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The reconstruction and control of supramolecular ropes using minimalist building units remains a fundamental challenge. Here the authors demonstrate self-assembly of cyclo-tryptophan-proline dipeptide stereoisomers into crystalline supramolecular triple-helical structures with tunable S- or Z- twists governed by the configuration of tryptophan residues.

The surface chemical ordering in high entropy alloys is revealed by the surface sensitive imaging tool - scanning tunneling microscopy – which is enabled by the subtle differences in the partial density of states among different elements.

Metabolic profiling of extracellular vesicles for diagnostic applications remains challenging. Here authors develop ACTIVITY, a cascade-catalysis strategy to detect metabolically active extracellular vesicles, enabling macrophage phenotyping and differentiation of pneumonia patients from healthy controls.

Treatment failure exists in Induction chemotherapy followed by concurrent chemoradiotherapy (CCRT) for locoregionally advanced nasopharyngeal carcinoma (LA-NPC) patients. Here this group reports a phase 2 randomized trial evaluating the efficacy and safety of adding nimotuzumab, to CCRT on 246 patients with untreated, non-keratinising, stage II–IVA LA-NPC.

Zinc isotopes in basalts along a 1,100-km transect of the Gakkel Ridge record widespread mantle recycling of surface carbonates via ancient oceanic subduction, explaining the unusually carbon-rich nature of the Arctic asthenosphere.

This study presents a prefusion-stabilized vaccine candidate against Hantaan virus. The DNA and mRNA-LNP formats induce lasting neutralizing immunity in female mice, highlighting a promising advance in vaccine development.

Maternal obesity is known to cause systemic lipid dysregulation, yet its effect on lipid reprogramming during the maternal-to-zygotic transition (MZT) remains unknown. Here, they show that obesity disrupts very-long-chain fatty acids (VLCFAs) storage in oocytes, impairing peroxisomal protein import in 2-cell embryos.

Gel-based soft materials are attractive for flexible electronics, though are constrained by unfavorable mechanical properties. Here the authors design a geometry programmed self-wrinkling strategy for organo-hydrogels, enhancing mechanical and electronic properties.

Osteoarthritis is driven by epigenetic dysregulation, yet targeted therapies remain elusive. Here, the authors develop a cartilage-targeting hydrogel delivering BRD4-degrading PROTACs to suppress the BRD4- Nav1.7 axis and alleviate osteoarthritis.

High-latitude soils are future soil organic carbon loss hotspots, with losses dominated by particulate organic carbon (POC). The fraction of POC in total SOC (f_POC) is a key indicator, emphasizing the climate importance of preserving POC.

Authors reconstruct the molecular evolution of severe fever with thrombocytopenia syndrome virus (SFTSV) in East Asia. SFTSV splits into two lineages with diversity driven by segment-specific reassortment; transmission occurs via distinct networks.

The COMPASSION16 trial showed survival benefits of cadonilimab plus standard therapy in advanced cervical cancer. Here, subgroup analysis confirms consistent progression-free and overall survival improvements across diverse patient profiles.

Current thermal wax refining methods are energy intensive. Here, the authors report a photothermal process using a nanoscale zero-valent iron catalyst and sunlight to refine low-grade waxes into high-grade waxes with narrow distributions.

The PD-1/PD-L1 pathway is central to immunotherapy, but PD-L1 recycling limits durable responses. This study identifies TM9SF2 as a key regulator of PD-L1 trafficking and shows that disrupting its PGK1-dependent complex depletes PD-L1 and enhances antitumor immunity.

RNA editing influences gene regulation in cancer. Here, the authors show that EZH2 regulates RNA editing by ADAR1 through remodeling its interactome and nuclear transport, thereby promoting MDM2 expression and prostate cancer progression.

This work presents a quantum-cutting heterostructure that emits tunable near-infrared light (900-2200 nm) under ultralow-power excitation. It enables AI-assisted multiplexed gas detection, offering a scalable strategy for broadband NIR light sources

The biological basis of afternoon nap remains unclear. Here, authors show that NPAS2 in mPFC TH-positive neurons activates POU2F2 to suppress TH level and dopamine production, thereby reducing wake-promoting neural activity and driving nap behavior.

Perovskite–silicon solar cells rely on buffer layers that avoid damaging the perovskite, but common tin-oxide layers force thicker transport layers that increase optical loss. The authors replace this layer with thermally evaporated antimony oxide, enabling thinner C₆₀ and higher-efficiency perovskite–silicon solar cells.

Conventional neuromorphic vision systems based on pixels-to-one-memristor architecture face efficiency challenge. Here, Sun et al. report an architecture employing one-pixel-to-multiple-memristor structure, mapping weight updates to voltage vectors to enhance both processing speed and energy efficiency.

Combining distinct confinement mechanisms can enable the engineering of novel electronic states. Here, the authors integrate a moiré potential with vertical quantum confinement in a heterostructure composed of twisted bilayer MoS₂ on (111)-oriented Bi nanofilms, revealing experimental signatures of a Wigner crystal.

Necrotizing enterocolitis (NEC) is a severe gastrointestinal disease of premature infants with unclear mechanisms. Here, the authors show that CD177⁺ neutrophil–platelet aggregates promote neutrophil extracellular trap (NET)-linked thromboinflammation in NEC and that blocking CD177/NET formation or low-molecular-weight heparin alleviates disease in mouse models.

Most kiwifruit species are vulnerable to high levels of heat stress. Here, the authors report natural variation at the GATA transcription factor binding site of EGY3 gene mediates chloroplastic ROS homeostasis to confer kiwifruit thermotolerance.

A genome-wide association study in rice identifies variation in SBRR1 associated with sheath blight resistance. Introducing the SBRR1-R allele into a commercial rice variety reduces yield loss under severe exposure to sheath blight disease.

The unfolded protein response is activated at the ER due to protein misfolding. Here the authors show that in Magnaporthe oryzae, the plasma membrane localized MoPh1 protein perceives stress through ER-PM contact sites and stimulates autophagy to support stress relief.

While previous studies of Kondo physics have largely focused on electronic properties, the authors here investigate magnon damping in the d-electron van der Waals magnet Fe₃GeTe₂. They observe logarithmic scaling of the damping at low temperatures and a minimum at an intermediate temperature, which they attribute to Kondo coupling between itinerant electrons and local moments.

High-strength lightweight steels are vital for saving energy and enhancing safety in engineering applications. Here, the authors tune atomic-scale strain waves in a steel alloy to expand dislocation storage capacity, significantly enhancing strength-ductility synergy.

Systemic lupus erythematosus (SLE) is a complex autoimmune condition and treatment options have limited efficacy. Here, by analysis clinical samples and employing preclinical models, the authors show that cGAMP levels are elevated in the plasma of patients with SLE and that loss of cGAS ameliorates symptoms in an imiquimod-induced lupus model. Importantly, they identify prasugel as a cGAS inhibitor with promising therapeutic potential.

This study presents azo-Q2a, a quinidine-derived photo-switchable molecule that enables optical control of Na_V1.5. It exhibits selectivity, and its binding mode is revealed by cryo-EM, offering a potential strategy for managing heart arrhythmia.

Natural variation in the promoter of OsTPS8 contributes to differences in grain chalkiness and seed vigor between indica and japonica rice subspecies by altering trehalose-6-phosphate biosynthesis and α-amylase levels.

Lactide is enantiomeric, and depolymerization of poly(lactic acid) (PLA) with mixed chirality typically produces a racemic mixture. Here, the authors use a chiral Aluminium catalyst for the stereoselective depolymerization of PLLA and PDLA towards chiral lactide with high optical purity.

This study reveals that reduced TIGAR expression in ulcerative colitis promotes G6PD/6PGD lactylation, inhibiting NADPH production, and promotes Trx1 and AGR2 S-nitrosylation, impairing mature MUC2 synthesis and damaging the intestinal mucus barrier.

Top-down trophic interactions are critical drivers of microbiome dynamics but are difficult to predict. Here, the authors demonstrate that nematode-driven shifts in microbiomes enhance pathogen suppression and promote plant health through a feedback loop involving nematodes and bacteria.

This study from Wei-Guang Li, Tian-Le Xu and colleagues shows that neuropeptide Y released by specific hippocampal inhibitory neurons can switch fear memories into extinction memories by acting on two distinct receptor-defined neuron populations.

Researchers identify FOXJ3 variants in focal epilepsy and cortical dysplasia and show that FOXJ3 regulates neuronal migration and cortical layer formation by controlling the PTEN–mTOR pathway; disruption of this process leads to abnormal brain development.

Here authors present an embryonic zeolite-mediated suture synthesis, which enables the scalable fabrication of high-flux SSZ-13 zeolite membrane bundles, showing >4 MPa pressure resistance and >220 days stability for humid CO₂/CH₄ separation, highlighting high industrial potential for biogas upgrading.

Frameworks of β-branched aromatic D-amino acids are crucial for the efficacy of pharmaceuticals, but the synthesis of such scaffolds remained undeveloped. Here, authors present the first asymmetric synthesis of β-branched aromatic D-amino acid analogues via the transaminase BsDAAT catalyzed dynamic kinetic resolution (DKR) process.

High cost and aggregation of single-component fullerenes hinder inverted perovskite solar cell development. The authors synthesize a fullerene composite in high yield that cross-links during annealing, improving stability and efficiency while maintaining performance in various device formats.

The Taiwan Precision Medicine Initiative (TPMI) has built a cohort of more than half a million individuals with Han Chinese ancestry, providing a rich resource of genetic and medical data for this group.

Measurement-based quantum computing implements quantum algorithms by performing sequences of measurements on special classes of entangled states, such as cluster states. This approach has now been demonstrated on a superconducting quantum processor.

Robustness checks and reproduction of analyses with existing and updated data based on 110 articles in economics and political science journals with data and code-sharing requirements found high levels of robustness and reproducibility and determined that robustness was not dependent on author characteristics or data availability.

BioMedAgent is a self-evolving LLM multi-agent framework that learns to use various bioinformatics tools and chain them into executable workflows for autonomously carrying out diverse biomedical data tasks initiated by natural-language prompts.

As the properties of polymer gels are influenced by solvent as well as the network, choice of solvent is important for determination of properties. Here, the authors report the use of polyethylene glycol as a solvent for the formation of a dissipative gel, with coupling of elasticity and viscosity.

Polar molecule-based magnetic materials capable of multistate switching have garnered significant interest for their potential applications in next-generation memory devices, sensors, and energy conversion. Here the authors report a trinuclear cyanide-bridged FeCo compound that exhibits photo- and thermo-induced ferroelectric phase transition and solvent-switched on-off ferroelectricity.

Aqueous zinc batteries suffer from poor reversibility due to interfacial instability. Here, the authors propose an electric field-responsive electrolyte design that modulates zinc-ion solvation and interfacial chemistry, leading to uniform deposition and extended cycling stability.

A large-scale study on the replicability of claims from social and behavioural science journals reports that about half of the results replicate in the same patterns as the original study.

The Taiwan Precision Medicine Initiative recruited and genotyped more than half a million Taiwanese participants, almost all of Han Chinese ancestry, and performed comprehensive genomic analyses and developed polygenic risk score prediction models for numerous health conditions.

The authors provide experimental evidence that Eu substitution in the spacer layer of Nd_1-xEu_xNiO₂ thin films enhances the superconducting gap, driving the system toward a strong-coupling regime. The Eu substitution also introduces exchange coupling between Eu 4f magnetic moments and Ni 3d_x²−y² electrons, leading to magnetic-field-enhanced “re-entrant” superconductivity.

Androgenetic alopecia is the most common type of hair loss, but its drivers remain poorly elucidated. Here, the authors show that hyperactive contraction of the follicle connective tissue sheath impairs hair growth by activating mechanosensitive signaling, suggesting a tractable therapeutic target.