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Researchers demonstrate a minimalist terahertz wireless transceiver in integrated photonics. They break the longstanding constraint between source purity and DSP complexity, realizing 144 Gbps high-speed transmission at subterahertz frequency.

The human LRP8 protein is a receptor for yellow fever viruses (YFVs). Knockdown of the mosquito orthologue reduces YFV infection in mosquitoes, whereas overexpression of human LRP8 aggravates YFV infection in mice. Purified LRP8 protein blocks YFV infection.

Real-time spectrum sensing (RT-SS) is essential for 6G networks to dynamically manage spectral resources and support integrated sensing and communication. Here, the authors develop a thin film lithium niobate photonic system for wideband RT-SS up to 120 GHz with nanosecond-level latency.

Radical C(sp³)–C(sp³) bond formation with stereocontrol is challenging. Now, photoredox catalysis and repurposed thiamine-dependent enzymes are combined to couple cinnamyl aldehydes with benzylic radicals, yielding enantioenriched carboxylic acids bearing one or even two stereocentres.

Researchers demonstrate thin-film lithium tantalate modulators fabricated using a copper Damascene process, achieving lower microwave loss, exceptional bias stability, and high-speed data transmission up to 540 Gbit/s, while enabling scalable chip-on-wafer integration with microelectronics.

Henry A. Martin and colleagues design co-packaged electronics with microfluidics to bridge the thermal gap between the device junction and the coolant. This is beneficial for mid-to-high power electronics, chiplet architectures, and multi-chip packages.

ERAST speeds up homology search and provides a vector database for 1 billion biological sequences.

Mutant isocitrate dehydrogenase 1/2-driven D-2-hydroxyglutarate (D2HG) and hypoxia-induced L-2-hydroxyglutarate (L2HG) are known to non-covalently inhibit α-ketoglutarate-dependent enzymes in several cancer types. Now, through use of chemical proteomics, stereoselective protein O-2-hydroxyglutarylation by D2HG or L2HG has been characterized as a distinct oncometabolite-induced post-translational modification with evidence for crosstalk with kinase activity.

Operando imaging of chemical reactions typically requires the inclusion of an extrinsic handle such as a fluorescent probe. Here quantum-sensing-enabled chemical operando microscopy is developed to intrinsically image the photocatalytic generation of free radicals on TiO₂.

Here, Li, Lu, Xia and colleagues identify the maternal complex MPU (PADI6–UHRF1–UBE2D), determine its cryo-electron microscopy structure and show that PADI6 maintains oocyte proteostasis by sequestering UBE2D with the assistance of UHRF1, thereby inhibiting protein ubiquitination. The study, thus, provides a molecular mechanism underlying PADI6-associated female infertility.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Mitochondrial damage is a central pathological mechanism of cerebral ischemia-reperfusion injury. This study develops a bioengineered nanolamellar system to sequentially restore neuronal cell mitochondrial function and modulate microglial polarization to mitigate ischemia-reperfusion injury.

Comprehensive annotating of cell types in spatially resolved transcriptomics to understand biological processes at the single cell level remains challenging. Here the authors introduce Spatial-ID, a supervision-based cell typing method, that combines the existing knowledge of reference single-cell RNA-seq data and the spatial information of spatially resolved transcriptomics data.

An in situ multistep edge-contact process is developed for MoS₂ transistors, achieving quasi-non-volatile capacitorless two-transistor dynamic random-access memory with 5-bit accuracy and nanosecond write speeds.

Scalable fabrication of perovskite films for large-area solar cells remains a critical challenge. Jin et al. identify the solvent-precursor interaction time as a crucial, yet overlooked, kinetic parameter controlling crystallization and propose a protocol for manufacturing high-quality perovskite films.

While neoadjuvant chemotherapy can improve outcomes in patients with esophageal squamous carcinoma, resistance often develops. Here, the authors identify elevated INCENP and CDCA8 via YTHDF3 mediated translation as markers of poor response to neoadjuvant chemotherapy in esophageal squamous carcinoma.

The youngest lunar regolith from the Moon’s nearside and farside show similar particle shapes despite different origins, indicating that space weathering rapidly reaches saturation in shaping surficial lunar regolith within ~2.2 million years.

The authors report an omnidirectional, strain-invariant MXene-based electronic system enabled by microgrid stiffness engineering, maintaining less than 5% performance variation under 40% tensile strain for battery-free physiological and blood pressure monitoring.

Inspired by the human eye’s dynamic focusing, this work demonstrates an integrated bionic LiDAR that achieves energy-efficient, adaptive 4D imaging, offering a compact and scalable path toward intelligent machine vision.

Maintaining facial warmth and humidity while ensuring adequate oxygen intake in cold environments is challenging for facial masks. Here, the authors design a MetaMask that recovers heat and moisture from exhaled air to warm inhaled air to 26.2 °C in a − 20 °C environment, while maintaining sufficient oxygen levels.

A colour correction array featuring red-, green- and blue-sensitive organic transistors integrated within a single pixel enables self-adaptive intensity and colour correction.

High-density dynamic random access memory is crucial for addressing the memory wall issue, yet its three-dimensional integration faces significant challenges. Liao et al. utilize a single-step self-aligned integration scheme, achieving 4 F² density and demonstrating 4-bit operation.

A pigeon-eye-inspired multimodal high-resolution tactile sensor, combined with a tactile language model, allows robots to achieve human-like tactile perception and understanding of their environment.

Here, the authors use cryo electron tomography to investigate the in-situ assembly mechanisms of clustered protocadherin γB4, uncovering the functional contributions of full-length γB4 and role played by specific domains.

The search for a room temperature superconductor is as old as the discovery of superconductors themselves and recent results for the superconducting hydrides has brough the community a step closer to this goal. Here, using a computational approach the authors investigate thermodynamically stable superconducting phases in the ternary Ba-Re-H system under high pressure, identifying several potential candidates.

In this work, the researchers realize the current-induced motion of Néel type chiral domain walls via spin-transfer-torque in the pristine van der Waals ferromagnet Fe₃GeTe₂ and via spin-orbit-torques in heterostructures with platinum or tungsten.

A wearable human–machine interface combines inertial and electromyography sensors with deep learning to robustly extract gesture signals and enable real-time robotic control under diverse motion artefacts in dynamic environments.

By unifying ultra-high optical gain and broadband electro-optic dynamics in an Er-doped lithium niobate thin-film platform, the authors demonstrate an exciting monolithic integration of amplification and modulation on a compact photonic chip. This exciting work showcases record performance for on-chip amplifiers while enabling self-amplified 50 Gbps digital encoding and pre-amplified RF front-end signal recovery.

This study introduces a meta-lens-based hyperspectral radiation thermometry that accurately measures temperatures up to 2973 K with error lower than 0.32%. The method is six times more precise than current methods and holds protentional for developing miniaturized, two-dimensional temperature sensors.

Mitochondria that are transported from satellite glial cells in dorsal root ganglia to peripheral sensory neurons through tunneling nanotube-like structures provide protection against peripheral neuropathy.

Cas13 can intrinsically target host RNA in mammalian cells through previously unrecognized mechanisms without the involvement of a CRISPR RNA, and host genes involved in viral processes can constrain the lentiviral delivery and expression of Cas13.

Correct diagnosis of primary central nervous system lymphoma is key in determining treatment, however, this depends on pathology analysis. Here, the authors develop a deep learning method to diagnose primary nervous system lymphoma from stained whole-slide images.

This study presents a neural symbolic regression approach that autonomously uncovers network dynamics from data. It was demonstrated to refine existing models of gene regulation and ecology, and identify epidemic transmission patterns across spatial scales to yield scientific insights.

A database from a survey of farmers, published articles and statistical yearbooks was developed to map crop- and county-specific yields, farm inputs, reactive N losses and greenhouse gas emissions in China. Optimized crop distributions combined with improved management are estimated to improve crop productivity and decrease farm inputs and environmental costs.

Here, the authors perform a large scale profiling of human gut prophages, revealing prophage-encoded disease-specific gene shifts, and further showing that prophage-encoded gene depleted in IBD helps reduce gut inflammation via oligosaccharide synthesis.

The intermolecular addition of O-centred radicals to alkenes is a challenging endeavour in synthetic chemistry. Now ene-reductases are used to tame reactive O-radicals for intermolecular and enantioselective radical hydroalkoxylation involving a ground-state single-electron radical mechanism.

Recently, anti-resonant hollow-core fibers have emerged as an important medium for high-power laser delivery. Here, authors demonstrate a highly efficient, all-fiber delivery of 2 kW laser over 2.45 km, using a self-fabricated AR-HCF with a record low transmission loss of 0.168 dB/km at 1080 nm.

Modeling antibody-antigen complexes boosts biomedical research and therapeutic design. To tackle slow antibody development, the authors’ tFold System designs epitope-specific antibodies, with their nanomolar affinities experimentally confirmed.

Sustainable management of soil organic carbon (SOC) in farmland is critical for mitigating climate change and improving soil health. Degradable film mulching is a promising alternative to plastic film mulching, sequestering SOC and reducing C loss in dryland agroecosystems under climate change.

Here, the authors report that SARS-CoV-2 M protein interacts with host ARF1 to facilitate viral assembly at the ER-Golgi intermediate compartment and demonstrate that targeting ARF1 or its interaction with the M protein disrupts virus production in vitro and in vivo, proposing a potential broad-spectrum therapeutic approach.

Robust Cu single-atom catalysts show promise for CO₂ electroreduction but face stability challenges. Here, the authors report a self-healing Cu single-atom catalyst that maintains high performance and stability for CO₂-to-CH₄ conversion at industrial current densities.