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Noise in optoelectronic memories causes harmful overlap of photoconductance states and degrades computing precision. Zhou et al. report an optoelectronic memory that achieves thousands of distinguishable states without denoising, enabling the detection of fast-moving objects.

Oral leukoplakia is a precancerous lesion that can transform into oral squamous cell carcinoma (OSCC). Here, the authors discover that OSCC migrasome-derived PTGES promotes oral leukoplakia carcinogenesis through macrophages reprogramming.

Skeletal muscle fiber type is key to metabolic health. Zhou et al. reveal that the protein BRD4 dictates muscle fiber identity, blocking it promotes energy-burning slow fibers and prevents obesity in mice, offering a new target for metabolic disease.

By introducing local ferroelectric regions into a high-entropy superparaelectric, researchers develop a design strategy for high-performance energy storage ceramics. They incorporate ferroelectric PbTiO₃ into a high-entropy matrix, achieving a high recoverable energy density.

A structural templating method transforms layered oxide materials to achieve stable ferroelectric phase with vertical polarization and thermal stability up to 350 °C, facilitating high-performance data storage for future computing technologies.

The study uncovers CBP/p300 as regulators of functional α cell mass via orchestrating Slc7a2/lysine-driven α cell identity gene.

Abdominal aortic aneurysm (AAA) is a life-threatening condition, but its underlying mechanisms are unclear. Here, the authors show that PDK4 contributes to abdominal aortic aneurysm by promoting metabolic reprogramming in vascular smooth muscle cells, leading to activation of NLRP3.

The authors highlight the role of miR-30a-3p from adipocyte small extracellular vesicle in driving hepatocyte lipotoxicity in metabolic dysfunction-associated steatotic liver disease.

Here the authors report that WNT10B, a ligand of the Wnt family, mediates renal inflammation and fibrosis. Mechanistic work in male mice with induced chronic kidney disease shows that the WNT10B/FOXO6 axis controls tubular senescence fate transition and pro-inflammatory microenviroment formation through metabolic reprogramming.

Inflammatory skin diseases are characterized by immune dysregulation often underpinned by metabolic dysregulation. Here the authors show that in human psoriasis and mouse skin inflammation models, adenosine-mediated crosstalk between fibroblasts and keratinocytes drive mitochondrial dysfunction and pro-inflammatory mediator release in keratinocytes, leading to epidermal inflammation.

Microbial biosynthesis of monoterpene esters remains a major challenge due to the limited repertoire of highly selective alcohol acyltransferases (AATs). Here the authors discovered and engineered AATs for various monoterpene esters using a dual-substrate microbial platform.

The authors report a 2D spin-LED based on CrSBr. Distinct from conventional circular polarization schemes, it actively transduces magnetic phase transitions into tunable electroluminescence, establishing a magnetic-order-modulated paradigm.

To address the interconnect scaling challenge in semiconductor technology, researchers created a sub-2-nm Turing-patterned Ta₂S₃ barrier that can block copper diffusion better than the state-of-the-art TaN barrier

A mesoscopic fluorescence imaging platform incorporating a double-helix phase mask enables realtime 3D mapping of cerebrovascular networks and blood flow dynamics in the living mouse brain under healthy conditions and in glioma.

Lithium metal batteries face critical challenges such as low ion transport efficiency under lean electrolyte conditions. Here, authors study a bifunctional ligand-bridged electrolyte containing ethyl difluoroacetate that can form interconnected ionic aggregates through hydrogen bonding and lithium-ion coordination interactions, suppressing parasitic reactions and enhancing interfacial charge transfer, enabling stable cycling of a 600 Wh kg-1 lithium metal 14 Ah pouch cell.

Jumbo phages are bacterial viruses with large genomes, oversized icosahedral capsids and complex tail architectures. Here, the authors use cryo-EM to provide a detailed structural analysis of jumbo phage phiKZ.

Rare cancers can be challenging to diagnose from imaging due to limited data and previous expert experience. Here, the authors develop the PathPT framework to improve subtyping and tumour localisation.

Researchers apply in situ 3D electron diffraction to LaTaO₄ nanocrystals during heating, allowing atomic-level structural determination through three phase transitions while providing insights into intermediate phases and structural modulation.

Bispecific immune cell engagers show limited efficacy in glioblastoma (GBM) therapy due to poor T cell infiltration and restricted drug penetration. Here this group reports a multifunctional lipid nanoparticle platform that enables brain tumor–targeted delivery and sustained in vivo expression of mRNA encoding a bispecific macrophage engager for GBM treatment.

The authors report that Ta-doped PbTiO₃ films with a p-i-n structure can generate a high photovoltaic current, offering the opportunity to advanced optoelectronic and imaging devices.

Here the authors show that microtubules guide the spatial distribution of cellulose synthase complexes in cotton fibers and produce a gradient of cellulose microfibrils that creates patterned cell wall mechanics that support tip-biased elongation.

The authors demonstrate a generative model-based inverse design strategy that synergistically optimizes the composition and polarization configurations in Bi_0.5Na_0.5TiO₃-based ceramics, achieving enhanced energy-storage performance under low fields.

Photoluminescent materials are widely used in information security applications, yet high-precision optical information encryption remains difficult to achieve. Here the authors report two monoclinic zero-dimensional organic–inorganic hybrid Mn(II) chloride crystals and characterize their phase-transition-induced photoluminescence quenching.

The manuscript describes two pathogenic mutations in GTPBP3 that cause defects in mitochondrial tRNA taurine modification, mitochondrial translation, structure and function. Mutant mice reproduce certain clinical features seen in patients and this can be reversed by virus-mediated exogenous expression of Gtpbp3.

This study uses genome-wide screening and mouse genetics to uncover how cells control proinsulin, identifying the Golgi as a central hub and revealing PDIA6 as a key regulator of proinsulin production in pancreatic β-cells.

Solid-state organic optical limiters for laser protection suffer from aggregation quenching. Here, the authors use coordination-bond anchoring strategy to overcome this and achieve an enhancement of nonlinear absorption coefficient.

This study identifies shared and distinct brain patterns underlying reappraisal and acceptance, showing how emotion regulation operates in dynamic naturalistic contexts and highlighting potential clinical markers.

Pathological neovascularization is a leading cause of vision loss. In this study, the authors identify FRZB and its NTR domain as suppressors of ocular angiogenesis. FRZB prevents CAV1 phosphorylation at Tyr42 which enhances downstream TGFβ signaling via ALK5 retention.

A graphene-inspired porous polymer network acts as a molecular sieve, efficiently separating ethane from ethylene and purifying methane. Its finely tuned pores deliver record selectivity, offering a new path toward cleaner and energy-efficient natural gas processing.

Cell-type-specific 3D genome maps are hard to generate experimentally. Here, the authors develop Hi-Compass, a deep-learning framework that predicts chromatin interactions from accessibility data across variable sequencing depths, recovering chromatin loops and linking disease variants to target genes.

Protein oligomerization can regulate cellular functions. Here, authors identify a small molecule that selectively induces WDR5 oligomerization using nanopore screening and show it disrupts cancer-driving interactions, highlighting a potential anti-tumor strategy.

Wang et al. report dual cationic imidazole ligands to control perovskite dimensionality, from 0D to parallel 1D, and bridged 1D structures. Bridged 1D/3D perovskite heterostructure enables solar cells with certified efficiency of 27.02% and 30×30 cm² solar modules with efficiency of 21.41%.

Intracellular bacterial infections remain difficult to treat. Here, the authors report enzyme-responsive peptide dendron nanoassemblies with size-transforming capabilities that target and eradicate intracellular drug-resistant bacteria while protecting macrophages from damage caused by intracellular bacterial infection.

Green ammonia co-firing enables coal-power decarbonization. This study shows that, through islanded production hubs and geospatial transport, green ammonia co-firing retrofits can effectively reduce CO₂ emissions, lower carbon capture requirements, and avoid carbon lock-in in young coal-fired units across China.

This work presents a quantum-cutting heterostructure that emits tunable near-infrared light (900-2200 nm) under ultralow-power excitation. It enables AI-assisted multiplexed gas detection, offering a scalable strategy for broadband NIR light sources

Authors present a framework that harmonizes electronic health record data across hospitals by integrating medical knowledge, large language models, and graph learning. It enables cross-institutional analysis without sharing patient-level data.

Hypoxia triggers distinct epidermal and dermal metabolic responses, driving skin organoids from spherical aggregates to planar embryonic-like structures. This reveals how cells use low oxygen to construct functional tissue.

LHAASO has detected γ-ray emission with a spectrum extending to 2 PeV from the pulsar wind nebula (PWN) powered by PSR J1849-0001, indicating an extreme particle acceleration efficiency and challenging the current particle acceleration theories.

An intrinsic hub that integrates the OsRALF4-THE3-RbohB pathway with the binding of OsRALF4-demethylesterified pectin modulates meristem homeostasis by balancing O₂⁻ and promotes cell expansion by pectin demethylesterification and condensation.

Hormone receptor-positive, HER2-negative advanced breast cancer lacks defined treatment options following CDK4/6 inhibitor (CDK4/6i) failure. Here, the authors present a phase Ib clinical trial where the CDK4/6i dalpiciclib is combined with the histone deacetylase inhibitor chidamide in this setting.

Molecular devices offer the potential for the scalability and energy efficiency required to develop energy-sustainable AI. Zhang et al. report a single-molecule neuromorphic device that consumes 6.34 aJ per operation and support both short-term to long-term memory, featuring over 10 distinct conductance states.

Tyrosine kinase inhibitors (TKIs) combined with immunotherapy have improved outcomes in advanced renal cell carcinoma (aRCC), yet resistance persists. This group presents single-cell transcriptomic profiling of aRCC patients treated with TKIs and immune checkpoint inhibitors, uncovering an immunosuppressive microenvironment linked to therapeutic resistance.

The behavior of liquids approaching the glass state is significantly influenced by their configurational entropy, which is crucial for understanding their dynamics and thermodynamics. This study successfully extends the potential energy landscape formalism to quantum liquids, demonstrating that configurational entropy can be defined similarly to classical liquids and that the Adam-Gibbs relation holds.

Not all deer are equally susceptible to SARS-CoV-2. Authors show that spike mutations reshape ACE2 compatibility across cervids, providing a structural basis for variant-dependent differences in spillover potential.

2D polarization-sensitive detectors are usually limited by a responsivity-speed-polarization ratio trade-off. Here, the authors report mid-infrared polarization photovoltage field-effect transistors based on black phosphorus/MoS₂ heterostructures, showing a polarization ratio of 510, polarization angle sensitivity of ~46.57 mA/(W·degree) and response times of ~0.8 μs under 3.5 μm illumination.

CAR-T therapy remains poorly effective in glioblastoma (GBM) due to the tumor’s high antigen heterogeneity and immunosuppressive microenvironment. This study reports a multimodal platform for GBM immunotherapy that combines dual-antigen oncolytic viruses with bispecific CAR-T (BiCAR-T) and CAR-NK cells.

Peripheral nerve modulation is promising for regulating physiological functions, but its performance relies on a stable electrode–tissue interface. Here, the authors present a tissue-adaptive bioelectronic fiber that thermo-contracts at body temperature, forming robust biointerfaces. Incorporating carbon nanotubes enables mixed ionic–electronic conductivity, supporting reliable neural stimulation and 99.5% signal retention in sciatic nerve recordings under repeated activation.

Transfer RNA-derived small RNAs (tsRNAs) emerge as crucial players in biological processes but their disease relevance is unknow. Here, the authors show that tsRNA-Glu-CTC is the most abundant hepatic tsRNA that plays a key role in regulating cholesterol homeostasis and atherosclerosis development.