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Self-assembled multidomain supramolecular peptide hydrogels that engage in dynamic covalent bonding with small-molecule drugs and biologics are shown to offer sustained release, extend the activity, and maintain safe and potent drug levels in vivo.

A Telluride Science Workshop on electrochemical separations was convened in early 2025. In this Feature, 17 of the workshop participants share their perspectives and future outlooks on this rapidly growing research area.

This Review summarizes recent technical advancements in generative AI, outlines how new models might improve healthcare and discusses validation approaches—using lessons from recent successes and failures in the field.

The composition of Earth’s inner core can be constrained by the supercooling required for its formation. Based on molecular dynamic simulations this work shows that inner core nucleation from an iron-carbon composition fits geophysical constraints.

When people recall a movie, their eye movements and brain activity resemble those observed during the viewing. These behavioral and neural reactivations are linked through a common process, likely reflecting the specific internal experiences that emerge in an instance of recall.

Measuring the bulk power laws of Luttinger liquids in semiconductors remains challenging. Here, the authors demonstrate the dominance of the end-tunneling effect in two fairly distinct Luttinger liquids coexisting in a single quantum wire.

In geometrically frustrated magnets, long-range magnetic order is typically suppressed, whereas at the same time non-trivial spin correlations are observed. Using time-domain terahertz spectroscopy, the authors find evidence for extended quantum string-like excitations in the quantum spin ice material Yb₂Ti₂O₇.

Here, the authors introduce Martini3-IDP, a refined model for disordered proteins that addresses prior over-compact structures. Validated across diverse systems, it captures IDP interactions and biomolecular condensates.

The neural basis of how the visual cortex processes complex features remains under active investigation. Here, the authors show that broadband stimuli increase neural responses and visual perception due to a reduction in center-surround suppression.

Here, the authors identify the microbiota-derived corisin as a driver of diabetic kidney fibrosis via cellular aging and show that targeting corisin with a monoclonal antibody alleviates disease in mice, suggesting a potential therapeutic avenue.

The Kondo effect has been observed in a variety of systems, including carbon nanotube quantum dots and graphene in the presence of impurities. Here, the authors report the observation of the Kondo effect in bilayer graphene quantum dots and study its interplay with weak spin-orbit coupling.

Erlich et al. show that soluble LTα and membrane-bound LTα1β2 lymphotoxins expressed by B cells play distinct roles to attenuate the pathology observed in ileitis.

Here the authors show that genkwanin glycosides from Phaleria nisidai leaf extract improve glucose homeostasis by enhancing glucose uptake into adipose tissue, with effects comparable to metformin in a study with male mice with obesity and insulin resistance.

Klebanoff and colleagues report that survival and persistence of CAR-T and CAR-NK cells are regulated by a FAS ligand–FAS autoregulatory circuit, showing that disabling FAS signaling enhances their antitumor efficacy in preclinical models.

Federated learning (FL) algorithms have emerged as a promising solution to train models for healthcare imaging across institutions while preserving privacy. Here, the authors describe the Federated Tumor Segmentation (FeTS) challenge for the decentralised benchmarking of FL algorithms and evaluation of Healthcare AI algorithm generalizability in real-world cancer imaging datasets.

This Perspective from Summerfield et al. considers the impacts of advanced artificial intelligence systems on the process and function of democracy. The authors explore a wide range of potential risks and opportunities.

Quantum spin Hall edge states are protected by time-reversal symmetry and are expected to disappear in a strong magnetic field. Here, the authors use microwave impedance microscopy and find, surprisingly, edge conduction in mercury telluride quantum wells that survives up to 9 T with little change.

Ferroelectric materials are characterized by a spontaneous polarization, which in practical applications is manipulated by an electric field. This study examines how defects affect the switching with atomic resolution, by usingin situaberration-corrected transmission electron microscopy.

Magnetization reversal in magnetic topological insulators drives quantum phase transitions between quantum anomalous Hall, axion insulator, and normal insulator states. Using novel analysis protocol, the authors investigate critical behaviours of these transitions and establish their electronic origin.

The ability to sequence oligonucleotides which consist entirely of artificial bases will facilitate their ongoing development and use. Here authors demonstrate de novo nanopore sequencing of DNA oligomers composed of “P” “Z” “S” and “B” bases with high sequencing accuracy.

Insufficient oxygen limits the efficacy of cell encapsulation therapies for type 1 diabetes. Here, the authors develop an implantable system that continuously generates oxygen to support high-density islet cell survival and function, enabling diabetes reversal in rats without immunosuppression.

LYMTACs are heterobifunctional small molecules that take advantage of lysosomal membrane proteins to degrade membrane targets via relocalization and lysosomal degradation, offering a modular approach to drug otherwise intractable membrane proteins.

The authors study a Pt/Nb hybrid structure by scanning microscopy and muon spin rotation. They find an anomalous absence of Meissner screening near the Pt/Nb interface due to spin-triplet pair correlations driven by spin-orbit coupling alone with no ferromagnetic layer necessary.

The authors present SVclone, a computational method for inferring the cancer cell fraction of structural variants from whole-genome sequencing data.

The authors report the implementation of a bilayer system of 2D ultracold Bose gases with controllable Josephson coupling. This allows characterisation of coupling-induced superfluid phases and their microscopic origin tracing back to vortex binding.

Shatter cones in rocks in the Pilbara craton provide unequivocal evidence for oldest known impact crater on Earth, which struck 3.5 billion years ago.

Observation-based modelling suggests that recent acceleration of Earth’s north magnetic pole towards Siberia can be linked to elongation of a lobe of negative magnetic flux at the core–mantle boundary beneath Canada.

The development of noninvasive methodology plays an important role in advancing lithium ion battery technology. Here the authors utilize the measurement of tiny magnetic field changes within a cell to assess the lithiation state of the active material, and detect defects.

A survey of geoscience researchers from across Africa highlights key challenges in conducting impactful research. Improved access to skills training can boost research success.

An image analysis framework makes use of rotation-invariant autoencoders and point clouds for morphology-appropriate representation learning to better understand the organization of complex subcellular structures.

Large-footprint, low-sensitivity charge sensors hinder scaling semiconductor quantum dot arrays for quantum computation. Here the authors present a potentially scalable approach using multiplexed gate-based readout and operation in a foundry-fabricated quantum dot array, demonstrating single-electron occupancy.

Birds have an excellent ability to learn to discriminate harmless insects from those that they mimic on the basis of subtle differences in appearance.

Nanoscale magnetic imaging based on single defects in diamond is extended to cryogenic temperatures and is used to study vortices in the iron pnictide superconductor BaFe₂(As_0.7P_0.3)₂.

Twisted double bilayer graphene (tDBG) comprises two Bernal-stacked bilayer graphene sheets with a twist between them. Here, the authors report a strong anomalous Hall effect in the correlated-metal regime of tDBG, indicating time reversal symmetry breaking from orbital ferromagnetism, likely associated with valley polarization.

A single-cell resolution image-based genome-wide CRISPR screen, analysed with deep learning and random forest models, identified host factors regulating Ebola virus infection at distinct stages in the viral life cycle.

This Review discusses multiomic approaches for the characterization and biological understanding of cellular senescence, including detailed case studies on skeletal muscle and adipose tissue that highlight current outstanding issues in the field.

Uneven zinc growth limits the reversibility of zinc metal batteries. Here, authors use in situ X-ray computed tomography and fluid dynamics simulations to reveal how synthetic clay coating suppresses chaotic ion flow, enabling uniform zinc growth and stable cycling in a large-scale pouch cell.

Tissue-resident macrophages (TRM) are important mediators of local immunity. Here the authors show that the deficiency or inhibition of a kinase, WNK1, unlinks macrophage colony-stimulating factor signaling and resulted macropinocytosis with the downstream, potentially IRF8-mediated genetic program to bias progenitor differentiation to neutrophil instead of TRM.

A comprehensive evaluation of memorization across datasets, including training samples and patient data copies, shows that latent diffusion models can memorize a diverse set of medical images with varying properties.

Recent work has shown that digital quantum simulations may be well suited for simulating non-perturbative quantum field theories. Here the authors use a superconducting quantum computer to obtain the energy spectrum of a strongly interacting quantum field theory mapped onto a quantum spin chain model.

An in-depth microbiological and metagenomic analysis of Colombian farm and fermentation facilities resulted in the design of a defined microbial community that can reproduce the flavour of fine chocolate.

Polymorphism, the presence of different crystal structures of the same molecular system, provides an opportunity to discover new phenomena and properties. Here, the authors crystallize coronene in the presence of a magnetic field, forming a different polymorph, which remains stable under ambient conditions.

Since the 1970s space missions have observed `equatorial noise' — noise-like plasma waves closely confined to the magnetic equatorial region of Earth s magnetosphere. Here, the authors uncover their structured and periodic frequency pattern, revealing that they are generated by proton distributions.