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A phase I trial of a neoantigen-targeting personalized cancer vaccine led to durable and polyfunctional T cell responses and antitumour recognition, and was associated with no recurrence in patients with high-risk clear cell renal cell carcinoma.

A versatile and rapid metallaphotoredox catalytic method of making ³H- and ¹¹C-labelled tracer compounds for use in positron emission tomography (PET) is reported.

Divergent trends in biogeochemical constituents of the six largest rivers in the Arctic from 2003 to 2019 support multi-faceted changes on the Arctic landscape under global environmental change.

Whole-genome sequencing data from more than 2,500 cancers of 38 tumour types reveal 16 signatures that can be used to classify somatic structural variants, highlighting the diversity of genomic rearrangements in cancer.

The Fermi surface is related to the energy distribution of electrons in a solid, and governs physical properties of metals and semiconductors. A new type of angle-resolved photoemission spectroscopy, probing the Fermi surface and combining short recording time with high resolution, is now presented.

Some next-generation computing may be based in physical systems that respond directly and reciprocally to environmental stimuli. Here, the authors describe a photoresponsive material that autonomously performs computations with incident beams of incoherent white light.

Some cancer patients first present with metastases where the location of the primary is unidentified; these are difficult to treat. In this study, using machine learning, the authors develop a method to determine the tissue of origin of a cancer based on whole sequencing data.

Fouling of solid surfaces is a problem when designing microchannel systems for applications such as bioassays and drug delivery. Here Hou et al. propose a way to overcome this issue by controlling fluid flow by means of an immiscible functional liquid partly infiltrated in a porous solid matrix.

The Fermi-LAT Collaboration reports a significant γ-ray detection (5.2σ) from the coronae of radio-quiet active galactic nuclei, revealing compact (~10 gravitational radii) and extended (~2.7 × 10⁶ gravitational radii) corona regions, challenging existing models.

The authors present a 2D screening approach using antibody libraries against a panel of antigen fragments exposed on the phage surface, which facilitates the mapping of monoclonal antibodies to panels of diverse antigens, even with unknown immunogens.

While global ocean redox patterns during the end Triassic were similar to today, pulses of localized anoxia were probably linked to mass extinctions on continental shelves, according to analysis of molybdenum records.

Wood density is an important plant trait. Data from 1.1 million forest inventory plots and 10,703 tree species show a latitudinal gradient in wood density, with temperature and soil moisture explaining variation at the global scale and disturbance also having a role at the local level.

A laser design that exploits multiple bound states on a flat band to tightly confine light in three dimensions yields an ultracompact terahertz quantum cascade laser cavity with a lateral size of ~3λ.

A broadband cascaded amplification scheme enables the generation of intense near-single-cycle pulses with excellent temporal contrast and waveform control.

The study provides a comprehensive transcriptomic atlas of the human gastrointestinal tract across the lifespan, highlighting inflammation-induced changes in epithelial stem cells that alter mucosal architecture and promote further inflammation.

Levantine Phoenicians made little genetic contribution to Punic settlements in the central and western Mediterranean between the sixth and second centuries bce; instead, the Punic people derived most of their ancestry from a genetic profile similar to that of Sicily and the Aegean, with notable contributions from North Africa as well.

Here, the authors present mtDNA and chronological data for sediments from excavations in the South Chamber of Denisova Cave, from which they construct a timeline of hominin and faunal occupation that fills stratigraphic gaps in other parts of the cave.

SuShiE is a multiancestry fine-mapping method for molecular quantitative trait loci that leverages linkage disequilibrium heterogeneity to improve resolution, infer cross-ancestry effect size correlations and estimate ancestry-specific expression prediction weights.

A selective shielding strategy achieves the differentiation and quantification of distinct plasmonic photocatalytic mechanisms including hot carrier-driven photochemistry, resonant field-mediated energy transfers, and thermal contributions.

Eye2Gene’s next-generation phenotyping of multimodal images increases diagnostic yield for inherited retinal diseases by improving screening, phenotype-driven variant prioritization and automatic similarity matching in phenotypic space to drive gene discovery.

The Connectome Annotation Versioning Engine (CAVE) is a platform for proofreading, annotating and analyzing datasets reaching the petascale. Currently, CAVE is used for electron microscopy datasets, but it can potentially be used for other large-scale datasets.

Structure of the Toxoplasma mitoribosome made of >50 short rRNA molecules reveals evolutionary solutions to rRNA fragmentation: addition of poly A tails to rRNAs, reused rRNA sequences, and repurposing of proteins with transcription factor domains.

This study presents a nuclear magnetic resonance-based method to determine local structure and bonding of Pt single-atom catalysts.

Direct dark matter searches need to take into account whether the total observation time is lower than the characteristic coherence time of the DM field. Analysing this generally overlooked scenario, here the authors quantify the impact on DM limits of the stochastic nature of the virialised ultralight field.

Cao et al. show that human amygdala and hippocampus neurons encode visual facial features, bridging perception-driven representations with mnemonic semantic representations.

Using a newly developed spatiotemporal phylogeographic path analysis method combined with phylogenetic niche modelling, the authors estimate clade-wide dispersal maps spanning the early Permian to end-Triassic periods for archosauromorph reptiles.

Bacterial attachment on implanted medical devices depends on surface topography. Here, the authors screen combinatorially generated shapes embossed into polymers to investigate topographical control of bacterial responses to surfaces.

Genome-wide association analyses comprising 14,256 cases and 1,199,156 controls and incorporating correlated cardiac magnetic resonance imaging traits provide insights into the molecular etiology of dilated cardiomyopathy.

A quantitative morphological framework for the human thymus reveals the establishment of the lobular cytokine network, canonical thymocyte trajectories and thymic epithelial cell distributions in fetal and paediatric thymic development.

Superconductivity is induced in an accidental Dirac semimetal via the proximity effect.

The critical floating phase can bridge crystalline orders and the disordered phase. Here, the authors experimentally observe the quantum floating phase in neutral atom qubit arrays, revealing domain walls and incommensurate quasi long-range order, and analyse its emergence via Fourier spectroscopy.

The transition to sustainable diets is challenging for countries that face malnutrition and limited resources. Now a study explores how various dietary transformations in China can improve public health, make food affordable and reduce environmental impacts, while evaluating the feasibility of the diet changes.

A genome-wide association study including over 76,000 individuals with schizophrenia and over 243,000 control individuals identifies common variant associations at 287 genomic loci, and further fine-mapping analyses highlight the importance of genes involved in synaptic processes.

Stepwise deuteration of protonated methane CH₅⁺ — a fluxional structure that undergoes ‘hydrogen scrambling’ — leads to dramatic changes in the infrared spectra of the isotopologues. The spectra can be assigned using ab initio quantum simulations that account for the non-classical occupation — by H and D atoms — of topologically different sites within the molecule.

Conodonts, early vertebrates, are thought to have evolved complex tooth tissue as an adaptation for feeding. Here, the authors use Electron Backscatter Diffraction to show increasing dental crystallographic order through conodont evolution, in parallel with dietary adaptations.

The collapse of tropical forests during the Permian–Triassic Mass Extinction weakened carbon sequestration, sustaining high CO2 and extreme global warmth for millions of years: an example of a runaway feedback in Earth’s climate-carbon system.

Subcellular mRNA localization is prevalent but with poorly understood physiological roles. Here, the authors show that Net1 mRNA targeting to the basement membrane controls epithelial tissue organization and keratinocyte-stromal connections.

A peripherally restricted CB1 agonist (VIP36) targeting a cryptic receptor pocket was developed, showing high efficacy in mouse pain models with minimal side effects and tolerance, potentially revolutionizing chronic pain treatment and GPCR drug design.

Meta-omic analyses are commonly used for large-scale studies of microbial eukaryotes. Here, Krinos et al. explore the potential pitfalls of common approaches to taxonomic annotation of protistan meta-omic datasets, highlighting the importance of database completeness and curation and proposing that precise taxonomic annotation of meta-omic data is a clustering problem rather than a feasible alignment problem.

Inorganic polyphosphates have been identified in the central nervous system. Holmström and colleagues examine neuroglial cultures in vitro and cardiorespiratory responses in vivo, and find that inorganic polyphosphates trigger calcium-dependent activation of astrocytes and increase cardiorespiratory activity.

Hexa-acylated lipopolysaccharides from the gut microbiota are associated with efficacy in patients with cancer receiving anti-PD-1 and stimulate host immune activation for enhanced anti-tumour immunity in mouse models.

Earth system models often categorize plants to just a few functional types, and plant characteristics are defined per type, neglecting their diversity. The authors show how the use of plant traits can improve the modeling of global carbon, water, and energy fluxes

Green hydrogen production via water electrolysis requires a low-cost solution to provide efficient catalysts. Here, the authors report an industrially scalable method for synthesizing NiFe layered double hydroxide at room temperature and atmospheric pressure, enhancing alkaline electrolysis.