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Seo et al. present a cerebrospinal fluid (CSF) proteomic profiling of cognitively normal individuals, identifying age-associated, sex-associated, APOE ε4-associated and amyloid-associated changes. They unveil early Alzheimer’s disease CSF-specific proteomic signatures and potential therapeutic targets.

Direct human actions such as hunting and bird deterrence at aquaculture sites kill up to 10% of the populations of some shorebird species migrating along China’s coast each year, suggesting that this direct mortality is an overlooked threat to migratory populations.

The quark structure of the f₀(980) hadron is still unknown after 50 years of its discovery. Here, the CMS Collaboration reports a measurement of the elliptic flow of the f₀(980) state in proton-lead collisions at a nucleon-nucleon centre-of-mass energy of 8.16 TeV, providing strong evidence that the state is an ordinary meson.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

SINGER is a method for creating ancestral recombination graphs to understand the genealogical history of genomes. The method has increased speed, and thus scalability, without sacrificing accuracy.

Telomere shortening marks cellular aging and links to heart disease. Here, the authors show shared genetic loci between leukocyte telomere length and coronary artery disease, highlighting genes such as SH2B3 and pathways involved in DNA biosynthesis and telomere maintenance.

Humpbacks have picked up a catchy tune sung by immigrants from a distant ocean.

Infants listened to lullabies and other songs recorded in cultures and languages that were unfamiliar to them. They relaxed more in response to the lullabies. This suggests that infants may be predisposed to respond to common features of lullabies.

Two phase 2 trials, along with translational analysis of prospective cohorts and experimental analysis, indicate that immunosenescence as a mechanism of resistance to immunotherapy can be overcome with the senolytics dasatinib and quercetin in patients with head and neck squamous cell carcinoma.

The tumour microenvironment often suppresses immune cell function and cancer-associated fibroblasts (CAF) are involved in the process. Here authors show in human tumours and in mouse models that AEBP1 is highly expressed in CAFs, and via autocrine stimulation of its receptor CKAP4, it induces the upregulation of PD-L1, which inhibits the anti-tumor T cell response.

Even after a motor skill is overlearned, some variation remains every time it is performed. Such variation enables trial-and-error learning for adult bengalese finch song. Birds rapidly learned to make adaptive shifts in their vocalizations in response to auditory perturbations delivered to a subset of natural variations in their songs, consistent with the idea that motor variability is a form of exploration that can support continuous learning and optimization of performance.

Arboviruses are climate sensitive, and their global distributions are changing. Here, the authors describe results of a One Health study programme to investigate the occurrence of Usutu and West Nile Virus in the Netherlands, a previously non-endemic area.

Spatial cell distribution within a tissue microenvironment is a rapidly advancing field. Here, authors assess three commercially available single-cell resolution spatial transcriptomics approaches (CosMx, MERFISH, and Xenium) to inform which technology outperforms for immune profiling of solid tumors using patient samples.

This study introduces the Cattle Cell Atlas, a single-cell expression resource including 1,793,854 cells from 59 tissues. Integrative analyses leveraging this atlas provide insights into the biology underlying bovine monogenic and complex traits.

Birdsong has long connected humans to nature. Historical reconstructions using bird monitoring and song recordings collected by citizen scientists reveal that the soundscape of birdsong in North America and Europe is both quieter and less varied, mirroring declines in bird diversity and abundance.

When songbirds sing, neurons in premotor areas fire coordinated bursts precisely timed to the dynamics of the song. The cellular mechanism for such sequence generation is unknown. These authors make the technical breakthrough of recording intracellularly in HVC neurons in singing birds, allowing them to test models of burst generation. They found that membrane potential rapidly depolarizes 5–10 ms before burst onset, consistent with models in which HVC neurons form synaptically connected chains.

Lampreys are jawless vertebrates that can offer unique insights into vertebrate evolution. Here they generate a comprehensive cell atlas of the lamprey, uncovering 70 distinct cell types across 14 tissues, and identify pancreas-like cells in the lamprey small intestine.

Uncovering the rules of microtubule network self-organization under confinement is key to understanding how cells build structure in complex environments. This study reveals a tunable boundary-sensing feedback mechanism, wherein pioneer microtubules navigate confined environments and generate nucleation sites for new microtubules, thereby shaping network architecture.

Thalamic activity is strongly inhibited by pallidal inputs from the basal ganglia, but the role of excitatory inputs from cortex is unclear. Recording from presynaptic pallidal axon terminals and connected postsynaptic thalamocortical neurons in zebra finches, the authors find that pallidal inputs control thalamic spike timing, whereas cortical inputs may be the principle drivers of thalamic activity during singing.

Preventing endosomal damage sensing or using lipids that create reparable endosomal holes reduces inflammation caused by RNA–lipid nanoparticles while enabling high RNA expression.

A covalent organic framework-based type-II heterojunction (TpPa/TpDz) enables efficient photocatalytic H₂O₂ production in pure water. The highest and lowest occupied molecular orbitals are spatially separated, driving directional photogenerated carrier transport and minimizing recombination, therefore enhancing photocatalytic activity.

A combination of large-scale phylogenomic analysis, mouse lethality experiments and bacterial growth assays shows that gene loss in the putrescine utilization pathway has enhanced biofilm formation and transmission-related characteristics in the pandemic clone of a bacterial pathogen, Vibrio parahaemolyticus, promoting successive waves of global transmission events.

DSS1 is reported to be involved in the maintenance of DNA repair and protein homeostasis. Here, authors show that DSS1 is upregulated in metastatic ccRCC, promoting tumor growth and metastasis by impairing autophagy and stabilizing TWIST1.

The LHCb experiment at CERN has observed significant asymmetries between the decay rates of the beauty baryon and its CP-conjugated antibaryon, thus demonstrating CP violation in baryon decays.

Neel domain walls are typically stabilized by an interfacial Dzyaloshinskii-Moriya interaction, with a chirality that is fixed by the sample materials. Here, Song, Huang and coauthors demonstrate the existence of two bistable Néel domain wall states with opposite chiralities, and the switching between these via magnetic field pulses

Recent research has revealed similarities between speech and birdsong on different levels. Bolhuis et al. discuss parallels between humans and songbirds in terms of vocal learning, the neural networks underlying vocalization and the role of FOXP2, highlighting both general and species-specific principles.

Lineage tracing in mice identifies a subpopulation of basal cells that express Tmprss2 and Nkx3 as the origin of ERG-driven prostate cancer. Upon expansion, these cells show an enrichment for STAT3 chromatin binding and elevated expression of KMT2A and DOT1L as dependencies for ERG oncogenicity.

IP6 is a critical host cofactor for HIV-1 assembly and infectivity. In this study, the authors uncover the structural basis by which HIV-1 adapts to a deficiency in IP6 packaging through a G225R mutation at the C-terminus of the capsid protein.

In two independent studies, Song et al. and Jiang, Dalgarno et al. present computational frameworks, perturbation-response score and Mixscale, respectively, to determine individual cellular variation in response to perturbation.

Analysis of soundscape data from 139 globally distributed sites reveals that sounds of biological origin exhibit predictable rhythms depending on location and season, whereas sounds of anthropogenic origin are less predictable. Comparisons between paired urban–rural sites show that urban green spaces are noisier and dominated by sounds of technological origin.

A photodiode with bio-plausible event sensing, filtering and adaptation behaviours to replicate the retinal nanostructure and visual pathway is presented, enabling consistent and high-performance machine vision under extreme lighting.