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A multi-institute, multi-platform initiative generates standard metrics and best practices for spatial transcriptomics analysis.

EGFR inhibitors are standard of care in patients with EGFR-mutant non-small cell lung cancer (NSCLC) but resistance often develops. Here the authors report that the evolution of EGFR inhibitor resistance in EGFR-mutant NSCLC results in a sensitivity to the compound, MCB-613, and investigate the underlying mechanism of action.

Dielectric materials are crucial for advancing nanoelectronics, yet their miniaturization poses significant challenges. Here, the authors synthesize atomically thin gallium oxide on graphene, achieving a clean interface and robust electronic properties, paving the way for scalable integration of conducting and insulating components in nanoelectronics and offering a versatile method for oxide synthesis.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

The authors demonstrate a cavity enhancement of single artificial atoms at telecommunication wavelengths in silicon by coupling them to highly optimized photonic crystal cavities, showing intensity enhancement and highly pure single-photon emission.

Analysis of a placebo-controlled trial of a BCMA-targeting CAR-T cell therapy in patients with myasthenia gravis shows that CAR-T cell infusion selectively remodels the systemic immune environment, with elimination of BCMA-high plasma cells and activated plasmacytoid dendritic cells and changes in the autoreactive B cell repertoire.

Metabolic and proteomic profiles derived from fossilized skeletal remains of animals enable inferences regarding physiological health and disease as well as diet to provide reconstructions of ancient soil, vegetation and palaeoclimate characteristics.

Germano-silicate used as a building material for integrated photonics circuits substantially reduces optical losses, approaching levels comparable to those in optical fibres.

This study shows that spatial contexts with more reliable brain representations better support memory for future experiences within them, revealing how stable neural maps help the brain organize and recall life events.

This study demonstrates that 16p11.2 hemideletion, a genetic deletion linked to neurodevelopmental disorders, affects male and female mice differently, altering specific striatal neuronal circuits and driving sex-specific behavioral changes.

Combining high-resolution mapping of foliar and herbivore faecal sodium concentrations across Africa, the authors show that plant-derived sodium availability constrains megaherbivore densities at a continental scale.

Here, the authors examine the mechanisms behind cheatgrass’s successful invasion of North American ecosystems. Their genetic analyses and common garden experiments demonstrate that multiple introductions and migrations facilitated cheatgrass local adaptation.

In geometrically frustrated magnets, long-range magnetic order is typically suppressed, whereas at the same time non-trivial spin correlations are observed. Using time-domain terahertz spectroscopy, the authors find evidence for extended quantum string-like excitations in the quantum spin ice material Yb₂Ti₂O₇.

The authors report superconducting topological surface states (TSS) on MBE-grown Fe(Te,Se) films by high-resolution laser-ARPES. Near the FeTe limit, the surface state disappears due to an electron-correlation-driven topological transition associated with decoherence of the d_xy-orbital-derived bands.

Multidrug efflux pumps help bacteria survive stress and promote antibiotic resistance. Here, authors define the molecular detail of an anaerobic-connected pump MdtF uncovering acid-responsive activity which may enable toxin control in certain niches.

The Kondo effect has been observed in a variety of systems, including carbon nanotube quantum dots and graphene in the presence of impurities. Here, the authors report the observation of the Kondo effect in bilayer graphene quantum dots and study its interplay with weak spin-orbit coupling.

ADGRL4 is a cancer-implicated adhesion GPCR whose ability to couple to G proteins had been unclear. Here, authors show that ADGRL4 weakly engages Gq and determine its 3.1 Å active-state structure, revealing its mechanism of activation.

Coordinated X-ray and radio observations reveal that disk winds and jets occur mutually exclusively in 4U 1630–472, providing new observational constraints on the interplay between different modes of outflow in X-ray binaries.

Quantum spin Hall edge states are protected by time-reversal symmetry and are expected to disappear in a strong magnetic field. Here, the authors use microwave impedance microscopy and find, surprisingly, edge conduction in mercury telluride quantum wells that survives up to 9 T with little change.

Ferroelectric materials are characterized by a spontaneous polarization, which in practical applications is manipulated by an electric field. This study examines how defects affect the switching with atomic resolution, by usingin situaberration-corrected transmission electron microscopy.

Biological nitrogen fixation may impose stronger constraints on the carbon sink in natural terrestrial biomes and represent a larger source of agricultural nitrogen than is generally considered in analyses of the global nitrogen cycle.

The authors present SVclone, a computational method for inferring the cancer cell fraction of structural variants from whole-genome sequencing data.

The International Brain Laboratory presents a brain-wide electrophysiological map obtained from pooling data from 12 laboratories that performed the same standardized perceptual decision-making task in mice.

Achieving nonlinear optical response of free-space planar solid devices in the few-photon regime will provide several technological advances. Here, the authors demonstrate a self-hybridised perovskite metasurface with strong nonlinear absorption at record low incident powers, by means of cavity critical coupling engineering

Pesnot Lerousseau and Summerfield compare humans to transformer neural networks in a learning task designed to distinguish ‘in-weights’ and ‘in-context’ learning processes.

Magnetization reversal in magnetic topological insulators drives quantum phase transitions between quantum anomalous Hall, axion insulator, and normal insulator states. Using novel analysis protocol, the authors investigate critical behaviours of these transitions and establish their electronic origin.

An exploratory analysis of the phase 3 ECOSPOR III trial shows that a higher dosage of the oral microbiome therapeutic VOWST led to enhanced pharmacokinetics, increased species engraftment and altered microbiome and metabolite profiles, providing mechanistic insights into how it may prevent Clostridioides difficile infection recurrence.

Observation-based modelling suggests that recent acceleration of Earth’s north magnetic pole towards Siberia can be linked to elongation of a lobe of negative magnetic flux at the core–mantle boundary beneath Canada.

The authors study a Pt/Nb hybrid structure by scanning microscopy and muon spin rotation. They find an anomalous absence of Meissner screening near the Pt/Nb interface due to spin-triplet pair correlations driven by spin-orbit coupling alone with no ferromagnetic layer necessary.

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

Allogenic mesenchymal stem cells are engineered with three mRNAs to bind to multiple myeloma B cells while activating T cells for cancer therapy.

Nanoscale magnetic imaging based on single defects in diamond is extended to cryogenic temperatures and is used to study vortices in the iron pnictide superconductor BaFe₂(As_0.7P_0.3)₂.

The development of noninvasive methodology plays an important role in advancing lithium ion battery technology. Here the authors utilize the measurement of tiny magnetic field changes within a cell to assess the lithiation state of the active material, and detect defects.

Challenges in mapping modern molecular and anatomical datasets into a common atlas are not fully addressed. Here authors present approaches to aligning multimodal neuroimaging data and quantifying geometric variability. Authors also make sure open-source code, dataset standards, and a web interface are available, enabling large scale integration of datasets essential to modern neuroscience.

An expert-elicitation process identifies current methodological barriers for monitoring terrestrial biodiversity, and how technological and procedural development of robotic and autonomous systems may contribute to overcoming these challenges.

Trends in global H₂ sources and sinks are analysed from 1990 to 2020, and a comprehensive budget for the decade 2010–2020 is presented.

Current systems of cancer research marginalize knowledge from low- and middle-income countries, where most future cancer cases will occur, by privileging high-income country evidence and often overlooking local expertise and context-specific needs.

Fractal analysis of structural MRI captures the formation of brain shape in human newborns and outperforms other morphological measures in predicting infant age and genetic similarity, including the identification of twins from their brain data.

STING–type-I interferon pathway regulates the immunogenicity of several cancer types, including head and neck squamous cell carcinoma. Here the authors describe that glutamine metabolism in the tumour microenvironment dampens the STING–type-I interferon pathway by epigenetically silencing the expression of BATF2, which functions as a tumour suppressor.

Twisted double bilayer graphene (tDBG) comprises two Bernal-stacked bilayer graphene sheets with a twist between them. Here, the authors report a strong anomalous Hall effect in the correlated-metal regime of tDBG, indicating time reversal symmetry breaking from orbital ferromagnetism, likely associated with valley polarization.

Early high-resolution images of two 2021 novae reveal eruptions unfolding in multiple stages with colliding outflows that produce shocks and gamma rays, reshaping our understanding of stellar explosions.

Tree longevity is thought to increase in harsh environments, but global evidence of drivers is lacking. Here, the authors find two different pathways for tree longevity: slow growth in resource limited environments and increasing tree stature and/or slow growth in competitive environments.

Mitochondrial respiration provides reducing power to the electron transport chain (ETC), driving proton pumping and ATP synthesis required for T cell activation and differentiation. Here, the authors use alternative oxidase (AOX) as a mechanistic probe to bypass cytochrome c oxidase deficiency and thereby isolate the role of respiration and demonstrate that intact mitochondrial respiration is important for T cell proliferation, effector function, memory formation, and regulation of apoptotic and metabolic signaling pathways.

The endoplasmic-reticulum (ER) transmembrane protein IRE1 mitigates ER stress through kinase-ribonuclease and scaffolding activities. However, a significant nonenzymatic IRE1 dependency has been shown in cancer. Here, the authors design a proteolysis-targeting chimera (PROTAC) to fully disrupt cellular IRE1 protein, selectively blocking growth of IRE1-dependent cancer cells.