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The study shows that lunar ilmenite preserves less solar wind-generated water than silicate minerals, likely due to faster water escape. This finding suggests that ilmenite may critically influence surface water variations within the lunar Procellarum KREEP Terrane.

The dilute CO₂ electrocatalysis suffers from low selectivity in membrane electrode assembly. Here, the authors report the design of self-reinforced CO₂ concentration gradient that breaks CO₂ mass transport limit, realizing direct and selective conversion of simulated flue gas in membrane electrode assembly.

In a model of acute kidney injury the authors show that Pannexin1 can mediate a leak of Calcium from the endoplasmic reticulum leading to mitochondrial calcium overload and pro-senescence signals, and ultimately driving fibrosis and kidney disease progression

Porphyrins are produced at scale through metabolic engineering and optimization of CPIII purification.

High-entropy alloy nanoparticles (HEA-NPs) have emerged as new materials in various fields, but their scalable synthesis still remains a challenge. Here, the authors report an ultrafast, one-step method for the continuous synthesis of HEA-NPs based on the thermal plasma jet technology.

Here Tai et al. unveil elevated formation of the C-terminal binding protein (CtBP)–tripartite-motif-containing protein 28 (TRIM28) complex in breast cancer cells and mutual protection between CtBP and TRIM28. This complex is required for mammary gland development and its high levels lead to breast cancer metastasis by repressing autophagy.

Hybrid density functionals are crucial for accurate materials calculations, yet their application is limited by the computational cost. Here, authors overcome this efficiency bottleneck through deep learning, enabling large-scale hybrid density functional calculations.

Ground subsidence partially compromised the flood protection capacity of rivers and damaged the flood control dam resulting in a 28% increase in flood risk and secondary flooding disaster in the Liaohe plain, China in 2022, according to a retrospective analysis of the disaster event and its impacts.

In a prespecified interim analysis of the randomized, double-blind phase 3 COMPASSION-15 trial, patients with advanced HER2-negative gastric/GEJ cancer treated with the anti-PD-L1/CTLA-4 bispecific Ab cadonilimab plus chemotherapy showed significantly improved overall survival compared with patients treated with placebo plus chemotherapy as first-line treatment.

Mechanoluminescence enables sensing applications of mechanical stimuli. Here, the authors reveal the importance of interfacial triboelectricity to this phenomenon in inorganic-organic composite materials.

In this study, the authors show that nanovaccines co-delivering EBV antigens and molecular adjuvants generate high levels of neutralizing antibodies targeting vulnerable EBV sites of gHgL, gB and gp42. Antibodies elicited by cocktail nanovaccine immunization provide durable protection against EBV-associated lymphoma.

The Anaphase Promoting Complex adaptor protein Cdh1 tightly controls cell cycle progression to restrain tumorigenesis but the mechanism is not completely known. Here, the authors show that reciprocal inhibition between Cdh1 and the c-Src signaling pathway regulate breast cancer tumorigenesis.

Seeing molecules in action under the influence of very short pulses is interesting. Here the authors demonstrate charge migration dynamics in molecules by using high harmonic spectroscopy and machine learning algorithm.

Heterozygous mutateons in the caspase-8 cleavage site of RIPK1 cause a range of autoinflammatory symptoms in humans, and caspase-8 cleavage of RIPK1 in a mouse model limits TNF-induced cell death and inflammation.

Spectropolarimetric observations of three tidal disruption events reveal that they are optically polarized at the 1–2% level by a cloud of electrons surrounding the black hole (in good agreement with theory).

The gut microbiome plays an important role in colorectal carcinogenesis and predictive microbiome signatures have been proposed for colorectal cancer (CRC) diagnosis. Here the authors perform a meta-analysis of 16S rRNA-based profiles to identify microbial markers able to discriminate patients with adenoma from control and CRC, building a model that can be applied for the early detection of CRC.

Here the authors show that myonectin functions as a protective factor against age-associated, disuse-induced or steroid-induced muscle atrophy, suggesting that myonectin represents a therapeutic target for preventing skeletal muscle dysfunction.

Chromosome-level genome assemblies of three Allium crops (onion, garlic and Welsh onion) and spatial RNA sequencing provide insights into Allium trait evolution and gene expression patterns during onion bulb formation.

The authors uncover a Père David’s deer-like design for long noncoding RNAs such as metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), which partially mimics the transfer RNA (tRNA) structure to recruit select tRNA processing enzymes for maturation and to create novel regulatory RNAs such as the MALAT1-associated small cytoplasmic RNA.

Hydrogen isotope effect in metal-hydrogen systems disturbs precise Deuterium/Tritium (D/T) ratio control. Here, the authors demonstrate a local coordination strategy that comprises thermodynamic destabilization with vibration enhancement of interstitial isotopes for isotope engineering.

Previous studies on high harmonic generation from molecules have been used to identify the spectral properties and orbital contributions. Here the authors measure the isotopic effects in the energy shift of the HHG spectra caused by the nuclear motion of the molecules.

2- arachidonoylglycerol (2-AG), an abundant endocannabinoid in the brain, regulates diverse neural functions. Here, the authors identified four loss-of-function mutations in dicylglycerol lipase β (DAGLB) from six patients with early onset Parkinsonism. In mice, loss of DAGLB in dopamine neurons reduced neuronal activity and impaired locomotor function and augmentation of 2-AG levels boosted neuronal activity and rescued locomotor deficits.

Analysis of lunar soils sampled by the Chang’e-5 mission suggests that impact glass beads may host a substantial inventory of solar wind-derived water on the Moon’s surface.

The lunar mantle may have remained reduced, according to the oxygen fugacity of 2.0 Ga Chang’e-5 basalt that is similar to 3.6 − 3.0 Ga Apollo basalts and pyroclastic glasses.

Kubo et al. report two kindreds that exhibit a deficiency of iRHOM2, which interacts with ADAM17, leading to defective release of TNF and CD62L and resulting in altered immune responses to opportunistic infections.

Body cavity macrophages reside on the serous surfaces of organs and believed to participate in organ repair following injury. Here the authors show with a fate-mapping reporter system that these cells, although accumulate at the surfaces of injured liver or lung, don’t penetrate deeply into the tissue.

Water abundance and hydrogen isotope compositions of two-billion-year-old basalt samples returned from the Moon by the Chang’e-5 mission suggest that the samples came from a relatively dry mantle source.

Cell-free DNA (cfDNA) released from damaged or dead cells can activate DNA sensors that exacerbate the pathogenesis of rheumatoid arthritis (RA). Here the authors use ~40 nm cationic nanoparticles to scavenge cfDNA, and demonstrate the potential for nanomedicine to relieve debilitating RA symptoms.

Some patients with COVID-19 fail to clear the viral infection quickly, yet our understanding for the underlying immune characteristics is still lacking. Here the authors use single-cell RNA sequencing and other data form such patients to show that persistent infection is associated with immune suppression and reduced expression of ribosomal protein genes.

Genetic lineage tracing in mice shows that endocardium-derived fibroblasts preferentially proliferate in response to pressure overload. Ablation of these cells alleviates cardiac fibrosis and reduces functional decline after pressure overload injury.

The mechanisms that restore endothelial barrier integrity following inflammation-induced breaching are incompletely understood. Here the authors show that the CD31 immune receptor contributes to reestablishing vascular integrity via its effects on endothelial cell metabolism.

Cocrystal and cryo-EM structures of Geobacillus kaustophilus glyQ and Bacillus subtilis glyQS T-box-tRNA complexes establish a universal mechanism of amino acid sensing on tRNAs and gene regulation by T-box riboswitches.