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Showing 1–50 of 6328 results
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  • Sulfilimines are a class of chiral molecules that bear S(IV) stereocentres, which are of high value in drug discovery but difficult to synthesize. Now the authors report a chemo- and enantioselective Chan–Lam S-arylation of sulfenamides with arylboronic acids that delivers diaryl and alkyl aryl sulfilimines.

    • Qingjin Liang
    • Xinping Zhang
    • Tiezheng Jia
    Research
    Nature Catalysis
    Volume: 7, P: 1010-1020
  • Sulfenamides are a class of divalent sulfur-derived scaffolds featuring an S-N bond with many industrial applications, however, they are also challenging substrates for synthetic transformations. Here, the authors present a highly chemoselective ligand-controlled Chan–Lam coupling of sulfenamides as a straightforward route to N-arylated sulfenamides.

    • Kaiming Han
    • Hong Liu
    • Tiezheng Jia
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-9
  • Lo and colleagues report that double-positive thymocytes from neonates express less Zap70 and show reduced Ca2⁺/NFAT signaling compared to double-positive thymocytes from older thymi. This diminished Ca2⁺ signaling alters negative selection for self-reactive TCRs, resulting in a cell-intrinsic temporal window for regulatory T versus conventional T cell development in the thymus.

    • Brian D. Stadinski
    • Elizabeth A. Mills
    • Wan-Lin Lo
    ResearchOpen Access
    Nature Immunology
    P: 1-14
  • Matrix viscoelasticity regulates cell behavior in a stiffness-dependent manner. Here, the authors reveal that the mechanosensitive channel Piezo1 transduces soft matrix viscoelastic cues, through a coordinated interaction with molecular clutch mechanisms.

    • Mariana A. G. Oliva
    • Giuseppe Ciccone
    • Manuel Salmeron-Sanchez
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18
  • A study of several longitudinal birth cohorts and cross-sectional cohorts finds only moderate overlap in genetic variants between autism that is diagnosed earlier and that diagnosed later, so they may represent aetiologically different conditions.

    • Xinhe Zhang
    • Jakob Grove
    • Varun Warrier
    ResearchOpen Access
    Nature
    P: 1-12
  • Yamazoe et al. show that B cell-derived autoantibodies contribute to the development of atrial fibrillation, suggesting that targeting the humoral immune response may represent a viable therapeutic approach.

    • Masahiro Yamazoe
    • Kenneth K. Y. Ting
    • Matthias Nahrendorf
    ResearchOpen Access
    Nature Cardiovascular Research
    Volume: 4, P: 1381-1396
  • Cationic polymers conventionally kill bacteria via physical membrane disruptions. Here, the authors report the development of carbon acid cationic polymers that show potent activity against multidrug-resistant strains in murine infection models and prevent bovine mastitis, and present evidence that these polymers translocate across bacterial membrane aided by N-heterocyclic carbene.

    • Chong Hui Koh
    • Mallikharjuna Rao Lambu
    • Mary B. Chan-Park
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18
  • Glutamatergic and GABAergic (γ-aminobutyric acid-producing) cortical neuronal activity drives proliferation of small lung cell cancer via paracrine interactions and through synapses formed with tumour cells.

    • Solomiia Savchuk
    • Kaylee M. Gentry
    • Humsa S. Venkatesh
    ResearchOpen Access
    Nature
    P: 1-11
  • Liang et al. estimate the prevalence of text modified by large language models in recent scientific papers and preprints, finding widespread use (up to 17.5% of papers in computer science).

    • Weixin Liang
    • Yaohui Zhang
    • James Zou
    Research
    Nature Human Behaviour
    P: 1-11
  • Over 20 species of geographically and phylogenetically diverse bird species produce convergent whining vocalizations towards their respective brood parasites. Model presentation and playback experiments across multiple continents suggest that these learned calls provoke an innate response even among allopatric species.

    • William E. Feeney
    • James A. Kennerley
    • Damián E. Blasi
    Research
    Nature Ecology & Evolution
    P: 1-13
  • Here the authors present a method to transform polygenic scores into disorder probabilities using only GWAS summary statistics, genotype data and a prior - no tuning sample is needed. The method enables individualized, well-calibrated predictions.

    • Emil Uffelmann
    • Cathryn M. Lewis
    • Wouter J. Peyrot
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13
  • The authors introduce the Neurolipid Atlas, a dynamic resource for the community to gain insight into lipid alterations in neurodegenerative disease, and they leverage the platform to show how cholesterol alterations in astrocytes can dysregulate neuroinflammatory pathways in Alzheimer disease.

    • Femke M. Feringa
    • Sascha J. Koppes-den Hertog
    • Rik van der Kant
    ResearchOpen Access
    Nature Metabolism
    P: 1-23
  • Tilt-corrected bright-field scanning transmission electron microscopy offers enhanced cryogenic electron microscopy contrast and substantial improvement in dose efficiency for thick samples such as bacterial cells and large organelles, while still being able to perform single-particle analysis.

    • Yue Yu
    • Katherine A. Spoth
    • Lena F. Kourkoutis
    ResearchOpen Access
    Nature Methods
    Volume: 22, P: 2138-2148
  • Genetic mutations causing hereditary deafness, including autosomal dominant non-syndromic deafness 15 (DFNA15), currently have no effective treatment. Here, authors establish a Pou4f3WT/Q113* mutant mouse model and engineer and deliver an adenine base editor for near-complete hearing recovery.

    • Man Wang
    • Ziyu Zhang
    • Renjie Chai
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15
  • Literature mining, such as systematic review and meta-analysis, is crucial for discovering, integrating, and interpreting emerging research. This study presents a specialized large language model for literature that outperforms six general LLMs and helps clinicians in study selection and data extraction tasks.

    • Zifeng Wang
    • Lang Cao
    • Jimeng Sun
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15
  • Sequencing analyses of human prefrontal cortex from donors ranging in age from 0.4 to 104 years show that ageing correlates with an accumulation of somatic mutations in short housekeeping genes and a reduction in the expression of these genes.

    • Ailsa M. Jeffries
    • Tianxiong Yu
    • Michael A. Lodato
    ResearchOpen Access
    Nature
    Volume: 646, P: 657-666
  • Systematic comparison of genome-wide association results for disease risk and disease-specific mortality for nine common diseases across seven biobanks finds limited overlap between genetic effects on disease susceptibility and survival.

    • Zhiyu Yang
    • Fanny-Dhelia Pajuste
    • Andrea Ganna
    ResearchOpen Access
    Nature Genetics
    Volume: 57, P: 2418-2426
  • Proteome allocation to anabolic and catabolic functions is significantly regulated by growth rate in the model bacterium Escherichia coli. By contrast, this article shows that proteome allocation is only partially controlled by growth rate, and metabolic rates are primarily controlled post-translationally, in the thermophilic acetogen Thermoanaerobacter kivui.

    • Franziska Maria Mueller
    • Albert Leopold Müller
    • Alfred Michael Spormann
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16
  • In a prospective study enrolling 1,222 patients from 22 emergency departments, a device using a machine-learning-based signature of blood mRNAs demonstrated clinically acceptable performance to diagnose bacterial and viral infections and to predict the all-cause need for critical care interventions within 7 days, with benchmark to established biomarkers and risk scores.

    • Oliver Liesenfeld
    • Sanjay Arora
    • Nathan I. Shapiro
    ResearchOpen Access
    Nature Medicine
    P: 1-11
  • This study reveals how cardiolipin governs mitochondrial morphology by modulating the activity of human OPA1 and how its replacement by monolyso-cardiolipin, as observed in Barth syndrome, impacts mitochondrial membrane-shaping mechanisms.

    • Sirikrishna Thatavarthy
    • Luciano A. Abriata
    • Halil Aydin
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18
  • Basal cells, rather than neuroendocrine cells, have been identified as the probable origin of small cell lung cancer and other neuroendocrine–tuft cancers, explaining neuroendocrine–tuft heterogeneity and offering new perspectives for targeting lineage plasticity.

    • Abbie S. Ireland
    • Daniel A. Xie
    • Trudy G. Oliver
    ResearchOpen Access
    Nature
    P: 1-11
  • UCHL5 is a deubiquitinating enzyme that cleaves Lys-48-linked polyubiquitin chains. Here, the authors discover through in-vivo CRISPR-Cas9 screens that Uchl5 is involved in immune evasion and modulation of extracellular matrix deposition in head and neck squamous cell carcinoma.

    • Cong Fu
    • Robert Saddawi-Konefka
    • Robert T. Manguso
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18
  • A hydrogel matrix fabricated by cryo-photocrosslinking enables the direct, scalable isolation of extracellular vesicles from diverse biofluids without preprocessing, allowing for in-gel preservation for long-term storage and biomedical applications.

    • Junbeom Kim
    • Minjin Kang
    • Nakwon Choi
    ResearchOpen Access
    Nature Nanotechnology
    P: 1-10
  • The Yamaji effect is a modulation of the electronic transport as the angle of an applied magnetic field is changed. This has been observed in a model cuprate and sheds light on the geometry of the Fermi surface and the nature of the pseudogap.

    • Mun K. Chan
    • Katherine A. Schreiber
    • Neil Harrison
    Research
    Nature Physics
    P: 1-6
  • Neurons that respond emergently to illusory contours drive pattern completion in V1. Pattern completion in lower cortical areas may therefore mediate perceptual inference by selectively reinforcing activity patterns that match prior expectations.

    • Hyeyoung Shin
    • Mora B. Ogando
    • Hillel Adesnik
    ResearchOpen Access
    Nature Neuroscience
    P: 1-11
  • Reliable measuring the voltage dynamics of individual neurons in the intact brain is significantly challenging. Here authors developed an all-optical method combining two-photon voltage imaging and optogenetics to measure and induce synaptic plasticity in vivo, revealing LTP of inhibition in cerebellar circuits and providing a blueprint to link synaptic changes to learning.

    • Jacques Carolan
    • Michelle A. Land
    • Michael Häusser
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12
  • The protein corona formed on nanoparticles can impact bioactivity. Here the authors show that the protein corona on lipid nanoparticles alters their function and reduces transfection efficiency, showing the importance of considering the protein corona in designing lipid nanoparticle-based therapeutics.

    • Elizabeth Voke
    • Mariah L. Arral
    • Markita P. Landry
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16
  • Genome-wide and targeted perturbation of DNA methylation at centromeres affects CENP-A positioning and centromere structure, resulting in aneuploidy and reduced cell viability.

    • Catalina Salinas-Luypaert
    • Danilo Dubocanin
    • Daniele Fachinetti
    ResearchOpen Access
    Nature Genetics
    Volume: 57, P: 2509-2521
  • Pressure overload in the heart, such as from aortic stenosis, triggers early molecular changes before visible damage occurs. Here, the authors show that combining proteomics, transcriptomics, and genetic data reveals key drivers of heart failure, highlighting potential targets for treatment.

    • Brian R. Lindman
    • Andrew S. Perry
    • Sammy Elmariah
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16
  • Authors measure plasma proteins in a cohort of hospitalised patients presenting to the emergency department with suspected infection, revealing six discrete host response clusters that were driven by pathogen exposure and organ dysfunction, and had distinct clinical characteristics, hospital courses, and responses to treatment.

    • Pratik Sinha
    • Alexandra B. Spicer
    • Matthew M. Churpek
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12
  • Aging drives distinct molecular changes in the brain. Here, the authors use scRNAseq and MERFISH and find that in mice, aging induces subtype-specific, regionally biased changes in striatal astrocytes, marked by transcriptional repression, inflammation, and impaired neuronal interactions.

    • Kay E. Linker
    • Violeta Duran-Laforet
    • Baljit S. Khakh
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15
  • Three-dimensional structures of two natural RNA nanocages reveal unique quaternary structures without the contribution of proteins.

    • Xiaobin Ling
    • Dmitrij Golovenko
    • Wenwen Fang
    Research
    Nature
    Volume: 644, P: 1107-1115
  • Few studies have evaluated how climate change may affect dietary habits and nutritional health. Here, using transaction data in the USA, the authors show that added sugar consumption increases with temperature, especially between 12 °C and 30 °C, with stronger effects among lower-income and lower-education groups.

    • Pan He
    • Zhuojing Xu
    • Yan Bai
    ResearchOpen Access
    Nature Climate Change
    Volume: 15, P: 963-970