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Matched ribosome profiling and RNA sequencing data quantify translation efficiency patterns across 140 human and mouse cell lines.

Introducing chirality has proved to be a fruitful method for inducing new functionalities, particularly direction-dependent properties. Here, Qian et al. realise chiral-magnon-photon coupling by combining a YIG sphere with a waveguide supporting spoof surface plasmon polaritons, allowing unidirectional transmission and perfect absorption.

Lu et al. characterize cis-regulatory element dynamics at different stages of colorectal cancer progression and identify a functional variant associated with increased colorectal cancer risk because of selective transcription factor binding.

The authors introduce and demonstrate a programmable optically-driven organic micro-actuator for precise manipulation of on-chip structures. This paves the way for adaptive, multifunctional photonic systems.

Together with an accompanying paper presenting a transcriptomic atlas of the mouse lemur, interrogation of the atlas provides a rich body of data to support the use of the organism as a model for primate biology and health.

Siyu Chen, Zheli Liu and colleagues propose a holistic co-design optical communication scheme based on the self-homodyne coherent structure, anti-resonant hollow core fibre, and Fermat number transform. This scheme provides a promising path for the realization of high-speed data centre optical interconnect with low power consumption and low latency.

Artificial intelligence-based detection of gastric cancer at different stages from noncontrast computed tomography is suggested to be feasible in a retrospective analysis of large and diverse cohorts, including real-world populations in opportunistic and targeted screening scenarios.

Ovarian metastases of gastric cancer are more likely to occur in young premenopausal women. Here authors show that estrogen regulates ovarian fibroblasts to promote ovarian metastasis of gastric tumors.

Experimental demonstrations of genuine high-dimensional multipartite quantum nonlocality have been lacking so far. Here, the authors fill this gap using entangled photons, surpassing qubit-based limits and paving the way for device-independent quantum information processing in more complex systems.

Wastewater is a promising source of data for continuous monitoring of pathogens in communities, but analysis protocols and methods are still being established. Here, the authors develop sequencing and analysis protocols and use them to evaluate the microbial content of longitudinal wastewater samples from Miami-Dade County, USA.

Raised serum urate levels are a risk factor for gout, a common form of inflammatory arthritis. Here Li et al.conduct a multistage genome-wide association study in a Han Chinese population and identify three novel loci likely associated with the progression from hyperuricemia to gout.

Microcombs are vulnerable to the environmental perturbations. Here, the authors propose a universal mechanism to fully control the microcombs. Based this reconfigurable microsoliton, a wavemeter with a precision of kHz is demonstrated.

Estimates of the severity of emerging infections did not consider the case ascertainment method, but secondary cases identified by contact tracing of index cases may be more reliable as they are less susceptible to ascertainment bias. Here, the authors perform a systematic review to quantify these differences and model their impacts for COVID-19.

Generation of multipartite entanglement between quantum states is crucial for developing quantum computation systems, although it has proven harder to achieve for photons than ions. Here, an eight-photon entangled state based on four independent photon pairs is observed, beating the previous record of six.

Excessive production of reactive oxygen species (ROS) in cancer cells can induce immunogenic cell death (ICD) and promote anti-tumor immune responses. Here the authors report that intermetallics modified with glucose oxidase and soybean phospholipid as nano-inducers promote cancer cell pyroptosis and disulfidptosis, resulting in ICD and anti-tumor immunity in preclinical models.

Covalent organic frameworks (COFs) show great promise in photocatalysis but are limited by slow charge transfer. Here, the authors report a strategy to enhance the built-in electric field of COFs via ionic polarization, resulting in a hydrogen evolution rate of 9.21 mmol g^-¹ h^-¹ without Pt co-catalysts.

Cardiac ischemia/reperfusion injury is a deleterious consequence of reperfusion therapy for myocardial infarction. Here, the authors show that FNDC4 alleviates cardiac ischemia/reperfusion injury through facilitating HIF1α-dependent cardiomyocyte survival and angiogenesis.

High-throughput computational screening of multicomponent molecular photocatalytic systems offers a strategy to minimize the screening of large numbers of photosensitizer–catalyst combinations. Here a machine learning-accelerated approach using multiple descriptors shows strong predictive power in experimentally validated systems for CO₂ reduction.

Achieving both high efficiency and narrow emission in organic light-emitting transistors (OLETs) remains a challenge. Here the authors demonstrate laterally integrated OLETs with an intrinsic microcavity that achieve both enhanced efficiency and narrow emission.

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Authors uncover room-temperature skyrmions in 2D van der Waals material, attributing their presence to Fe-deficiency-induced symmetry breaking, enabling topological Hall effect and small Néel-type skyrmions with femtosecond laser writability.

Biochemical and structural studies of the interactions between antibodies and spike proteins from SARS-CoV-2 Omicron subvariants indicate how these variants have evolved to escape antibody-mediated neutralization.

A bimolecular doping strategy enables the realisation of white organic polarized emissive semiconductor single crystals, emitting white light with a maximum degree of polarization as high as 0.96. Organic polarized light-emitting diodes and light-emitting transistors with tuneable emission wavelength are also demonstrated.

Full-fledged quantum communication networks would allow distributed quantum computing across multiple remote nodes, but typical implementations are stuck at meters-scale distances. Here the authors demonstrate teleportation-based nonlocal CNOT gates, distributed Deutsch-Jozsa algorithm and quantum phase estimation across 7 km space separation.

‘Gastric cancer metastasis to the ovary is difficult to treat and is not fully understood. Here, the authors characterized mutations in a cohort of matched primary and metastatic disease, and found mutations, including in CLDN18, could predict treatment response to paclitaxel.

C-type lectins and SIGLEC1 function as attachment receptors for SARS-CoV-2 and enhance ACE2-mediated infection.

Engineered T cells kill leukemic cells with little off-target toxicity.

Observational analyses from the China Kadoorie Biobank found that alcohol consumption was associated with higher risks of 61 diseases in Chinese men, with most of these associations confirmed by genetic analyses.

In this study, the authors report a mutation that increases the production of recombinant SARS-CoV-2 Spike and exposure of the RBD. In animal models, a Spike-based vaccine containing the mutation induces strong immunogenicity, provides protection from disease and results in faster tissue viral clearance.

Meiotic drivers of the wtf family kill progeny lacking the driver by producing a toxin and an antidote. Here, authors reveal that ubiquitination-mediated sorting of the antidote prevents it from becoming toxic and enables it to neutralize the toxin.

Although it may never be possible for a single animal model to recapitulate all of the features of HIV-1 infection of humans, there have been great advances in the development of small-animal and non-human primate models, as well as in the development of recombinant challenge viruses. Here, the authors review the advantages and disadvantages of the different animal models of HIV/AIDS with respect to their use in the preclinical development of vaccines and antiretroviral therapies.

From 1980 to 2018, the levels of total and non-high-density lipoprotein cholesterol increased in low- and middle-income countries, especially in east and southeast Asia, and decreased in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe.

Changes of left ventricular structure are used to predict morbidity and mortality in cardiovascular diseases. Here the authors conducted a study using advanced deep learning technology to analyze left ventricular regional wall thickness (LVRWT) in a large population, identifying 72 significant genetic loci linked to LVRWT traits.

Cepharanthine is a secondary metabolite isolated from Stephania with a variety of medicinal properties. Here, the authors assembled three Stephania genomes, propose cepharanthine biosynthetic pathway, and assess the antiviral potential of cepharanthine-related metabolites.

Absorption, transmission and reflection are three processes characterizing optical devices. Absorption allows for signal conversion and transmission is important for signal transfer, however, reflection is frequently detrimental to device performance. Here, Qian et al demonstrate a magnonic device with controllable absorption and transmission while maintain zero reflection.

Dual-comb spectroscopy with time–frequency dissemination and high-power frequency combs enables sensing CO₂ and H₂O over a 113 km turbulent open-air path, with a sensing precision as high as 2 parts per million of CO₂.

Fine-mapping prioritizes risk variants identified by genome-wide association studies to uncover biological mechanisms underlying complex traits. Here, the authors develop a reliable fine-mapping method (XMAP) by leveraging genetic diversity and accounting for confounding bias.

Cardiac I/R injury is a deleterious issue in the clinic. Here, the authors show that Tisp40 facilitates HBP flux and protein O-GlcNAcylation through binding to the promoter of GFPT1, thereby preventing cardiac I/R injury.

A van der Waals crystal, niobium oxide dichloride, with vanishing interlayer electronic coupling and considerable monolayer-like excitonic behaviour in the bulk, as well as strong and scalable second-order optical nonlinearity, is discovered, which enables a high-performance quantum light source.

A strategy for the transfer-free direct growth of ultralong, high-quality graphene nanoribbons, which have desirable electronic properties, between layers of a boron nitride insulator is reported.