severe fever with thrombocytopenia syndrome virus (SFTSV) in East Asia. SFTSV splits into two lineages with diversity driven by segment-specific reassortment; transmission occurs via distinct networks.

Efficient cryogenic electronics are essential for quantum computing at millikelvin temperatures. Yang et al. report a SiC-based negative differential resistance device with high on/off ratio at millikelvin and demonstrate programmable cryogenic neuromorphic circuits including sensory, logic and spiking neurons.

Achieving high power scaling in ultrawide bandgap electronics remains challenging. Here, the authors present a Ga₂O₃ module using a high permittivity interface that enables fast megawatt pulsed switching with improved thermal performance.

Yu et al. report a self-assembled heterogeneous microstructure consisting of chiral-deficit grains and chiral-rich grain boundaries in chiral perovskite with the former as in-plane spin valves for spin selection. Retinomorphic sensor arrays based on the chiral perovskite film enable binocular artificial visual systems.

Hu et al. report a low-temperature polar-solvent strategy for high-yield (162 mg mL⁻¹) perovskite nanocrystal synthesis with suppressed self-absorption. The scintillator films achieve ~7 ns fast decay, 28,800 photons MeV⁻¹ light yield, and dynamic X-ray imaging at 7,680 frame per second.

Given the interest in extracellular vesicles there is a need for simple short scaffold proteins for efficient targeting and cargo loading. Here, the authors identify a candidate scaffold protein and find the truncated version allows for efficient loading which outperforms current scaffold proteins, demonstrating application in sepsis therapy.

Global cropland subsoil hides a “biogeochemical engine” where crop roots, soil texture, nitrifier communities, and hydrological conditions interact to fuel nitrification, silently driving soil acidification and groundwater nitrate pollution.

Systemic lupus erythematosus (SLE) is a complex autoimmune condition and treatment options have limited efficacy. Here, by analysis clinical samples and employing preclinical models, the authors show that cGAMP levels are elevated in the plasma of patients with SLE and that loss of cGAS ameliorates symptoms in an imiquimod-induced lupus model. Importantly, they identify prasugel as a cGAS inhibitor with promising therapeutic potential.

The authors propose a new mechanism for non-reciprocal magneto-transport that results from the cooperative action of skew scattering and Lorentz force and does not require spin-orbit coupling. The mechanism is strongly enhanced by topological band features near the Fermi level and is expected to dominate in highly-conductive systems.

The morphology of hole-selective contacts is key to the stability of perovskite solar cells. Feng et al. use self-assembled molecules with extended conjugation and hydroxyl groups to form dense, amorphous films that suppress degradation induced by ion migration.

Liu, Liu, Wu and Yao et al. developed a peptide inhibitor that selectively blocks the Ada-two-A-containing histone complex by targeting the YEATS2 YEATS domain and suppresses tumor growth in non-small cell lung cancer.

Photoinduced ligand-to-metal charge transfer is used to enable abiotic cross-couplings in metalloenzymes. Engineering a 2-histidine metal site and substituting iron with nickel activates PsEFE for nickel-catalysed C(sp²)–S coupling reactions between thiols and aryl bromides. Directed evolution yielded metalloenzyme variants that can produce a range of thioethers with high efficiency.

A self-regulated photothermal superhydrophobic film with strong solar modulation, energy storage, and durability is reported, switching between black and white as temperature changes, enabling winter anti-/deicing and summer overheating prevention.

Understanding precise structures of two-/three- dimensional covalent organic polymers through single-crystal X-ray diffraction analysis is interesting however, to grow high-quality single crystals of these materials is challenging. Here, the authors incorporate tellurium into the backbones covalent organic polymers as a concise and fast method to grow large single crystals.

Zhang, Han, Tan, Lu, Ma et al. report that kynurenine derived from peritumoural adipose tissue is hijacked by cancer cells to mediate ferroptosis resistance, a process that could potentially be targeted with immunotherapy to inhibit tumour growth.

A clinical trial testing whether monitoring ctDNA clearance during treatment for nasopharyngeal cancer could be used to inform decisions about an individual’s subsequent therapeutic programme shows promising results.

Measurement-based quantum computing implements quantum algorithms by performing sequences of measurements on special classes of entangled states, such as cluster states. This approach has now been demonstrated on a superconducting quantum processor.

Sclerostin impairs whole-body lipidandglucosemetabolism. Here, the authors further demonstrate that adipocytic sclerostin loop3-LRP4 interactionparticipatesin the impairment effect of sclerostin on whole-body lipid and glucose metabolism.

The role of soluble angiotensin converting enzyme 2 (sACE2) in SARS-CoV-2 infection is not well understood. Here, authors show that membrane type 1 matrix metalloproteinase (MT1-MMP) releases sACE2 to promote SARS-CoV-2 cell entry in vitro and in vivo, and the upregulation of MT1-MMP may contribute to increased susceptibility to SARS-CoV-2 infection in ageing.

Hong-Xuan Lin, Ji-Ping Gao, Jun-Xiang Shan and colleagues show that natural variation in a proteasome α2 subunit gene contributes to thermotolerance in African rice. Their follow-up studies suggest that the variant allele protects cells from heat stress by enhancing the elimination of cytotoxic denatured proteins and maintaining heat-response processes.

Radiative cooling is an emerging technology for cooling with reduced energy consumption. Here the authors present photoluminescent composites that combine subambient cooling with aesthetic colour, hydrophobicity and durability.

Intestinal epithelium is continuously exposed to osmotic changes. Here, the authors show that this volume-regulated anion channel, a key osmo-sensitive ion channel, protects against colitis by balancing nutrient absorption and antimicrobial defense.

Age-related macular degeneration (AMD) is a major cause of blindness worldwide. Here, the authors carry out a two-stage genome-wide association study for AMD and identify three new AMD risk loci, highlighting the shared and distinct genetic basis of the disease in East Asians and Europeans.

Yang et al. compare neoadjuvant triple therapy versus direct hepatectomy in patients with resectable intermediate or advanced hepatocellular carcinoma. The findings indicate that the neoadjuvant regimen improves overall and event-free survival but is associated with a higher risk of serious adverse events and postoperative complications.

Photons carrying orbital angular momentum inherit chirality from their twisted wavefront. Here, authors propose a twisted bilayer photonic structure - consisting of semiconductor membrane metasurfaces - where helical wavefronts are combined with non-Hermitian coupling, yielding orbital chiral lasing at telecom wavelengths.

Li et al. report feedback neurons based on perovskite memristors with a nickel single-atom modified reduced graphene oxide cathode. The device successfully implements an unsupervised learning network with over 50% clustering accuracy and cooperative learning for solving NP-hard combinatorial optimisation problem.

Atomic catalytic pairs enable multistep transformations, yet the roles of spatial arrangement and coordination symmetry in homonuclear pairs remain unclear. Here, the authors construct atomically dispersed homonuclear Pt₁–Pt₁ pairs with asymmetric Pt₁C₃–Pt₁O₁C₃ coordination on reduced graphene oxide, enabling efficient transfer hydrogenation of azobenzene.

Recent studies on path multiplicity have shown strong heterogeneity in shortest paths between node pairs in real-world networks. Here, authors reveal that community structure is a key factor shaping path multiplicity.

CNS injuries cause persistent deficits. Here, the authors show that regenerated axons in an optic tract injury model form functional synapses, restoring the pupillary light reflex, and highlight neuronal types and presynaptic activity in recovery.

Rechargeable zinc batteries are promising for grid energy storage but can suffer from short circuits and side reactions. Here, the authors design low-surface-tension electrolytes that enable dense, dendrite-free zinc deposition, achieving long-lasting batteries even under harsh operating conditions.

Biohybrid microrobots combine biological and synthetic components to navigate complex in vivo environments for applications such as drug delivery, microsurgery and diagnostics. This Review introduces a biophysics-informed design framework for biohybrid microrobots that translates natural adaptive strategies into engineering solutions across deformation, actuation, navigation and programming.

Less is known about the entire microbial pathogen profile of small mammals. Here, the authors analyse 2,408 tissue-resolved metatranscriptomes to map the infectome in small mammals, uncovering high viral, bacterial, fungal and parasitic diversity and showing how geography, hosts, and seasons shape zoonotic risk.