Search

By artificial superlattice design, the authors achieve stable polarization over wide frequency, temperature, and thickness ranges in epitaxial HfO₂/ZrO₂ superlattices, along with reduced coercive fields. This work offers a route to overcome polar phase metastability in HfO₂-based films.

Patients with unresectable stage III non-small-cell lung cancer without EGFR or ALK mutations typically receive the PACIFIC regimen — concurrent chemoradiotherapy (cCRT) followed by consolidation with durvalumab — whereas those with EGFR-mutant disease typically receive cCRT followed by an EGFR inhibitor. Nonetheless, a subset of patients within this heterogeneous group might be able to completely avoid consolidation therapy, whereas others are unable to tolerate cCRT. In this Review, the authors describe the standard-of-care approach in this setting, followed by discussions of treatment optimization for specific subgroups, as well as important future research questions.

Artificial gauge fields unlock additional degrees of freedom to manipulating light in structured photonic systems. This Review strives to unify topological, non-Abelian and non-Hermitian photonics using the concept of gauge fields.

T-cell enrichment has attracted great interest but currently fails to fully replicate the complex natural immune interactions. Here, the authors report on magnetic polymerised antigen-presenting cells that mimic natural interactions to isolate rare tumour-reactive T cells, offering a platform for enhancing cancer immunotherapy and neoantigen discovery.

Observations of SN 2021yfj reveal that its progenitor is a massive star stripped down to its O/Si/S core, which remarkably continued to expel vast quantities of silicon-, sulfur-, and argon-rich material before the explosion, informing us that current theories for how stars evolve are too narrow.

Santos et al found that the ubiquitin ligase adaptor Fbxo42 is a critical regulator of terminal Unfolded Protein Response signaling through its control of Ataxin-2 granules containing Xbp1 mRNA.

Multimodal large language models (MLLMs) hold promise for a range of medical applications. Here, the authors use MLLMs for 3D brain CT radiology report generation, demonstrating that combining anatomy-aware model fine-tuning with robust evaluation metrics establishes a comprehensive and effective framework.

A deep generative model is developed for de novo molecular design and optimization by leveraging electron density. Wet-laboratory assays validated its reliability to generate diverse bioactive molecules—orthosteric and allosteric, inhibitors and activators.

The use of biomarkers of ageing is crucial for investigating age-related processes. This Review discusses biomarkers of ageing and of ageing-associated physiological changes, at the cellular, tissue and organism levels in humans and non-human primates.

Li et al. uncover a lysosomal surveillance response whereby intestinal lumen deacidification induces a transcriptional programme that boosts lysosomal activity and improves protein aggregate clearance in multiple worm disease models, extending healthspan.

The authors analyze rare coding variants in 1990 individuals with congenital kidney anomalies, finding diagnostic variants in 14.1% of cases. They identify two new causal genes, ARID3A and NR6A1, along with 38 candidate genes, providing evidence for shared genetics with other developmental disorders.

Despite the frequent presence of para-cyclophane scaffolds in natural products and bioactive molecules, their synthesis remains challenging. Now a series of para-cyclophanes bearing bent 1,4-disubstituted benzene subunits with a high degree of distortion are readily prepared between cyclic tertiary amines and aryne intermediates via a N-arylation–ring-expansion [5,5]-sigmatropic rearrangement process.

Parity-time symmetry breaking and related non-Hermitian phenomena, such as high-order exceptional points, have attracted significant interest across various experimental platforms. Here the authors demonstrate a third-order exceptional point induced by parity-time symmetry breaking in a dissipative trapped ion.

An in-depth microbiological and metagenomic analysis of Colombian farm and fermentation facilities resulted in the design of a defined microbial community that can reproduce the flavour of fine chocolate.

Authors demonstrate an AI-based method that generates high-quality 4K holograms with real-time, adjustable depth control. This overcomes the fixed-focus limitation of prior techniques, enabling flexible and interactive holographic displays without hardware changes.

The authors find low-energy magnetic excitations and a flat band near the Fermi level in kagome metal superconductor CsCr3Sb5 by angle-resolved photoemission and resonant inelastic X-ray scattering. They suggest that the flat band plays a role in the emergence of charge/magnetic order at low temperatures.

While graphite negative electrodes pose dendrite risks, high-potential fast-charging titanium-based alternatives limit battery energy. Here, authors develop a titanium oxide negative electrode with tailored atomic distortions that safely operates at 0.5 V vs. Li ⁺ /Li, boosting cell voltage by 50%.

Tetrandrine is one of the most potent inhibitors of Ebola Virus infection. Here the authors identify LIMP-2 as a direct cellular target of Tetrandrine and establish a functional connection between lysosomal sphingosine homeostasis and calcium regulation.

The Einstein Probe has discovered a fast X-ray transient, EP240414a, associated with a broad-lined type Ic supernova. Its unusually soft spectrum and weak jet add to the diversity of stellar deaths and suggest a previously unknown Wolf–Rayet star explosion mechanism.

Sequencing the genome and microbiome of about 1,500 tick samples from regions across China revealed host–microbe associations in ticks that could have implications for controlling ticks and tick-borne diseases.

Here the authors use single-cell RNA sequencing data to identify genetic variants associated with gene expression (eQTLs) within the context of “trained immunity”, the immunological memory of innate immune cells. They establish a framework for understanding the genetic basis of complex traits by combining single-cell eQTLs with multi-omics data from patients and public databases.

Together with an accompanying paper presenting a transcriptomic atlas of the mouse lemur, interrogation of the atlas provides a rich body of data to support the use of the organism as a model for primate biology and health.

The Yang’s charge is proposed as a metric for evaluating the coupling performance in this study. Compared to the conventional charge coupling factor which only considers the relative performance change, the Yang’s charge also considers the absolute performance of the device.

Two impact-melt fragments in Chang’e-6 lunar soils reveal that the Apollo basin was formed at ~4.16 Ga, implying a non-cataclysmic late heavy bombardment on the Moon between 3.8 and 4.0 Ga.

The study of isotopes away from the beta stability valley is crucial for the understanding of nuclear structure, especially for neutron-deficient heavy nuclei. Here, the authors report the observation of the alpha-decay isotope 210-protactinium (Pa), extending the alpha-decay systematics of underexplored regions of the nuclides chart.

A nonantibiotic-dependent therapy capable of destroying the biofilm is desired for the treatment of drug-resistant fungal infections but underdeveloped. Here, the authors engineer semiconductor coated upconversion nanohybrids for the synergistic actions of ultrasound and near-infrared light that promote drug penetration and reactive oxygen species-mediated disruption of Candida albicans biofilms.

Understanding the pathophysiological pathways of mental disorders and identifying reliable biomarkers remain challenging. This study introduces a large-scale knowledge graph tailored to mental disorders to improve knowledge discovery, disease prediction, and clinical validation

The authors propose a method for high-capacity information encoding and long-distance image transmission by utilising Hermite-Gaussian eigenmodes in defective states. The enables the generation over 10ⁿ varying laser states for encoding, or an information capacity of tens of bits.

E2F transcription factors coordinate the timely expression of genes during early cell-cycle progression. In addition, the E2F-1 subunit can induce apoptosis in response to DNA damage. New results reveal an unexpected function for E2F-1 in suppressing apoptosis, which may be important in explaining the contribution of E2F-1 to tumorigenesis.

Together with a companion paper, the generation of a transcriptomic atlas for the mouse lemur and analyses of example cell types establish this animal as a molecularly tractable primate model organism.

How tree diversity effects on ecosystem functioning vary along climatic gradients is unclear. Here, analysing data from 15 experimental forest sites, the authors show that tree growth responses to neighbourhood species diversity are stronger in wetter climates but are unaffected by interannual climatic variation within sites.

Abnormal T cell proliferation often triggers autoimmune disorders. Here the authors show that T cell-specific deficiency of the enzyme N-acetyltransferase 10 ameliorates experimental autoimmune encephalitis potentially by RACK1-mediated regulation of T cell metabolism and expansion.

Exploiting resonant quantum electron tunnelling empowered by an optically resonant, doubly periodic plasmonic nanowire metasurface, a biosensor with no external light source is demonstrated, boosting the integrability of the biosensor.

Two-color lasers often suffer from low coherence at large frequency spacings. Herein, the authors use the Pound-Drever-Hall technique to synchronize two lasers to a common ultra-stable optical cavity, achieving high coherence and generating microwave signals with remarkable phase noise via 2-point frequency division.

The extracellular matrix (ECM) is assembled through liquid–liquid phase separation and directed phase transition. Now—inspired by tropoelastin—a designer minimalistic model incorporating alternating hydrophobic moieties and crosslinking domains can template the assembly of a biomimetic matrix that mimics the ECM, promoting the mechanosensing of stem cells.

A preclinical covalent compound, CMX410, contains a aryl fluorosulfate warhead that targets the acyltransferase domain of Mtb Pks13, an essential enzyme in cell-wall biosynthesis, making it a promising candidate for tuberculosis treatment regimens.

DeepRETStroke is a deep learning system using retinal photographs to detect silent brain infarction and predict future stroke events.

The contribution of myelin plasticity to autism spectrum disorder remains poorly understood. Here authors demonstrate that mutations in Nlgn3 lead to hypomyelination and reduced parvalbumin interneuron activity, while enhancing myelination ameliorates autism-like sensory processing deficits.

Coupling of a FREP1 variant to a gene-drive system allows the spread of a host malaria resistance allele through the mosquito population.

ALI is an approach for analyzing voltage imaging data that is inspired by algorithms used in super-resolution microscopy. It allows resolving the activity of single neurons in densely labeled populations in scattering conditions.

Superconducting qubits, a leading platform for quantum information processing, suffer from decoherence. Interfacing them with nanomechanical oscillators allows quantum information to be stored in motional states with longer lifetimes.

The forelimbs of two Late Cretaceous theropod dinosaurs show the presence of the pisiform bone, previously thought to have been lost early in theropod evolution and regained in birds during the evolution of flight, indicating that a birdlike pisiform appeared prior to the evolution of flight.

Developing highly active and robust catalysts remains a challenge for the implementation of nitrate reduction. The authors introduce a screw dislocation-mediated 3D printing strategy to fabricate curvature-controlled electrodes with 3D lattice strain, enhancing nitrate reduction performance.

A survey across 90 societies reveals that variation and change in everyday norms are explained by a single value dimension: the priority societies place on individualizing versus binding moral concerns.

Electrolyte design is key for high-energy lithium metal batteries, but structure–performance links are hard to predict. A framework using the normalized cation/anion–solvent affinity enables quantitative prediction of microstructure, transport and interphase, driving exceptional performance.

Electronic wound bandages have to balance conformability and wound healing properties. Here, the authors develop a smart patch (iSAFE) using biomaterials with bioelectronics to facilitate permeability with waterproofing. This achieves intelligent wound management with real-time wound monitoring and active therapy.