Search

Global analysis of obesity trends from 1980 to 2024 in 200 countries and territories using data from 4,050 population-based studies reveals that framing obesity as a single global epidemic masks the highly varied dynamics across countries and age groups.

Chemically induced dimerization (CID) systems allow control over cellular processes. Here, the authors present a proof-of-principle demonstration that a complete CID system can be de novo designed, reporting a designed ligand and protein pair where a protein homodimer is induced by a macrocyclic peptide.

Advancing Li-CO₂ systems as a sustainable alternative technology requires a deep understanding of the reaction mechanisms. Here, authors establish a controlled supply of O₂ in Li-CO₂ batteries as a strategy to increase performance and reveal the distinct reaction pathways under CO₂ and CO₂/O₂ gas.

FLT3-ITD mutations drive relapse in acute myeloid leukemia (AML) despite targeted therapies. This group studies therapeutic potential and resistance mechanisms of FLT3-ITD inhibition with QUIZartinib and Omacetaxine Mepesuccinate (QUIZOM) in preclinical and clinical AML specimens.

Ferromagnetic systems produced by the transition metal doping of semiconductors may be used as components of spintronic devices. Here, a new ferromagnet, Li_1+y(Zn_1-xMn_x)As, is prepared in bulk quantities and shown to have a critical temperature approaching 50 K.

The CMS experiment at CERN reports one of the highest-precision measurements of the W boson mass, finding it in line with standard model predictions and at odds with recent anomalous measurements.

Pt-based alloy clusters within zeolite channels are promising catalysts for the dehydrogenation of alkanes, but controlling their distribution under operation is challenging. Now a water-soaking treatment to regenerate and minimize atom migration in K–PtSn@MFI catalysts is introduced, resulting in enhanced stability for non-oxidative ethane dehydrogenation.

How low-energy particles are pre-accelerated and injected into the diffusive shock acceleration process has long been a mystery. Here, the authors show the shock discontinuity interaction induces intense electron acceleration and may be a solution.

Short-read sequencing-based approaches are limited to gene-level expression and cannot identify full-length transcript isoforms. Here, the authors apply single-cell long-read RNA sequencing to glioblastoma and identify tumor-specific isoforms and peptides deriving from them as neoantigens.

Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

Lipid nanoparticle formulation requires a mixing step which can impact performance. Here, the authors report on a study into the differences different mixing techniques have showing that hand pipetting and microfluidic mixers produce different lipid nanoparticles to commercial turbulent flow mixers

LHAASO has detected γ-ray emission with a spectrum extending to 2 PeV from the pulsar wind nebula (PWN) powered by PSR J1849-0001, indicating an extreme particle acceleration efficiency and challenging the current particle acceleration theories.

The fungus Candida albicans is ubiquitous and usually harmless in the human gut, but can also cause systemic infection. Here, Kakade et al. show that fungal secretion of an immunomodulatory toxin, candidalysin, activates a host IL-17-DUOX2 axis that regulates C. albicans colonization of the intestine.

Diluted magnetic semiconductors are promising spintronic materials, however the simultaneous doping of charge and magnetic moment has prevented synthesis of bulk samples. This work reports the synthesis of a bulk magnetic semiconductor (Ba_1−xK_x)(Zn_1−yMn_y)₂As₂with Curie temperatures up to 180 K.

PTCHD1-AS, which encodes a long non-coding RNA, is associated with the aetiology of autism spectrum disorder in humans through striatal molecular and circuit-level dysregulation.

High-latitude soils are future soil organic carbon loss hotspots, with losses dominated by particulate organic carbon (POC). The fraction of POC in total SOC (f_POC) is a key indicator, emphasizing the climate importance of preserving POC.

This study develops a platform that enables simultaneous, multiplexed tracing of 30 nitrogen isotope-labelled metabolites, uncovering differences in pyrimidine synthesis pathway choice between primitive and differentiated cells.

Triplet excitons in OPVs can redissociate via the charge-transfer state into free carriers, reducing losses and improving efficiency, enabled by molecular design controlling singlet–triplet energetics through exciton delocalization.

The authors from the ALICE collaboration identify multiple species of mesons and baryons and measure the anisotropic flow with non-flow removal techniques in pp and p-Pb collisions at the LHC, identifying the hallmark of quark flow associated with an expanding quark-gluon plasma.

Here the authors report real-world evidence through a retrospective analysis of a multinational cohort of 1.8 M older adults showing that GLP1RAs and SGLT2 inhibitors carry lower risk for hyperkalemia than sulfonylureas. However, SGLT2 inhibitors increased risk of ketoacidosis. Findings support safety-conscious prescribing for older adults, who are often underrepresented in clinical trials.

The understanding of the reemergence of pressure induced superconductivity in alkali-metal intercalated FeSe is hampered by sample complexities. Here, Sun et al. report the electronic properties of (Li_1–xFe _x )OHFe_1–ySe single crystal not only in the reemerged superconducting state but also in the normal state.

Enhancing the superconducting temperature is often the main driver of synthetic studies of novel superconducting materials. Now, an approach yielding an air-stable iron selenide system that superconducts up to 40 K is reported.

Symmetry rules usually prevent interactions between distinct vibrational modes. Now it is shown that charge order fluctuations can mix modes, enhancing the chiral lattice response in a ferroaxial electronic crystal.

Self-assembled hole-selective molecules can enable high performance in perovskite solar cells, but controlling the hole extraction efficiency is challenging. Tianyu Li et al. address this by designing molecules that adopt a quasi-random orientation on the substrate.

The Human Development Multiomic Atlas catalogues single-cell accessibility and gene expression data from human fetal cells across 12 organs, enabling the inference of syntactic rules for motifs that govern cell-type-specific transcription factor binding and chromatin accessibility during human development.

Modular RNA nanostar motifs spontaneously assemble into programmable synthetic condensates in the nucleus and cytoplasm, with RNA design controlling localization, sequence-specific target recruitment and orthogonal assembly.

Highly axial lanthanide complexes with strong magnetic anisotropy are attractive candidates for high-performance single-molecule magnets. Now dysprosium(III) and terbium(III) homoleptic bis(stannolediide) complexes have been synthesized, with the dysprosium compound exhibiting a high energy barrier to relaxation and a high blocking temperature. Access to a rare divalent Dy(II) analogue displaying magnetic anisotropy has also been demonstrated.

The OCTCube models integrate optical coherence tomography and other imaging modalities to achieve state-of-the-art performance in predicting retinal diseases with strong generalizability across cohorts, devices and modalities.

Li-rich oxides suffer from severe degradation in lithium-ion batteries. To investigate this, authors employ operando methodologies to follow microstructural changes and demonstrate that interlayer twinning structures and intralayer frustrations formed during cycling drive performance degradation.

Owing to electron localization, two-dimensional materials are not expected to be metallic at low temperatures, but a field-induced quantum metal phase emerges in NbSe₂, whose behaviour is consistent with the Bose-metal model.

Androgen activity in the male embryonic hindbrain prolongs hindbrain differentiation in male individuals and drives sex differences in the incidence and prognosis of posterior fossa type A (PFA) ependymoma, an aggressive childhood brain tumour.

Reti-Pioneer, a retinal imaging artificial intelligence framework, identified diverse systemic diseases and demonstrated feasibility in a primary care silent trial, offering a pathway toward scalable clinical evaluation.

Bioactivity-guided isolation of specialized metabolites is an iterative process. Here, the authors demonstrate a native metabolomics approach that allows for fast screening of complex metabolite extracts against a protein of interest and simultaneous structure annotation.

Identifying jets originating from heavy quarks plays a fundamental role in hadronic collider experiments. In this work, the ATLAS Collaboration describes and tests a transformer-based neural network architecture for jet flavour tagging based on low-level input and physics-inspired constraints.

Nonlinear optical micropolarimetry and atomistic Monte Carlo simulations of monolayer NiPS₃ evidence a Berezinskii–Kosterlitz–Thouless phase that, with decreasing temperature, gives way to long-range order consistent with a six-state clock model.

Solid-state synthesis of single-crystalline battery cathodes is widely used but remains poorly understood. Here, authors reveal competing multiscale chemical and structural processes during sintering that are crucial for understanding structure–property relationships and guiding materials optimization.

A high-resolution spectroscopic analysis reveals ultralow amounts of heavy elements in the star SDSS J0715−7334. The star originates from the Large Magellanic Cloud and probably formed directly after the first stars through dust cooling.

When 100 social and behavioural science claims were examined, 34% of reanalyses closely matched the original results, with 74% reaching the same conclusion, revealing limited robustness of single-path analyses and the need to address analytical uncertainty.

Molecular frameworks featuring perovskite-related topologies rarely exhibit strong magnetic correlations and high-temperature magnetic order. Now it has been shown that the cubic molecular framework Cr(pyrazine)₃ exhibits persistent compensated ferrimagnetism with oxide-strength magnetic coupling and nearly zero net moment. The ferrimagnetism is sustained across a broad temperature range and extends well above room temperature.

Two distinct types of atomic insulator can be distinguished by the distribution of charges within the unit cell. Now, real-space imaging of WSe₂ shows that it is a so-called obstructed insulator.

Soft and conducting organic materials are promising for electronic devices, though their nanostructures are not fully understood, due to the lack of high resolution real spacing imaging of these complex systems. Here the authors use cryogenic transmission electron microscopy methods to investigate the morphology of PEDOT:PSS in the presence of additives and upon hydration.

This study explores the clonal architecture of aplastic anemia across age using single-cell approaches. Somatic inactivation of specific human leukocyte antigen risk alleles is a frequent event and often occurs in multiple independent events.

Electrochemical CO₂ reduction to multicarbon products is hindered by difficulties in microenvironment control at high current densities. Here the authors demonstrate that biopolymer coatings on electrocatalysts enhance local conditions, achieving high Faradaic efficiencies and challenging assumptions about the need for hydrophobic materials in such systems.

Reducing dissipation when generating spin currents remains a central challenge in spintronics. Now, an artificial ferrimagnet is shown to produce spin current output and simultaneously lower magnetic damping.

Vascular smooth muscle cells undergo complex transitions to multiple disease-related phenotypes in coronary artery disease. Using vascular smooth muscle lineage-traced single-cell RNA and ATAC sequencing, the authors map molecular spatiotemporal patterns of murine atherosclerosis and discover molecular mechanisms of TCF21-mediated coronary artery disease risk.

Exposome analyses across 34 countries showed that social exposures were associated with faster functional brain aging and physical exposures with faster structural brain aging.

Radiocarbon analyses show that dryland soils store organic carbon with a mean age of ~2100 years and release carbon averaging ~520 years old, suggesting that long-stored carbon in drylands is vulnerable to environmental change.

Genome-wide analyses identify genetic loci and plasma proteins associated with polycystic ovary syndrome (PCOS). This study highlights the hormonal and metabolic foundations of the disease and explores the impact of polygenic risk for PCOS in both sexes.

Coupling two ionic thermoelectric effects in n-type materials is scarce, restricting the development of high-performance systems. Here, the authors present an ionic-thermoelectric material with interactive thermo-diffusion/galvanic coupling effect based on coordination chemistry.

The STAR experiment at the Relativistic Heavy Ion Collider at Brookhaven National Laboratory demonstrates evidence of spin correlations in \(\Lambda \bar{\Lambda }\) hyperon pairs inherited from virtual spin-correlated strange quark–antiquark pairs during QCD confinement.