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The authors synthesize bee assemblage data from 681 crop fields across three continents, finding that local pesticide hazards and decreasing adjacent semi-natural habitats both negatively affected wild bee abundance and species richness in crop fields, while pesticides also reduced functional diversity.

Genome-wide analyses of 10 educational fields identify 17 associated loci. Analysis of genetic clustering across specializations identifies two key dimensions that show genetic overlap with personality traits, behavioral traits and socioeconomic status.

This study of magic-angle twisted trilayer graphene moiré superconductors using scanning tunnelling microscopy and spectroscopy identifies two energy gaps that develop from many-body resonance in this highly tunable class of materials.

Here the authors compare genetic testing strategies in rare movement disorders, improve diagnostic yield with genome analysis, and establish CD99L2 as an X-linked spastic ataxia gene, showing that CD99L2–CAPN1 signaling disruption likely drives neurodegeneration.

Structural mapping of the female genital representation in somatosensory cortex reveals experience-dependent plasticity and associations with childhood sexual abuse, and adult sexual behavior.

Luppi et al. identify transcriptomic and connectomic controllers of information integration and its breakdown induced by anaesthesia in humans, macaques, marmosets and mice.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

The researchers show that a subwavelength film of indium tin oxide, the bulk permittivity of which is strategically modulated via optical pumping, can be dynamically tuned to act as both a non-resonant amplifier and a perfect absorber. The findings extend the concept of coherent perfect absorption to the temporal domain and may enable coherent manipulation of light in Floquet-engineered complex photonic systems.

Tests of the predictions of the renormalization group in biological experiments have not yet been decisive. Now, a study on the collective dynamics of insect swarms provides a long-sought match between experiment and theory.

Using single broadband X-ray pulses from a free-electron laser on a gaseous neon target, coherent, nonlinear four-photon interactions with core–shell electrons is demonstrated, representing a strategy for multidimensional correlation spectroscopy at the atomic scale.

The first melts generated in any solid-state mantle upwelling are kimberlitic CO₂-rich silicate melts that form at about 250 km depth through oxidation of elemental carbon to CO₂.

Strongly enhanced optical nonlinearities and an ultrafast transition from coherent to incoherent polariton excitations are demonstrated by coupling an atomically thin WS₂ layer to a plasmonic nanostructure using ultrafast multidimensional spectroscopy.

Juno radio occultations precisely redefine Jupiter’s shape, measuring a polar diameter of 66,842 km and an equatorial diameter of 71,488 km, both smaller than long-used values, bringing models of the planet’s interior into better agreement with observations.

Atmospheric transport models coupled with methane fluxes underestimate methane pollution events in the Alpine region, according to analysis of continuous methane measurements from the Plateau Rosa observatory in the Italian Alps.

Optically active spin defects in diamond and hBN are promising solid-state quantum sensors but often fall short for chemical sensing. Here the authors show that BN nanotubes hosting such defects create a nanoporous, omnidirectional quantum “mesh” sensor at room temperature, enhancing chemical detection through high surface area and improved sample accessibility.

On-demand laser-induced frequency tuning of coherent magnons in a 20 nm thick magnet at room temperature is demonstrated. By tuning the laser fluence and magnetic field, red- or blueshift of the frequency up to 40% of its original value are achieved.

This study associates p53 loss and brain metastasis in breast cancer. Mechanistically, p53-null tumors recruit astrocytes that provide substrates for enhanced fatty acid synthesis via upregulated SCD1 expression, representing a targetable axis in the disease.

Reduced order modeling is of paramount importance for accelerating engineering design and characterization. Here, authors propose a SHallow REcurrent Decoder-based Reduced Order Model (SHRED-ROM) to reconstruct high-dimensional, parametric and complex dynamics from limited sensor measurements.

Qudits, higher-dimensional analogues of qubits, expand quantum state space for information processing using fewer physical units. Here the authors demonstrate control over a 16-dimensional Hilbert space, equivalent to four qubits, using combined electron-nuclear states of a single Sb donor atom in Si.

A closed-loop in-memory computing accelerator, implemented in a fully integrated chip with on-chip mixed-signal circuits, can be used to solve multiple inverse matrix–vector problems.

There has been considerable interest in using magnons for information processing. Such ‘magnonic’ devices will require magnetic patterning analogous to the lithographic patterns of integrated circuits. Here, Levati, Vitali and coauthors present one possible approach to this, demonstrating laser induced changes in the perpendicular magnetic anisotropy of Yttrium Iron Garnet.

Mapping of the neutrophil compartment using single-cell transcriptional data from multiple physiological and patological states reveals its organizational architecture and how cell state dynamics and trajectories vary during health, inflammation and cancer.

In recent decades, zoonotic disease outbreaks have become increasingly frequent, necessitating strategies to improve the accuracy of predictive modelling. This Review discusses the importance of macroecological variables in such modelling efforts to improve preparedness for future potential outbreaks.

Riboswitches are allosteric RNA molecules that change conformation upon ligand binding to regulate downstream genes. Here, the authors use Restricted Boltzmann machines trained on natural sequences to design new riboswitch aptamer domains, and validate their functionality via chemical probing.

Despite exhibiting ferroelectric features, SrTiO₃ fails to display long-range polar order at low temperatures due to quantum fluctuations. An ultrafast X-ray diffraction experiment now probes polar dynamics of this material at the nanometre scale.

Using a reconfigurable integrated photonic platform, the authors reveal the appearance of non-Hermitian topology and the existence of edge modes emerging exclusively from optical loss modulation.

Genetic mapping in mice identified Homer1a as a key modifier of attention. Developmental downregulation in the prefrontal cortex enhances inhibitory tone, neural signal to noise and adult attentional performance, revealing a new control mechanism and target.

Reanalysis of radiometric data from Cassini indicates that Titan does not contain a subsurface ocean, as strong tidal dissipation observed in its gravity field is not consistent with the presence of a liquid layer.

A miniaturized frequency up-converted electrically tunable single-mode photonic source in the 9.0–10.5 THz range is demonstrated.

In the layered magnetic semiconductor CrSBr, emergent light–matter hybrids (polaritons) increase the spectral bandwidth of correlations between the magnetic, electronic and optical properties, enabling largely tunable optical responses to applied magnetic fields and magnons.

The authors introduce a machine-learning framework that predicts how materials respond to electric fields with quantum-level accuracy, capturing vibrational, dielectric, and ferroelectric behaviors up to the million-atom scale.

The development of a universal protein coarse-grained model has been a long-standing challenge. A coarse-grained model with chemical transferability has now been developed by combining deep-learning methods with a large and diverse training set of all-atom protein simulations. The model can be used for extrapolative molecular dynamics on new sequences.

A new method for detecting axion-like particles through stacked spectra of active galactic nucleus–galaxy-cluster pairs probes previously inaccessible regions of their parameter space.

Graphene possesses a nonlinear optical response arising from its electronic dispersion. Here, the authors measure the response of graphene to an ultrafast optical field and provide an explanation of the quantum dynamics of Dirac carriers mediating the material’s nonlinear response.

The engineering of localized fields is at the base of ultra-compact plasmonic devices. The authors demonstrate that localized plasmon skyrmions provide a unique way to build arbitrarily shaped skyrmionic textures promising high flexibility and robustness for real applications like information processing.

Pathogenic variants in UNC13A underlie a novel neurodevelopmental syndrome, with three subtypes defined by distinct genotypes with varying clinical and functional impacts characterized in cellular and animal models.

Here the authors show that the dipole-active phonon resonance of semiconducting nanocrystals can be hybridized by a strongly concentrated terahertz vacuum field of a plasmonic nanocavity, thus achieving strong plasmon–phonon coupling even in the absence of direct terahertz illumination.

Observations of a fast X-ray transient reveal that it is a gamma-ray-burst explosion from a very distant galaxy that emits light with the wavelength necessary to drive cosmic reionization, the last major phase change in the history of the Universe.

Topological order for sound remains largely unexplored. Here, Khanikaevet al. introduce the concept of topological order in classical acoustics, realizing robust topological protection and one-way edge propagation of sound in a suitably designed resonator lattice, thus expanding the ability to tailor acoustic waves.

Therapeutic options for patients with renal medullary carcinoma (RMC) are limited. Here the authors report the results of a phase II clinical trial of anti-PD1 nivolumab plus anti-CTLA4 ipilimumab in RMC, associating the activation of a myeloid mimicry program in tumor cells to the rapid disease progression and hyper-progression observed in treated patients.

The presence of a scalar charge around a small compact object during its final inspiral into a supermassive black hole could be detected by LISA, providing a way to test deviations from general relativity and the existence of new fields in nature.

How the environment regulates neuronal maturation during brain development is poorly understood. Here, Kreysing et al. identify brain stiffness as a key factor and determine a mechanotransduction pathway linking tissue mechanics to neuronal maturation.

Josephson plasma solitons are a kind of excitation predicted to occur in cuprate superconductors subject to strong electromagnetic fields. By using intense radiation from a free-electron laser, these modes are now demonstrated experimentally in the copper oxide material La_1.84Sr_0.16CuO₄.

Introducing spin–orbit coupling by substrate proximity effect leads to an enhancement of superconducting phases in rhombohedral trilayer graphene.