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In the dose-expansion cohort of this phase 1b trial, the EGFR×HER3 bispecific antibody–drug conjugate BL-B01D1 given to patients with metastatic esophageal squamous cell carcinoma led to encouraging clinical response rates, which need to be confirmed in larger efficacy trials.

A highly potent and selective small-molecule catalytic inhibitor of the protein lysine methyltransferase NSD2 shows therapeutic efficacy in preclinical models of KRAS-driven pancreatic cancer and lung cancer.

Using an electrolyte micro-emulsion strategy, a lithium anode and high-voltage cathode can be simultaneously stabilized by liquid–liquid interfacial tension to achieve high-energy-density lithium-metal batteries.

The authors present a 3D map of nearly all cells in C. elegans embryos, revealing how cell shape, size, and fate change over time. They show how Notch and Wnt signaling, along with mechanical forces, influence development, including organ formation.

A ligand oxidation structure-adaptive strategy creates an ultra-thin passivation nanolayer that enables copper and its alloys to resist corrosion and oxidation in harsh environments while retaining intrinsic electrical and thermal conductivities.

Organozinc compounds have become ubiquitous and versatile intermediates, finding widespread applications in synthetic chemistry, but structurally characterized zinc-boryl species are extremely rare. Here, the authors synthesize a zinc-Bcat compound which exhibits amphiphilic reactivity.

These authors contributed equally.

Influenza A virus neuraminidase (NA) is an important target for universal influenza vaccines. Here, the authors identify two monoclonal antibodies, CAV-F6 and CAV-F34, that inhibit NA activity across multiple subtypes, offering protection against seasonal and emerging avian influenza strains, thus advancing the development of broadly protective vaccines and therapeutics.

Hypoxic stress remodels key cellular pathways in tumor. Here the authors identify that hypoxia induces glucokinase phosphorylation and nuclear localization, contributing to TAZ activation and tumor growth.

To better understand the etiology of frailty, the authors perform a large genetic study. They identified 45 additional variants and implicated MET, CHST9, ILRUN, APOE, CGREF1 and PPP6C as potential causal genes, linking frailty to immune regulation, metabolism and cellular signaling.

Shen, Gao and Luo et al. show that the epigenetic regulator Cxxc1 plays an important role in maintaining homeostasis and function of group 3 innate lymphoid cells that are involved and key in regulating intestinal immunity during aging.

Retrograde chloroplast signals are essential in coordinating nuclear gene expression, but the mechanism that relays chloroplast signals to the nucleus remains elusive. In this study, a chloroplast envelope-bound transcription factor PTM is shown to transmit chloroplast signals to the nucleus.

Retrograde signalling co-ordinates nuclear gene expression in response to stress perceived in the chloroplast. Here Guo et al. show that a MAPK cascade acting downstream of a plastid derived Ca²⁺signal contributes to the regulation of nuclear gene expression by phosphorylation of ABI4 during retrograde signalling.

By resonant excitation of an InAs quantum dot embedded in a microcavity, a deterministic single-photon source is demonstrated. Single-photon purity of 0.9795(6), photon indistinguishability of 0.9856(13), and an overall end-to-end efficiency of 0.712(18) are simultaneously obtained.

Controlling selectivity between H₂O splitting and CO₂ reduction remains challenging in artificial photosynthesis. Here, the authors report light-driven conversion of Fe to FeCo bimetallic sites in nitroprusside, switching catalytic selectivity from H₂ evolution to CO₂ reduction.

The production of hematopoietic stem cells in the embryo is precisely regulated by various intrinsic and extrinsic factors. Here, the authors find that autophagy is involved in the maturation of hematopoietic precursors through nucleolin pathways.

Developing strong, thermally resistant adhesives for load-bearing applications remains challenging. Here, the authors report a class of solution-sheared supramolecular oligomers that exhibit exceptional adhesive strength and toughness across a broad temperature range.

This study establishes a molecular classification of keloids based on fibroblast differentiation via integrated single-cell/bulk RNA-seq, offering novel insights into pathogenesis and enabling precision clinical management with therapeutic avenues.

Transcriptomic and proteomic analyses of cells and matrix along the fibrotic trajectory in mouse lung identified PI16 as an anti-fibrotic factor with potential for therapeutic application in humans.

Here the authors present a large genetic study in East Asians that identifies 97 genetic regions linked to kidney function. These findings aim at better understanding chronic kidney disease in diverse populations.

MultiSTAAR provides a general and flexible statistical framework for functionally informed multi-trait rare variant analysis of biobank-scale sequencing studies by jointly analyzing multiple traits and incorporating annotation information.

Heterogeneous single-atom catalysts (SACs) offer high atom utilization and well-defined active sites but face challenges in multi-stage cross-couplings due to limited coordination and reactivity. Here, the authors introduce SACs on reducible carriers, enabling adaptive coordination to bypass oxidative addition in cross-couplings.

Type 1 conventional dendritic cells (cDC1) play a pivotal role in the cross-presentation of antigens, enabling efficient CD8 + T cell response. Here authors show that the transcription factor Zeb1 essentially regulates this process via facilitating the reactive-oxygen-species-dependent rupture of phagosomal membrane to allow antigen export to the cytoplasm.

DeepRETStroke is a deep learning system using retinal photographs to detect silent brain infarction and predict future stroke events.

The authors demonstrate that warming will reduce connectivity for ocean species, potentially limiting their capacity to adapt to warming through habitat shifts. The results show particularly strong losses of connectivity in deeper ocean strata, affecting 95% of abyssopelagic species.

How oxidative stress impacts neurons is poorly understood. Here the authors reveal that overactivation of autophagy following oxidative stress contributes to neuronal death and discover a protective function of OSP-1 in modulating this process.

Anxiety-like behaviour in mice, as a result of psychological stress, is shown to be mediated by GDF15 release in response to adipose tissue lipolysis.

Clear cell renal cell carcinoma (ccRCC) usually metastasizes to the lungs. Here, the authors discover that SWI/SNF ATPase subunit SMARCA4 silencing of HLF regulates ccRCC lung metastasis by modulating the integration of collagen's mechanical cues with the actin cytoskeleton through leupaxin.

Direct CO₂ conversion into high-value organic products faces significant selectivity challenges. This work presents a FeCo carbide-based tandem catalyst enabling high-efficiency, stable production of C2+ alcohols.

CRISPR screens identify hepatic ABCC4 as a modulator of LDLR. Inhibiting ABCC4 increases hepatic LDLR, lowers plasma LDLC and acts via the cAMP-Epac2/Rap1a signaling pathway to suppress PCSK9, preventing LDLR degradation.

When used in Chinese (versus English), generative artificial intelligence exhibits a more interdependent (versus independent) social orientation and a more holistic (versus analytic) cognitive style embedded in large-scale textual training.

Leukemic stem cells (LSCs) drive chemoresistance and relapse in acute myeloid leukemia. Here, the authors show that the splicing factor RBM17 supports LSCs through avoiding nonsense-mediated decay of pro-leukaemic factors such as the translation initiation factor EIF4A2.

Cholecystectomy is associated with an increased risk of colorectal cancer, and the underlying mechanism remains elusive. Here, the authors show that cholecystectomy-related microbiome and bile acid alterations disrupts the FXR/β-catenin interaction, and ultimately exacerbates colorectal tumorigenesis.

While Bell inequalities have been violated several times—mostly in photonic systems—their violations within particle physics experiments are less explored. Here, the BESIII Collaboration showcases Bell-violating nonlocal correlations between entangled hyperon pairs.

Diatomic catalysts show promise for the oxygen reduction reaction, but their complex kinetics hinder rational design. Here, the authors synthesize strongly bonded Fe-Co diatomic catalysts where Co acts as the main active site and Fe aids *OH adsorption, revealing a synergistic effect.

Tongue Squamous Cell Carcinoma (TSCC) is a subtype of head and neck cancer with poor prognosis. Here, the authors show that TSCC influences the transdifferentiation of tongue muscle cells into cancer-associated fibroblasts, transforming the tumor microenvironment into a tumor-supporting microenvironment.

The authors present a dual-chiral photonic platform that enables amplification, elimination, and reversal of chiroptical response at visible wavelengths. Using this platform, they demonstrate a switchable metalens for polarized light.

In this multicenter phase 1 trial, treatment with IBI343, a CLDN18.2-targeting antibody–drug conjugate, was safe and showed encouraging clinical responses in patients with advanced gastric or gastroesophageal junction adenocarcinoma.

Pancreatic cancer detection can be challenging, and is often diagnosed at a late stage. Here, the authors present a cfDNA-based liquid biopsy model that enables early detection and prognosis prediction of pancreatic cancer.

A deeper knowledge of the immune cell profile within the brain cancer tumor microenvironment (TM) could identify targets to improve immunotherapy efficacy. Here, in glioblastoma, the authors find haematopoietic stem and progenitor cells in the TM, which are associated with poor prognosis and increased immunosuppression.

A nanobody was identified that targets the N-terminal fragment of the adhesion G-protein-coupled receptor ADGRG2, allosterically enhances activation by the natural agonist dehydroepiandrosterone and restores signaling in mutant receptors.

The DNA methylation landscape of triple-negative breast cancer remains to be characterised. Here, the authors analyse tumour methylome profiles and the genomic context of CpG methylation and identify two epigenetic subtypes with distinct transcriptional patterns.