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Guan et al. report a strategy of moisture-triggered selective hydrolysis of Sn4+ into Sn(OH)4, eliminating Sn4 + -induced defects in tin-based perovskites and enhancing the electron injection in NIR-II LED devices with peak emission of 945 nm and external quantum efficiency of 7.6%.

Abasic (AP) sites represent a prominent type of DNA damage, yet the genomics of this lesion remains unexplored. Here, the authors report a method to map such sites at the nucleotide level in complex genomes and use it to extract complex age- and tissue-dependent patterns of AP sites in mammals.

The 1,2 migration reaction on tetracoordinate boron species have been well investigated but less work looked on 1,2-boryl radical shift for the construction of organoborons. Here, the authors demonstrate a visible-light-induced photoredox neutral decarboxylative radical cross-coupling reaction, which undergoes a radical 1,2-boron shift to give a translocated C-radical for further capture of versatile radical acceptors

Single strand breaks represent the most common form of DNA damage yet no methods to map them in a genome-wide fashion at single nucleotide resolution exist. Here the authors develop such a method and apply to uncover patterns of single-strand DNA “breakome” in different biological conditions.

Selective CO₂-to-liquid conversion remains a major challenge due to inertness of CO₂. This work designs Pd nanoneedles with bent Pd–Pd bonds, enabling >99% selective formic acid production under mild conditions by enhancing CO₂ activation.

The asymmetric inverse-electron-demand oxa-Diels–Alder reaction (IODA) between activated α,β-unsaturated carbonyl compounds with highly polarized alkenes has been reported before but acroleins or simple alkenes were so-far rarely employed as substrates. Here, the authors study the catalytic asymmetric intermolecular IODA reaction between acroleins and simple alkenes.

The authors present a chip-based plasmonic scattering microscope (Chip-PSM) for labelfree imaging of single nanoparticles over a large field-of-view, with isotropic point spread function and high spatial resolution. They demonstrate imaging of diverse nanoparticles, highlighting applications in biological, physical, environmental, and chemical sciences.

The defect-rich surface of wide-bandgap perovskite solar cells leads to severe interfacial carrier loss and phase segregation. Here, the authors reconstruct the surface through nano-polishing followed by passivation, achieving certified efficiency of 33.1% for perovskite/silicon tandem solar cells.

The conventional method for synthesizing thioether compounds typically relies on thiol, disulfide, and sulfinyl halide as initial substances, suffering from strong odors, limited availability, and reactivity issues. Here, the authors present an approach for assembling S-thiosulfonates and SS-thiosulfonates through the integration of dual copper/photoredox catalysis

H-bonded assembly of multiple components into well-defined icosahedral capsules has been elusive, and constructing stable sophisticated cluster-based supramolecular frameworks without coordinative bonding linkages remains challenging. Here, the authors report a cluster-based icosahedral H-bonded capsule Cu₆₀ and its self-propagation into a 3D robust zeolitic-like supramolecular framework.

IL-33-ST2 activation upregulates CCL2 to drive inflammatory pain via activation of TRPV1 and TRPM8 in hindpaw skin and enhancement of LTP in spinal cord.

Alternative carbene precursors for metal-catalyzed cross coupling may expand the portfolio of methods for C-C bond construction. Here, the authors report a Suzuki−Miyaura coupling of Pd−carbene complexes formed by desulfurization of thioureas or thioamides and affording a broad array of amidinium salts and diaryl ketones.

As immune checkpoint therapy is more frequently used for cancer, side effects such as Stevens-Johson syndrome / toxic epidermal necrolysis (SJS/TEN) are becoming more common. Here the authors use single cell transcriptomics to implicate TNF and CXCL10 in recruitment of CXCR3⁺ cytotoxic T cell in SJS/TEN skin lesions.

The efficiency and operating lifetimes of perovskite light-emitting diodes is improved by using a fluorinated triphenylphosphine oxide additive to control the cation diffusion during film deposition and passivate the surface.

Evaluating soil metal(loid) mobility at large scales is nearly intractable by laboratory experiments. This study uses theory-guided machine learning methods to map the global distribution of soil metal(loid) mobility and analyzes its primary drivers.

The use of Mn-rich layered cathodes in Na-based batteries is hindered by inadequate cycling reversibility and sluggish anionic redox kinetics. Here, the authors report a strategy to stabilize the structure and promote anionic redox via configurational entropy and ion-diffusion structural tuning.

Over-lithiation often causes structural transformation in electrodes and may lead to safety issues in Li-ion batteries. Here, authors investigate the over-discharged mechanism of LiCoO2/graphite pouch cells, and spatially resolve the morphological, surface phase, and local electronic structure of LiCoO2 electrode.

Optically enriched 1,1-diboron compounds are significantly underdeveloped because of the paucity of the straightforward synthetic protocols. Herein, the authors report an enantioselective copper-catalyzed cascade double hydroboration of terminal alkynes to access highly enantioenriched gem-diborylalkanes.

Endogenous retroviruses (ERVs) are remnants of ancient viruses embedded in animal DNA. This study found that the solitary long terminal repeats of ERVs in birds, particularly Passeriformes, have evolved to influence gene expression, potentially contributing to adaptive diversification of species.

The incorporation of electron transport layers based on single-crystalline TiO₂ rhombohedral nanoparticles enables the realization of stable and efficient large-area perovskite solar cell modules.

Suzuki-type cross-coupling for C(sp²)–C(sp³) bond formation with aliphatic halides remains challenging with tertiary aliphatic halides and under transition-metal-free conditions. Now, a transition-metal-free C(sp²)–C(sp³) cross-coupling of α-(pseudo)halo aliphatic ketones with boronic acids via a 1,4-metallate shift is reported which is compatible with tertiary aliphatic halides, allowing for 1,3-disubstituted products.

Xiao et al. report a weaker adaptive immune response in older adults after inactivated SARS-CoV-2 vaccination compared to young adult controls, identifying altered immune cell function and decreased antigen-specific receptor repertoire diversity as potential underlying mechanisms.

Food allergy is a growing clinical and public health burden. Here, the authors carry out a genome-wide association study in samples with well-defined allergies to a variety of foods, and identify the 6p21.32 region that significantly increases risk of developing peanut allergy.

Amino acid changes in a newly identified spike epitope enabled the Delta variant to evade a population antibody response.

The clinical application of magnetic hyperthermia therapy (MHT) is limited by the poor magnetic-to-thermal conversion efficiency of MHT agents. Here, the authors develop encapsulin-produced magnetic iron oxide nanocomposites (eMIONs) with excellent magnetic-heat capability and catalysis-triggered tumor suppression ability to overcome the critical issues of MHT.

One-dimensional atomic metal wires can exhibit useful properties distinct from their bulk equivalents; however they typically suffer from limited stability. Here, Chen et al create atomic silver wires which are stable and exhibit a temperature dependent metal to insulator transition.