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Orthogonal chimeric receptors containing intracellular domains for IL-4R, IL-20R, IL-22R and GCSFR reprogram T cells to promote distinct natural and synthetic cell states with functional and therapeutic implications.

The authors report resonant soft x-ray scattering and polarimetry measurements on epitaxial thin films of La3Ni2O7. They find a diagonal bicollinear double spin stripe order, with no evidence of charge modulation.

A compact platform for quantum magnetometry and thermometry can be created by integrating nitrogen–vacancy-based quantum sensing with complementary metal–oxide–semiconductor (CMOS) technology.

With the generation of large pan-cancer whole-exome and whole-genome sequencing projects, a question remains about how comparable these datasets are. Here, using The Cancer Genome Atlas samples analysed as part of the Pan-Cancer Analysis of Whole Genomes project, the authors explore the concordance of mutations called by whole exome sequencing and whole genome sequencing techniques.

Twisted double bilayer graphene (tDBG) comprises two Bernal-stacked bilayer graphene sheets with a twist between them. Here, the authors report a strong anomalous Hall effect in the correlated-metal regime of tDBG, indicating time reversal symmetry breaking from orbital ferromagnetism, likely associated with valley polarization.

This Review discusses the potential benefits of prehabilitative interventions in patients with and survivors of testicular cancer. Although there are few studies in the field, available data suggest a benefit of prehabilitation in improving mental health and quality of life in these patients, highlighting the need for additional research in this field.

CMOS-based circuits can be integrated with silicon-based spin qubits and can be controlled at milli-kelvin temperatures, which can potentially help scale up these systems.

A data-efficient deep learning model developed to predict ground-state and photophysical properties of molecules and nanomaterials by learning many-body Green’s functions achieves an accuracy surpassing the state-of-the-art density functional theory calculations.

Polymorphism, the presence of different crystal structures of the same molecular system, provides an opportunity to discover new phenomena and properties. Here, the authors crystallize coronene in the presence of a magnetic field, forming a different polymorph, which remains stable under ambient conditions.

Ousdal et al. investigate whether global or regional hippocampal volume increase after Electroconvulsive therapy (ECT) for major depressive episodes relate to cognitive side effects. Their findings suggest that pronounced structural change in the posterior hippocampus (i.e., body and tail) associates with reduced cognitive performance following ECT.

RNA interference therapy has huge potential in pesticide applications, however delivery and stability remain an issue. Here, the authors report on a metal-organic framework, polydopamine nanoparticle for increasing delivery and stability of RNA to plants. Demonstrating application in targeting the fall armyworm.

A single-cell resolution image-based genome-wide CRISPR screen, analysed with deep learning and random forest models, identified host factors regulating Ebola virus infection at distinct stages in the viral life cycle.

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Phosphorene nanoribbons demonstrate extraordinary magnetic properties, ranging from large internal fields in films to macroscopic alignment in solution, which can be coupled to photoexcitations that localize to the magnetic edge of these ribbons.

Competition for pollinators weakens plant coexistence by destabilizing interactions between plant species; this is crucial for determining the effects of the decline in pollinators.

Accounting for the diurnal cycle in low clouds more than doubles estimated aerosol radiative warming in the southeast Atlantic, according to radiative transfer modelling and satellite observations.

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 cancer whole genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

Pocock et al. reveal that transient activation of 5′ AMP-activated protein kinase and estrogen-related receptor drives robust maturation of multicellular human cardiac organoids, enabling modeling of desmoplakin cardiomyopathy dysfunction, which could be rescued using the bromodomain and extra-terminal inhibitor INCB054329.

The development of electronic flying qubits requires the ability to generate and control single-electron excitations. Here the authors demonstrate quantum coherence of ultrashort single-electron plasmonic pulses in an electronic Mach-Zehnder interferometer, revealing a non-adiabatic regime at high frequencies.

Climate change is expected to impact microbes degrading organic matter in northern peatlands. Here, using a warming experiment, the authors show that communities remain stable after three years of warming, likely due to metabolic versatility and an ability to obtain electron acceptors from organic matter cleavage.

The catalytic performance of dilute Pd-in-Au alloys depends on the Pd ensemble size on the bimetallic nanoparticle surface. Here the authors reveal how Pd ensemble formation on Au nanoparticles depends on the deposition sequence and nanoparticle–support wetting interactions, consequently affecting reactivity.

The authors assess the growing field of climate change health impact attribution. They show literature bias towards direct heat effects and extreme weather in high-income countries, highlighting the lack of global representation in current efforts.

Nanoscale magnetic imaging based on single defects in diamond is extended to cryogenic temperatures and is used to study vortices in the iron pnictide superconductor BaFe₂(As_0.7P_0.3)₂.

In this study, the authors assess the global response to the toxic aldehyde glyoxal (GO) in Pseudomonas aeruginosa, suggesting that GO controls quorum sensing during infection through a mechanism involving a novel protein, ArqI.

Observation-based modelling suggests that recent acceleration of Earth’s north magnetic pole towards Siberia can be linked to elongation of a lobe of negative magnetic flux at the core–mantle boundary beneath Canada.

Shen et al. show that pre-existing neural similarity in strangers predicts future friendship and changes in social distance over time in an emerging social network of MBA students.

Recent work has shown that digital quantum simulations may be well suited for simulating non-perturbative quantum field theories. Here the authors use a superconducting quantum computer to obtain the energy spectrum of a strongly interacting quantum field theory mapped onto a quantum spin chain model.

Nardone et al. identify a metazoan protein complex (mRAVE) that assembles V-ATPases from two subcomplexes, enabling lysosome acidification, neurotransmitter vesicle loading and a lysosome damage response pathway.

A set of neurons in the peri-locus coeruleus region controls arousal and avoidance states, providing an understanding of the neurobiological basis of arousal and exploratory behaviours.

The authors measure picosecond spin pumping in FeRh as a function of temperature by optical pump-THz emission spectroscopy. In the antiferromagnetic phase of FeRh enhanced spin pumping above the value measured in the ferromagnetic phase is observed.

A remora-inspired mechanical underwater adhesive device adheres securely to a range of soft substrates and maintains performance under extreme pH and moisture conditions, with potential applications in biosensing and drug delivery.

A consensus cell type atlas for the fly brain provides both an intellectual framework and open-source toolchains for brain-scale comparative connectomics.

The neural circuits that transmit cool signals remain not fully understood. Here, authors identify a spinal circuit in mice that transmits cool sensations from the skin to the brain, revealing a dedicated neural pathway for detecting innocuous cool temperatures.

A large international panel of experts reach consensus on a new standard for reporting settings in psychedelic trials, identifying 30 key non-pharmacological factors to strengthen the rigor of psychedelic research.

Many tumours exhibit hypoxia (low oxygen) and hypoxic tumours often respond poorly to therapy. Here, the authors quantify hypoxia in 1188 tumours from 27 cancer types, showing elevated hypoxia links to increased mutational load, directing evolutionary trajectories.

The neural processes involved in memory formation for realistic experiences remain poorly understood. Here, the authors found that ripple-like activity in the human hippocampus and neocortex tracks key moments during movie watching and predicts which events are later remembered.

Hyperspectral reporter genes allow imaging of ground bacteria from aerial vehicles

Weak perturbations couple solitons—nonlinear pulses—to low-amplitude linear waves. Longstanding mathematical results indicate that this phenomenon is universal. The authors verify these predictions experimentally by demonstrating that the coupling amplitude satisfies a general scaling law.

A long-lived photoinduced metastable state in a quasi-one-dimensional cuprate, Sr₁₄Cu₂₄O₄₁, is reported.

Pesticide impact on honey bees under field conditions remains elusive. Here, the authors combine a systems biology approach and laboratory experiments to show that the immune suppressive effect of the pathogen deformed wing virus can be responsible for the disparity amongst honey bee experiments.

Velocimetry diagnostics such as photon Doppler velocimetry (PDV) are essential to the field of shock and high energy density physics. Here, the authors demonstrate a system that dramatically extends the velocity dynamic range of PDV into the regime of fusion experiments by harnessing a time lens.

The Aurora hydrothermal field (Arctic Ocean) is hosted in volcanic rocks but also shows evidence of mantle rock influence in the shallow sub-surface. Our discovery is pertinent to disciplines from marine mining to the search for life beyond Earth.