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The homocatenation of electron-deficient Group 13 metals to form metal-metal multiple bonds through covalent self-assembly remains extremely challenging. Here, the authors demonstrate the synthesis and characterization of N-heterocyclic carbene-stabilized digallyl digallenes which exhibit unsaturated Ga-Ga=Ga-Ga chains with trans-bent geometries.

KP.3.1.1 S S31del confers enhanced immune escape and increased infectivity, which is counterbalanced by NSP10 S33C. The opposing effects of these mutations highlight the complex interplay of viral genomic elements in shaping their overall fitness.

Reflection interference microscopy provides dynamic, non-invasive, operando imaging capabilities that enable the solid–electrolyte interphase formation and evolution of a battery to be mapped in real time with high sensitivity.

Although ammonia synthesis represents a major chemical industry, developing highly effective non-iron catalysts is a challenging task. Now it has been shown that anchoring fullerene onto non-iron transition metals separates and activates catalytic sites for hydrogen and nitrogen intermediates, boosting ammonia synthesis rates.

The aetiology of primary biliary cholangitis (PBC) remains unclear. Here, the authors find that the numbers of DUOX2⁺ ACE2 ⁺ small cholangiocytes in human and mouse livers are inversely associated with disease severity, and present data indicating that they may be the target of polymeric immunoglobulin receptor (pIgR) -mediated humoral responses, suggesting that preservation of these cells and targeting anti-pIgR autoantibodies may be valuable strategies for therapeutic interventions in PBC.

Biomedical X-ray imaging requires high spatial and temporal resolution of the detectors. Liu et al. report a screen-printed perovskite direct-conversion X-ray CMOS imager with a spatial resolution of 5 lp mm⁻¹ and a speed of 300 fps for low-dose 2D radiography and 3D computed tomography imaging.

Aqueous rechargeable batteries are promising for grid storage and electric vehicles, but they suffer from poor cycle life due to anode instability. Exploiting stable ion-coordination charge storage and chemical inertness towards aqueous electrolytes, quinones are now reported as stable anodes.

Secreted isoform of endoplasmic reticulum membrane complex subunit 10 (scEMC10) is a secreted protein of incompletely understood physiological function. Here the authors show that scEMC10 is upregulated in people with obesity, and that that genetic EMC10 deletion or antibody-based neutralization of EMC10 prevents diet-induced obesity in mice.

The controlled transport of gas bubbles in liquids is crucial for applications like microfluidics and energy systems, yet achieving stable, high-speed motion remains a significant challenge. The authors demonstrate a spark discharge–driven ring bubble generator that produces high-circulation bubbles with velocities up to 12 m/s and travel distances of 800 mm, offering programmable, resilient, and scalable bubble transport in confined spaces.

Owing to sluggish Mg-ion dissociation and diffusion, Mg-based batteries have low power densities. Here the authors carry out rational designs for both the cathode and the electrolyte to enable ultrafast kinetics of a Mg metal battery.

Here, the authors show that a single mutation in JN.1 spike, L455S, confers better spike cleavage and enhances virus infectivity in differentiated primary human nasal epithelial cells while increasing immune evasiveness, contributing to the efficient spread of JN.1.

While the promise of low metal utilization has brought single-atom catalysts (SACs) into the spotlight, intrinsic limits in reactivity still restrict their application to a small set of reactions. Here, the authors expand the repertoire of SAC transformations with a nitrogen-doped, carbon-supported, Ru single-atom catalyst that exploits the effect of peripheral N species to promote propane dehydrogenation.

Tetik-Elsherbiny et al. demonstrate that the E3 ubiquitin ligase RNF20 mediates RNA polymerase II promoter-proximal pausing and alternative splicing, regulating the bioavailability and signaling of pro-angiogenic factors and angiogenesis.

Porous covalent organic frameworks have arisen as tunable photocatalysts for H₂ production. Here, authors report frameworks engineered with co-catalyst binding sites to improve photocatalytic H₂ evolution performances.

Bose-Einstein condensates (BEC) of ultracold atoms serve as low-entropy sources for a multitude of quantum-science applications. Here, the authors realize a non-ground-state caesium BEC with tunable interactions and tunable loss, opening up new possibilities for polaron and impurity physics.

Xiaowen Sun and colleagues report the whole-genome sequencing of the common carp, Cyprinus carpio. They also resequenced 33 representative accessions from a worldwide collection and provide insights into population structure and evolution.

The inactivation of natural enzymes by radiation hinders their utility for radiotherapy. Here the authors report a single-atom copper nanozyme that can be utilized for enhanced radio-enzymatic therapy to resolve the crucial issues for the applications of natural enzymes.

FBXL5 deficiency in CD11c⁺ myeloid cells causes iron overload, enhancing NF-κB recruitment to the IL-6 promoter and increasing IL-6 production. This exacerbates neutrophil infiltration and liver injury in mice, while IL-6 neutralization mitigates damage, revealing iron regulation as a therapeutic target.

Catfish represent 6.3% of all vertebrate species, and occupy a phylogenetic position close to the common ancestor of bony fish. Liu et al. present a reference genome of the channel catfish, and reveal a genomic basis for the evolutionary loss of scales in these species.

Magnesium rechargeable batteries potentially offer high-energy density, safety, and low cost. Here the authors show a battery that reversibly intercalates magnesium monochloride cations with excellent rate and cycle performances in addition to the large capacity.

Batteries based on multivalent metal anodes hold great promise for large-scale energy storage but their development is still at an early stage. This Review surveys the main complexity arising from anodes, electrolytes and cathodes, and offers views on the progression path of these technologies.

The emergence of new materials and cell designs is enabling the transition of aqueous batteries into competitive candidates for reliable and affordable energy storage. This Review critically examines the scientific advances that have enabled such a transition and explores future research prospects.

Single-cell RNA sequencing reveals that the Hippo pathway in cancer cells influences the composition of cancer-associated fibroblasts and modulates the tumor microenvironment, thereby promoting cancer growth.

A facile chemical vapor method is developed for large-scale synthesis of CsPbX₃-ZSM-5 composites. Owing to the effective confinement and encapsulation of CsPbBr₃ QDs by ZSM-5, the composites possess excellent photophysical properties and ultrahigh stability. The prepared composites are applied in white light-emitting diodes (WLEDs) and multicolor-coded anti-counterfeiting inks. This technique provides the probability for commercial production of these perovskite composites with robust stability.