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Organic solar cells (OSCs) rely on morphological optimization for high efficiency. The authors show cyclobutyl-mediated interchain supramolecular interactions among acceptors, suppressing electron-phonon coupling and optimizing acceptor alloy phase morphology in ternary OSCs to achieve efficiencies approaching 21%.

The electron-phonon coupling in organic semiconductors is key to improving performance for devices. Here, the authors show that modulating the penetrated donor-acceptor interface with low electron-phonon coupling, reduces non-radiative voltage loss for high-performance organic solar cell devices.

Paracrine signalling between tuft cells and enterochromaffin cells is a key mode of immune–sensory and gut–brain communication, and accounts for the pattern of gastrointestinal symptoms that occurs during parasite infections.

This study leverages single-nucleus multiomics to map cellular senescence atlas in aging human skeletal muscle and uncovers potential targets and senotherapeutics for treating age-associated sarcopenia.

Liu et al. report Chinese normative lifespan brain charts showing later neurodevelopmental milestones than those detected in Western cohorts. Individual deviations from these norms are valuable in assessing clinical risk and outcomes.

Here the authors investigated DHX36-induced RNA structurome changes by conducting Structure-seq and uncovered that DHX36 binding-induced 3’UTR structural accessibility enhances m6A dependent YTHDF1 binding to promote target mRNA degradation.

This study shows that the transcriptional targets of NANOG recruits UTP15 to gene promoters in mESCs. There, UTP15 supports the formation of Pol II condensates, thereby activating pluripotency gene transcription independently of its classic role.

cfDNA is a promising tool to detect early cancer, however, it has been limited by detection limits and technological ability. Here, the authors develop a method for simultaneous cfDNA methylation, fragmentation and copy number alteration sequencing and apply to a cohort of healthy and cancer patients.

A memristive blinking neuron—relying on atomic-scale filamentary dynamics for resistive switching and emitting photon pulses on integrating a critical number of incoming electrical spikes—can be used to build photonically linked three-dimensional spiking neural networks.

Yu et al. show that at least two distinct serotonergic DRN-to-BA pathways are involved in different aspects of anxiety-related behaviors via different molecular mechanisms.

While pyrocatalysis offers a means to store energy in chemical bonds from temperature changes, most materials show low conversion efficiencies. Here, authors examine Au nanoparticles on BaTiO3 and demonstrate localized plasmonic heat sources to enhance pyrocatalytic H₂ evolution.

The ability to manipulate the flux of ions across membranes is a key aspect of diverse sectors including water desalination, blood ion monitoring, purification, electrochemical energy conversion and storage. Here the authors illustrate the potential of using daily changes in environmental humidity as a continuous driving force for generating selective ion flux.

Conventional super-oscillatory devices suffer from numerical-aperture related issue including depth of focus, chromatic dispersion, and focusing, Here, the authors utilised multi-objective genetic algorithm to optimise the design and experimentally demonstrated lens with an extended depth of focus, ultra-large working distance and suppressed side-lobes.

In this triple-arm, placebo-controlled phase 3 trial, first-line treatment of patients with extensive-stage small-cell lung cancer with the anti-PD-L1 benmelstobart, tyrosine kinase inhibitor anlotinib and chemotherapy (CT) showed improved survival outcomes compared with anlotinib and CT or CT alone.

The design of easily synthesized high molecular weight giant molecular acceptors is urgently needed. Here, the authors report a branch-connected dendritic hexamer acceptor that exhibits enhanced charge transport ability, achieving device efficiency of 19.4% for binary organic solar cells.

A heteroepitaxial-strain-based strategy for enhancing the stability of perovskite quantum dots for spectrally narrow (pure) red LEDs is reported.

The authors present a simple and rapid way for fabricating gold microsphere arrays through a laser-irradiated ripening strategy. These gold microspheres are suitable for reliable high-resolution bonding applications due to their stable conductivity.

Rice and potato plants are more productive after epitranscriptome engineering.

In a large-scale, international, multicenter, phase 1/1b trial, treatment of patients with advanced solid tumors with the B7H3-targeting antibody–drug conjugate YL201 was safe and showed preliminary clinical efficacy.

Lactylation of NBS1 by TIP60 promotes homologous recombination-driven DNA repair and resistance to chemotherapy in cancer cells and links altered cancer cell metabolism to increase genome stability.

Effective synthetic anion receptors are challenging to design. Now, star-shaped macrocycles, with a cavity defined by multiple convergent amide NH and phenyl CH groups, have been synthesized in one pot from their monomeric building blocks. These macrocycles strongly bind a variety of anions, selectively transport chloride across cell membranes and restore the function of cystic fibrosis cells.

A sensor for oxytocin reveals mechanisms of oxytocin action with high spatiotemporal precision.

The batch reproducibility of polymer donor materials limits the performance of polymer solar cells. Here Wu et al. develop a polymer donor PM1 by random terpolymerization strategy with a high efficiency of 17.6% in the device and excellent batch-to-batch reproducibility.

Biocrude via hydrothermal liquefaction of biomass is a sustainable substitute for petroleum. Upgrading biocrude will consume hydrogen or encounter high-yield solid residue. Here, the authors report a hydrogen-free paradigm for nearly complete valorization via co-generating green coal and lubricant.

Insufficient glucagon signalling results in hyperaminoacidemia, which drives adaptive proliferation of glucagon-producing α cells. Here the authors report that the amino acid sensitive calcium sensing receptor (CaSR) is necessary for α cell proliferation via Gq signalling during hyperaminoacidemia.

Egg-laying performance is an important phenotype for breeding chicken. Here, the authors explore the regulatory networks driving phenotypic differences in egg-laying, and identify laying-related variants and endocrine factors.

Electrified thermal energy storage converts electricity into heat for thermal energy use. This Review assesses available and emerging technologies, identifying research needs for scalable, long-duration and efficient deployment.

A genetically encoded sensor reveals the dynamics of endocannabinoid signaling.

Single cell transcriptomic sequencing (scRNA) can identify genes that are differentially expressed in cell populations in specific diseases. Here the authors perform scRNA sequencing in a high-altitude pulmonary hypertension (HAPH) cohort and show transcriptional differences in monocyte populations.

The parasitic capacitance of conductive yarns greatly affects the performance of e-Textile devices. Here, Qu et al. show the parasitic capacitance varies from 1-3 fF/cm depending on yarn microstructure, offering valuable insights for the design and use of conductive yarns in e-textile.

Amacrine interneurons act as integrators of visual information in the retina; however the developmental mechanisms that determine this cell fate remain unclear. Liu et al. find that amacrine differentiation in the retina is driven by the transcription factor RORβ1.

The second messenger cAMP modulates a wide range of important biological processes. Here, the authors developed a fluorescent indicator termed G-Flamp1, which can accurately report levels of cAMP in living cells.

Cu-SSZ-13 zeolites are highly active for standard NH₃-SCR, but their activity is unexpectedly inhibited in the presence of NO₂. This work demonstrates that strong oxidation by NO₂ forces Cu ions to exist mainly as Cu^II species with low mobility, which is responsible for this distinctive behavior.

Elucidating the nature of the Fe active sites in Fe-zeolite catalysts and the reaction mechanism operating during the concurrent removal of NO and N₂O is very challenging. Now, complementary transient operando spectroscopies are deployed to disentangle the structure and activity of diverse Fe species and elementary reaction steps.

The phase separation behaviour of non-structure protein nsp8 of SARS CoV2 in the primer synthesis mechanism is presented, underpinning the replication of coronavirus.

Lithium dendrite and parasitic reactions are two major challenges for lithium metal anode. Here, the authors show suppression of lithium-dendrite and elimination of continuous parasitic reactions by tuning the reduction kinetics of lithium-ion through a uniform nano-porous separator.

Fat uptake and storage in subcutaneous adipose tissue (SAT) prevents ectopic fat accumulation and associated metabolic complications, however, the underlying mechanisms are incompletely understood. Here, the authors show that adipose angiopoietin-2 (Angpt2) enhances SAT size via increased endothelial fatty acid transport.

Blood-retinal barrier (BRB) is composed of tightly connected endothelium and supporting pericytes and glia. Here, the authors show that pericytes are crucial for BRB buildup during retinal development and its maintenance in adult retinas in response to VEGF-A-induced endothelial sensitization by regulating the Tie2/FOXO1/Ang2 axis.

A polymeric protein complex consisting of a newly identified magnetoreceptor protein and known magnetoreception-related photoreceptor cryptochromes exhibits spontaneous alignment in magnetic fields.