Search

Enhanced polyamine depletion in neuroblastoma models decreases translation of mRNA codons with adenosine in the third position, reprogramming the tumour proteome away from cell cycle progression and towards differentiation.

The functional roles of circular RNAs (circRNAs) in the progression of colorectal cancer remain to be studied. Here the authors report that an alternatively-circularized circMAN1A2(2,3,4,5) promotes colorectal cancer cell proliferation via enhancing target mRNA stability.

Ovarian cancer cells invade and metastasize into adipose tissue. By designing biomimetic organo-hydrogels, the authors reveal how the mechanical anisotropy and microstructure of adipose tissues jointly guide invasive migration.

Rigorous measurement of adaptation policies is crucial to implementing successful climate policy. Policy analysis of 41 countries shows an 87% increase in adaptation initiatives since 2010, suggesting that concrete adoption of such practices is growing.

Amino acids possess a new and broad colloidal property: they stabilize patchy nanoscale colloids, such as proteins, by adsorbing onto their surfaces through weak interactions.

Prenatal stress triggers molecular dysregulations in fetal neuroimmune circuits, leading to altered mast cell and sensory neuron function, which predisposes offspring to develop eczema in response to otherwise harmless mechanical friction after birth.

Confocal microscopy enables high-resolution, high-plex 3D cyclic immunofluorescence of 30- to 50-µm-thick tissue sections. The approach allows for rich phenotypic assessments of intact cells and intercellular interactions with subcellular resolution.

Phase singularities are known to have applications in various branches of optics. Here the authors demonstrate that phase singularities can be created and controlled, all optically, in a simple thin film of organic molecules using cavity-free strong light-matter coupling.

Here, a combination of forward genetics and genome-wide association analyses has been used to show that variation at a single genetic locus in Arabidopsis thaliana underlies phenotypic variation in vegetative growth as well as resistance to infection. The strong enhancement of resistance mediated by one of the alleles at this locus explains the allele's persistence in natural populations throughout the world, even though it drastically reduces the production of new leaves.

The regulatory landscape controlling Hoxd gene expression in tetrapod digit development was probably co-opted from a pre-existing cloacal regulatory mechanism, as evidenced by the effects of genetic deletion experiments in zebrafish fin, cloaca and mouse urogenital development.

Electronic health records are a rich source of clinical data but identifying associations with outcomes is complex. Here, the authors propose a modelling framework ‘InfEHR’ that identifies patient trajectories in electronic health records and generates a likelihood for clinical phenotypes.

Oxaloacetate is sensed by MDH1, which primes innate immune antiviral defence against influenza virus infection, thus resulting in the activation of ETS2 to promote TBK1-centred type I interferon signalling.

The International Brain Laboratory presents a brain-wide electrophysiological map obtained from pooling data from 12 laboratories that performed the same standardized perceptual decision-making task in mice.

In advancing the design of electronic devices, the dielectric tunability of barium strontium titanate is enhanced by an order of magnitude relative to the previously reported values through the manipulation of polar domain characteristics.

Owing to electron localization, two-dimensional materials are not expected to be metallic at low temperatures, but a field-induced quantum metal phase emerges in NbSe₂, whose behaviour is consistent with the Bose-metal model.

The number of individuals in a given space influences animal interactions and network dynamics. Here the authors identify general rules underlying density dependence in animal networks and reveal some fundamental differences between spatial and social dynamics.

A covalent organic framework-based type-II heterojunction (TpPa/TpDz) enables efficient photocatalytic H₂O₂ production in pure water. The highest and lowest occupied molecular orbitals are spatially separated, driving directional photogenerated carrier transport and minimizing recombination, therefore enhancing photocatalytic activity.

The predicted increase in frequency of droughts and rising temperatures in Europe will lead core populations of a temperate plant to an evolutionary dead-end unless they acquire genetic alleles that are present only in extreme edge Mediterranean, Scandinavian, or Siberian populations.

Many protein–protein interactions depend on Short Linear Motifs (SLiMs). In this study, the authors use large-scale binding assays, deep mutational scanning, and structural analysis to map SLiMs recognised by human cyclins and uncover the rules that determine their specificity and affinity.

While the electronic strong coupling with radiation field is known to modify the photophysics of molecular complexes, this is often attributed to kinetic effects and energy changes. Here, the authors observe photophysical properties of Chlorin e6 trimethyl ester (Ce6T) molecules reflecting instead the modified intermolecular interactions resulting from light-matter strong coupling.

This article provides a comprehensive overview of the epidemiology of spondyloarthritis — including axial spondyloarthritis, psoriatic arthritis and peripheral spondyloarthritis — worldwide, as well as the epidemiology of genetic factors implicated in these diseases.

Managing power exhaust in fusion reactors is a key challenge, especially in compact designs for cost-effective commercial energy. This study shows how alternative divertor configurations improve exhaust control, enhance stability, absorb transients and enable independent plasma regulation.

Haptotaxis was traditionally seen as migration up protein gradients. It is now shown that cells can also oscillate or migrate down the gradient.

Chemical doping allows for boosting the conductivity in conjugated polymers but the relationship between doping and the polymers’ complex, multiscale morphology remains elusive. Here the authors report that supramolecular chirality, which up to now had not been considered a parameter relevant to doping, significantly boosts the underpinning redox reaction in conjugated polymer thin films.

Key neurons in the orbitofrontal cortex form memories for best action strategies when mice seek rewards. Here, the authors show that these neurons have more mature dendritic spines than neighboring cells, this maturation requiring concurrent plasticity in the amygdala.

Although ice plays a crucial role in shaping our ecosphere, its microstructures formed by freezing water remain unclear. Here, the authors employ cryogenic liquid-cell TEM to gain atomic-level insights into ice defects frozen from liquid water.

Integrated multi-omic analyses using samples from the TRACERx study highlight cross-talk between DNA hypermethylation and genomic lesions in non-small cell lung cancer.

The transcriptional regulation of oligodendrocytes has an essential role in myelin formation and maintenance. Here, the authors identify the transcription factor Tfii-i as a regulator of myelin genes expression in the nervous system and show that its loss enhances myelin thickness and nerve conduction.

Genetic background, plasma metabolome and dietary data from 4,215 women and 1,490 men reveal 57 metabolites whose associations with dementia risk vary by APOE4 genotype and other risk variants.

A PICALM allele associated with increased risk of late-onset Alzheimer’s disease has a microglial-specific role in lipid droplet accumulation.

Aging drives distinct molecular changes in the brain. Here, the authors use scRNAseq and MERFISH and find that in mice, aging induces subtype-specific, regionally biased changes in striatal astrocytes, marked by transcriptional repression, inflammation, and impaired neuronal interactions.

The precise role of the spinal cord in copulatory behavior remains not fully understood. Here, authors identify a population of spinal galanin-expressing neurons that regulate sexual arousal and mating in male mice, revealing a broader role for spinal circuits in copulation than previously acknowledged.

Tilt-corrected bright-field scanning transmission electron microscopy offers enhanced cryogenic electron microscopy contrast and substantial improvement in dose efficiency for thick samples such as bacterial cells and large organelles, while still being able to perform single-particle analysis.

The authors show that, in addition to rising daily mean near-surface air temperature, the faster increase in daily maximum temperature compared to minimum temperature has contributed to increasing near-surface air dryness since the 1980s.

The author demonstrates that laser-driven ultracold Fermi gases can exhibit color-orbit-like coupling with SU(3) symmetry. This leads to color-like oscillations and other quantum-chromodyamics-like phenomena in an atomic physics laboratory.

Spatial cell distribution within a tissue microenvironment is a rapidly advancing field. Here, authors assess three commercially available single-cell resolution spatial transcriptomics approaches (CosMx, MERFISH, and Xenium) to inform which technology outperforms for immune profiling of solid tumors using patient samples.

Using a zebrafish-based screen, Civiletto and colleagues identify the herb-derived metabolites thymol and carvacrol as activators of autophagy and mitophagy, demonstrating their therapeutic potential in C. elegans and mouse models.

Helicity-overriding behaviour in supramolecular copolymers is reported by manipulating the energy landscape of chiral co-monomers, where one chiral monomer can override the intrinsic helical preference of another, even when present in the minority. This finding offers insights into asymmetry amplification in multicomponent supramolecular systems.

An analysis of the 3.45-Gyr-old volcanic sediments from the Kitty’s Gap Chert in Australia shows the presence of microfossils and highlights the difficulty of determining the biotic nature of structures in future extraterrestrial samples.

Analysis of crop yields, farmer income and bird species abundances identifies multiple positive outcomes of a large-scale Indian government-incentivized agroecology initiative.

A new artificial intelligence model, DeepSeek-R1, is introduced, demonstrating that the reasoning abilities of large language models can be incentivized through pure reinforcement learning, removing the need for human-annotated demonstrations.

The authors present a molecular classification of acute leukemia using 5-methylcytosine signatures, together with a neural network-based classifier for clinical use.

In vitro transcribed circular RNAs (ivcRNAs) offer a stable and efficient platform for protein replacement therapy. Here, the authors show that localized ivcRNA delivery restores MSI2 and SOX5 expression in chondrocytes, mitigating osteoarthritis progression in mice.

The diversity of ponerine ants varies widely across the globe. This study finds that the origin and early colonization in Gondwana’s tropical regions mainly shaped this distribution, while differences in diversification and dispersal have balanced regional diversity over time.

Small cell lung cancer cells form functional synapses with glutamatergic neurons, receiving synaptic transmissions and deriving a proliferative advantage from these interactions.

The Panoptes antiphage system defends bacteria by detecting phage-encoded counter-defences that sequester cyclic nucleotide signals, triggering membrane disruption and highlighting a broader strategy of sensing immune evasion through second-messenger surveillance.

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Individual proteins tend to adopt preferred orientations when subjected to vitrification for cryo-electron microscopy analysis. A laser flash melting procedure followed by rapid revitrification provides a simple approach to mitigate this issue, reducing the number of micrographs required for successful structure determination at high-resolution.

An optical sieve—an array of optically resonant voids in gallium arsenide—enables sorting, detecting and counting nanoplastics as small as a few hundreds of nanometres at concentrations as low as 150 μg ml⁻¹ in lake water samples.