Search

Zhang, Huang, Wang, Long et al. report that NAT10 enhances serine uptake and biosynthesis in an ac4C-dependent mechanism, thereby promoting stemness and progression in acute myeloid leukaemia.

Aqueous zinc batteries possess advantages in safety, cost and environmental friendliness. To address side reaction, limited cycle life and other challenges, the authors formulate a dual-salt electrolyte that decouples the interfacial electrolyte from the bulk, enabling suppressed hydrogen evolution, fast zinc transport and resilience against low temperature.

Metal–CO₂ batteries offer the dual benefits of energy storage and carbon utilization, but their commercial viability is limited by drawbacks in performance, cost and safety. This Review discusses barriers to the development and commercialization of aqueous and non-aqueous metal–CO₂ batteries and how to overcome them.

Communication between room-temperature and cryogenic environments is a bottleneck to the scaling of cryogenic devices. Here, the authors introduce a technique for in situ writing and erasing of circuits at low temperatures, enabling reversible construction of patterns without a photoresist.

The authors demonstrate fidelity colour prints and binocular stereoscopic images in multilayer MoS₂ integrated on an Au substrate, showing nanometric layer sensitivity in the Fabry-Perot resonance changed by a facile laser recipe.

The low activity of PylRS hinders the efficient production of ncAA containing proteins. Here, authors apply machine learning to engineer the tRNA-binding domain of PylRS, obtaining variants with improved stop codon suppression efficiency and achieving higher yields of proteins containing various ncAAs.

A suite of bridged rhodamine dyes (BriDyes) offers excellent brightness, solubility, photostability, and tunable cell permeability along with resistance to photoblueing, making them exceptional all-purpose dyes for fluorescence biomaging.

High-quality genome of the modern soybean cultivar Nongdadou2 and deep resequencing of 547 accessions provide insights into the role of structural variations in soybean improvement.

Ruiqiang Li and colleagues report the whole-genome sequencing of a Tibetan female wild boar, as well as resequencing of 48 domestic pigs and wild boar from Tibet and China. Their analysis provides insights into the genetic diversity, population structure and evolution of the wild boar.

A comparative analysis of bat genomes, including five newly assembled chromosome-scale genomes, provides insights into the diversification of horseshoe bats and reveals molecular adaptations with a potential role in antiviral immune response.

Ganoderma lucidumis a macrofungus in traditional Chinese medicine known to produce different bioactive compounds. In this study, the genome ofG. lucidumis sequenced, making this organism a potential model system for future studies of secondary metabolic pathways and their regulation in medicinal fungi.

Aqueous zinc metal batteries utilized in wearable and implanted devices require good biosecurity, long lifespan, and high flexibility. Here, the authors proposed a biocompatible hyaluronic acid-based gel electrolyte to improve the reversibility of zinc anodes and prolong the cycle life of batteries.

Regulating oxidative phosphorylation and restoring redox homeostasis are crucial in neurological disorders. Here, the authors develop a top-down membrane self-assembly strategy to develop stem cell-derived artificial organelles (SAOs) that mimic mitochondrial oxidative phosphorylation without the risks associated with stem cell therapy.

The authors resequence a core collection of upland cotton (Gossypium hirsutum) comprising 419 accessions. They analyze genomic variation and conduct a genome-wide association study for 13 fiber quality and yield traits in 12 different environments.

Phylogenomic analysis of 7,923 angiosperm species using a standardized set of 353 nuclear genes produced an angiosperm tree of life dated with 200 fossil calibrations, providing key insights into evolutionary relationships and diversification.

Peach is an economically important fruit crop. Here, the authors carry out a large-scale population genomics analysis of peach, describing its demographic history as well as genes associated with domestication and edibility traits.

So far infinite-layer nickelates have only been observed to superconduct in single-thin-film form. Here, the authors demonstrate superconductivity in [(Nd_0.8Sr_0.2NiO₂)₈/(SrTiO₃)₂]₁₀ superlattices.

Allen et al. identify a pathogenic role for microbial small RNAs enriched on low-density lipoprotein to activate TLR8 signalling, thereby promoting polarization of inflammatory macrophages and facilitating the development of atherosclerosis.

High-quality genomes of two cultivated tetraploid cottons Gossypium hirsutum cv. NDM8 and Gossypium barbadense acc. Pima90 and resequencing of 1,081 G. hirsutum accessions provide insights into the role of structural variations.

Astragaloside IV, the key active compound in Radix Astragali, a medicinal plant used for immunomodulation in Asia and Europe, now has a fully elucidated biosynthetic pathway, enabling its efficient production through synthetic biology.

Cepharanthine is a secondary metabolite isolated from Stephania with a variety of medicinal properties. Here, the authors assembled three Stephania genomes, propose cepharanthine biosynthetic pathway, and assess the antiviral potential of cepharanthine-related metabolites.

Accurate localization of abnormalities is crucial in the interpretation of chest X-rays. Here the authors present a deep learning framework for simultaneous localization of 14 thoracic abnormalities and calculation of cardiothoracic ratio, based on large X-ray dataset with bounding boxes created via a human-in-the-loop approach.

Imaging methods, such as CT or MRI, cannot provide accurate diagnosis between malignant thymomas and other thymic abnormalities. Here the authors show that the levels of IL-8 in circulating naive T cells are elevated in patients with thymoma compared with other thymic masses, proposing IL-8 as a candidate biomarker for thymoma diagnosis and recurrence surveillance.

Gas sensors typically detect only few specific gases; the authors show a broad-spectrum sensor based on correlated 2-dimensional electron gas (C-2DEG), which detects various gases quantitatively and measures partial pressures, through a purely physical mechanism.

D-LMBmap is a fully automated pipeline for mesoscale connectomics including deep-learning modules for axon segmentation, brain region segmentation and whole-brain registration. D-LMBmap works accurately across cell types and modalities.

Lone pairs are essential for exploring the mechanism behind the phenomena in the areas of opto-spintronics. In this paper, the effect of lone pairs on spin resonance and magnetic properties was studied. Using donors with different nitrogen substitutions, three charge transfer crystals were fabricated. In cocrystals, lone pairs could enlarge the distance between donors and acceptors, leading to the shorten of lifetime and the decrease of dielectric constant. Moreover, lone pairs possess the ability to enhance spin-lattice interactions, enabling the three crystals to display diverse and intriguing behaviors under light and magnetic fields, such as light-dependent electron spin resonance.

DNA methyltransferase 3A, a mutated gene associated with hematologic malignancies in age-related clonal haematopoiesis lacks targeted therapies. Here, the authors screen carbon nanomaterials and find graphdiyne oxide binds to mutant cells and disrupts cellular processes with a therapeutic effect in vitro and in vivo.

Whole-genome resequencing of 418 diverse rapeseed accessions and genome-wide association analyses for 56 agronomic traits provide insights into the genetic architecture and artificial selection or adaptation during modern rapeseed breeding.

A meta-analysis of 335 studies reveals that microbial inoculants have overall positive effects on the biomass of soil microbial communities. These effects were weakened by environmental stress and strengthened by the use of fertilizers and native inoculants.

Developing effective treatments for noncompressible hemorrhages remains a challenge. Here the authors engineer alkylated chitosan sponges with highly interconnective microchannels and demonstrate anti-infective activity, as well as higher pro-coagulant, hemostatic and wound healing capacities compared to clinically-used materials in rat and pig liver models.

Lipopolysaccharide-induced breakdown of the blood–brain barrier requires activation of GSDMD-mediated plasma membrane permeabilization and pyroptosis in brain endothelial cells.

Coptis chinensis represents an early-diverging eudicot lineage with diverse medicinal applications. Here, the authors report its chromosome-scale genome assembly, infer a single ancient whole-genome duplication, and characterize the function of CYP719 in diversification of protoberberine-type alkaloids.

In thermally stimulated phosphorescent materials a thermal stimulus inevitably quenches the emission due to intensive non radiative transition. Here, the authors report an abnormal thermally stimulated phosphorescence behavior in organic phosphors and show enhancement of phosphorescence and change of the emission color upon temperature increase.

Yuxian Zhu and colleagues report the draft genome of a diploid cotton Gossypium raimondii. This species is a wild South American cotton, whose progenitor is thought to have been the contributor of the D subgenome of the allotetraploid commercial species Gossypium hirsutum and Gossypium barbadense, which account for ~95% of the worldwide cotton crop.

Accurate monitoring of chronic kidney disease (CKD) progression is essential for efficient disease management. Here Chen et al. identify five serum metabolites in patients with stage 1–5 CKD whose levels associate with disease progression, and find that 5-methoxytryptophan and its regulatory enzyme TPH-1 exert anti-fibrotic effects in mouse models of kidney injury.

The compartmentation of monoterpenoid indole alkaloid biosynthesis in periwinkle leaves was determined using single-cell RNA-seq, which reveals the spatial distribution of plant specialized metabolism at the single-cell resolution.

Hume’s ground tit (Parus humilis) was once thought to belong to the Corvidae family, which includes crows and jays. Qu et al.sequence and analyse Hume's ground tit genome, as well as two additional tits and a ground jay, and establish its evolutionary position as the world's largest tit.