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The development of moderate magnetic hyperthermia (MH) for tumor ablation while concurrently restoring bone homeostasis shows potential for osteosarcoma (OS) therapy. Here this group combines magnetothermal nanoparticles with MH temperature-controlled borosilicate bioactive glass achieving OS cell impair while activating TNF signaling pathway for therapeutic purpose.

Using siRNA screening, Chen et al demonstrate that Rab27a and its effector SYTL4 mediate the transport of influenza viral membrane proteins to the plasma membrane, highlighting their role in virion assembly and identifying SYTL4 as a potential therapeutic target for antiviral drug development.

The quark structure of the f₀(980) hadron is still unknown after 50 years of its discovery. Here, the CMS Collaboration reports a measurement of the elliptic flow of the f₀(980) state in proton-lead collisions at a nucleon-nucleon centre-of-mass energy of 8.16 TeV, providing strong evidence that the state is an ordinary meson.

Protocol for fabricating synthetic viscoelastic antigen-presenting cells and their application in T cell engineering. These synthetic cells support robust T cell activation and expansion and improve chimeric antigen receptor transduction efficiency.

Crystal structures of M. tuberculosis elongation factors EF-Tu and EF-Ts in complex and GDP-bound Ef-Tu reveal the molecular basis of EF-Tu’s representative recycling and inactive forms in protein translation.

Red light- or ultrasound-controlled proximity labelling is engineered to stimulate clustering-induced receptor activation and downstream signalling amplification to promote antitumour immune responses.

Li et al. reveal the mechanism by which the ribosome termination complex catalyzes dissociation of GDP from release factor RF3 in Escherichia coli. The findings explain the guanine nucleotide exchange factor activity of the ribosome.

A high-quality genome assembly of Weining rye sheds new light on gene duplications and their effects on starch biosynthesis genes, gene expression features underlying early heading trait and putative domestication-associated chromosomal regions.

Complicated and labor-intensive processes for sulfur host materials fabrication hinder their practical production for lithium-sulfur batteries. Here, authors propose a single-step laser printing strategy to directly print the integrated sulfur cathodes with high performance in both coin and pouch cells.

This study maps chromatin accessibility at single-cell resolution in rice and related grasses, revealing how regulatory DNA elements evolve across cell types and species and identifying potential silencers that control gene expression.

This research identifies a regulatory role for the receptor-like kinase FERONIA in Arabidopsis roots, finding that it balances growth and immunity by activating localized immunity in response to bacterial colonization.

A tunable magnetic nanochains platform (EVGpro) enables tandem enrichment, proteomic, and N-glycoproteomic analysis of extracellular vesicles from ultratrace biofluids. EVGpro identifies N-glycoprotein signatures and two asthenozoospermia subtypes.

Neural circuit mechanisms underlying feeding behavior regulation are not fully understood. Here authors provide quantitative mapping of the brain-wide input and output configuration of tuberal nucleus somatostatin neurons, a key player of feeding regulation, in mouse brain for a deeper understanding of the feeding regulation network.

Huang et al. identify that lnc-Snhg18 promotes BMSCs osteogenesis by facilitating Cav1–Ywhah interaction and Yap nuclear translocation. Loss of Snhg18 worsens bone loss, while delivery restores bone mass, suggesting a therapeutic target for osteoporosis.

State-of-the-art graphite anodes cannot meet the extremely fast charging requirements of ever-demanding markets. Here the researchers develop a Li₃P-based solid–electrolyte interphase, enabling fast (down to 6 min) charging of graphite-based Li-ion batteries.

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

Achieving cathodes with large areal capacities is crucial for advancing aqueous aluminum-based batteries. Here, authors report a hydrate-melt electrolyte based on AlCl₃ and organic halide salts that enables reversible Br⁻ /Br⁰ /Br⁺ chemistry with a high areal capacity of 5 mAh cm⁻².

Yu et al. report a parameter for screening photoactive materials for semitransparent organic photovoltaics, enabling a light utilization efficiency of 6.05%. Geographical analysis are also conducted and indicates that the hot summer/warm winter zone is more suitable for deploying smart windows.

Understanding base excision repair leads to the development of more efficient mitochondrial adenine editors.

Lewis acid catalyzed tittle reaction of 1,3-dicycloalkenlidine ketones is recognized as so far the shortest and most effective 1-step method for construction of angular tricyclic scaffolds, which are extensively found in bioactive terpenoids. Here, the authors disclose the structure-reactivity relationship and a regioselectivity predicting model based on in situ IR technology, DFT calculations and machine leaning algorithms.

Dual-scale chemical ordering in CoNiV-based alloys improves the synergy of strength and ductility at cryogenic temperatures, providing an approach for obtaining high-performance metallic materials for cryogenic applications.

Mitophagy is crucial for mitochondrial function and is implicated in Alzheimer’s disease. Here, the authors introduce an AI-assisted fluorescence microscopy system to track mitophagic intermediates in live cells and identify Y040-7904, a potential modulator that enhances mitophagy and reduces amyloid-β pathologies.

The transcription factor ATF6 causes an enrichment in long-chain fatty acids in the colonic epithelium, which leads to changes in the gut microbiota and contributes to the development of colorectal cancer in humans and mice, thereby linking endoplasmic reticulum stress responses to lipid metabolism and tumorigenesis.

Here, the authors conducted a whole genome sequencing (WGS)-based genome-wide scan for non-small cell lung cancer in 13,722 Chinese individuals and identified genes including PARPBP, PLA2G4C, and RITA1 in the context of non-coding regulation.

The endoplasmic reticulum (ER) and lysosome are central to cellular stress responses, but it is unclear how ER stress is signaled to lysosomes. Here the authors show that ER stress activates chaperone-mediated autophagy (CMA) via direct phosphorylation of the CMA receptor LAMP2A by the lysosomal p38 MAPK.

Results from the phase 2/3 clinical trial of gantenerumab or solanezumab in dominantly inherited Alzheimer’s disease reveal no beneficial effects on cognitive measures despite a significant reduction in amyloid plaques and other key biomarkers in those treated with gantenerumab.

The endoplasmic/sarcoplasmic reticulum (ER/SR) plays a crucial role in calcium signaling, but there are few methods capable of efficiently capturing ER/SR Ca²⁺ dynamics. Here authors develop a set of genetically encoded indicators enabling ratiometric super-resolution imaging and detection of elementary Ca²⁺ release in cardiomyocytes.

A data-efficient deep learning model developed to predict ground-state and photophysical properties of molecules and nanomaterials by learning many-body Green’s functions achieves an accuracy surpassing the state-of-the-art density functional theory calculations.

A study reveals that most transcripts in Mycobacterium tuberculosis are incomplete, likely because of the tendency of the transcription machinery in this species to pause on genomic DNA.

Olfactory perception of food-derived odors influences feeding behavior, but the underlying neural pathways remain unclear. Here, the authors show that prolonged exposure to food odor suppresses food intake and body weight gain by activating an olfactory bulb–hypothalamus circuit.

Cholecystectomy is associated with an increased risk of colorectal cancer, and the underlying mechanism remains elusive. Here, the authors show that cholecystectomy-related microbiome and bile acid alterations disrupts the FXR/β-catenin interaction, and ultimately exacerbates colorectal tumorigenesis.

Integrated structural biology approach leveraging in situ cryo-electron tomography reveals molecular details of the native malarial translation elongation cycle and its perturbation by cabamiquine, a potent antimalarial drug candidate.

Enhanced expression of chloroplast elongation factors StTuA/B increases potato disease resistance and photosynthesis, while oomycete effector Pi22926 inhibits their entry into the chloroplasts by disrupting their phosphorylation by StMAP3Kβ2.

Low-temperature operation remains challenging for batteries. Here, the authors report an electrolyte solvation structure design strategy to break solvation dominance of ethylene carbonate to facilitate the desolvation process that improves the low-temperature performance of lithium-ion batteries even below −100 °C.