Search

This study demonstrates that simple alkali etching enables in-situ regeneration of oxygen vacancies on CuO, enhancing peroxymonosulfate activation for efficient pollutant degradation with a 42-fold increase and long-term stability.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Self-supervised reconstruction structured illumination microscopy (SSR-SIM) is a reconstruction approach for SIM that improves image reconstruction by including light modulation priors and information on reconstruction artifacts, while simultaneously eliminating the need for ground-truth images. The improvements allow long-term imaging of sensitive cellular processes.

Biosynthetic pathway of limonoids after azadirone is still unclear. Here, the authors report the genomes of neem tree and chinaberry and reveal acetyltransferases that determine limonoid structure diversity in the two species.

Zygotic genome activation coincides with extensive chromatin remodeling coordinated by maternal transcription factors. Here, by mapping accessible chromatin during early embryonic development of Xenopus tropicalis, the authors show how maternal factors E2f1 and Otx1 work together to control zygotic genome activation.

Late-stage aromatic chlorination of active pharmaceutical ingredients has enormous potential in drug discovery yet still features limited applicability due to issues of functional-group tolerance. Now, dimethyl sulfoxide is reported as catalyst for the chlorination of a diverse family of bioactive molecules in combination with N-chlorosuccinimide.

Single-cell RNA sequencing, whole-exome sequencing and spatial transcriptome sequencing of gallbladder adenocarcinomas from 75 patients stratifies the disease into groups with distinct clinical outcomes.

A Leptotrichia buccalis Cas13a diagnostic platform can be used to cleave and detect small concentrations of viral and human DNA.

Direct synthesis of large area crystalline black phosphorus films is still challenging. Here, the authors report growth of high-quality black phosphorus films on insulating silicon substrates through a gas-phase epitaxial growth strategy with field-effect and Hall mobilities of over 1200 and 1400 cm2 /Vs at room temperature, respectively and a current on/off ratio of up to 10⁶, comparable to the exfoliated flakes.

Authors introduce an unsupervised framework for automatic modulation recognition. By using multi-domain signal representation and contrastive learning, it extracts high-quality features from unlabelled data, outperforming existing methods and reducing the need for labelled samples in wireless communications.

Alpine plants exhibit phenological adaptations to germinate and complete their reproductive cycles during the most favorable growing seasons. Here, the authors show that allelic variation in the GA20ox3 gene is crucial for the adaptability of fruit length and seed germination timing in high-altitude ecotypes of A. thaliana.

In C. elegans, systemic RNAi is initiated by SID-1-mediated dsRNA internalization. Here the authors present cryo-EM structures of SID-1 homologs and the SID-1–dsRNA complex, elucidating the structural basis for dsRNA recognition and uptake by SID-1.

RNA m6A methylation is known to be dysregulated in many cancers. Here, the authors show that m6A methylation of Snail mRNA regulates its translation with potential effects on epithelial mesenchymal transition.

Plant ubiquitin regulatory domain-containing proteins (PUX) play vital roles in CDC48-mediated protein quality control processes. Here Shi et al. show that a conserved core Magnaporthe oryzae effector (MoNLE1) can specially target the rice PUX protein OsPUX8B.2 and interfere with host immune responses.

Here, the authors fabricate printed Ag/MoS₂/Ag heterostructures that can be used as zero-static power switches. When combined with a printed graphene metasurface, the platform enables reconfigurable electromagnetic wave manipulation and control.

Multivalent interactions are crucial in transcriptional regulation. Here, by integrating specific multivalent molecules into dCas9-based activators, the authors provide valuable strategies to refine CRISPRa applications and achieve highly efficient gene transcription.

The treatment of Parkinson’s disease (PD) is hampered by the lack of effective blood–brain barrier (BBB) traversing drugs. Here, the authors report nanozyme-integrated metal-organic frameworks with antioxidant activity and chiral-dependent BBB transendocytosis as anti-neuroinflammatory agents for PD treatment.

Here the authors deploy Ni single atom-decorated carbon membranes as integrated gas diffusion electrodes to construct an extremely stable three-phase interface for CO₂ electroreduction, producing CO with a partial current density of 308.4 mA cm^–2 and a Faradaic efficiency of 88% for up to 120 h.

Understanding intracellular phase separation is essential for transcriptional control, cell fate, and disease. Here the authors report PSPHunter which accurately predicts key residues, aiding in disease-associated protein identification and mechanistic insights.

Carbon dioxide hydrogenation is an important industrial reaction. Here, the authors design a CeCuZn catalyst through a metal organic framework template for CO₂ hydrogenation to methanol with excellent methanol yield and stability.

The authors show a reductive interlayer structure that renders semi-transparent solar cells with a favourable combination of high efficiency and improved operational stability. When integrated in greenhouses, plant growth is comparable to that in the traditional glass-roof mode.

The functional role of DPF3, a component of the SWI/SNF chromatin remodelling complex associated with clear cell renal cell carcinoma (ccRCC), remains unknown. Here, the authors characterise the mechanism by which DPF3 promotes metastasis via the activation of the TGF-β signalling pathway in ccRCC.

Here the authors develop a single-cell multiomics sequencing method (scCARE-seq), which allows the simultaneous probing of 3D chromatin architecture and transcription for single cells. Using scCARE-seq they explore the relationship between the 3D genome and transcriptome in cell fate transitions and the cell cycle.

The flavanol quercetin rescues endothelial dysfunction and preeclampsia-like manifestations in a pre-clinical model via inhibition of ferroptosis and inflammation.

The modulation of ASK1-p38/RORγt signaling by OLFM4 suggests a novel mechanism in the regulation of ILC3-mediated gut inflammation, providing valuable insights for potential therapeutic interventions.

Functional characterization of preferential and potent small molecule modulators that allosterically enhance the gating of the Otop1 channel by targeting its key gating apparatus

A T/C variant in miR-27a is associated with bipolar disorder, potentially by reducing the ability of this microRNA to target important neurodevelopmental genes like NCAM1.