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Timothy Frayling, Joel Hirschhorn, Peter Visscher and colleagues report a meta-analysis of genome-wide association studies for adult height in 253,288 individuals. They identify 697 variants in 423 loci significantly associated with adult height and find that these variants cluster in pathways involved in growth and together explain one-fifth of the heritability for this trait.

The improvement of thermoelectric performance of materials by reducing lattice thermal conductivity is challenging. Here, the authors find the side chains covalent modification of transition metal disulfides reducing the lattice thermal conductivity.

The structure of the human NALCN channelosome and a model of the gating mechanism are determined.

Developing recyclable circular plastics is a viable approach to reshape the currently unsustainable plastics consumption pattern. Here the authors show a design to obtain recyclable polyolefin plastics with a tailored macromonomer–polymer–tailored macromonomer circular lifecycle.

Nanopore direct RNA sequencing is promising for epitranscriptome study but remains limited in single-molecule resolution. Here, the authors develop SingleMod, a tool for accurate single-molecule m6A detection from DRS and reveal cross-species epitranscriptome landscapes at single-molecule level.

Crystalline dispersoids are commonly used to strengthen metals by obstructing dislocation movement, but this often comes at the cost of ductility. Here, the authors demonstrate that amorphous nanoparticles, introduced via additive manufacturing, enhance both the tensile strength and fatigue resistance of metallic materials.

Synthetic biology can be used to create rationally designed living therapeutics. Here the authors engineer E. coli Nissle to target STING activation in antigen presenting cells for the treatment of solid tumors and demonstrate preclinical activity in murine models.

Topological magnonic materials display exotic properties which may enable high-efficiency and low-cost spintronic devices. Here the authors demonstrate a three-dimensional antiferromagnet Cu₃TeO₆ that hosts symmetry-protected Dirac and triply degenerate magnons.

Axially chiral biaryl amino-alcohols play a pivotal role in organic synthesis and drug discovery. Here, the authors report a cooperative strategy consisting of desymmetrization followed by kinetic resolution to deliver non-classical NOBIN derivatives in high yields and enantioselectivity via NHC catalysis.

Transition metal carbides are attractive for electrochemical energy storage and catalysis, but cost effective preparation on a large scale is challenging. Here the authors use a direct pattern method to fabricate transition metal carbides for supercapacitors and solar energy harvesting for steam generation.

Copy number alterations occur frequently in patients with triple-negative breast cancer. Here, the authors identify copy number amplification of the role of FAD synthase enzyme (FLAD1) in TNBC and mechanistically demonstrate that this amplification drives tumorigenesis by increasing lipid metabolism via a FLAD1/LSD1/SREBP1 axis.

Few aerobic hyperthermophilic microorganisms are known to degrade polysaccharides. Here, Nou et al. use genomic information to enrich and optical tweezers to isolate an aerobic hyperthermophilic bacterium that can grow at 65–87.5 °C using polysaccharides as sole carbon sources.

Monitoring the level of hypoxia in a tumour is of use when treating by chemotherapy or photodynamic therapy, but can be challenging. Here, the authors report the development of a theranostic combination for light activated hypoxia imaging and modulation, and prodrug activation.

Lightweight and flexible energy storage devices are needed to persistently power wearable devices. Here the authors employ metallized carbon fabrics as hosts for sulfur and lithium to achieve flexibility, electrochemical stability and high energy density in a lithium-sulfur battery.

The search for low-dimensional condensed matter platforms that host correlated electronic states has recently revolved around kagome lattices. Here, the authors evidence kagome-like bands in a 2D coloring-triangle lattice with a semiconducting bandgap.

Continuous monitoring of arterial blood pressure is limited by bulky connecting systems and poor interfacial contact. Here, Li et al. report a wearable thin, soft, miniaturized system that integrates sensing, active pressure adaptation, and signal processing for improved performance and accuracy.

The isolation and characterization of glycoprotein-specific monoclonal antibodies from a patient with Rift Valley fever (RVF) provide insights into the humoral immune responses elicited by the RVF virus as well as the therapeutic potential of antibody-based strategies.

Na_X is an atypical member of the voltage-gated sodium channel family that may contribute to Na⁺ homeostasis. Here, the authors describe the structural and functional attributes of the human Na_X channel to reveal new insights into its physiology.

Glucocorticoid resistance is partly due to epigenetic alterations, but the regulatory mechanisms driving these remain poorly understood. Here, a link between the activity of a lineage-specific transcription factor PU.1 and epigenetic modulators mediating the response to glucocorticoids is described in acute lymphoblastic leukemia.

Perinatal traits such as birth weight are influenced partly by indirect maternal genetic effects, i.e. mediated through the intrauterine environment. Here the authors present a method to increase the power of locus discovery in genome-wide association studies of these traits.

Two-dimensional transition metal dichalcogenides with peculiar spin–orbit coupling may lead to exotic phenomena. Here, the authors report a large in-plane upper critical field with a two-fold symmetry, suggesting a novel asymmetric spin–orbit coupling in few-layer 1T_d-MoTe₂.

Palladium is an effective but expensive catalyst used in catalytic converters. Here, the authors show that defective Co₃O₄nanocrystals, synthesized via oxidation of carbon-encapsulated cobalt nanoparticles, display similar or even comparable catalytic activity to palladium for hydrocarbon combustion.

There is a pressing need for therapeutic agents against Zika virus (ZIKV). Here the authors present cryoEM structures of a neutralizing antibody (C10) complexed with ZIKV that show C10 preventing structural changes required for virus entry into the cell, suggesting it might be effective in treating Zika infections.

How chromatin-associated RNAs (caRNAs) are spatially organized in the context of the multiscale genome architecture is unclear. Here the authors suggest how the 3D genome architecture can modulate the spatial distribution of caRNAs at different scales, and how in turn caRNA could affect the dynamic 3D genome organization.

6R-TaS2 is a natural van der Waals heterostructure formed by 1H- and 1T-phase TaS₂ layers, which can individually exhibit Ising superconductivity, correlated states and charge density waves. Here, the authors show experimental evidence of emergent nematic Ising superconductivity with simultaneous hidden magnetism (extrinsic anomalous Hall effect and Kondo screening) in 6R-TaS₂ under 30 K.

The conventional method for synthesizing thioether compounds typically relies on thiol, disulfide, and sulfinyl halide as initial substances, suffering from strong odors, limited availability, and reactivity issues. Here, the authors present an approach for assembling S-thiosulfonates and SS-thiosulfonates through the integration of dual copper/photoredox catalysis

The molecular mechanism underlying the resistance of AKT inhibitors in breast cancer is still elusive. Here, the authors demonstrate that BRD4/FOXO3a axis upregulates CDK6 promoter activity to promote resistance to AKT inhibition in breast cancer cells and that blocking the action of CDK6 re-sensitizes resistant cancer cells to growth inhibition.

A genome-wide association study and Metabochip meta-analysis of body mass index (BMI) detects 97 BMI-associated loci, of which 56 were novel, and many loci have effects on other metabolic phenotypes; pathway analyses implicate the central nervous system in obesity susceptibility and new pathways such as those related to synaptic function, energy metabolism, lipid biology and adipogenesis.

A genetic study identifies hundreds of loci associated with risk tolerance and risky behaviors, finds evidence of substantial shared genetic influences across these phenotypes, and implicates genes involved in neurotransmission.

The authors investigate junctions made of two flakes of the cuprate superconductor Bi₂Sr_2-xLa_xCuO_6+y (Bi2201) twisted by 45 degrees. They find evidence for an isotropic pairing component, and call into question theoretical predictions of d+id superconductivity in this system.

Genome-wide association studies (GWAS) have become a key tool to discover genetic markers for complex traits; however, environmental factors that interact with genes are rarely considered. Here, the authors conduct a GWAS of obesity traits, and find that smoking may alter genetic susceptibilities.

Suppressing surface Cs⁺ accumulation in methylammonium-free α-FA_1−xCs_xPbI₃ perovskite with an intermediate phase-assisted strategy enables high-efficiency and thermally stable photovoltaics.

Erik Ingelsson and colleagues report a large-scale genome-wide meta-analysis for associations to the extremes of anthropometric traits, including body mass index, height, waist-to-hip ratio and clinical obesity. They identify four loci newly associated with height and seven loci newly associated with clinical obesity and find overlap in the genetic structure and distribution of variants identified for these extremes of the trait distributions and for the general population.

Developing electronic skins for sensing the spatial location of objects beyond two-dimensional space is difficult. The authors present a flexible, lightweight, and transparent electronic skin for non-contact accurate 3D motion sensing. This achieves micron-level precision, reducing complexity and power consumption.

A certified efficiency of 26.4% in all-perovskite tandem solar cells, exceeding that of the best-performing single-junction perovskite solar cells, is achieved by control over surface defects in the Pb–Sn subcell.

The 3.7 Å cryo-electron microscopy structure of Zika virus is presented, revealing a typical flavivirus architecture; in contrast to the related flavivirus dengue virus, Zika virus is thermally stable at 40 °C, and this structural stability may be a feature that helps it to survive in semen, saliva and urine.

Orbital occupancy by electrons has a large effect on electronic properties of correlated oxides. Here, the authors report a chemical doping strategy of a perovskite nickelate, leading to the observation of a new insulating phase and a reversible resistivity modulation greater than eight orders of magnitude.

Double Asteroid Redirection Test (DART) mission impact on asteroid Dimophos resulted in an elliptical ejecta plume. Here, the authors show that this elliptical ejecta is due to the curvature of the asteroid and makes kinetic momentum transfer less efficient.

Enhancing the catalytic activity of noble-metal alloys is frequently accompanied by side reactions. Here, the authors describe an approach to break the scaling relationship for propane dehydrogenation, by assembling single atom alloys, to achieve simultaneous enhancement of propylene selectivity and propane conversion.

The plant metabolome is often considered as a bridge between genomic and phenotypic variation. Here, the authors perform metabolic and phenotypic genome-wide association studies in rice grain, and compare to prior studies on rice leaf and maize kernel, to demonstrate a new strategy to investigate complex traits.

A freeform multimaterial assembly process (FMAP) is demonstrated, synchronizing laser induction with 3D printing for seamlessly integrating multimaterials into 3D objects, enabling streamlined, flexible, and precise electronic device fabrication.

There is growing interest in designing electrolytes to enable Li-metal batteries. Here the authors show that asymmetric solvents improve lithium redox kinetics and achieve long cycle life in anode-free cells under electric vertical take-off and landing conditions, demonstrating potential for future high-power applications.

Electrochemical epoxidation by water is mainly hindered by the sluggish activation of C₂H₄ and the stiff formation of *OH intermediate. Here, the authors report an Ag/SnO₂ interface to promote C₂H₄ adsorption and electrophilic *OH generation, leading to promoted production of ethylene oxide.

The use of heparan sulfate mimetics is an attractive target for organ regeneration. Here, the authors identify how highly 3-O-sulfated heparan sulfate domains regulate FGFR signaling and basement membrane metabolism to control epithelial differentiation.

There is an urgent need to control food pests more sustainably. This study assesses and confirms the potential and feasibility of growing pest insect sex pheromones from high-productivity oil-crop seeds.