Search

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Chronic inflammation affects the male reproductive system, contributing to infertility. Using a mouse model of epididymitis, here, the authors report on the formation of tertiary lymphoid structures (TLS) under conditions of chronic inflammation, and show that TLSs sustain immune activation, contributing to anti-sperm autoantibody production and epididymal injury.

A pangenome of oat, assembled from 33 wild and domesticated oat lines, sheds light on the evolution and genetic diversity of this cereal crop and will aid genomics-assisted breeding to improve productivity and sustainability.

There’s an emerging body of evidence to show how biological sex impacts cancer incidence, treatment and underlying biology. Here, using a large pan-cancer dataset, the authors further highlight how sex differences shape the cancer genome.

The current known two-dimensional topological insulators with small band gaps limit the potential for room temperature applications. Here, Chen et al. observe a sizable gap of 129 meV in a 1T'-WSe₂ single layer grown on bilayer graphene with in-gap edge state near the layer boundary.

Analyses of 2,658 whole genomes across 38 types of cancer identify the contribution of non-coding point mutations and structural variants to driving cancer.

Genome-wide CRISPRi screens for modulators of androgen receptor (AR) protein levels using live-cell quantitative endogenous AR fluorescence reporters identify PTGES3 as a new regulator of AR stability and function in prostate cancer.

A super-pangenome analysis incorporating 123 newly sequenced bryophyte genomes reveals that bryophytes exhibit a larger number of unique and lineage-specific gene families than vascular plants.

Integrative analyses of transcriptome and whole-genome sequencing data for 1,188 tumours across 27 types of cancer are used to provide a comprehensive catalogue of RNA-level alterations in cancer.

A pooling–deconvolution algorithm identifies cooperative catalyst behaviours with low experimental cost while accommodating potential inhibitory effects between catalyst candidates.

‘Ultrathin’ gold interlayers are shown to form nanoparticles that balance optical losses and electrical contact, enabling efficient perovskite–perovskite integration for scalable and durable triple-junction photovoltaics.

Huang and colleagues report that TIM4–AMPK signaling induces downregulation of the mitochondrial HSP90 chaperone TRAP1 in tumor-associated macrophages, thereby enhancing their immunoinhibitory function and promoting immune evasion and tumorigenesis.

Engineered polar nanoclusters in tin-doped barium titanate thin films enable microwave tunability of ~74% at 6 GHz under low bias, offering a strategy to achieve high tunability with minimal dielectric loss for microwave communication.

Stereoselective synthetic routes use P3HB (a polyester produced by bacteria) as a chiral feedstock for related polymers that have properties more amenable to processing and use.

A meta-analysis of biodiversity effects on plant productivity found that complementarity effects increased over time whereas selection effects decreased, and both remained consistent across global variations in climate.

A pan-cancer genomic analysis reports the effects of structural variations on chromatin domains (TADs). Most TAD disruptions do not result in appreciable changes in expression of nearby genes.

High-density multimodal soft bioelectronic fibres provide a platform for minimally invasive implantable electronics, where diverse sensing and stimulation functionalities can be effectively integrated.

Using simultaneous EEG-PET-MRI, this study reveals tightly coupled physiological dynamics during the descent from wakefulness into NREM sleep and identifies network-specific activity underlying sensory arousal in NREM sleep.

Investigating the inner structure of baryons is important to further our understanding of the strong interaction. Here, the BESIII Collaboration extracts the absolute value of the ratio of the electric to magnetic form factors and its relative phase for e + e − → J/ψ → ΛΣ decays, enhancing the signal thanks to the vacuum polarisation effect at the J/ψ peak.

The CMS Collaboration reports the study of three simultaneous hard interactions between quarks and gluons in proton–proton collisions. This manifests through the concurrent production of three J/ψ mesons, which consist of a charm-quark–antiquark pair.

The authors report a meta-analysis of methylome-wide association studies, identifying 15 significant CpG sites linked to major depression, revealing associations with inflammatory markers and suggesting potential causal relationships through Mendelian randomization analysis.

It is thought that only climate change drives temporal tree mortality increases in old forests. Here, Luo and Chen show that both forest dynamics and climate change drive temporal tree mortality increases in young and old forests, and that climate change-associated mortality increases are higher in the young forests.

A genome-wide association meta-analysis study of blood lipid levels in roughly 1.6 million individuals demonstrates the gain of power attained when diverse ancestries are included to improve fine-mapping and polygenic score generation, with gains in locus discovery related to sample size.

The Verwey transition of magnetite is complex due to the coexistence of strong correlations and electron-phonon coupling. Here, the authors use resonant inelastic X-ray scattering to show evidence for magnetic polarons in magnetite and provide insight into the nature of the transition.

An analysis of 2,954 genomes from 38 cancer subtypes identified 19,166 retrotransposition events in 35% of samples. Aberrant LINE-1 retrotranspositions can lead to the deletion of tumor-suppressor genes as well as the amplification of oncogenes.

Typical quantum error correcting codes assign fixed roles to the underlying physical qubits. Now the performance benefits of alternative, dynamic error correction schemes have been demonstrated on a superconducting quantum processor.

The LHCb experiment at CERN has observed significant asymmetries between the decay rates of the beauty baryon and its CP-conjugated antibaryon, thus demonstrating CP violation in baryon decays.

In this study the authors consider the structural variants (SVs) present within cancer cases of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. They report hundreds of genes, including known cancer-associated genes for which the nearby presence of a SV breakpoint is associated with altered expression.

Ferromagnetism is observed at ferroelastic domain walls in strontium titanate and its heterostructures with other oxides. Applying strain can reverse the magnetism. This suggests the possibility of device engineering using domain walls.

The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 cancer whole genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

In a quantum simulation of a (2+1)D lattice gauge theory using a superconducting quantum processor, the dynamics of strings reveal the transition from deconfined to confined excitations as the effective electric field is increased.

Ferromagnetic systems produced by the transition metal doping of semiconductors may be used as components of spintronic devices. Here, a new ferromagnet, Li_1+y(Zn_1-xMn_x)As, is prepared in bulk quantities and shown to have a critical temperature approaching 50 K.

De novo synthesis of amino acids supports the production of matrix proteins by fibroblasts. Here, Meliton et al. demonstrate a critical role for mitochondrial one-carbon metabolism in the production of glycine, and glycine-rich collagen proteins.

Inbreeding depression has been observed in many different species, but in humans a systematic analysis has been difficult so far. Here, analysing more than 1.3 million individuals, the authors show that a genomic inbreeding coefficient (FROH) is associated with disadvantageous outcomes in 32 out of 100 traits tested.

Whole-genome sequencing data from more than 2,500 cancers of 38 tumour types reveal 16 signatures that can be used to classify somatic structural variants, highlighting the diversity of genomic rearrangements in cancer.

The coupling of ferroelectric and antiferromagnetic order in BiFeO₃ makes it appealing for applications however the presence of domain structure acts to undermine this potential. Here, the authors demonstrate BiFeO₃thin films with a single domain of electrical polarization and canted antiferromagnetic order.

Finite momentum superconducting pairing refers to a class of unconventional superconducting states where Cooper pairs acquire a non-zero momentum. Here the authors report a new superconducting state in bulk 4Hb-TaS₂, where magnetic fields induce finite momentum pairing via magnetoelectric coupling.

The ATLAS Collaboration reports the observation of the electroweak production of two jets and a Z-boson pair. This process is related to vector-boson scattering and allows the nature of electroweak symmetry breaking to be probed.

Whole-genome sequencing data for 2,778 cancer samples from 2,658 unique donors across 38 cancer types is used to reconstruct the evolutionary history of cancer, revealing that driver mutations can precede diagnosis by several years to decades.

Topological superconductivity is a promising concept for generating fault-tolerant qubits. Here, the authors report surface superconductivity at 5 K in a topological semimetal—trigonal PtBi₂.

Quantum simulators offer a test bed to emulate physical phenomena that are difficult to reproduce numerically. Using a multi-element superconducting quantum circuit, Chen et al.emulate weak localization for a mesoscopic system using a control sequence that lets them continuously tune the level of disorder.

Surface Fermi arcs (SFAs) are characteristic features of a topological Weyl semimetal but there is no easy way to manipulate them so far. Here, the authors report manipulation of the shape, size and connections of SFAs in a Weyl semimetal NbAs, leading to an unusual topological Lifshitz transition.

A special class of topological Weyl semimetal state is predicted without respecting Lorentz symmetry. Here, Jianget al. report direct visualization of the unique surface Fermi arcs of MoTe₂, confirming its type-II topological Weyl semimetal nature.