Search

Preserving anal function in advanced-stage colorectal cancer (CRC) treatment remains challenging. Here this group reports a hydrospongel consists of cellulose nanofibers crosslinked with Fe₃O₄@PDA nanoparticles which enables delivery of 5-FU to the tumor site thereby achieving CRC chemotherapy.

Developing positive electrodes with high stability and rapid ion migration kinetics faces challenges for sodium ion batteries. Here, authors report a universal synthesis approach for layered transition-metal oxides by updating the conventional solid-state reaction with only dicyandiamide introduced.

A DNA matrix material potentiates humoral response through multiple administration routes, generating neutralizing antibodies and conferring robust protection against infection.

KP.3.1.1 S S31del confers enhanced immune escape and increased infectivity, which is counterbalanced by NSP10 S33C. The opposing effects of these mutations highlight the complex interplay of viral genomic elements in shaping their overall fitness.

A DNA nanoruler platform enables precise measurement of the labeling radii of TurboID and APEX2, uncovering their contact-dependent mechanisms. These findings redefine the enzymology of proximity labeling and highlight the promise of DNA nanotechnology for spatially resolving enzyme reactivity with nanometer precision.

Nanoemulsion modular assembly is emerging as a versatile strategy for synthesizing diverse functional mesoporous nanomaterials. This Review highlights the capabilities of nanoemulsion modular assembly for precise control over pore size, structure, composition and morphology, as well as discussing possible applications of functional mesoporous nanomaterials.

Yersinia pseudotuberculosis senses fungal tyrosol signalling through EnvZ–OmpR which triggers T6SS activation and antifungal effector release to reduce fungal competitors in the mouse gut.

The authors provide evidence of the secretion of mitochondrial components in extracellular vesicles dependent on GPRC5A as a pathway of mitochondrial quality control in AEC2s, which is essential for lung homeostasis maintenance.

Unlocking the complexities of protein structures and interactions within subcellular organelles is challenging. Here, the authors introduce SPACX, a method for spatially resolved protein complex profiling using biocompatible chemical cross-linking, enabling the analysis of protein conformation, interactions, and translocation in living cells.

Authors present a bispecific antiviral design targeting the virus and the host that simultaneously offers broad-spectrum protection against multiple existing transmissible human-pathogenic coronaviruses, including the Paxlovid-resistant SARS-CoV-2 mutants.

China’s microelectromechanical systems (MEMS) sensor industry is surging, but technical gaps, fragmented production and coordination challenges hinder its full potential. As global demand accelerates, it is important to consolidate this sector and forge greater independence in innovation to enhance China’s global competitiveness in the field.

Developing efficient methods for the formation and cleavage of amide species is a primary research goal, but the amide C–N bond cleavage is exceptionally challenging. Here, the authors report the development of an organocatalyst that can effectively catalyze the atroposelective ring-opening of biaryl lactams via amide C–N bond cleavage.

Multi-omics integrating genetic, transcriptomic, and phenotypic variation, coupled with mutant validation, identified 85 high-confidence WUE and drought resilience genes in wheat, with TaMYB7-A1 confirmed as a key regulator.

Porous graphene integrated into graphene oxide membranes yields smart molecular sieves that switch separation based on the solvent. This allows for graded separations of different-sized molecules.

In this study, Yang et al. compile a global dataset to uncover the degree to which plants coordinate root and seed traits. They report a global positive correlation between root diameter and seed size, driven by dual roles of arbuscular mycorrhiza in phosphorus uptake and pathogen defence.

Despite great success in generation of ultralong organic phosphorescence (UOP) by suppressing non-radiative transitions through attractive interactions, consideration of repulsive interactions on UOP remains largely unexplored. Here, the authors introduce carboxyl groups into organic phosphors, enabling formation of the intense repulsive interactions between the isolated molecules and the matrix in rigid environment.

The structure of the mitochondrial inner membrane, or cristae, is important for functional oxidative phosphorylation and energy production. Here, the authors show that loss of myosin 19 impairs cristae structure as well as energy production, connecting motor activity to membrane potential.

The effects of non-reacting components on polyatomic reactions are still largely unclear. Here, the authors show through a combined experimental and theoretical study of the D + CH₄ reaction that the CH₃ umbrella bending mode serves as a reporter mode, revealing how the D atom dynamically approaches CH₄.

Metastasis of pancreatic cancer has been associated with epithelial-mesenchymal transition (EMT). Here, the authors identify STN1 as a regulator of pancreatic cancer metastasis by promoting transcription of EMT-activator ZEB1, which is independent of its known role in telomere maintenance.

Ubiquitination plays an essential role in intracellular pathogen infections. Here, Wan et al. report how Legionella pneumophila hijacks the host ubiquitin system by building modified poly-ubiquitin chains at the Legionella-containing vacuole, preventing the recognition by host autophagy adaptors.

This study shows that Galectin-3 promotes wound healing by binding to and undergoing phase separation with integrin α5β1, a process disrupted by AGEs in pre-clinical models of diabetes. Topical Galectin-3 restored healing in synergy with insulin.

The country’s publication policies should balance the need to promote science locally with the benefits of disseminating research internationally.

Yin et al. discover that the phosphatase PTENα acts as an RNA-binding protein, mitigating viral-induced inflammation in the brain by constraining RIG-I activation, suggesting PTENα as a potential therapeutic target for viral infection.

A stereotaxic atlas of the whole mouse brain, based on a Nissl-stained cytoarchitecture dataset with isotropic 1-μm resolution, achieved through continuous micro-optical sectioning tomography, promises to be a versatile brainsmatics tool for studying the whole brain at single-cell level.

By recognizing double-stranded RNA, RIG-I is implicated in anti-viral immune responses, but also in cancer development and intestinal inflammation. Here the authors identify frameshift germline mutations of RIG-I, resulting in the generation of a circular RNA associated with increased susceptibility to colitis-associated colon cancer.

Malignant pleural effusion is a challenge for cancer therapy. Here, the authors report on a piezoelectric nano-system that inhibits tumor growth in the thoracic cavity by piezo-generated reactive oxygen species using the intrapleural pressure, triggering immunogenic cell death, to treat malignant pleural effusion.

It’s challenging to produce natural products using single strains of engineered microbes fed by renewable carbon sources. Here, the authors assemble a microbial consortium consisting of engineered S. stipitis and S. cerevisiae for streamlined production of (S)-norcoclaurine from glucose and xylose simultaneously.

It has long been believed that topological phases are solely determined by their lattice structures. Here, the authors report the observation of cavity-tunable topological phases of polaritons by modifying the surrounding photonic environment without altering the lattice structure.

Breast cancer cells interact with cancer-associated adipocytes in the microenvironment. Here, the authors report that the cross-talk between these two cell types is dependent on Zeb1, which remodels the tumor-associated adipose microenvironment to confer breast cancer progression.

Respiratory complications after a COVID infection are a growing concern, but follow-up chest CT scans of COVID-19 survivors hardly present any recognizable lesions. A deep learning-based method was developed that calculates a scan-specific optimal window and removes irrelevant tissues such as airways and blood vessels from images with segmentation models, so that subvisual abnormalities in lung scans become visible.

Open-shell organic radicals possess narrow energy gaps making them efficient solar absorbers. Here the authors synthesize robust triarylamine radicals enabling near unity absorption of the full solar spectrum for efficient photothermal applications.

Zika virus impairs male fertility by utilizing its NS2A protein to block the translation of CYP17A1 mRNA in Leydig cells, thereby suppressing testosterone synthesis and sperm production in vivo.

Methods for the wireless, continuous monitoring and analysis of activities directly from the throat skin have not been developed. Here, the authors present a stretchable device platform that provides wireless measurements and machine learning-based analysis of vibrations and muscle electrical activities from the throat.

Current industrial methods of ethylene glycol production generate substantial CO₂ emissions. Here electrocatalytic ethylene-to-ethylene glycol conversion is coupled to electrochemical CO₂ capture, decreasing carbon intensity by an order of magnitude.

A mild electrochemical exfoliation method has been developed to obtain large-size two-dimensional superconductor monolayers with high crystallinity and production yield, which enables the easy fabrication of twisted van der Waals heterostructures and printed films.

PTENα is an N-terminally extended isoform of PTEN, a gene frequently mutated in human cancers. Here the authors show that PTENα remains active in PTEN-mutant cancers and is associated with tumor immune escape by promoting tumor cell resistance to T cell cytotoxicity.

An artificial nerve that is based on a vertical n-type organic electrochemical transistor with a gradient-intermixed bicontinuous structure can operate at high frequencies and mimic basic conditioned reflex behaviour in animals.

Toxin-antitoxin (TA) systems are common in bacteria and archaea and contribute to phage defense. Here, the authors structurally and biochemically characterize a new anti-phage TA system, ShosTA.

Demand for data recovery from monolithic storage devices is high but current methods are inefficient. Here, authors develop a robotic OCT-guided inspection and microsurgery method, minimizing damage to device and enhancing data recovery efficiency.

DSS1 is crucial for BRCA2 dependent genome repair. Here, the authors reveal how DSS1 restricts the dsDNA binding ability of BRCA2 to ensure BRCA2/RAD51 loading on ssDNA. Mutations in DSS1 disrupt this regulation, leading to impaired DNA repair, replication fork protection and R-loop suppression.