Search

Giotto Suite provides a comprehensive, flexible and scalable platform for technology-agnostic spatial omics analysis using R.

Thermal lepton pairs are ideal probes for the temperature of quark-gluon plasma. Here, the STAR Collaboration uses thermal electron-positron pair production to measure quark-gluon plasma average temperature at different stages of the evolution.

The quark structure of the f₀(980) hadron is still unknown after 50 years of its discovery. Here, the CMS Collaboration reports a measurement of the elliptic flow of the f₀(980) state in proton-lead collisions at a nucleon-nucleon centre-of-mass energy of 8.16 TeV, providing strong evidence that the state is an ordinary meson.

Whole genome sequences enable discovery of rare variants which may help to explain the heritability of common diseases. Here the authors find that ultra-rare variants explain ~50% of coronary artery disease (CAD) heritability and highlight several functional processes including cell type-specific regulatory mechanisms as key drivers of CAD genetic risk.

The authors present evidence based on satellite observations that the local cooling effect of potential forestation in Europe has intensified over the past two decades, driven by the reduced winter snow cover and declining summer soil moisture under global warming.

Human cortical functions rely on intricate spatial arrangements and interactions among neuronal cell types. Here, authors show a comprehensive cellular atlas illustrating detailed neuron distribution and communication patterns across cortical regions.

Padawer-Curry et al. show that the hallucinogenic 5-HT2A receptor agonist DOI alters neurovascular coupling in mice, with implications for the interpretation of human fMRI studies of psychedelics.

A planet in a retrograde orbit around a star with a close-in white dwarf companion reveals the role of binary stellar evolution in the formation and evolution of planets.

Cis regulatory elements endow genomes with sequence-encoded logic to drive cellular differentiation. Here, the authors introduce a biophysically principled sequence model that characterises complex TF-DNA interactions with accuracy that rivals state-of-the-art blackbox sequence foundation models.

A complementary analysis of DESI DR2 distance measurements along with supernova and CMB data shows consistent, moderate evidence that dark energy changes over time rather than behaving as a simple cosmological constant.

In large prospectively enrolled validation cohorts of patients with cancer and controls and a prospective study of asymptomatic individuals with average risk for cancer, a multicancer early detection test based on plasma cell-free DNA genomics and fragmentomics showed encouraging accuracy in identifying ongoing disease as well as the tissue of origin.

Cells struggle to migrate on soft substrates, which don’t provide enough traction. Here, the authors show that rapid, cyclic changes in substrate rigidity allow cells to overcome this limitation and move quickly.

The intrinsic robustness to perturbations makes antiferromagnets ideal building blocks for spintronic devices, however, it also manipulation and detection of antiferromagnetic ordering difficult. Here, Xu et al demonstrate an anisotropic tunnelling magnetoresistance in an all-antiferromagnetic tunnel junction.

Binning is an essential step in genome-resolved metagenomic analysis in which assembled contigs originating from the same source population are clustered. However it is challenging, especially for low abundance microbial species. Here the authors introduce a toolkit that integrates multiple prominent binning tools and AI for efficient and high-resolution recovery of non-redundant bins from short- and long-read metagenomic sequencing datasets.

Artificial assembly of small functional proteins provides effective strategies for downsizing RNA degraders. Here, authors develop STAR, a hypercompact RNA degrader with evolved toxin endoribonucleases and engineered Cas6- CBS system, enabling efficient degradation of cytoplasmic and nuclear RNAs.

Pluto’s haze is revealed to have two types of particles: small spherical organic haze particles and micron-size fluffy aggregates. The persistence of these two populations has important implications for haze formation and properties on icy worlds.

Xu et al. identify the MondoA–TXNIP signalling axis as a regulator of antitumour immune surveillance in response to lactic acid in the tumour microenvironment.

Generalizable Pathology Foundation Model (GPFM) consolidates expertise from a variety of existing models for use in a broad spectrum of computational pathology tasks.

How lateral entorhinal cortex (LEC) neurons integrate both spatial and temporal information are not fully understood. Here authors showed that LEC neurons could change their firing rate at specific locations to signal temporal information, which provides a way to combine spatial and temporal information in the hippocampal episodic memory system.

NanoVar is a structural variant caller for low-depth long-read sequencing data, allowing repeat element annotation of non-reference insertion variants. This is a comprehensive guide, from quality assessment of raw data to downstream analysis.

EpiVerse is a deep-learning framework that integrates imputed epigenetic signals to improve cross-cell-type Hi-C prediction, enhance interpretability, and enable in silico perturbation of chromatin architecture.

How hippocampal cells encode space during development is not well understood. Using longitudinal calcium imaging, the authors show that a subset of place cells early in development consistently represented spatial information across environments and days, while a later-developing subset of place cells showed enhanced spatial coding ability.

Clear cell renal cell carcinoma (ccRCC) usually metastasizes to the lungs. Here, the authors discover that SWI/SNF ATPase subunit SMARCA4 silencing of HLF regulates ccRCC lung metastasis by modulating the integration of collagen's mechanical cues with the actin cytoskeleton through leupaxin.

Temperature-related risks among the climate-sensitive diseases in northwestern and southwestern China have been historically high, with associated hospitalization burdens projected to rise consistently.

Synthetic biology enables sustainable chemical production. Here, authors develop a modular enzymatic platform to biosynthesize non-natural amino acids with C–S, C–Se, and C–N side chains from renewable substrate glycerol, achieving high efficiency and scalability.

Zheng et al. identify a role for CD160 in regulating CD8⁺ T cell exhaustion and cytotoxicity through the AKT–NF-κB pathway. The transfer of CD160⁺CD8⁺ T cells overcomes resistance to anti-PD-1 treatment in colorectal cancer models.

Here the authors identify RNA G-quadruplexes as temperature-sensitive regulators of alternative splicing and gene expression, opening potential therapeutic avenues such as neuroprotection with potassium channel blockers.

AfCycDesign: Cyclic offset to the relative positional encoding in AlphaFold2 enables accurate structure prediction, sequence redesign, and de novo hallucination of cyclic peptide monomers and binders.

Analysis of whole-genome sequences of 25,465 individuals of European ancestry shows that rare variants contribute substantially to the heritability of height and body mass index.

Trained and validated on multimodal data from 14.5 million images from multicountry datasets, a foundation model is shown to increase diagnostic and referral accuracy of clinicians when used as an assistant in a trial involving 16 ophthalmologists and 668 patients.

Observations of γ-rays with energies up to 1.4 PeV find that 12 sources in the Galaxy are PeVatrons, one of which is the Crab Nebula.

An analysis of 2,954 genomes from 38 cancer subtypes identified 19,166 retrotransposition events in 35% of samples. Aberrant LINE-1 retrotranspositions can lead to the deletion of tumor-suppressor genes as well as the amplification of oncogenes.

Double Asteroid Redirection Test (DART) mission’s impact on asteroid Dimorphos has led to various impact related features. Here, the authors show that those features result naturally from the dynamical interaction of the ejecta with the binary system and solar radiation pressure.

Solid waste disposal is a major source of anthropogenic methane, yet estimating these emissions is difficult. Here the authors use satellite data to assess emissions from high-emitting landfills and find that transforming open sites to sanitary landfills could offer a large mitigation potential.

Gene dynamics of concurrent biological processes are unraveled by considering gene trajectories instead of cell trajectories.

Here, the authors introduce a single-cell Hi-C method to study mammalian sperm, suggesting chromatin compartments but absent topological domains (TADs) or loops. It clarifies the unique 3D nuclear architecture of sperm and offers a foundation for investigating structural anomalies associated with male infertility.

By resonant excitation of an InAs quantum dot embedded in a microcavity, a deterministic single-photon source is demonstrated. Single-photon purity of 0.9795(6), photon indistinguishability of 0.9856(13), and an overall end-to-end efficiency of 0.712(18) are simultaneously obtained.

Gene expression is regulated by a variety of mechanisms, which have been difficult to study in a unified way. The authors propose a flexible framework that can integrate different types of data for studying their joint effects on gene expression. The framework uses a general network representation for data integration, metapaths for inputting prior knowledge of gene regulatory mechanisms, and embedding techniques for capturing complex structures in the data.

Tracing cellular changes in complex biological systems is challenging. Here, authors present a flexible framework that integrates multi-sample data with in-house algorithms to infer comparative and spatiotemporal cell-gene patterns, advancing understanding of cellular dynamics.

A standardized, realistic phantom dataset consisting of ground-truth annotations for six diverse molecular species is provided as a community resource for cryo-electron-tomography algorithm benchmarking.

Li et al. introduced tract-geometry coupling (TGC) to quantify the coupling between white matter tracts and cortical geometry in the human brain, shedding light on how the brain’s wiring and shape evolve together and its support for behavior and growth.

Analyses of 2,658 whole genomes across 38 types of cancer identify the contribution of non-coding point mutations and structural variants to driving cancer.

Lanbow, a palette of fluorophores with tunable near-infrared absorption and single-band emission in the shortwave infrared, enables up to nine-colour imaging in deep tissue and precise image-guided surgery in mammals.

Integrated structural biology approach leveraging in situ cryo-electron tomography reveals molecular details of the native malarial translation elongation cycle and its perturbation by cabamiquine, a potent antimalarial drug candidate.

Renewable energy sources have become the dominant power sources in China's electricity system. By investigating the influence of extreme weather combinations on the country's hydropower–wind–solar system, the authors project that there will be a decline of nearly 12% by 2060 in annual utilization hours under conditions of extreme drought, low wind and weak solar radiation.

Certain antimetabolites used to treat cancer are more neurotoxic than others, and it is now shown that this is due to their greater tendency to generate DNA double-stranded breaks, whereas less neurotoxic agents induce single-stranded breaks.

Some cancer patients first present with metastases where the location of the primary is unidentified; these are difficult to treat. In this study, using machine learning, the authors develop a method to determine the tissue of origin of a cancer based on whole sequencing data.

SwitchSeeker combines computational and experimental techniques to identify functional RNA structural switches. Applied to the human transcriptome, it identified a novel RNA switch in the 3ʹUTR of RORC, linked to nonsense-mediated decay.

How the position of conspecifics is represented in the brain is not fully understood. Here authors show that the position of conspecifics is represented relative to self-position in the hippocampus of female mice, which is modulated by context and identity and improved through learning.