Search

Artificial assembly of small functional proteins provides effective strategies for downsizing RNA degraders. Here, authors develop STAR, a hypercompact RNA degrader with evolved toxin endoribonucleases and engineered Cas6- CBS system, enabling efficient degradation of cytoplasmic and nuclear RNAs.

Here, the authors demonstrate increased global lactylation levels and in the joints of rheumatoid arthritis patients. NFATc2 is identified as a key target gene regulated by histone H3 lysine 9 lactylation that exacerbates disease progression by enhancing the cartilage invasive function of fibroblast-like synoviocytes.

An Ohmic contact interface engineering strategy was proposed by loading copper nano islands on indium hydroxide nanocubes, which could trigger and stabilize the polarized Cu0 -Cuδ+ active sites. Such catalyst enabled effective ammonia electrosynthesis with nitrate under ambient conditions

This study reports that the gene SMPED1, located in a previously identified dichogamy-determining region in Alpinia species, controls the timing of sex-organ synchrony, improving our understanding of the evolutionary mechanisms of plant sexual diversity.

High-resolution computed tomography is used to reconstruct and analyse fossils of the herbivorous tritylodontid Polistodon and a newly named morganucodontid species called Camurocondylus, providing key insights into the evolution of the mammalian jaw joint.

The design and assembly of interlocked supramolecular cages is of interest due to their exquisite topological configuration and excellent performance in a variety of applications. Here, the authors synthesize interlocked cages from half-sandwich rhodium building blocks and prepare membranes for applications in photothermal seawater desalination.

An asymmetric self-assembled monolayer improves the efficiency of perovskite/silicon tandem solar cells compared with symmetric self-assembled monolayers, resulting in a certified power conversion efficiency of up to 34.58%.

Primary angle-closure glaucoma is a leading cause of blindness. Here, the authors identify rare deleterious variants in UBOX5 as risk factors and implicate BIP ubiquitination as a potential disease mechanism.

Hong-Xuan Lin, Ji-Ping Gao, Jun-Xiang Shan and colleagues show that natural variation in a proteasome α2 subunit gene contributes to thermotolerance in African rice. Their follow-up studies suggest that the variant allele protects cells from heat stress by enhancing the elimination of cytotoxic denatured proteins and maintaining heat-response processes.

Coating additive solutions onto wet perovskite films in situ enables flexible all-perovskite tandem solar cells with a certified power conversion efficiency of 23.0% for a module with an aperture area of 20.26 cm². The modules maintain 97% of their initial efficiency after 10,000 bending cycles with a 10 mm radius.

A DNA matrix material potentiates humoral response through multiple administration routes, generating neutralizing antibodies and conferring robust protection against infection.

This manuscript presents a non-contact ultrasonic system for large-scale additive manufacturing, where the low-intensity ultrasound without cavitation refines grains via dendrite fragmentation through acoustic streaming and Marangoni-driven melt flow.

Sepsis-associated encephalopathy (SAE) is a severe and often fatal consequence of sepsis. Here authors show in a mouse model of sepsis that γδ T17 cells, migrating from the small intestine to the meninges, play a pathological role via activation of STING in microglia, leading to an increase in C1q-tagged synapses, which are subsequently pruned.

Developing highly active and robust catalysts remains a challenge for the implementation of nitrate reduction. The authors introduce a screw dislocation-mediated 3D printing strategy to fabricate curvature-controlled electrodes with 3D lattice strain, enhancing nitrate reduction performance.

The mechanism of superconductivity in layered kagome metals remains unclear, however its coexistence with charge order suggests exotic interpretations. Here the authors study the vortex lattice in the superconducting state of Ta-doped CsV₃Sb₅ with suppressed charge order, suggesting conventional pairing.

On-target, off-tumour toxicity is a major concern in immunotherapy. Here, aided by computer docking analysis, the authors introduce a single oxygen atom into the TLR7/8 agonist R848, generating a radiotherapy-activatable prodrug agonist that in mice helps mitigate systemic toxicity while triggering effective anti-tumor immunity responses upon radiation.

Torpor is an adaptive hypometabolic state in response to energy scarcity. Here, Cheng et al. show that catecholaminergic neurons in the ventrolateral medulla induce torpor in mice by lowering body temp and heart rate (heart rate decline precedes cooling).

Systemic administration of TRL7/8 agonists enhances anti-tumor immunity by enhancing dendritic cell (DC) activation, but also causes systemic toxicity. Here, the authors show that, in tumor mouse models, a radiotherapy-activated, N-oxide imidazoquinoline prodrug promotes controlled, local activation of intratumoral DC-T cell dynamics, while promoting systemic anti-tumor responses.

Secondary phases or multi-step phase formation lead to poorly crystallized and defective kesterite films. Now Zhou et al. convert precursors into kesterite in a single step, using low partial pressure of selenium, and achieve solar cells with 13.8% certified efficiency.

In contrast to the classical streaming potential relying on downstream ionic diffusion, an upstream proton diffusion within two-dimensional nanochannels is found to continuously generate electricity, advancing hydrovoltaic technology.

It is unclear how higher brain areas use feedback to help early visual cortex analyze complex scenes. Here, the authors show that feedback is crucial for various figure-ground percepts and involves distinct facilitatory and inhibitory signals.

Flexible mobile phones require bendable electronic components that operate at high frequency. Here, the authors demonstrate such a diode made of an amorphous material on a plastic substrate that operates in the frequency bands applicable to cellular communication, Bluetooth, Wi-Fi and GPS.

Previous hypotheses cannot fully explain the large lightning excess over land compared to ocean. It is found that coarse sea spray that create large drops precipitates cloud water before it can freeze, thus robbing the fuel for cloud electrification

Yin et al. discover that the phosphatase PTENα acts as an RNA-binding protein, mitigating viral-induced inflammation in the brain by constraining RIG-I activation, suggesting PTENα as a potential therapeutic target for viral infection.

Double-stranded RNA (dsRNA) is key in immunity and cellular regulation. Here, using the PISA workflow, the authors find 218 proteins with altered solubility upon dsRNA binding. ZNF385A knockout activates interferon-β transcription and increases endogenous dsRNA levels, enhancing the bioactivity of 5-Aza-2’-deoxycytidine and NK cell-mediated cytotoxicity.

Naphthalene is a challenging arene towards transition-metal-catalyzed dearomative difunctionalization. Here, the authors show that naphthalene may act as a masked conjugated diene in palladium-catalyzed dearomative 1,4-diarylation or 1,4-vinylarylation via a tandem Heck/Suzuki sequence.

This study utilizes Stereo-seq to comprehensively map the geospatial architecture of breast cancer, revealing venular niches that promote immune infiltration and better clinical outcomes, offering new insights into tumor microenvironment regulation.

The understanding of kagome bands, which are characterized by Dirac-like bands capped by a flat band, remains largely elusive. Here, Liu et al. report the observation of a flat band and Dirac bands as ideal features of kagome bands in CoSn, revealing orbital-selective character.

Age-related macular degeneration (AMD) is a major cause of blindness worldwide. Here, the authors carry out a two-stage genome-wide association study for AMD and identify three new AMD risk loci, highlighting the shared and distinct genetic basis of the disease in East Asians and Europeans.

A power conversion efficiency of 33.89% is achieved in perovskite/silicon tandem solar cells by using a bilayer passivation strategy to enhance electron extraction and suppress recombination.

The record-breaking atmospheric methane growth rates in 2020 and 2021 revealed heightened emissions from inundated areas in tropical Africa and Asia. However, current processed-based wetland models fail to capture emission surges in these regions.

Experimental systems in which non-trivial topology is driven by spontaneous symmetry breaking are rare. Now, topological gaps resulting from two excitonic condensates have been demonstrated in a three-dimensional material.

The conductance of single-molecule junctions is affected by the structure of the molecule and how it is bound to the electrodes, which may be examined using Raman spectroscopy. Liuet al. have developed 'fishing-mode' tip-enhanced Raman spectroscopy, which allows the simultaneous determination of conductance and Raman spectra.

The recently discovered phenomena arising from 2D nanomaterials have led to an increased interest in the fabrication of other ultrathin materials from those typically only observed in the bulk. Here, the authors demonstrate the synthesis of micron-sized, single-crystalline ZnO nanosheets via solution based methods.

The authors reveal that interfacial dead layers in ferroelectric ScAlN originate from nitrogen vacancies and strain, highlighting their critical role in unlocking the full potential of nitride ferroelectrics for advanced device architectures.

Histone crotonylation is implicated in transcriptional regulation. Here, the authors perform genome-wide mapping of histone crotonylation in mouse and human early embryos. Suppression of histone crotonylation results in developmental arrest at 2-cell stage due to impaired transcriptional activity. Embryos from aged female mice exhibit diminished histone crotonylation, while sodium crotonate supplementation facilitates blastocyst formation.

Despite great success in generation of ultralong organic phosphorescence (UOP) by suppressing non-radiative transitions through attractive interactions, consideration of repulsive interactions on UOP remains largely unexplored. Here, the authors introduce carboxyl groups into organic phosphors, enabling formation of the intense repulsive interactions between the isolated molecules and the matrix in rigid environment.

Authors report an oblique photothermal microscope system for ultrasensitive infrared spectroscopic imaging of live subjects at sub-micron resolutions. The method enables low-dose skin imaging without photodamage, and is a highly sensitive platform for in vivo and in situ molecular analysis.

The zoonotic parasite Toxoplasma has complex developmental programs to accommodate different lifestyles that are important for parasite transmission and pathogenesis. Here, the authors discover a novel chromatin remodeling complex containing SNF2L in Toxoplasma and report its crucial roles in regulating the parasite’s developmental programs.

The introduction of 3TPYMB, an n-type molecule into inverted perovskite solar cells, enables a power conversion efficiency of 25.6%, with devices maintaining up to 98% of the initial efficiency after 1,800 h of operation.

Zinc gluconate in oral supplements associates with plasma proteins to form renal-tumour-accumulating ZnO nanoparticles, which have antitumoural immune activity and can also be used for the delivery of chemotherapeutic agents.

Single-atomic impurities may induce novel quantum state, but they are unexplored in topological magnets. Here, the authors report spin-down polarized bound states which further interact with neighboring states to form spin-orbit split quantized orbitals in a topological magnet Co₃Sn₂S₂.

The ongoing uncoordinated emission abatement of anthropogenic volatile organic compounds and NO_x has increased condensable oxygenated organic vapor concentrations and in turn promoted atmospheric new particle growth in Beijing.