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Zhuang, Zi et al. identify cyclin-dependent kinase 3 (CDK3) as a driver of neuron loss in Alzheimer’s disease that is associated with brain atrophy and memory decline in mice. Inhibition of CDK3 (BMX330) is shown to limit neuronal loss and improve cognition.

Peritoneal metastasis remains a major clinical challenge due to the lack of effective therapeutic options. In this study, the authors present intraperitoneal programming of tailored chimeric antigen receptor macrophages (CAR-Ms) as a strategy against peritoneal metastasis.

Macrophages secrete diverse signaling proteins critical for intercellular communication and immune responses, processes tightly regulated by post-translational modifications (PTMs). Here, the authors present a PTM-based secretome profiling (PBSP) method, which allows exploring PTM roles in protein secretion, offering insights into PTMs’ regulatory functions in cell-cell communication.

Polyurethane materials are used for flexible sensors, though they face stability issues. Here the authors design a fluorine-rich polyurethane optimizing electronic and mechanical properties.

Lampreys are jawless vertebrates that can offer unique insights into vertebrate evolution. Here they generate a comprehensive cell atlas of the lamprey, uncovering 70 distinct cell types across 14 tissues, and identify pancreas-like cells in the lamprey small intestine.

Coordinated gene segment rearrangement across a long genomic distance is essential for antibody gene production, but how this is regulated at the chromatin level is still unclear. Here the authors show that an architectural protein, CTCF, modulates both chromatin loop extrusion and diffusion to enforce diverse Vκ gene segment utilization for a diverse Igκ repertoire.

Phenolic compounds have long captivated the interest of organic synthesis, particularly in their quest for selective hydroxylation of arenes using H₂O as a hydroxyl source but the inherent high reactivity and low redox potential of phenols often lead to undesirable overoxidation byproducts. Here the authors develop an electrophotochemical approach, finetuning substrate oxidative potential and enabling para-selective hydroxylation of anilides.

Red light- or ultrasound-controlled proximity labelling is engineered to stimulate clustering-induced receptor activation and downstream signalling amplification to promote antitumour immune responses.

A method for detecting Salmonella enterica subsp. enterica serovar Typhimurium, Staphylococcus aureus and Listeria monocytogenes is developed, enabling simultaneous and rapid artificial-intelligence-assisted food-borne pathogen detection.

Generalizable Pathology Foundation Model (GPFM) consolidates expertise from a variety of existing models for use in a broad spectrum of computational pathology tasks.

Chili pepper (Capsicum) is an important vegetables known for fruit pungency given by capsaicinoids. Here, the authors assemble the telomere-to-telomere genomes of a pungent pepper C. annuum and its non-pungent wild relative C. rhomboideum and reveal insights into Capsicum evolution and capsaicinoid biosynthesis.

Efficient electro-optic conversion is central to photonic computing, and thin-film lithium niobate (TFLN) offers this capability. Here, the authors demonstrate computing circuits on the TFLN platform, enabling the next generation of photonic computing systems featuring both high-speed and low-power.

This study is an analysis of carbapenem-resistant Klebsiella pneumoniae from 2005 to 2024, which showed significant differences across countries, and Clone Group 1 emerged as the principal dissemination vector globally.

Selective chemical upcycling of polyolefin mixtures remains challenging due to the structural similarity of their backbones. Now it has been shown that a single-site nickel catalyst can preferentially and efficiently cleave branched C–C bonds, enabling the hydrogenolytic separation of isotactic polypropylene from mixtures containing both isotactic polypropylene and polyethylene.

The authors realize low-pressure-driven polarization switching in PbTiO₃ membranes by leveraging their structural tunability and substrate elasticity, enabling ferroelectric field-effect transistors on silicon, operatable mechanically and electrically.

Efficient oxygen activation limits oxidative catalysis. Here, incorporating single-atom Zr into CeO₂-supported Pt catalysts creates Zr₁–O–Pt₁ structures, significantly enhancing catalytic performance via boosted surface and chemisorbed oxygen activation.

Central memory CD8+ T cells (Tcm) are important for lasting anti-tumour immunity and their differentiation is determined by underpinning transcriptional and metabolic regulation. Authors here show that although microwave ablation (MWA) cancer therapy induces T cells to acquire some of the gene expression features of Tcms, but the full metabolic remodeling required for functionality is only achieved if glycolysis is inhibited simultaneously.

In the prevention and treatment of acute ventricular arrhythmia, rapid and accurate photothermal autonomic neuromodulation is crucial but challenging. Here, the authors report Pt nanoparticle shells with a photothermal conversion efficiency of 73.7% at 1064 nm that contributes to efficient and precise autonomic nerve modulation.

Using a cross-species integrative approach, this study identifies Brd9 as a critical osteogenic regulator that modulates Sp7 expression through cooperation with Wnt/β-catenin signaling.

The dynamic spatial chromosomal configurations in 3D space demonstrate cell-to-cell variation. Here, authors develop Tensor-FLAMINGO to reconstruct high-resolution single-cell specific 3D genome structures, leading to insights into chromatin folding, gene regulation and disease SNPs.

A semifloating molybdenum disulfide homojunction exhibits a photoelectric response with a tunable amplitude and relaxation time, which can be used for reconstructive spectroscopy with high resolution and a small device footprint.

SedaDNA can facilitate reconstruction of past species distributions. Here, the authors generate metagenomes from 156 stratigraphically-sampled sediments and use them to reconstruct the history of 10 Adélie penguin colonies, including penguin diet and diversity, spanning 6000 years.

This study documents equine ACE2 (eqACE2) binding to the RBDs of SARS-CoV-2 and related CoVs, revealing a mechanism of eqACE2 binding with RaTG13-RBD, SARS-CoV-2 prototype-RBD and Omicron BA.1-RBD.

Chen et al. report a large-area white LED with sunlight-like emission by regulating the heterophase γ/σ-CsPb(I/Cl)₃ at nanoscale, in which a fraction of carriers recombines in γ-CsPbI₃ for deep-red emission, while other carriers diffuse to the heterophase interface for broadband emission.

Solid-state lithium batteries suffer from lithium dendrite formation that compromises safety. Here, authors reveal how grain boundary structures affect lithium behavior and show that selective amorphization can suppress dendrites and enhance battery stability.

Upcycling of mixed plastics containing polyvinyl chloride is challenging. This study reports a strategy to co-upcycle polyvinyl chloride with polypropylene to obtain dechlorinated liquid hydrocarbons at high yields at room temperature without the use of external hydrogen or noble metal catalysts.

Xu et al. report reconfigurable phototransistors based on MAPbI₃/Bi₂O₂Se heterostructure, with momentum conservation promotes hot carrier extraction and interlayer carrier transport. Heterotransistor array enables traffic light signal detection under dim light, assisted by YOLOv4 neural network.

Dandelions exhibit adaptive abilities, continuously adjusting seed pappus shape for dispersal on demand. Haoyang Sun and colleagues propose solar-powered microfliers with shape memory alloy actuators and a drone-mount releasing module for programmable flight and robust self-sustaining operation.

Polymers formed with non-covalent bonds are increasingly being developed, but often show inferior mechanical properties. Here, the authors report the development of high performances polyurethane-urea elastomer with shape-memory assisted self-healing behaviour

Bolstering the broad and deep applicability of graph neural networks, Heydaribeni et al. introduce HypOp, a framework that uses hypergraph neural networks to solve general constrained combinatorial optimization problems. The presented method scales and generalizes well, improves accuracy and outperforms existing solvers on various benchmarking examples.

Transition metal carbides are attractive for electrochemical energy storage and catalysis, but cost effective preparation on a large scale is challenging. Here the authors use a direct pattern method to fabricate transition metal carbides for supercapacitors and solar energy harvesting for steam generation.