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The authors show that ~100-kyr climate cycles over the past ~800 ka, and even since ~34 Ma, likely arose from a ~2.4-Myr eccentricity-modulated competition between low- and high-latitude continental carbon reservoirs for dominance in carbon cycles.

The performance of inorganic, wide-bandgap perovskite solar cells is hindered by unsuitable electron transport layers. Han et al. design an acidic magnesium-doped tin oxide quantum dot layer, improving efficiency and stability in single-junction and tandem cells.

The combined role of cellular junctions and actomyosin networks in tissues remains unclear. Here, the authors identify a tissue-scale star-shaped network of actomyosin that preserves cell shape, limits migration, and coordinates the intestinal epithelium.

A layered hybrid lead halide intercalated with Ru(bpy)₃²⁺ is assembled through Pb²⁺-carboxylate coordination. The material has broad visible light absorption and drives photocatalytic CO₂ reduction to CO with a quantum yield of ~3.0% at 500 nm.

In this multicenter phase 1 trial, treatment with IBI343, a CLDN18.2-targeting antibody–drug conjugate, was safe and showed encouraging clinical responses in patients with advanced gastric or gastroesophageal junction adenocarcinoma.

The mainstream passivation strategies routinely rely on crystalline materials for perovskite photovoltaics. Here, authors utilize a solid phase reaction to prepare an amorphous (lysine)₂PbI₂ layer to neutralize surface and interface defects, achieving device efficiency of over 26% for solar cells.

SAT1 is a rate-limiting enzyme in polyamine catabolism. Here, authors discover a non-canonical function of SAT1 regulating H3K27ac marks within genes required for mitosis regulation and chromosome segregation, enabling anchorage-independent cell survival and peritoneal metastasis of ovarian cancer cells.

During nanocluster crystallization, weak supramolecular interactions result in independent monomers, while strong intermolecular coordination promotes omnidirectional crystal packing into 3D superstructures. Designing 2D assembly structures is more challenging. Here a series of atomically precise 2D crystalline materials is assembled from metal nanoclusters and applied as electrolytes in Li-ion batteries.

Detecting early allopolyploidy events and understanding the specific subgenomic evolution contributing to the origin of adaptive innovations for species radiation are challenging. Here, the authors address these problems by analyzing nine newly assembled genomes of Salicaceae species from different genera.

The random orientation of spontaneously formed 2D phase atop 3D perovskites limits the performance of solar cells. Here, authors introduce a meta-amidinopyridine ligand with solvent post dripping to generate highly ordered 2D perovskites, achieving maximum efficiency of 26.05% for stable devices.

In this multicenter phase 1 trial, patients with advanced gastric and gastroesophageal junction cancer were safely treated with the CLDN18.2-targeting antibody–drug conjugate SHR-A1904, leading to encouraging objective response rates.

The authors achieve a high electrocaloric temperature change (ΔT = 3.9 K) in c-textured BaTiO₃-KNbO₃ ceramics via compositional tuning and grain orientation engineering. The ΔT variation remain within ±10% across 30–80 °C, demonstrating exceptional stability.

Cytotoxic chemotherapy remains the standard treatment for triple negative breast cancer (TNBC), an aggressive subtype of breast cancer associated with poor prognosis. Here the authors report the results of a phase 1b trial of the liposomal irinotecan HE072 in patients with metastatic triple-negative breast cancer after ≥ 2 prior lines of chemotherapy.

Nie et al. report a multi-site binding ligand to suppress the formation of defects and increase the structural and water stability of perovskites. Solar cells fabricated fully in air achieves an efficiency of 25.03% and retain 98.98% of the performance after aging in air for 1,584 h without encapsulation.

Polysubstituted arenes are ubiquitous structural cores in natural products and drugs but their synthesis through programmable arene modification remains a challenge. Now, a palladium- and norbornene-catalysed Catellani-type reaction of aryl ketones, through successive acylation and deacylation, allows the synthesis of polysubstituted arenes.

A gene-edited pig liver transplanted into a human recipient remains functional after 10 days and indicates that porcine organs could help meet the growing demand for liver transplants.

ctDNA is a promising method to monitor tumor burden in triple negative breast cancer. Here, the authors show that ctDNA detection correlated with prognosis after neoadjuvant chemotherapy but not at baseline.

This manuscript presents a non-contact ultrasonic system for large-scale additive manufacturing, where the low-intensity ultrasound without cavitation refines grains via dendrite fragmentation through acoustic streaming and Marangoni-driven melt flow.

A photodiode with bio-plausible event sensing, filtering and adaptation behaviours to replicate the retinal nanostructure and visual pathway is presented, enabling consistent and high-performance machine vision under extreme lighting.

The design of low-dimensional interface materials for perovskite solar cells is limited in the choice of the metal cation. By processing metal and ammonium halides together, Ye et al. expand the metal cation library for these interface materials.

By encoding vectors and matrices at different frequencies within a single device, a device-aware neural network based on lithium niobate integrated nonlinear phononics can be created that can perform a four-class classification task with an accuracy of 98.2%.

STING agonist-based endoplasmic reticulum-targeting molecules can be conjugated directly onto antigens to deliver them to the cross-presentation pathway, improving CD8⁺ T cell responses against tumours and viruses.

The role Tibetan Plateau uplift played in Asian inland aridification remains unclear due to a paucity of accurately dated records. Here, the authors present a continuous aeolian sequence for the period >51–39 Ma, analysis of which indicates that aridification was driven by global climatic forcing rather than uplift.

Giant cell tumor of bone (GCTB) is a rare primary osteolytic bone tumor with high local recurrence rate after surgical resection. Here the authors conduct a phase Ib/II trial, evaluating the efficacy and safety of JMT103 (RANK-RANKL inhibitor) in patients with unresectable or surgically-challenging GCTB.

Inspired by the regenerative capacity of deer antlers, Hao and colleagues report that antler blastema progenitor cell-derived extracellular vesicle treatment counteracts bone loss and epigenetic aging and is neuroprotective in mice and macaques.

Upscaling perovskite solar cells requires control of the crystallization of perovskite films over large areas. Here, the authors tailor the composition of the precursor ink and achieve 15.3% efficient solar cells over a 205 cm² area without the use of anti-solvent.

Energy decay, describing the leakage of system energy into the surrounding environment, has been used to characterize the energy interactions for individual resonators. Here, authors utilize energy decay to analyze and observe coherent energy transfer and beating phenomena in coupled micromechanical resonators.

The management of ulcerative colitis (UC) remains challenging due to the complexity of its etiology. Here, the authors establish that argininosuccinate synthetase 1 (ASS1) and its metabolite arginine are pivotal inducers of UC, through the triggering of mTOR and iNOS activation, and the induction of gut microbiota dysbiosis by metabolomics and proteomics. Inhibition of ASS1 by C-01 provides a viable strategy for the treatment of UC.

Preliminary results from an investigator-initiated clinical trial showed that an AAV-OTOF gene therapy was safe and led to hearing improvements in ten patients with congenital deafness with 6–12 months of follow-up, including in a teenager and a young adult, expanding the age range from previous trials.

Nationwide implementation of a series of stringent multisectoral air pollution prevention and air-quality monitoring policies in China was associated with reduced hospital admissions for a wide range of cardiorespiratory, neuropsychiatric and kidney diseases due to substantial reductions in PM_2.5 and black carbon pollution over a period of 5 years.

The authors present SVclone, a computational method for inferring the cancer cell fraction of structural variants from whole-genome sequencing data.

This work introduces an accurate liquid identification strategy by integrating droplet mechanics and solid–liquid interface contact electrification in a ZnO–PDMS superhydrophobic solid–liquid sensor.

The growth of wide-bandgap perovskites remains insufficiently controlled under hybrid deposition. Here, the authors introduce n-propylamine hydrochloride for regulating the oriented crystal growth, achieving maximum efficiency of 26.46% for two-terminal perovskite/organic tandem solar cells.