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2D polarization-sensitive detectors are usually limited by a responsivity-speed-polarization ratio trade-off. Here, the authors report mid-infrared polarization photovoltage field-effect transistors based on black phosphorus/MoS₂ heterostructures, showing a polarization ratio of 510, polarization angle sensitivity of ~46.57 mA/(W·degree) and response times of ~0.8 μs under 3.5 μm illumination.

Li-dendrite growth is an inherent problem for the application of Li-metal anodes in batteries. Here the authors coat the separator with functionalized nanocarbon with immobilized Li ions, regulating the dendrite growth direction and thereby improving the battery performance.

NatD is an acetyltransferase responsible for N-α-terminal acetylation of the histone H4 and H2A and has been linked to cell growth. Here the authors show that NatD-mediated acetylation of histone H4 serine 1 competes with the phosphorylation by CK2α at the same residue thus leading to the upregulation of Slug and tumor progression.

Organo-electrocatalysts that can be used for both inorganic and organic conversions have been reported, ranging from laboratory-scale to large-scale reactions. This work demonstrates the application of a range of amide-based catalysts on electrodes to drive various reactions, including the chlorine evolution reaction and other chlorine-related organic transformations.

Young, cognitively normal APOE4 mice display hippocampal network hyperactivity that predicts later memory decline. This phenotype is driven by neuronal APOE4 expression, which causes hyperexcitability of hippocampal neurons and can be reversed by targeting Nell2.

Lampreys are jawless vertebrates that can offer unique insights into vertebrate evolution. Here they generate a comprehensive cell atlas of the lamprey, uncovering 70 distinct cell types across 14 tissues, and identify pancreas-like cells in the lamprey small intestine.

Intercalation-type metal oxides are promising anodes for Li-ion batteries but suffer from low energy and power density together with cycling instability. A nanostructured rock-salt Nb₂O₅ formed via amorphous-to-crystalline transformation during cycling with Li⁺ is shown to exhibit enhanced performance.

Vanadium pentoxide is considered a promising lithium battery electrode, but suffers from poor rate capability and cyclability. Here, the authors synthesize graphene-modified nanostructured vanadium pentoxide and show significant improvement in rate performance and cycle life.

DECODE is a universal deconvolution framework for both cell types and cell states that can be applied to transcriptomic, proteomic and metabolomic data.

FUNDC1 in endothelial cell (ECs) via endothelin (ET) 1 release regulates insulin sensitivity and adiposity and that high fat diet feeding promotes obesity, insulin resistance and diabetes by increasing FUNDC1 and consequent ET1 release from ECs.

Future spintronic devices may be based on the transport of electronic spin without an associated charge current in thin film materials. Here, the authors demonstrate the interconversion of spin current at the interface between a normal metal and magnetic insulator via magnon-mediated current drag.

Single-atom catalysts have proven successful in many catalytic applications. Now, Li, Wu and co-workers show that single-atom catalysts can be prepared directly from bulk metals using an ammonia atmosphere, owing to the formation of volatile metal–ammonia species that are trapped by the nitrogen-rich carbon support.

C–H bond functionalization has become an important tool for many organic transformations, however such reactions typically require stoichiometric amounts of external oxidants. Here the authors report the photo-driven decarboxylative C–H trifluoromethylation of arenes using only low amounts of oxidant.

Atomically dispersed surficial iron in silver-doped zinc selenide quantum dots with an in situ self-assembly peptide act as efficient catalysts in anti-cancer multitherapy through controlled, ultrasound-induced oxidation.

This work showcases a versatile and scalable synthetic platform for photochromic single-atom catalysts, which effectively upcycle diverse waste polyesters into value-added monomers.

Defective oxides are attractive for energy conversion and storage applications, but it remains challenging to implant defects in oxides under mild conditions. Here, the authors develop a versatile lithium reduction strategy to engineer the defects of oxides at room temperature leading to enhanced photocatalytic properties.

The charge transport properties of organic semiconductors limit their low-dose X-ray imaging capability. Here, authors report 3D 4-methyl hydroxybenzoate for enhanced π-π stacking, achieving stable X-ray detection with detection limit of 4.22 nGy_air s⁻¹ and high-resolution imaging at 1.6 lp mm⁻¹.

This work demonstrates that stress-coupled atomic ordering at nanoscale Mn–Al–B interfaces will convert brittle boundaries into energy-absorbing zones, explaining the unusual coexistence of high strength, ductility, and low thermal expansion in magnesium alloys.

Water splitting provides an appealing route to generating carbon-neutral fuel, however the scarcity and cost of platinum, often used as a catalyst, necessitates a search for alternatives. Here, authors show cobalt atoms in ruthenium nanosheets to afford excellent hydrogen production activities.

Nelson et al. report that the APOE-R136S mutation protects against APOE4-promoted Alzheimer’s disease pathologies, including phosphorylated Tau accumulation, neuroinflammation and neurodegeneration, in mouse and human neuron models.

Future spintronic devices may exploit topological insulators, bulk insulators with unique spin-momentum locked conductive surface states. Here, the authors demonstrate the detection of thermally-generated spin currents in a ferromagnetic-insulator/topological-insulator heterostructure.

A monomer molecular dopant with high electron affinity is shown to accept up to two electrons from conjugated polymers with low ionization efficiency and then generate free charge carriers with an efficiency of up to 170%.

Egg-laying performance is an important phenotype for breeding chicken. Here, the authors explore the regulatory networks driving phenotypic differences in egg-laying, and identify laying-related variants and endocrine factors.

High-entropy nanocarbides (HENCs) containing 5–22 metal elements are synthesized through a nanoconfined impulse synthetic strategy enabled by Joule heating-induced in situ reactions in carbon nanotube films. These HENCs exhibit multi-element effects and enhanced electrocatalytic activities due to their nanoscale size and modified catalytic sites.

Selective neurodegeneration is a critical causal factor in Alzheimer’s disease. Zalocusky et al. demonstrate a causal chain linking neuronal ApoE expression to MHC-I expression and, subsequently, to tau pathology and selective neurodegeneration.

Human iPSC-derived neurons are generated from individuals with or without Alzheimer's disease carrying different APOE alleles and reveal a toxic, neuron-intrinsic gain of function of the ApoE4 variant that is a strong genetic risk factor for AD.

APOE4 is produced by neurons under stress, but the role of neuronal APOE4 in Alzheimer’s disease pathogenesis is still unclear. Here the authors report that selective removal of neuronal APOE4 in tauopathy mice mitigates many prominent Alzheimer’s disease-related pathologies.

Adult zebrafish possess the ability to regenerate injured hearts through a complex orchestration of molecular and cellular activities. Here, the authors present a single cell and spatially-resolved atlas of the regenerating zebrafish heart, which serves as a valuable resource for research on heart regeneration.

The inactivation of natural enzymes by radiation hinders their utility for radiotherapy. Here the authors report a single-atom copper nanozyme that can be utilized for enhanced radio-enzymatic therapy to resolve the crucial issues for the applications of natural enzymes.

An in situ phase-separation method at microscale level creates stretchable superelastic porous nanocomposite conductors, reduces conductive filler usage and enables strain-resilient wireless wearable and implantable bioelectronics.

An integrated smart capsule that encapsulates an array of electrochemical sensors can provide real-time, continuous and multiplexed monitoring of the gastrointestinal tract.

The mechanisms regulating protein lactylation, a post-translational modification, are not fully understood. Here, the authors discover that Histone deacetylase 6 (HDAC6) acts as the primary lactyltransferase for α-tubulin, regulating microtubule dynamics.

Cardiovascular diseases, underscore an urgent need for long-term cardiac monitoring and early detection of abnormalities. Here, the authors present a RF-based sensing system that monitors long-term heart rate variability with clinical-grade accuracy.

Enveloped viruses encased within a lipid bilayer membrane are highly contagious and cause diseases like influenza and COVID-19, so strategies for their prevention and inactivation are needed. Here, the authors develop a diatomic iron nanozyme with lipoxidase-like activity for the inactivation of enveloped viruses, where the diatomic iron sites destroy the viral envelope via lipid peroxidation.

Symmetry breaking at metamaterial interfaces is increasingly being used to obtain new optical device functionalities. Xu et al. discuss its use for building polarization-independent waveguides with asymmetric propagation properties and build such a device that operates at microwave frequencies.

Materials with higher-order multistates are desired for non-Boolean high-density storage. Here the authors realized sextuple intrinsic polarization states in vdW CuInP₂S₆, and reversible transformation among sextuple-, quadruple-, and double-polarization orders.

Precise displacement measurement via sound is crucial in science and engineering, yet limited by its low resolution. Here, the authors proposed the concept of topological pairs for achieving acoustic displacement metrology, and experimentally demonstrated an acoustic micrometer with resolving power of 1.2 μm at operating wavelength of 100 mm.

Single-atom catalysts maximize metal atom efficiency and exhibit properties that can be considerably different to their nanoparticle equivalent. Now a general host–guest strategy to make various single-atom catalysts on nitrogen-doped carbon has been developed; the iridium variant electrocatalyses the formic acid oxidation reaction with high mass activity and displays high tolerance to CO poisoning.