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Anti-TSLP biologics have shown promise for the clinical treatment of type 2 respiratory disease. Here the authors present a clinical trial of CM326, a monoclonal antibody against TSLP, and show the clinical effects in patients with eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP), who present with type 2-dominant inflammation.

The authors demonstrate standing ceramic circuit boards (S-CCBs) with high-resolution and high aspect-ratio fabricated via sacrificial coating-assisted micro-3D printing, which have both high-density integration and large current-carrying capacity

Although kinetic resolution is a promising strategy for accessing enantioenriched molecules from racemic mixtures, it has not previously been realized in the synthesis of chiral sulfinyl scaffolds via S(IV) − X bond exchange. Here the authors report a kinetic resolution reaction of sulfinamides with alcohols.

TGF-β stimulated tumor-associated neutrophils (TANs) can exert pro-tumoral functions. Here the authors show that Smad3 activation in TANs is associated with an N2-like polarization state and poor outcome in patients with non-small cell lung carcinoma and that Smad3 targeting reprograms TANs to an antitumor state suppressing tumor growth in preclinical lung cancer models.

A chemical bonding engineering strategy is proposed in this work to realize the improvement of dielectric performance. A colossal permittivity of 2.37 × 10⁵ and a low loss of 0.005 are ultimately achieved in high-entropy CaTiO₃-based ceramics.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Bioplastics are desirable materials for the replacement of petrochemical-derived plastics, but achieving the desired properties can be challenging. Here, the authors report a bioplastic formed from a combination of polysaccharide sources and DNA from living organism waste, with biodegradability and recyclability.

Methods to integrate association evidence across multiple traits often focus on individual common variants GWAS. Here the authors present multi-trait analysis of rare-variant associations (MTAR), a framework for joint analysis of association summary statistics between multiple rare variants and different traits.

Hydrogels are essential for stem cell-based tissue regeneration but struggle with hard tissue repair. The authors report a shell-hardened macroporous hydrogel with spatiotemporally programmed mechanics to enhance stem cell-driven bone regeneration.

The roles of extracellular RNAs present in bacterial biofilms are poorly understood. Here, Mugunthan et al. show that specific mRNAs associate with extracellular DNA in the matrix of bacterial biofilms, facilitating the formation of viscoelastic networks.

An efficient and durable alternative catalyst to iridium oxide is essential for acidic oxygen evolution. Here, the authors report a catalyst based on RuO₂ co-doped with tantalum and boron, creating Ru-O-Ta frameworks and Ru-O-B active sites that stabilize the catalyst and enhance performance.

Infection with SARS-CoV-2 causes interstitial pneumonia and viral replication in the lungs of transgenic mice that express a human version of ACE2, confirming the pathogenicity of the virus in this model.

‘Atomic-scale precision alignment is a bottleneck in the fabrication of next generation nanoelectronics. Here, the authors used redox-coupled inherently selective atomic layer deposition of tantalum oxide on Cu/SiO₂ and achieved 100% selective deposition on SiO₂ and no observable growth on copper.’

Whole-genome sequencing of 175 Mongolians representing six tribes highlights population-specific genetic architecture and substantial gene flow among northern Eurasian populations, including derived alleles shared by Mongolians and Finns.

Addressing the stability challenges from metal electrodes/perovskite components chemical interactions is essential for high-performance perovskite solar cells. Here, authors design a bilayer polymer buffer to mitigate metal/ion interdiffusion, realizing a certified efficiency of 26.46%.

Treg cells play a pivotal role in suppressing allograft rejection but their presence in tumours hamper antitumour immunity. Here authors show that T cells, in which Setdb1 is genomically deleted, give rise to Treg cells that prevent allograft rejection but don’t compromise the antitumour immune response.

Generating arbitrary orientation of light polarization has been an elusive goal, yet it is important to light interactions with nano-objects. By combining azimuthally and radially polarized beams, Liet al. overcome this obstacle and demonstrate its use for polarization-based encryption with gold nanorods.

Two-dimensional van der Waals materials enable control of atomic-scale magnetic spin textures for spintronic devices. Here, the authors demonstrate an electric-field-driven, reversible transition between skyrmions and bimerons in a MoTeI/In₂Se₃ heterostructure, stable under static and dynamic conditions without magnetic fields, enabling efficient spintronics.

Geospatial estimates of the prevalence of anemia in women of reproductive age across 82 low-income and middle-income countries reveals considerable heterogeneity and inequality at national and subnational levels, with few countries on track to meet the WHO Global Nutrition Targets by 2030.

Until now, efforts to enhance the performance of nanolasers have focused on reducing the rate of non-radiative recombination. Here, Burgess et al.employ controlled impurity doping to increase the rate of radiative recombination.

The engineering of localized fields is at the base of ultra-compact plasmonic devices. The authors demonstrate that localized plasmon skyrmions provide a unique way to build arbitrarily shaped skyrmionic textures promising high flexibility and robustness for real applications like information processing.

Here, the authors employed Hi-C and low-input itChIP-seq in four rare populations of the hematopoietic stem cell (HSC) ontogeny trajectory across early arterial endothelial cells (eAECs), hemogenic endothelial cells (HECs), pre-HSCs, and long-term HSCs (LT-HSCs) from mouse embryos to show that active histone modifications are largely set up in eAECs and 3D genome is then subsequently configured.

Fullerene cages that break the isolated pentagon rule are rare and often unstable. Now a range of fullerenes that feature three sequentially fused pentagons of carbon have been stabilized by chlorination.

Using over 600 genetic matches of elephant tusks from the same individual or close relatives, from 49 ivory seizures across Africa, Wasser et al. reveal the scale, connectivity and movements of transnational criminal organizations that trade in ivory.

2D semiconductors are promising candidates for next-generation electronics, but the realization of competitive 2D p-type transistors remains challenging. Here, the authors report the characterization of nitric-oxide-doped monolayer and bilayer WSe₂ p-type transistor arrays, showing on-state currents up to 300–448 μA/μm, contact resistance down to 390–875 Ω·μm and on/off ratios of ~ 10⁶−10⁹.

Genomic analysis of Mycobacterium tuberculosis (Mtb) isolated from tuberculosis patients identifies the transmission dynamics of Mtb in Vietnam including frequent transmission of Beijing lineage and positive selection for EsxW Beijing variant.

Wang et al. reveal that epigenetic changes driven by zinc finger MYND-type containing 8 promote the transition from adenocarcinoma to antiandrogen-resistant neuroendocrine prostate cancer and offer a therapeutic approach by targeting the histone reader with a small molecule.

Genome-wide association studies (GWAS) have improved our understanding of the genetic basis of lung adenocarcinoma but known susceptibility variants explain only a small fraction of the familial risk. Here, the authors perform a two-stage GWAS and report 12 novel genetic loci associated with lung adenocarcinoma in East Asians.

A multi-ancestry genome-wide gene–smoking interaction study identifies 13 new loci associated with serum lipids.

Bhattacharjee and Schaeffer et al. map exclusive breastfeeding (EBF) in 94 low- and middle-income countries (LMICs), finding increased EBF practice and reduced subnational variation across the majority of LMICs from 2000 to 2018. However, only six LMICs will meet WHO’s target of ≥70% EBF by 2030 nationally, and only three will achieve this in all districts.

The imbalance in structural tension between crystalline materials and surfactant micelles makes the synthesis of crystalline mesoporous metal–organic frameworks (meso-MOFs) challenging. Now single-crystalline meso-MOFs featuring ordered mesopores have been prepared through the assembly of surfactant micelles and subunits of crystalline MOFs—a process co-mediated by strong and weak acids.

An analysis of the impact of logging intensity on biodiversity in tropical forests in Sabah, Malaysia, identifies a threshold of tree biomass removal below which logged forests still have conservation value.

Electrocatalytic nitrite reduction is a green alternative to the Haber-Bosch process, but its ammonia production remains inefficient at low nitrite levels. Here the authors report an intermetallic single atom alloy CuZn catalyst for nitrite reduction to ammonia with high efficiency and stability at low nitrite concentration of 1−10 mM.

The implementation of parity–time symmetry in a complementary metal–oxide–semiconductor process technology enables the realization of wide-band high-quality microwave generation and broadband strong microwave isolation at gigahertz frequencies.

Brain iron accumulation has been associated with multiple brain disorders, but the mechanism is not well understood. Here, the authors investigate the genetic determinants of brain iron accumulation and their implications for neuropsychiatric disorders.

In this study, Qin et al. present a murine-adapted SARS-CoV-2 strain, MASCp36, as a model for studying the pathogenicity, evolution and adaptation of the virus to human and animal hosts.

A foundation model learns transcriptional regulatory syntax from chromatin accessibility and sequence data across a range of cell types to predict gene expression and transcription factor interactions, with generalizability to unseen cell types.

Ribonulease P is a conserved ribozyme present in all kingdoms of life that is involved in the 5′ maturation step of tRNAs. Here the authors determine the structure of an archaeal RNase P holoenzyme that reveals how archaeal RNase P recognizes its tRNA substrate and suggest a conserved catalytic mechanism amongst RNase Ps despite structural variability.