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This study delineates lifespan changes in the sensorimotor-association gradient using multimodal neuroimaging data from 33,247 participants, revealing a pattern aligned with evolutionary, structural, and cognitive hierarchies within a unified neurodevelopmental framework.

Tang, Dai, Qing, Zhang and colleagues describe a role for N-glycosylation in the nucleus: N-glycans modify inner nuclear membrane proteins, and the modification is implicated in the maintenance of H3K9me3 heterochromatin and genome stability.

Macrophage-to-myofibroblast transition (MMT) contributes to CaOx-induced fibrosis in nephrocalcinosis. EZH2 is the critical regulator that promotes kidney fibrosis by meditating MMT via the DUSP23/SMAD3 pathway.

Loss of FDFT1 or SQLE promotes colorectal cancer metastasis and stemness through alleviating BiP independent ER stress and strengthening PDIA4/ACLY or SYVN1/SCD1 co-complex association, a process modified by tryptophan.

The work presents a model that predicts battery degradation using field-accessible data without historical cycling information. It combines a mixture of expert’s network with features from partial charging curves and relaxation voltage to classify degradation modes and predict long-term trajectories under uncertain future conditions.

Multistate photoswitches are an interesting class of photochromic materials which exhibit complex stimulus response. This Perspective explores this rapidly advancing field discussing design strategies, applications, and the current challenges facing researchers.

The authors find that O-GalNAc transferase 2 (GALNT2) restricts viral infection, probably through the regulation of the proteolytic processing of viral glycoproteins via its O-linked glycosylation activity, impairing virus–cell fusion.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Early and accurate clinical assessment of disease severity in COVID-19 patients is essential for planning the allocation of scarce hospital resources. An explainable machine learning tool trained on blood sample data from 485 patients from Wuhan selected three biomarkers for predicting mortality of individual patients with high accuracy.

Tpt1 family proteins are highly conserved and play essential roles in nucleic acid phosphate transfer in an NAD + -dependent manner. Here, the authors present several crystal structures of TkoTpt1 and reaffirm the two-step catalytic mechanism of the Tpt1-catalyzed reactions.

Plant Augmin cryo-EM structures reveal a 40-nm hetero-octameric fork with coiled-coil interfaces, dual CH domains at V-junction switch for microtubule binding and NEDD1 β-propeller binding to the V-junction boosts anti-parallel Augmin dimerization, recruiting γ-TuRC for branch nucleation.

The occupied anti-bonding states at the Fermi level in metavalently bonded systems stems from the interplay between metavalent bonds and the phase of orbitals. This provides a recipe for identifying superior dopants to improve the thermoelectric performance of metavalently bonded materials.

The mechanism through which auxin regulates chilling tolerance remains unclear. Here, the authors discover a negative regulator of chilling tolerance in japonica rice, which encodes an ABCB transporter with auxin efflux function, and show its potential to increase indica rice chilling tolerance.

CCR5-deficient gamma–delta CD19 CAR T cells show resistance to HIV-mediated depletion and antitumour efficacy in B cell malignancies.

Ovarian endometriomas, with distinct microenvironment and heightened hormonal sensitivity, are recognized as precursors of ovarian carcinomas. This study decodes ovarian endometriomas by integrating single-cell and spatial transcriptomics with spatial metabolomics to reveal key markers and altered pathways, offering new avenues for diagnosis and therapy.

This review systematically summarizes the recent advances in organic small-molecule NIR-II fluorophores for phototheranostics, providing insights into further innovation and facilitating clinical translation.

Han et al. report the design and characterization of a pressure-fused biomineral tablet for the long-acting sustained release of IL-2, promoting antitumor immune responses in preclinical models of melanoma.

The paraventricular hypothalamus (PVH) exerts an indispensable role in body weight control. Here, authors demonstrate the role of PVH RUVBL2 in suppressing food intake and reveal two anorexigenic circuits of PVHRUVBL2 → ARCPOMC and PVHRUVBL2 → DMH.

Simultaneous neural activation and inhibition in the same brain region of animals is highly desirable. Here the authors report a wireless, dual-colour optogenetic probe with the co-expression of two spectrally distinct opsins to allow for bidirectional neuronal activity manipulation in a rodent model.

Kasatkina, Ma, and colleagues propose a bacterial phytochrome-based approach for multimodal imaging and optogenetic manipulation enabled by biliverdin reductase knockout. This enables deep high-resolution photoacoustic and two-photon imaging, and light-controlled therapy in diabetes.

The stability and delivery of biopesticides limits application. Here, azadirachtin is co-assembled with plant secondary metabolites for efficient drug delivery, demonstrating pest management, the activation of plant defensive capacity, while increasing the production yield of crops.

Adding nanobodies into DNA computing has proven difficult due to there always on state. Here, the authors propose a spatial segregation-based molecular computing strategy to program nanobodies into DNA molecular computation and elucidate the kinetic mechanism of microenvironment-confined DNA molecular computation.

The high non-radiative energy loss is a bottleneck issue for efficient organic solar cells. Here, the authors regulate the charge transfer state disorder and rate of back charge transfer through a ternary system, achieving low non-radiative energy loss of 0.183 eV and device efficiency of 20.25%.

Using a large multisite dataset of people with major depressive disorder and healthy controls, the authors show global brain connectivity alterations in the sensorimotor, visual, and default mode networks.

The authors propose a matrix plainification strategy to eliminate lattice vacancies in the Cu2Se matrix of the Cu2Se/SnSe composites, resulting in obvious improvement in carrier mobility and power factor, obtaining a high figure of merit of 3.3.

N-type polycrystalline SnSe shows inferior ZT to p-type polycrystalline due to its high thermal conductivity and lower power factor. The authors overcome the problem via the synergy of divacancy defect and introducing resonance level into the conduction band.

This study reports the genomics- and metabolomics-guided discovery of aminovinyl-(methyl-)cysteine-containing peptides (ACyP). One of these peptides, massatide A, demonstrates excellent activity against drug-resistant gram-positive pathogens.

Ye et al. reveal the critical role of micropolarity in controlling the structure and miscibility of subcompartments in multiphasic biomolecular condensates, thereby providing new insights into multiphasic condensation regulation.

The authors demonstrate a chemopiezoelectric effect in which the displacive migration of oxygen vacancies driven by an electric field induces a large strain in the surface layer of thin (K,Na)NbO₃ ceramics. They achieve an electrostrain of 1.9% under a field of −3 kV mm⁻¹, with thermal stability up to 200 °C.

A wireless optoelectronic probe integrates a microscale light-emitting diode and a photodetector coated with oxygen-sensitive dyes to monitor the partial pressure of oxygen in the deep brain of freely moving mice.

Addition of a multifunctional ionic additive in mixed two-dimensional–three-dimensional bromide/chloride perovskites enables efficient blue perovskite LEDs with external quantum efficiency of up to 21.4% and half-lifetime of 129 min at an initial luminance of 100 cd m^–2.

Acute myeloid leukemia cells are often resistant to radiotherapy and chemotherapy. Here, the authors suggest that hCINAP contributes to the resistance of acute myeloid leukemia cells by regulating SUMOylation of Nucleophosmin during the DNA-damage response.

Phototunable full-color circularly polarized luminescence (CPL) features large storage density which is important for the field of information encryption and decryption. Here, the authors present a device-friendly solid film with color-tunability by employing Förster resonance energy transfer among a chiral donor and achiral molecular switches in a liquid crystal photonic capsules.

Enriching the chemical space of polycyclic heterocycles is of high value in chemical biology. Here, the authors report an electrooxidative protocol for the regioselective dearomative annulation of indoles and benzofurans under undivided cell conditions and obtain five- to eight-membered fused heterocycles.

Sun et al. report human lifespan changes in the brain’s functional connectome in 33,250 individuals, which highlights critical growth milestones and distinct maturation patterns and offers a normative reference for development, aging and diseases.