Nature Search

PLAGL1-IGF2 axis regulates osteogenesis of postnatal condyle development

Jinrui Sun
Jingyi Xu
Xinquan Jiang

ResearchOpen Access25 Sept 2025

International Journal of Oral Science

Volume: 17, P: 1-13

A network of velocity-coherent filaments formed by supersonic turbulence in a very-high-velocity H i cloud

High-resolution FAST observations of a very-high-velocity cloud in the warm neutral medium reveal a network of hierarchical filaments formed by shock compression. These findings suggest a viable mechanism for early structure formation in the interstellar medium.

Xunchuan Liu
Tie Liu
Zhiqiang Shen

Research16 Jul 2025

Nature Astronomy

Volume: 9, P: 1366-1374

ABCC4 impairs the clearance of plasma LDL cholesterol through suppressing LDLR expression in the liver

CRISPR screens identify hepatic ABCC4 as a modulator of LDLR. Inhibiting ABCC4 increases hepatic LDLR, lowers plasma LDLC and acts via the cAMP-Epac2/Rap1a signaling pathway to suppress PCSK9, preventing LDLR degradation.

Jiaxin Chen
Hui Huang
Xiaoqing Wang

ResearchOpen Access02 Oct 2025

Communications Biology

Volume: 8, P: 1-16

Lac-Phe induces hypophagia by inhibiting AgRP neurons in mice

This study reveals neuronal targets of Lac-Phe in the hypothalamus that mediate its suppression of food intake.

Hailan Liu
Veronica L. Li
Yong Xu

Research16 Sept 2025

Nature Metabolism

P: 1-14

An interpretable hybrid deep learning framework for gastric cancer diagnosis using histopathological imaging

Tengfei Ren
Vijay Govindarajan
Shanbao Ke

ResearchOpen Access01 Oct 2025

Scientific Reports

Volume: 15, P: 1-20

Single-cell and spatial transcriptomics reveal mechanisms of radioresistance and immune escape in recurrent nasopharyngeal carcinoma

Multi-omic analysis of 39 samples of treatment-naive and recurrent nasopharyngeal carcinomas highlights the importance of the tumor microenvironment in promoting radioresistance and immune escape.

Rui You
Qunlun Shen
Mingyuan Chen

Research21 Jul 2025

Nature Genetics

Volume: 57, P: 1950-1965

Chaperone-mediated autophagy manipulates PGC1α stability and governs energy metabolism under thermal stress

Thermogenic proteins like PGC1α are downregulated under thermal stress, but the underlying mechanisms are unclear. Here, the authors show that chaperone-mediated autophagy, regulated by PARK7, controls PGC1α stability and BAT function at thermoneutrality.

Yixiao Zhuang
Xinyi Zhang
Xingxing Kong

ResearchOpen Access14 May 2025

Nature Communications

Volume: 16, P: 1-16

A cohort of mRNAs undergo high-stoichiometry NSUN6-mediated site-specific m⁵C modification

mRNA modifications like m⁵C are typically introduced by tRNA-modifying enzymes, while the catalytic mechanism and function remain debated. Here, the authors show that NSUN6 catalyzes tRNA and mRNA substrates in different ways, and that NSUN6 promotes breast cancer cell migration through mRNA m⁵C modification.

Yuan-Yuan Zhang
Cai-Tao Li
Ru-Juan Liu

ResearchOpen Access04 Jul 2025

Nature Communications

Volume: 16, P: 1-19

AAV gene therapy for autosomal recessive deafness 9: a single-arm trial

Preliminary results from an investigator-initiated clinical trial showed that an AAV-OTOF gene therapy was safe and led to hearing improvements in ten patients with congenital deafness with 6–12 months of follow-up, including in a teenager and a young adult, expanding the age range from previous trials.

Jieyu Qi
Liyan Zhang
Renjie Chai

Research02 Jul 2025

Nature Medicine

Volume: 31, P: 2917-2926

Murine hematopoietic progenitor cell lines with erythroid and megakaryocyte potential

This study presents an experimental system to conditionally immortalize murine megakaryocyte-erythroid progenitor cells, providing a versatile system for investigation of red blood cell and platelet biology in vitro and in vivo.

Ruiqiong Wu
Faraz Salehi
Hans Häcker

ResearchOpen Access07 Aug 2025

Nature Communications

Volume: 16, P: 1-16

Disruption of the ATP-dependent unfoldase ClpX reverses antifungal resistance in Cryptococcus neoformans

Here, the authors reveal that the ATP-dependent unfoldase ClpX is a key driver of fluconazole resistance in Cryptococcus neoformans, and show that targeting ClpX restores drug susceptibility, offering a potential therapeutic strategy to reverse antifungal resistance and to render current drugs effective.

M. Woods
A. Bermas
J. Geddes-McAlister

ResearchOpen Access07 Jul 2025

Nature Communications

Volume: 16, P: 1-16

Large-scale genome-wide analyses with proteomics integration reveal novel loci and biological insights into frailty

To better understand the etiology of frailty, the authors perform a large genetic study. They identified 45 additional variants and implicated MET, CHST9, ILRUN, APOE, CGREF1 and PPP6C as potential causal genes, linking frailty to immune regulation, metabolism and cellular signaling.

Jonathan K. L. Mak
Chenxi Qin
Juulia Jylhävä

ResearchOpen Access05 Aug 2025

Nature Aging

Volume: 5, P: 1589-1600

Age-specific tumor-associated macrophage biomarkers underlie metastasis and immune dysregulation in thyroid cancer

Tianyao Chu
Shenglong Xu
Peng Zhang

ResearchOpen Access09 Oct 2025

npj Aging

Volume: 11, P: 1-6

Serine-arginine protein kinase 1 (SRPK1) is under-expressed in mucinous colorectal cancer, and may mediate resistance to oxaliplatin

William P. Duggan
Mohammedreza Azimi
John P. Burke

Research03 Oct 2025

The Pharmacogenomics Journal

Volume: 25, P: 1-10

Type 1 innate lymphoid cell–immature neutrophil axis suppresses acute tissue inflammation

Mobilization of immature neutrophils (imNeu) can migrate from bone marrow (BM) to circulation and inflamed tissues. However, the mechanism of its mobilization and function remains unknown. Here the authors identify ILC1 mediates IL-10 producing imNeu mobilization to inflamed tissue via IFN-γ, thus tempering the acute inflammation.

Kenshiro Matsuda
Natsuki Ide
Akira Shibuya

ResearchOpen Access17 Jul 2025

Nature Communications

Volume: 16, P: 1-16

Decompartmentalization of the yeast mitochondrial metabolism to improve chemical production in Issatchenkia orientalis

An inadequate supply of cofactors often limits the production of target molecules in metabolic engineering. Here, the authors report cofactor engineering through decompartmentalization of the yeast mitochondrial metabolism to improve succinic acid production in Issatchenkia orientalis.

Vinh G. Tran
Shih-I Tan
Huimin Zhao

ResearchOpen Access02 Aug 2025

Nature Communications

Volume: 16, P: 1-15

Efficacy and safety of induction immunotherapy plus chemotherapy in patients with locoregionally advanced nasopharyngeal carcinoma: a meta-analysis

Kun-Peng Wu
Xu-Qiang Luo
Yang-Si Li

Research05 Sept 2025

British Journal of Cancer

P: 1-8

PNPLA7 mediates Parkin-mitochondrial recruitment in adipose tissue for mitophagy and inhibits browning

PINK1/Parkin-mediated ubiquitin-dependent mitophagy is a key regulator of browning in inguinal white adipose tissue (iWAT). Here, the authors report that PNPLA7, an Endoplasmic Reticulum and mitochondria-associated membrane (MAM) protein, inhibits browning of iWAT by promoting PINK1/Parkin-mediated mitophagy upon cold challenge or adrenergic receptor agonist treatment.

Xuetao Ji
Xu Zhang
John Zhong Li

ResearchOpen Access19 Jul 2025

Nature Communications

Volume: 16, P: 1-20

Age-dependent accumulation of mitochondrial tRNA mutations in mouse kidneys linked to mitochondrial kidney diseases

The tissue-specific accumulation patterns of pathogenic mtDNA mutations during aging remain incompletely understood. In this study, the researchers developed three mouse models with distinct mitochondrial tRNA mutations, revealing age-dependent accumulation of these mutations in the kidneys, leading to mitochondrial kidney disease.

Leping Zhang
Zhe Xu
Min Jiang

Research27 Jun 2025

Nature Aging

Volume: 5, P: 1317-1339

Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study

SARS-CoV-2 vaccines containing Omicron subvariant XBB 1.5 were introduced in the United States in 2023. Here, the authors assess the safety of these vaccines by analysing the occurrence of 15 adverse events of special interest following vaccine receipt using electronic health record data.

Yuanyi Pan
Yun Han
Christopher G. Chute

ResearchOpen Access15 Jul 2025

Nature Communications

Volume: 16, P: 1-10

Dissection of the trans-endocytosis and signal inhibition functions of CTLA-4 through the study of a disease-associated Y139C mutation

Zhishan Zhao
Peng Wu
Linrong Lu

Research09 Oct 2025

Cellular & Molecular Immunology

P: 1-13

A nanoengineered lithium-hosting carbon/zinc oxide composite electrode material for efficient non-aqueous lithium metal batteries

A nanoengineered, zero-volume-change, complete-sealing Li-based composite electrode, comprising multilayer reduced graphene oxide and zinc oxide, is developed, achieving Li plating/stripping Coulombic efficiencies of ≥99.99%.

Lequan Deng
Yaoyao Liu
Hao Chen

Research29 Jul 2025

Nature Nanotechnology

P: 1-10

Obesity exacerbates experimental colitis due to the activation of the local renin–angiotensin system in the colon

Maomao Pan
Qiang Xu
Yibing Tang

ResearchOpen Access10 Oct 2025

Scientific Reports

Volume: 15, P: 1-11

Non-coding genetic elements of lung cancer identified using whole genome sequencing in 13,722 Chinese

Here, the authors conducted a whole genome sequencing (WGS)-based genome-wide scan for non-small cell lung cancer in 13,722 Chinese individuals and identified genes including PARPBP, PLA2G4C, and RITA1 in the context of non-coding regulation.

Dan Zhou
Ming Wu
Xifeng Wu

ResearchOpen Access09 Aug 2025

Nature Communications

Volume: 16, P: 1-15

Fusobacterium lineage profiling facilitates the clarification of the associations between non-nucleatum Fusobacterium and colorectal cancer

Yuli Wu
Guo Ji
Dexi Bi

ResearchOpen Access09 Oct 2025

npj Biofilms and Microbiomes

Volume: 11, P: 1-13

Mogat1 drives metabolic adaptations to evade immune surveillance

Despite initial clinical success of immune checkpoint blockade, unfortunately not all patients respond to these therapies due to immune evasion mechanisms. Here, the authors discover that Monoacylglycerol OAcyltransferase 1 (Mogat1) regulation of lipid homeostasis modulates tumor immune evasion in breast cancer.

Huan Wei
Congyi Niu
Zhenjie Xu

ResearchOpen Access31 Jul 2025

Nature Communications

Volume: 16, P: 1-19

Intravenous lidocaine enhances the efficacy of ondansetron and dexamethasone in postoperative vomiting prophylaxis among high-risk children

Jin-fei Xu
Ming-cheng Du
Yuan Gong

ResearchOpen Access18 Aug 2025

Scientific Reports

Volume: 15, P: 1-8

TUG protein acts through a disordered region to organize the early secretory pathway

TUG protein localizes to the endoplasmic reticulum-Golgi intermediate compartment, forms biomolecular condensates, and organizes and stabilizes these membranes to support their function in diverse secretory and degradative trafficking pathways.

Anup Parchure
Helen Tejada
Jonathan S. Bogan

ResearchOpen Access01 Jul 2025

Nature Communications

Volume: 16, P: 1-20

Retraction Note: Brown adipose tissue-derived Nrg4 alleviates endothelial inflammation and atherosclerosis in male mice

Lingfeng Shi
Yixiang Li
Guangda Xiang

Amendments and CorrectionsOpen Access02 Jul 2025

Nature Metabolism

Volume: 7, P: 1493

Inducing hour-level humification of Enteromorpha prolifera to fabricate fulvic-like acid fertilizer with Fenton’s reagent

The phenomenon of Enteromorpha prolifera (EP) flooding caused by marine eutrophication has resulted in serious environmental impact. Here, the authors demonstrate an application of Fenton’s reagent in the rapid recovery and utilization of EP.

Dongqing Cai
Yezhen Lu
He Xu

ResearchOpen Access01 Jul 2025

Nature Communications

Volume: 16, P: 1-14

Author Correction: Alkaline ceramidase 1–mediated platelet ceramide catabolism mitigates vascular inflammation and abdominal aortic aneurysm formation

Xu Zhang
Ze Gong
Wei Kong

Amendments and Corrections01 Sept 2025

Nature Cardiovascular Research

Volume: 4, P: 1206

Clinical application research on the titanium metal metatarsal prosthesis designed through FEA and manufactured by 3D printing

Chao Wu
Danwei Shen
Taicong Yang

ResearchOpen Access10 Oct 2025

Scientific Reports

Volume: 15, P: 1-10

The interplay of ferroelectricity and magneto-transport in non-magnetic moiré superlattices

The coupling of ferroelectricity and magnetic order enables the tunability of material properties. Here, authors realize magnetic-field-enhanced ferroelectricity and electrical-field-controlled magneto-transport in non-magnetic moiré superlattices.

Siqi Jiang
Renjun Du
Geliang Yu

ResearchOpen Access01 Jul 2025

Nature Communications

Volume: 16, P: 1-9

A phase III clinical trial of monthly minodronate in the treatment of Chinese postmenopausal women with osteoporosis

Hao Zhang
Ya-nan Huo
Zhen-lin Zhang

Research01 Oct 2025

Acta Pharmacologica Sinica

P: 1-8

Genetic variation at transcription factor binding sites largely explains phenotypic heritability in maize

Pan-cistrome of the maize leaf under well-watered and drought conditions profiled by haplotype-specific MOA-seq highlights the relevance of transcription factor binding QTLs for understanding phenotypic diversity in maize.

Julia Engelhorn
Samantha J. Snodgrass
Thomas Hartwig

ResearchOpen Access11 Aug 2025

Nature Genetics

Volume: 57, P: 2313-2322

CircCNOT6L modulates alternative splicing of SLC7A11 via splicing factor SRSF2 to confer ferroptosis resistance and promote metastasis in prostate cancer

Ji Liu
Maskey Niraj
Xudong Yao

ResearchOpen Access29 Sept 2025

Experimental & Molecular Medicine

Volume: 57, P: 2106-2120

Microbiota and short chain fatty acid relationships underlie clinical heterogeneity and identify key microbial targets in irritable bowel syndrome (IBS)

Andrea S. Shin
Yue Xing
Xiang Gao

ResearchOpen Access09 Oct 2025

Scientific Reports

Volume: 15, P: 1-14

The impact of the ratio of renal parenchyma to renal volume on stone-free rates after RIRS: a retrospective study

Xingshu Zhen
Mei Huang
Dehui Lai

ResearchOpen Access01 Sept 2025

Scientific Reports

Volume: 15, P: 1-8

Soil drivers of food-borne pathogen persistence

A study of Escherichia coli O157:H7 survival in soils across eastern China highlights the role of soil properties in pathogen persistence and the need for policies to reduce food-borne disease risks from soil reservoirs.

Ningqi Wang
Gaofei Jiang
Zhong Wei

News & Views15 Jul 2025

Nature Food

Volume: 6, P: 747-748

Soft X-ray prompt emission from the high-redshift gamma-ray burst EP240315a

The death of massive stars has traditionally been discovered by explosive events in the gamma-ray band. Liu et al. show that the sensitive wide-field monitor on board Einstein Probe can reveal a weak soft-X-ray signal much earlier than gamma rays.

Y. Liu
H. Sun
X.-X. Zuo

Research23 Jan 2025

Nature Astronomy

Volume: 9, P: 564-576

Cross-ancestry and sex-stratified genome-wide association analyses of amygdala and subnucleus volumes

Cross-ancestry and sex-stratified genome-wide association analyses for 21 amygdala volumetric traits in East Asian and European individuals provide insight into the genetic architectures of amygdala and subnucleus volumes.

Yuan Ji
Nana Liu
Chunshui Yu

Research17 Mar 2025

Nature Genetics

Volume: 57, P: 839-850

Comprehensive evaluation of plasma tau biomarkers for detecting and monitoring Alzheimer’s disease in a multicenter and multiethnic aging population

Lan et al. demonstrate the high performance of plasma p-tau217 in detecting and tracking multiple aspects of Alzheimer’s disease pathology, outperforming other plasma tau biomarkers across two Chinese cohorts (GHABS and Huashan) and the North American ADNI cohort.

Guoyu Lan
Mengjie Wang
Tengfei Guo

Research23 Jun 2025

Nature Aging

Volume: 5, P: 1601-1618

Direct observation of the spin texture in SmB₆ as evidence of the topological Kondo insulator

The study and application of the conductive surface states of topological insulators are often restricted by the presence of bulk conduction states. Here, Xu et al. present evidence for such topological surface states with true bulk insulation in the strongly correlated Kondo insulator SmB₆.

N. Xu
P. K. Biswas
M. Shi

Research30 Jul 2014

Nature Communications

Volume: 5, P: 1-5

Optogenetic induction of subcellular Ca²⁺ events in megakaryocytes and platelets using a highly Ca²⁺-conductive channelrhodopsin

The authors present a novel channel rhodopsin variant with enhanced Ca²⁺ conductance in megakaryocytes and platelets.

Yujing Zhang
Jing Yu-Strzelczyk
Markus Bender

ResearchOpen Access07 Oct 2025

Communications Biology

Volume: 8, P: 1-16

Synthetic carbon-based lanthanide upconversion nanoparticles for enhanced photothermal therapy

Photothermal therapy using photo agents developed with high photothermal conversion efficiency under long-wavelength laser irradiation has been investigated in preclinical cancer treatment. Here this group reports coating mesoporous carbon nanomaterials with a lanthanide oxysulfide up-conversion material (Y₂O₂S:Yb³⁺, Er³⁺) with tumor targeting capability for in situ ocular melanoma tumor treatment.

Mei Yang
Yida Huang
Jinhai Huang

ResearchOpen Access09 Jul 2025

Nature Communications

Volume: 16, P: 1-21

Mechanical behavior prediction of tunnel with single-layer steel fiber shotcrete lining

Wu Jianting
Yuan Hongchao
Xu Bo

ResearchOpen Access03 Oct 2025

Scientific Reports

Volume: 15, P: 1-21

Temperature-tunable Fano resonance induced by strong coupling between Weyl fermions and phonons in TaAs

The study of lattice vibrations coupled to electronic excitations may provide an avenue for exploring exotic physical phenomena. Here, Xuet al. observe a Fano resonance in the Weyl semimetal TaAs, revealing evidence for a strong coupling between phonons and Weyl fermions.