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Spherical polar topological structures are of interest as they could enable high-density memory applications; however, such texture formation requires superlattices with delicately balanced boundary conditions to form. Here it is found that these textures can form in free-standing CuInP₂S₆, and that mechanical force can generate high-density domains.

CAR-T targets are identified using logic gates and single-cell expression data.

In a randomized phase 3 trial, neoadjuvant anti-PD-1 plus either paclitaxel and cisplatin or nab-paclitaxel and cisplatin elicited a significantly superior pathological complete response rate versus neoadjuvant paclitaxel and cisplatin alone in patients with resectable locally advanced esophageal squamous cell carcinoma.

While Bell inequalities have been violated several times—mostly in photonic systems—their violations within particle physics experiments are less explored. Here, the BESIII Collaboration showcases Bell-violating nonlocal correlations between entangled hyperon pairs.

Genome-wide association studies (GWAS) have improved our understanding of the genetic basis of lung adenocarcinoma but known susceptibility variants explain only a small fraction of the familial risk. Here, the authors perform a two-stage GWAS and report 12 novel genetic loci associated with lung adenocarcinoma in East Asians.

Typical quantum error correcting codes assign fixed roles to the underlying physical qubits. Now the performance benefits of alternative, dynamic error correction schemes have been demonstrated on a superconducting quantum processor.

Non-alcoholic fatty liver disease (NAFLD) has become a prevalent chronic liver disease, however, drugs to treat this disease are still lacking. Here, the authors show that PPDPF inhibits the development of hepatic steatosis by negatively regulating mTORC1-S6K-SREBP1 signaling, which provides a potential therapeutic candidate for NAFLD treatment.

Heterostructures consisting of ferromagnets and heavy metals have become a focus of interest because their strong spin–orbit coupling allows for efficient current-induced magnetization switching phenomena. Now, a magnetically doped topological insulator bilayer is shown to display a range of appealing characteristics for current-induced magnetization switching, including a significantly enhanced efficiency.

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

MultiSTAAR provides a general and flexible statistical framework for functionally informed multi-trait rare variant analysis of biobank-scale sequencing studies by jointly analyzing multiple traits and incorporating annotation information.

A single-cell multi-omics atlas of rice is revealed, providing insight into cell-type functions and molecular programs.

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

The semileptonic decay channels of the Λc baryon can give important insights into weak interaction, but decay into a neutron, positron and electron neutrino has not been reported so far, due to difficulties in the final products’ identification. Here, the BESIII Collaboration reports its observation in e+e- collision data, exploiting machine-learning-based identification techniques.

Efficient charge carrier separation is a substantial roadblock to achieving high performance in photoelectrochemical systems based on transition-metal oxides. Here a metal vacancy strategy is used to enhance hole mobility, resulting in general enhancement of photocurrent density in WO₃, TiO₂ and Bi₂O₃ photoanodes.

Crystal structures of human CB₁ bound to two cannabinoid agonists reveal key features, including a twin toggle switch and binding pocket reduction, advancing understanding of receptor dynamics and guiding cannabinoid drug design.

In this clinical trial, the authors demonstrate that recombinant gE-Fc Fusion Protein Vaccine LZ901 for herpes zoster induces superior cellular immunogenicity and exhibits a better safety profile than HZ/su in adults ≥50 years, supporting its potential as vaccine candidate.

Schrank et al. report the design and characterization of an antibody–toxin conjugate targeting CD47, promoting anti-tumor immunity in preclinical cancer models.

Biosynthesis of hyaluronan (HA) with controlled molecular weights is challenging due to the poorly understood function of the HA synthase (HAS). Here, the authors characterise and engineer HAS and conduct strain engineering to expand the molecular weight range and achieve high titres of both high and low molecular weight HA.

Asymmetric histone modifications in parental pronuclei displays epigenetic regulation. Here the authors reveal the role of LSM1-mediated Major Satellite RNA decay in the H3 variant incorporation and modifications in male pronucleus.

Here, the authors identify key DNA methylation sites associated with incident acute coronary syndrome (ACS), improving ACS prediction and highlighting potential biomarkers and therapeutic targets for ACS.

Using data from a single time point, passenger-approximated clonal expansion rate (PACER) estimates the fitness of common driver mutations that lead to clonal haematopoiesis and identifies TCL1A activation as a mediator of clonal expansion.

H₂O₂-dependent haem-peroxygenase-catalysed C–H bond oxyfunctionalization reactions have attracted much attention, but elevated concentrations of H₂O₂ are detrimental to the enzyme. Now, it is reported that this biocatalyst can operate via an alternative pathway using O₂ and small-molecule reductants.

While SARS-CoV-2 S protein targeting monoclonal antibodies (mAbs) are well studied, little is known about N protein-targeting mAbs. Here, Kang et al. provide the crystal structure of the N protein RNA binding domain with a mAb derived from a convalescent patient and show that it compromises the N protein-induced complement hyperactivation.

Renal cell carcinoma consists of several subtypes, and recurrence is highly dependent on subtype. Here, the authors develop a multi-classifier using imaging, lncRNA and clinical data to predict recurrence in papillary renal cell carcinoma.

Artificial photosynthesis of urea from NH₃ and CO₂ remains difficult to achieve. Herein, by three altering the number of heterocyclic N atoms within a series of covalent organic frameworks, the authors report an increase in urea photosynthesis yields and efficiencies.

Despite the ease of fine-tuning their reactivity, high-performance homogeneous photocatalysts competent for acetylene semihydrogenation are scarce. Here the authors introduce an effective cobalt catalyst for the production of polymer-grade ethylene, which is amenable to scale-up in a continuous-flow photoreactor.

Zhang et al. illustrate a spatial activation pattern of JNK signaling within the intestinal stem cell lineage and uncover a paracrine JNK-EGFR-JNK feedforward loop that sustains ISC proliferation during stress-induced gut regeneration.

Entanglement entropy exhibits rich phenomenology connected to different kinds of phases in condensed matter. Here, the authors confirm some of these predictions by experimentally probing nonlocal correlations in 1D and 2D phononic crystal based on interconnected resonating acoustic cavities.

Autoimmunity is triggered by trafficking of self-reactive T cells into tissues. Joonsoo Kang and colleagues show that the kinase ITK regulates T cell trafficking. ITK inhibition or genetic ablation prevents homing of autoreactive T cells into tissues and reduces islet destruction in models of type 1 diabetes without affecting T cell activation or antiviral T cell responses, suggesting that this kinase may be targeted in autoimmune disease.

The LHCb experiment at CERN has observed significant asymmetries between the decay rates of the beauty baryon and its CP-conjugated antibaryon, thus demonstrating CP violation in baryon decays.

A highly efficient, stable, low-cost and environmentally friendly photocathode is the goal of practical solar hydrogen evolution applications. Here, authors report a Cu₃BiS₃-based photocathode and Cu₃BiS₃-BiVO₄ tandem cell for unbiased overall solar water splitting with a STH efficiency over 2%.

Venous thromboembolism is a serious condition influenced by genetics, but current protein-based analyses often miss complex patterns. Here, the authors show that a new non-linear analysis method reveals 43 associated proteins, including eight missed by traditional models, offering deeper insight into disease mechanisms.

The full exploitation of back contact silicon solar cells is crucial to achieve a high performance for potential industrialization. Here, authors incorporate a double-sided light management strategy to reduce optical losses, achieving a total-area efficiency of 27.03% for 350 cm2 solar cells.

An increasing number of preclinical and clinical studies have investigated the antitumor efficacy of combined radiotherapy and immunotherapy. Here the authors report that low-dose radiotherapy enhances the antitumor effect of dual VEGFA and PD-L1 blockade in preclinical models of hepatocellular carcinoma.

Si-based hydrogen generation via hydrolysis/methanolysis faces reactivity challenges. Here, zintl-phase alkali–Si alloys, featuring discrete Si clusters with unpaired electrons, efficiently lower activation barriers, enabling high-yield, low-temperature H₂ release.

Spermine is a polyamine dysregulated in different cancers. This group shows that Serpinb9 prevents spermine synthase degradation, raising spermine levels and impairing the tumor immune microenvironment, and identifying Serpinb9 as a potential therapeutic target for pancreatic cancer immunotherapy.

Smart monitoring devices with integrated mechanical protection and piezoelectric induction are limited. Here, the authors report a strategy to grow piezoelectric Rochelle salt crystals in 3D-printed cuttlebone-inspired structures to produce smart monitoring devices with integrated mechanical protection and electrical sensing capability.

Solar water splitting holds great promise for hydrogen production but is significantly hindered by rapid recombination of photogenerated charges. Now a metal–organic framework photocatalyst has been shown to undergo, upon photoexcitation, a dynamic excited-state structural twist that greatly suppresses charge recombination to enable efficient photocatalytic overall water splitting.

The δ-lactone 3-ethylidene-6-vinyltetrahydro-2H-pyran-2-one (EVP), synthesized by telomerization of CO₂ with 1,3-butadiene, is a promising monomer for the direct use of CO₂ in the synthesis of polymers, but its ring-opening polymerization (ROP) remains challenging. Here the authors report its chemoselective ROP using a phosphazene/urea binary catalyst, affording exclusively a linear unsaturated polyester which can be recycled back to the pristine monomer.