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Here the authors utilize magnetic attraction and elastic tension to create instabilities that amplify vibrations and induce inertia-driven hysteresis. The design enables efficient mechanical memory with both volatile and non-volatile modes.

The Taiwan Precision Medicine Initiative (TPMI) has built a cohort of more than half a million individuals with Han Chinese ancestry, providing a rich resource of genetic and medical data for this group.

HMGCR is upregulated by E2F1, driving ferroptosis resistance by reducing oxidative damage triggered by T cell-based therapy. Notably, targeting HMGCR restores ferroptosis sensitivity in immune-refractory tumors, enhancing response to PD-1 blockade as well as adoptive T cell transfer therapy.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Ultralow-power ferroelectric field-effect transistors are used to achieve low-power NAND flash memory, overcoming the trade-off between multi-level capability and power efficiency and paving the way for next-generation storage memory.

SARS-CoV-2 variants resistant to current antivirals pose a significant threat, especially to high-risk patients. The authors identify a deletion mutation in M^pro that confers resistance to ensitrelvir but increases susceptibility to nirmatrelvir, suggesting potential for sequential or alternative therapeutic strategies in prolonged antiviral treatments.

Light trapped in the active polymeric layer limits the total efficiency of polymer light-emitting diodes. Here, Lee et al.get round this bottleneck by enhancing light extraction in waveguide optical modes via ripple-shaped nanostructures that spontaneously form on ZnO electrode surfaces.

Ultrafast lasers can drive materials into states beyond equilibrium. Here, the authors use single-pulse X-ray imaging to show that surface plasmons channel energy relaxation into distinct pathways, leading to different shape deformations.

Lee et al. report blue fin-LEDs with improved brightness and light extraction efficiency comparing to nanorod-LEDs by using a face-selective dielectrophoretic assembly technology. The wafer utilization ratio exceeds 90%, with a vertical assembly ratio of 91.3% and pixel production yield of 99.93%.

Kinetic energy harvesting often requires high-frequency inputs and durable materials. Here, the authors present an electrochemical system using immiscible liquid electrolytes and Prussian blue analogue electrodes to harvest low-frequency kinetic energy in a microfluidic device.

CAR T cell manufacturing faces significant challenges that impact cell quality and in vivo efficacy. This necessitates reliable cellular characterization methods. Here the authors present a real-time, label-free, microfluidic method that profiles cellular biophysical properties and correlates them to activation state and CAR T potency, facilitating the rapid phenotypic cell assessment during production.

Swanton and colleagues present a clonal expression signature, ORACLE, which, in combination with clinicopathological and molecular risk factors, can predict survival of patients with lung adenocarcinoma, and they prospectively validate its prognostic value.

Ultrathin film photovoltaic cells are a promising energy device, but suffer from low power conversion efficiency. Here, the authors construct a double-junction tandem cell using a hydrogenated amorphous silicon and a polymer as the front and back cell, respectively, which achieves 10.5% efficiency.

Genome-wide association studies (GWAS) have improved our understanding of the genetic basis of lung adenocarcinoma but known susceptibility variants explain only a small fraction of the familial risk. Here, the authors perform a two-stage GWAS and report 12 novel genetic loci associated with lung adenocarcinoma in East Asians.

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Lithium–sulfur batteries are a promising electrochemical energy storage technology; however, they are limited by the dissolution of polysulfide intermediates. Now, it has been shown that sparingly solvating electrolytes containing a phase mediator can avoid polysulfide dissolution and accelerate surface-localized solution-phase sulfur reaction to improve battery performances.

Peripheral and central circuit adaptations can be flexibly coordinated in Drosophila, and such a modular circuit organization may facilitate the evolution of mate recognition systems by allowing novel sensory modalities to become linked to male arousal.

Analysis of genomic and transcriptomic data from 462 patient-derived tumor cell (PDC) samples across 14 cancer types, along with pharmacological responses to 60 agents, indicates that PDC-derived drug sensitivities might be predictive of clinical response to targeted therapies.

The underlying mechanism behind charge density wave formation in Kagome metals is still not fully understood. Here, the authors propose that the phonon modes become frustrated in the charge density wave phase of CsV₃Sb₅.

The prognosis and treatment of gastric cancer is complicated by heterogeneity. Here, the authors reveal two molecular subtypes, the mesenchymal subtype associated with poor survival and chemoresistance, and the epithelial phenotype associated with better survival and sensitivity to chemotherapy.

Uninterrupted monitoring of pressure and temperature at skin interfaces can help to minimize the potential for pressure injuries in hospitalized or bedridden patients. Here, the authors introduce a soft, skin-mountable sensor that can continuously provide readings via antennas mounted under bedding, and demonstrate the functionality and robustness of the devices on patients.

Kinetically pumped avalanche multiplication has been demonstrated in a colloidal quantum dot photodetector, achieving an 85-fold multiplication gain. This proposes new opportunities for developing colloidal quantum dot single-photon detectors.

Seo et al. present a cerebrospinal fluid (CSF) proteomic profiling of cognitively normal individuals, identifying age-associated, sex-associated, APOE ε4-associated and amyloid-associated changes. They unveil early Alzheimer’s disease CSF-specific proteomic signatures and potential therapeutic targets.