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Besides killing infected or transformed cells, interferon-activated natural killer cells can kill T follicular helper cells and may contribute to poor antibody responses in some individuals infected with SARS-CoV-2.
A preprint by Breuer et al. reports that type I IFN signalling in tumour cells promotes lymph node metastasis but suppresses metastasis to distant organs such as lung.
A study in Nature reports that heterotypic T cell clusters identifed in clinical samples of melanoma metastases are biologically relevant to tumour control and might have therapeutic potential.
A preprint by Liu et al. shows proof-of-concept for a treatment for autoimmune diseases such as SLE using synthetic immune receptor T cells that target 9G4 idiotope B cells.
A preprint by Bockman et al. reports a cDC2-CD4+ T cell axis that mediates local tumour control after ablation of intratumoral Treg cells, without eliciting autoimmunity.
A preprint by Zhijie et al. identifies somatic mutations in TYK2 that are enriched in tumour-infiltrating lymphocytes and associated with an increased antitumour response.
This poster provides an overview of the current subset-based nomenclature for T cells and a newly proposed modular nomenclature for T cells. It is based on the 2025 consensus statement Guidelines for T cell nomenclature.
This Consensus Statement clarifies the existing subset-based nomenclature for T cells. Furthermore, it proposes an alternative modular nomenclature that is designed to be brief and flexible and to avoid ambiguity and unwanted implications. The authors also provide guidance on how T cell nomenclature should be described in research papers.
In this Review, the authors consider a long-standing immunological conundrum — why do neutrophils have a segmented nucleus? They discuss the mechanisms that may underlie segmentation of the neutrophil nucleus and explain how nuclear segmentation may affect neutrophil functions, including migration and phagocytosis.
A preprint by Guo et al. reports a mechanism of transcriptional control of RORγt expression in intestinal antigen-presenting cells that are important for oral tolerance involving the cis-regulatory region OCR369.
A preprint by Srinivasan et al. describes the role of the gut microbiota and serum amyloid A in regulating retinoid flux that is important for myeloid cell migration and T cell priming.
A preprint by Rivera et al. explores how retroelement expression establishes a tolerogenic environment towards food antigens in the gut, shedding new insights into the immune regulatory role of retroelements.
Sanchez-Garcia et al. report that systemic hypoxia-induced epigenetic reprogramming of neutrophil progenitors in the bone marrow reduces their effector function to limit lung tissue damage.
In this Review, Li and Underhill discuss recent advances in understanding the process of phagocytosis. The authors highlight how phagocytosis is integral for innate immune sensing and explain how the phagocytosed material itself shapes the phagocytosis process.
This Perspective presents a framework of ‘structural immunity’ that positions immune cells as architects of tissue structure. Beyond their roles in antimicrobial defence, we posit that immune cells contribute to tissue homeostasis by guiding structural composition and, in some cases, directly building barrier components.
