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Showing 1–50 of 56 results

Advanced filters: Author: Jingwen Gao Clear advanced filters

Delaying pyroptosis with an AI-screened gasdermin D pore blocker mitigates inflammatory response

Wang and colleagues show that an AI-assisted designed peptide obstructs GSDMD pores and inhibits IL-1β and IL-18 release and pyroptosis.

Jianhui Sun
Jun Yang
Gan Wang
ResearchOpen Access15 Sept 2025
Nature Immunology

Volume: 26, P: 1660-1672
Comparative analysis of methodologies for detecting extrachromosomal circular DNA

Sequencing-based studies have advanced our understanding of the diverse functions of extrachromosomal circular DNA (eccDNA). Here the authors systematically compare the performance of several bioinformatic pipelines and experimental methods that have been developed for eccDNA detection.

Xuyuan Gao
Ke Liu
Kun Qu
ResearchOpen Access25 Oct 2024
Nature Communications

Volume: 15, P: 1-14
m⁶A/IGF2BP3-driven serine biosynthesis fuels AML stemness and metabolic vulnerability

Serine metabolism is essential for leukemogenesis and stemness in acute myeloid leukemia (AML). Here the authors show that targeting IGF2BP3 disrupts the serine synthesis pathway in AML cells in an RNA N⁶-Methyladenosine modification dependent manner, sensitizing AML cells to serine and glycine deprivation.

Feng Huang
Yushuai Wang
Hengyou Weng
ResearchOpen Access06 May 2025
Nature Communications

Volume: 16, P: 1-18
A TLK2-mediated calcium-driven cell death pathway links neuronal degeneration to nuclear envelope disruption

Programmed cell death is a crucial process in biology and medicine. Here, authors identify that calcium overload enhances TLK2 activity, causing nuclear envelope rupture and neuronal death via a complex with LC8 and myosin IIA.

Yajie Li
Huaiyuan Huang
Lei Liu
ResearchOpen Access10 Apr 2025
Nature Communications

Volume: 16, P: 1-16
A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity

A recombinant vaccine that targets the receptor-binding domain of the spike protein of SARS-CoV-2 induces a potent antibody response in immunized mice, rabbits and non-human primates, and protects primates from infection with the virus.

Jingyun Yang
Wei Wang
Xiawei Wei
Research29 Jul 2020
Nature

Volume: 586, P: 572-577
Mycobacterium tuberculosis antigens repress Th1 immune response suppression and promotes lung cancer metastasis through PD-1/PDl-1 signaling pathway

Shuhui Cao
Jingwen Li
Hua Zhong
ResearchOpen Access18 Jan 2019
Cell Death & Disease

Volume: 10, P: 1-12
Birdlike broadband neuromorphic visual sensor arrays for fusion imaging

Traditional silicon vision chips often challenge in emulating complex biological behaviors. This work reports birdlike broadband neuromorphic visual sensor arrays with 5 bits of in-memory sensing and computing. The built reservoir computing system achieves motion and UV grayscale information extraction, leading to fusion visual imaging.

Pengshan Xie
Yunchao Xu
Johnny C. Ho
ResearchOpen Access27 Sept 2024
Nature Communications

Volume: 15, P: 1-12
Author Correction: Loss of Phd2 cooperates with BRAF^V600E to drive melanomagenesis

Shujing Liu
Gao Zhang
Xiaowei Xu
Amendments and CorrectionsOpen Access11 Mar 2019
Nature Communications

Volume: 10, P: 1
Rural credit and new technology adoption among family farms: evidence from two demonstration areas in China

Qianling Wang
Li Gui
Jingwen Hu
ResearchOpen Access16 Jul 2025
Humanities and Social Sciences Communications

Volume: 12, P: 1-13
Accuracy of blood heparin-binding protein (HBP) for diagnosis bacteremia in patients with sepsis

Zhi Mao
Wenshan Yang
Feihu Zhou
ResearchOpen Access17 Feb 2025
Scientific Reports

Volume: 15, P: 1-9
An integrated SOR and SCT model approach to exploring chinese public perception of autonomous vehicles

Jingwen Wu
Sok-Tae Kim
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-19
Correction: Author Correction: Menin enhances c-Myc-mediated transcription to promote cancer progression

Gongwei Wu
Mengqiu Yuan
Ping Gao
Amendments and CorrectionsOpen Access30 Mar 2018
Nature Communications

Volume: 9, P: 1
Constitutively active glucagon receptor drives high blood glucose in birds

Hepatic expression of constitutively active glucagon receptor may have contributed to the glucose and lipid metabolism and the high metabolic rates that enabled the evolution of flight in birds.

Chang Zhang
Xiangying Xiang
Cheng Deng
ResearchOpen Access03 Mar 2025
Nature

Volume: 641, P: 1287-1297
Publisher Correction: A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity

Jingyun Yang
Wei Wang
Xiawei Wei
Amendments and Corrections19 Jan 2021
Nature

Volume: 590, P: E23
Single-cell analysis of two severe COVID-19 patients reveals a monocyte-associated and tocilizumab-responding cytokine storm

Tocilizumab has been used to treat the excessive inflammatory responses in COVID-19 patients. Here, the authors use single-cell RNA sequencing results from two severe COIVD-19 patients to provide high-dimensional immune profiling data, and to implicate potential cellular and molecular insights for the therapeutic effects of tocilizumab.

Chuang Guo
Bin Li
Kun Qu
ResearchOpen Access06 Aug 2020
Nature Communications

Volume: 11, P: 1-11
Adipose-specific deletion of the cation channel TRPM7 inhibits TAK1 kinase-dependent inflammation and obesity in male mice

Adipose tissue inflammation contributes to the pathogenesis of obesity-related metabolic disorders. Here the authors report that adipocyte-specific genetic deficiency or pharmacological inhibition of TRPM7, a cation channel, attenuates adipose tissue inflammation, improves glucose homeostasis, and suppresses weight gain in obese male mice.

Weiting Zhong
Mingming Ma
Min Gao
ResearchOpen Access30 Jan 2023
Nature Communications

Volume: 14, P: 1-19
Humidity response in Drosophila olfactory sensory neurons requires the mechanosensitive channel TMEM63

Humidity detection is a feature of many species. Here the authors show that in Drosophila, Or42b neurons, located in sensilla with humidity-dependent shape act as humidity sensors via the mechanically gated channel TMEM63.

Songling Li
Bingxue Li
Zhiqiang Yan
ResearchOpen Access02 Jul 2022
Nature Communications

Volume: 13, P: 1-12
Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data

Analysis of whole-genome sequences of 25,465 individuals of European ancestry shows that rare variants contribute substantially to the heritability of height and body mass index.

Pierrick Wainschtein
Deepti Jain
Peter M. Visscher
Research07 Mar 2022
Nature Genetics

Volume: 54, P: 263-273
An engineered CRISPR-Cas12a variant and DNA-RNA hybrid guides enable robust and rapid COVID-19 testing

As the COVID-19 pandemic continues, variants of the virus are emerging. Here the authors present a diagnostic assay that can detect wildtype and known variants using engineered Cas12a.

Kean Hean Ooi
Mengying Mandy Liu
Meng How Tan
ResearchOpen Access19 Mar 2021
Nature Communications

Volume: 12, P: 1-23
Loss of Phd2 cooperates with BRAF^V600E to drive melanomagenesis

Prolyl hydroxylase domain protein 2 (PHD2) regulates cellular response to hypoxia. Here the authors show that PHD2 is downregulated in melanoma and that PHD2 depletion, in a mouse model, promotes the progression of benign melanocytic lesions into melanoma, via activation of the Akt/mTOR signaling cascade.

Shujing Liu
Gao Zhang
Xiaowei Xu
ResearchOpen Access21 Dec 2018
Nature Communications

Volume: 9, P: 1-12
Correction: Comparative analysis of adiposity indices for predicting 2-year hypertension incidence in children and adolescents: a retrospective study

Bowen Zhu
Shumin Zhan
Junfen Fu
Amendments and CorrectionsOpen Access11 Jul 2025
Pediatric Research

P: 1
A framework for detecting noncoding rare-variant associations of large-scale whole-genome sequencing studies

STAARpipeline is a comprehensive framework for flexible and scalable rare-variant association analysis using whole-genome sequencing data and annotation information.

Zilin Li
Xihao Li
Xihong Lin
Research27 Oct 2022
Nature Methods

Volume: 19, P: 1599-1611
Single-cell transcriptome atlas and genome-wide Mendelian randomization reveal chemokine involvement in diverse immune cells in type 2 diabetes

Yang Liu
Tao Wang
Yunliang Yao
Research20 Jul 2025
International Journal of Obesity

P: 1-16
Concise, scalable and enantioselective total synthesis of prostaglandins

Current methods for the synthesis of prostaglandins suffer from low yields and lengthy steps. Now, a strategy for their enantioselective synthesis has been developed with rhodium-catalysed enyne cycloisomerization as the key step. This concise route was scaled up, enabling the preparation of fluprostenol on a 20-gram scale.

Fuhao Zhang
Jingwen Zeng
Xumu Zhang
Research27 May 2021
Nature Chemistry

Volume: 13, P: 692-697
Susceptibility of tree shrew to SARS-CoV-2 infection

Yuan Zhao
Junbin Wang
Xiaozhong Peng
ResearchOpen Access29 Sept 2020
Scientific Reports

Volume: 10, P: 1-9
Menin enhances c-Myc-mediated transcription to promote cancer progression

Menin is a protein with context-dependent oncogenic or oncosuppressive roles; the oncogenic activity is mainly due to its function as a cofactor of the MLL1 histone methyltransferase complex. Here the authors show that Menin regulates c-Myc-dependent transformation independently of the MLL complex.

Gongwei Wu
Mengqiu Yuan
Ping Gao
ResearchOpen Access05 May 2017
Nature Communications

Volume: 8, P: 1-15
Author Correction: PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas

Hezhe Lu
Shujing Liu
Wei Guo
Amendments and Corrections10 Dec 2018
Nature

Volume: 565, P: E4
One-Step to Prepare Self-Organized Nanoporous NiO/TiO₂ Layers and its Use in Non-Enzymatic Glucose Sensing

Zhi-Da Gao
Yuyao Han
Yan-Yan Song
ResearchOpen Access25 Nov 2013
Scientific Reports

Volume: 3, P: 1-7
Genetic Diversity of Avian Influenza A (H10N8) Virus in Live Poultry Markets and Its Association with Human Infections in China

Mingbin Liu
Xiaodan Li
Yuelong Shu
ResearchOpen Access15 Jan 2015
Scientific Reports

Volume: 5, P: 1-8
CapZ regulates autophagosomal membrane shaping by promoting actin assembly inside the isolation membrane

Mi et al. show that CapZ regulates autophagosomal membrane shaping by controlling the assembly of an actin scaffold in the autophagosomal precursor.

Na Mi
Yang Chen
Li Yu
Research03 Aug 2015
Nature Cell Biology

Volume: 17, P: 1112-1123
Accumulated quiescent neural stem cells in adult hippocampus of the mouse model for the MECP2 duplication syndrome

Zhifang Chen
Xiao Li
Zilong Qiu
ResearchOpen Access31 Jan 2017
Scientific Reports

Volume: 7, P: 1-9
Microbiota in disease-transmitting vectors

In this Review, Wang, Gao and Aksoy delve into the influence of microbiota on vector physiology and competence, provide an overview of the common and unique characteristics of microbiota in major disease vector systems and examine the potential applications of manipulating vector microbiota for vector control purposes.

Jingwen Wang
Li Gao
Serap Aksoy
Reviews22 May 2023
Nature Reviews Microbiology

Volume: 21, P: 604-618
Making China’s water data accessible, usable and shareable

This Perspective characterizes the major challenges to open-access water data in China. A potential data management infrastructure to improve the collection, sharing, and use of water data is outlined.

Jingyu Lin
Brett A. Bryan
Zhifeng Yang
Reviews06 Apr 2023
Nature Water

Volume: 1, P: 328-335
PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas

BRAF-inhibition resistance in metastatic melanoma occurs through p21-activated kinase-mediated reactivation of ERK, whereas resistance to combined BRAF and MEK inhibition occurs through p21-activated kinase-mediated regulation of JNK and β-catenin phosphorylation, mTOR pathway activation and apoptosis inhibition in many patients.

Hezhe Lu
Shujing Liu
Wei Guo
Research27 Sept 2017
Nature

Volume: 550, P: 133-136
Global alignment reference strategy for laser interference lithography pattern arrays

Xiang Gao
Jingwen Li
Xinghui Li
ResearchOpen Access04 Mar 2025
Microsystems & Nanoengineering

Volume: 11, P: 1-11
Machine learning prediction of glaucoma by heavy metal exposure: results from the National Health and Nutrition Examination Survey 2005 to 2008

Xinchen Wang
Gang Chen
Zhengxuan Jiang
ResearchOpen Access10 Feb 2025
Scientific Reports

Volume: 15, P: 1-12
Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale

STAAR is a powerful rare variant association test that incorporates variant functional categories and complementary functional annotations using a dynamic weighting scheme based on annotation principal components. STAAR accounts for population structure and relatedness and is scalable for analyzing large whole-genome sequencing studies.

Xihao Li
Zilin Li
Xihong Lin
Research24 Aug 2020
Nature Genetics

Volume: 52, P: 969-983
Targeting PSAT1 to mitigate metastasis in tumors with p53-72Pro variant

Jingwen Jiang
Hai-Ning Chen
Canhua Huang
ResearchOpen Access15 Feb 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-14
Comparative analysis of adiposity indices for predicting 2-year hypertension incidence in children and adolescents: a retrospective study

Bowen Zhu
Shumin Zhan
Junfen Fu
ResearchOpen Access10 Jun 2025
Pediatric Research

P: 1-10
Dysfunction of AMPA receptor GluA3 is associated with aggressive behavior in human

Shi-Xiao Peng
Jingwen Pei
Yun Stone Shi
Research13 Jun 2022
Molecular Psychiatry

Volume: 27, P: 4092-4102
Author Correction: Two distinct trajectories of clinical and neurodegeneration events in Parkinson’s disease

Cheng Zhou
Linbo Wang
Minming Zhang
Amendments and CorrectionsOpen Access16 Jan 2024
npj Parkinson's Disease

Volume: 10, P: 1
MCT1 relieves osimertinib-induced CRC suppression by promoting autophagy through the LKB1/AMPK signaling

Ping Jin
Jingwen Jiang
Ke Xie
ResearchOpen Access13 Aug 2019
Cell Death & Disease

Volume: 10, P: 1-15
Two distinct trajectories of clinical and neurodegeneration events in Parkinson’s disease

Cheng Zhou
Linbo Wang
Minming Zhang
ResearchOpen Access13 Jul 2023
npj Parkinson's Disease

Volume: 9, P: 1-11
Effect of ultrasonication on the stability and storage of a soy protein isolate-phosphatidylcholine nanoemulsions

Fei Teng
Mingyu He
Yang Li
ResearchOpen Access19 Aug 2020
Scientific Reports

Volume: 10, P: 1-9
Analyses of air pollution control measures and co-benefits in the heavily air-polluted Jinan city of China, 2013–2017

Liangliang Cui
Jingwen Zhou
Ying Zhang
ResearchOpen Access25 Mar 2020
Scientific Reports

Volume: 10, P: 1-10
Microstructural but not macrostructural cortical degeneration occurs in Parkinson’s disease with mild cognitive impairment

Xueqin Bai
Tao Guo
Minming Zhang
ResearchOpen Access09 Nov 2022
npj Parkinson's Disease

Volume: 8, P: 1-9
Association of the fat mass index with hepatic steatosis and fibrosis: evidence from NHANES 2017–2018

Lihe Liu
Jiaxi Lin
Airong Wu
ResearchOpen Access23 Mar 2024
Scientific Reports

Volume: 14, P: 1-11
Magmatic-hydrothermal fluid evolution of the tin-polymetallic metallogenic systems from the Weilasituo ore district, Northeast China

Xu Gao
Zhenhua Zhou
François Holtz
ResearchOpen Access06 Feb 2024
Scientific Reports

Volume: 14, P: 1-22
Apoptotic caspase-7 activation inhibits non-canonical pyroptosis by GSDMB cleavage

Xu Li
Tianxun Zhang
Zhaoyu Lin
Research17 Aug 2023
Cell Death & Differentiation

Volume: 30, P: 2120-2134
Comparison of nonhuman primates identified the suitable model for COVID-19

Shuaiyao Lu
Yuan Zhao
Xiaozhong Peng
ResearchOpen Access19 Aug 2020
Signal Transduction and Targeted Therapy

Volume: 5, P: 1-9

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