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Multipole datasets and targeted sensitivity simulations reveal interannual variability in Middle Eastern dust accounts for ~36 % of the Indian Ocean Dipole variance during boreal autumn, surpassing the influence of El Niño-Southern Oscillation.

Yin and colleagues propose that diffraction-limited fluorescence videos contain hidden binding-type information. The authors present a deep learning model, T2C CNN, which exploits that hidden information to classify molecular interactions with high accuracy using a single dye in seconds.

Retinal prostheses aim to restore sight by stimulating residual retinal cells. Here, the authors develop a photoacoustic stimulation technology using a PDMS and carbon-based flexible film that activates retinal cells with near-infrared laser pulses, ex vivo and in vivo.

Understanding the mechanism of high-temperature tolerance will help to breed crops adaptive to warming climate. Here, the authors show SLG1, a cytosolic tRNA 2-thiolation protein 2 encoding gene, is differentiated between the two Asian cultivated rice subspecies and confers high temperature tolerance of indica rice.

Interferometric imaging based on phase-sensitive OCT in living rat eyes demonstrates electromechanical deformation of the rod outer segment associated with reversible isomerization of rhodopsin, providing a new assay for studying visual transduction.

Codelivery of an antifungal drug within antifungal micelles achieves effective combinatorial therapy.

Natural disasters induce power outages with unequal impacts on poverty and non-poverty counties in China. Climate change will further exacerbate this disparity.

ESKAPE pathogens-induced meningitis threatens human health due to antimicrobial resistance and low permeability of blood-brain barrier (BBB). Here, the authors report that biguanide-functionalized poly(2-oxazoline) exhibits potent activity against drug-resistant ESKAPE pathogens and effectively penetrates the BBB, providing a promising strategy for combating ESKAPE pathogens and meningitis.

Mutation detection in cfDNA is crucial for cancer diagnosis and monitoring. Here, the authors develop an Enzymatic Cleavage-directed Single Nucleotide Variant Sequencing by integrating Argonaute-mediated cleavage and stem-loop DNA-initiated PCR amplification for cfDNA mutation detection.

Achieving selective propylene epoxidation with molecular oxygen is a highly sought-after yet difficult objective. Here, the authors present a novel approach involving ligand protection and selective facet etching to synthesize internally hollow Cu₂O nanoframes, which exhibit outstanding catalytic activity for the reaction.

The Jahn-Teller effect is the spontaneous symmetry breaking of the molecular structure caused by the coupling of electrons and nuclei. Here the authors use ultrafast Coulomb explosion imaging to map the evolution of the fundamental symmetry lowering process in photoionized methane within around 20fs.

Iron oxide nanoparticles are used for iron supplementation and as contrast agents for magnetic resonance imaging. Here, Kaittanis et al. show that these nanoparticles can also be used as pH-sensitive drug delivery vehicles, and that drug loading and release can be monitored in vivoby magnetic resonance imaging.

There lacks a comprehensive analysis on the large-scale deployment of solar photovoltaic projects and its impact on poverty alleviation. Here the authors show that solar photovoltaic poverty alleviation pilot policy increases per-capita disposable income in a county by approximately 7%-8%.

Selective CO₂-to-liquid conversion remains a major challenge due to inertness of CO₂. This work designs Pd nanoneedles with bent Pd–Pd bonds, enabling >99% selective formic acid production under mild conditions by enhancing CO₂ activation.

Global land cover conversions increased carbon uptake during 1982 to 2019, with newly established forests in the Northern Hemisphere driving gains that counterbalanced emissions from tropical deforestation.

The proton-sensing GPCRs detect extracellular low pH and regulate diverse physiological responses. Here, the authors report cryo-EM structures of GPR4, which provide insight into the structural features of proton sensing mechanism.

Power outages have a statistically significant and negative impact on electric vehicle adoption. A doubling of power outages in one year in China can create a decline of more than $ 31.3 million per year in carbon reduction benefits.

How does the brain encode complex movement sequences? Qi et al. reveal that the brain decomposes sequences into temporal states, each corresponding to a small movement fragment, with motor cortex neurons dynamically altering their encoding across states.

Diagnosing rare diseases, such as choroid neoplasias, remains a critical challenge. Here, the authors develop a multimodal concept-based interpretable model (MMCBM) to distinguish uveal melanoma from hemangioma and metastatic carcinoma, obtaining performance comparable to senior ophthalmologists in a large cohort of Asian patients with choroid neoplasms.

The potassium channel KCNQ2 can be activated by analgesics and antiepileptic drugs via an unclear mechanism. Here authors report structures of KCNQ2-CaM in complex with cannabidiol, PIP2, and HN37 and elucidate the mechanisms of activation.

The molecular mechanism by which acetylation regulates manganese superoxide dismutase (MnSOD) activity and its oncogenicity is unclear. Here the authors show that an acetylation mimicking MnSOD mutant is a monomer, has peroxidase function and acts as a tumor promoting factor.

Optoretinography-based detection of phototransduction and cell deformations in the retina has been mostly centered on photoreceptors. Here, the authors use prolonged and multilayered optoretinography to study light-evoked deformations in rod photoreceptors, retinal pigment epithelium, and subretinal space.

MGAT1 is a glycosyltransferase critical for the synthesis and maturation of complex N-glycans. Here, the authors show that MGAT1 modulation of CD73 glycosylation and function regulates tumor immune response in triple-negative breast cancer.

Co-lead authors Wang, Zhang, Qiu, Lu and their colleagues model an incentive-based emergency demand response to counter heatwaves. The modelled responded leads to the peak load reduction of 7.32% for the covered households, and can achieve a 1.02% peak load reduction when reaching a wide audience with no additional financial burden on vulnerable groups.

Here, the authors provide evidence that SARS-CoV-2 N protein leads to autophagic degradation of Dicer, XPO5, SRSF3, and hnRNPA3, inducing DNA damage and proteotoxic stress, eventually causing pneumonia. The small-molecule drug PJ34 or anastrozole alleviates N protein-induced pneumonia.

This study shows the light-driven morphology conversion from gold nanospheres to gold nanoplates through an aggregation-coalescence-dominated growth pathway, demonstrated by the nanopore sensing technique.

AI-enabled cognitive assistance for therapeutic procedures has rarely been pre-clinically validated. Here, the authors propose an intelligent surgical workflow recognition suit AI-Endo for endoscopic submucosal dissection, extensively validated on external and animal trial datasets.

While SARS-CoV-2 S protein targeting monoclonal antibodies (mAbs) are well studied, little is known about N protein-targeting mAbs. Here, Kang et al. provide the crystal structure of the N protein RNA binding domain with a mAb derived from a convalescent patient and show that it compromises the N protein-induced complement hyperactivation.

The probability of purchasing an energy-efficient air conditioner increases as the temperature deviates from 20–22 °C in the United States, with the response varying by electricity price, background climate, and demographic characteristics.

Molecular catalysts provide an ideal model system to investigate the relationship between active site structure and catalytic performance. Here, the authors explore how electrochemical CO reduction to methanol can be controlled through modification of the active cobalt site in cobalt phthalocyanine.

Addressing mass and electron transfer challenges hinders practical application of photoelectrochemical (PEC) devices. Here, authors report a simulation-guided development of hierarchical triphase diffusion photoelectrodes, achieving an improved mass transfer and ensuring electron transfer for PEC gas/liquid flow conversion.

The development of new methodologies to convert plastics into fuels without relying on noble metal-based catalysts is desirable. Now it is shown that a layered self-pillared zeolite enables the conversion of polyethylene to gasoline with a selectivity of 99% and yields of >80% without the need to use external hydrogen.

In the summer, low-income households in the Arizona, US wait 4 - 7 °F (2.6–4.2 °C) longer than high-income households to turn on their AC units to save money on energy bills. This energy limiting behavior indicates a hidden form of energy poverty.

Using a self-referenced attosecond photoelectron interferometry on helium atoms, the electron subcycle motion along the light propagation direction is observed in the 15 pm range. A time delay of 15 ± 10 as between the electric-dipole and electric-quadrupole transitions is also revealed.

Real-time mid-infrared photothermal imaging of nitrile chameleons enables simultaneous, multiplexed measurement of enzymatic activity in living systems and is poised to reveal the spatiotemporal regulation of enzymes in health and disease.

A membrane- and DNA-targeting approach is used to design a compound that displays potent activity against multidrug-resistant fungal pathogens without inducing antifungal resistance.

Zhou et al. developed a specific small-molecule inhibitor of astrocytic Kir4.1 channels, Lys05, which exerts rapid-onset antidepressant effects in rodents without unwanted side effects, indicating Kir4.1 as a promising drug target.