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Hyperuricemia, a major cause of gout, results from impaired urate excretion. Here, the authors reveal how key anti-gout drugs block URAT1, providing structural insights for designing better hyperuricemia treatments.

Zhao et al. report bilateral Geiger mode avalanche in 2D graphene/InSe/Cr asymmetrical Schottky junction. The asymmetrical Schottky junction benefits to initiate impact ionization and multiplication for the injected majority carriers, leading to a multiplication factor up to 10 ^ 7 and a breakdown voltage of 1.4 V.

Clinical diagnosis of temporomandibular joint (TMJ) disorders is complex and requires evaluation by a qualified physician. Here, Yan et al. develop a hydrogel electronic sensor to detect TMJ movement, able to accurately detect and classify disc displacement with reduction, a common TMJ disorder.

Preserving anal function in advanced-stage colorectal cancer (CRC) treatment remains challenging. Here this group reports a hydrospongel consists of cellulose nanofibers crosslinked with Fe₃O₄@PDA nanoparticles which enables delivery of 5-FU to the tumor site thereby achieving CRC chemotherapy.

By utilizing an AI-accelerated silicon photonic slow-light technology, researchers demonstrate a record 400 Gbps/λ PAM-4 transmission based on pure silicon modulators, paving the way for next-generation optical interconnects in computing centers.

Single-cell transcriptomic profiling of immune cells in the blood and liver of a human decedent receiving a pig liver xenograft reveals impaired adaptive immunity and monocyte features that may induce T cell exhaustion and contribute to platelet activation.

Siltartoxatug, a first-in-class recombinant monoclonal antibody for tetanus prophylaxis, was shown to be safe and superior to plasma-derived human tetanus immunoglobulin in achieving anti-tetanus neutralizing antibody titers 12 hours after administration.

Spin-1/2 Heisenberg chains are fabricated through on-surface synthesis and reduction. As the chain length increases, the spin excitation gaps decrease, suggesting a gapless state in the thermodynamic limit. Spinon dispersion observed in the spin chains highlights the potential of this approach for realizing custom quantum spin systems.

Authors present a bispecific antiviral design targeting the virus and the host that simultaneously offers broad-spectrum protection against multiple existing transmissible human-pathogenic coronaviruses, including the Paxlovid-resistant SARS-CoV-2 mutants.

Tergaonkar and colleagues identify a noncanonical interaction between the NF-κB transcription factor family member p52 and the ETS family member ETS1. They find that the p52–ETS1 complex is required for splenic germinal center B cell formation and T cell-dependent antibody responses.

Recent advancements in mercury bioremediation highlight the potential of engineered organisms to transform toxic mercury into less harmful forms. Two pioneering studies demonstrate the ability of genetically modified animals and bacteria to mitigate mercury toxicity. However, these approaches face challenges, including intracellular toxicity and limited bioconversion efficiency.

Whether multimorbidity accelerates brain Aβ deposition in humans remains largely unknown. Here, the authors demonstrate that higher self-reported multimorbidity burden predicts increased brain Aβ accumulation rates in the ADNI cohort.

Group 2 Innate lymphoid cells (ILC2) have been shown to promote type 2 immune responses. Here the authors show a TLR4⁺ILC2 population in type 2 airway diseases and that this population responds more vigorously to type 2 stimuli and contributes to persistence of type 2 immunity.

CRISPR screens identify hepatic ABCC4 as a modulator of LDLR. Inhibiting ABCC4 increases hepatic LDLR, lowers plasma LDLC and acts via the cAMP-Epac2/Rap1a signaling pathway to suppress PCSK9, preventing LDLR degradation.

Palladium catalysed C-H functionalization ofsp³carbons typically requires the installation and subsequent removal of a temporary directing group. Here the authors report a method allowing C-H functionalization in carboxylic acids in which the carboxylate acts as a directing group.

The diagnosis and prognosis of chronic kidney disease (CKD) relies on invasive renal biopsies, which can be clinically constrained. Here, the authors develop a non-invasive model using retinal images that can be used to screen for CKD and identify five common pathological types of CKD.

In flowering plants, the sperm cells travel attached to the vegetative nucleus, forming a unit known as the male germ unit in pollen. This study reports that two kinesins, HUG1 and HUG2, are key for assembling and transporting male germ unit for successful reproduction.

The authors add GaSb to PbSe as an n-type dopant to form stable solid solutions with high power factor and high figure of merit. They find that the Ga and Sb atoms co-occupied the Pb sites, causing local structural distortion.

The impact of mercury (Hg) mitigation on microbe-mediated greenhouse gas (GHG) dynamics remains elusive. In this Perspective, the authors fill this gap by synthesizing fragmented evidence on the Hg-microbe-GHG nexus, proposing a roadmap to align Hg mitigation with climate action.

Sadhu et al. identify and functionally validate ferredoxin-1 (FDX1) as a determinant of cholesterol metabolism and cardiovascular risk in Asian populations.

A microphase crosslinking strategy, leveraging aziridine-based crosslinkers, is used to render organic thermoelectric materials stretchable and elastic.

Scattering in the archetypal oxide SrRuO₃ is shown to enhance orbital currents. This counter-intuitive effect establishes a transformative paradigm for energy-efficient spintronic devices.

The mechanism underlying abnormal pain perception in autism remains unclear. Here authors show that histone lactylation decreases Dock4, an autism-related gene, to modulate heat pain by impairing Dynein-mediated Nav1.7 membrane trafficking, providing insights into thermosensor-independent mechanisms.

By resonant excitation of an InAs quantum dot embedded in a microcavity, a deterministic single-photon source is demonstrated. Single-photon purity of 0.9795(6), photon indistinguishability of 0.9856(13), and an overall end-to-end efficiency of 0.712(18) are simultaneously obtained.

R9AP is a key receptor for entry of Epstein–Barr virus into human epithelial and B cells, and interacts directly with the viral glycoprotein gH/gL complex to mediate virus–host membrane fusion.

Zhang, Chang et al. identify the protein TMEM65 as the mitochondrial Na⁺/Ca²⁺ exchanger, showing that it dimerizes to mediate ion transport and contains a binding site for a well-known inhibitor of mitochondrial Na⁺/Ca²⁺ exchange.

Lewis acid additive semicarbazide hydrochloride improves the formation of α-phase FAPbI₃-based films and promotes a homogeneous vertical distribution of A-site cations through a deprotonation–reprotonation process. The upgraded device performance reaches up to 26.12% with high stability, and mini-module perovskite solar cells achieving 21.47% (area, 11.52 cm²) demonstrate great scalability.

This study presents an optical cloud computing system that enables long-distance, high-speed AI processing and communication with low power consumption. The approach offers a scalable and secure alternative to electronic cloud computing, addressing key energy and privacy challenges.

This paper explores how voltage-gated potassium channels can plug the pore to prevent the conductance of ions during inactivation.

The α6β4 receptor has been considered an appealing therapeutic target for pain. Here, the authors determined the structures of α6β4 bound with its agonists, nicotine and tebanicline, providing molecular insights into its function.

Observations of SN 2021yfj reveal that its progenitor is a massive star stripped down to its O/Si/S core, which remarkably continued to expel vast quantities of silicon-, sulfur-, and argon-rich material before the explosion, informing us that current theories for how stars evolve are too narrow.

Using more renewable energy to produce exported goods can cut global trade emissions, but current data lack detail. This study now provides a global dataset of renewable energy use in exports from 2011 to 2022, complementing trade analyses and revealing trends and gaps between countries and industries.

A versatile nano-adaptor is used to construct multi-specific nano-antibodies for treatment of tumours in mice.

This study reveals that α-lipoic acid (ALA) is reduced in aged mouse and human intestine and ALA supplementation reduces aging hallmarks. Paneth cells play a role in the effects of ALA.

Mitophagy is crucial for mitochondrial function and is implicated in Alzheimer’s disease. Here, the authors introduce an AI-assisted fluorescence microscopy system to track mitophagic intermediates in live cells and identify Y040-7904, a potential modulator that enhances mitophagy and reduces amyloid-β pathologies.

Ni, Wei, Vona and colleagues use human brain organoids to dissect patient AIRIM variants associated with neurodevelopmental features. A subset of variants impaired ribosome production and protein synthesis, and delayed radial glial cell specification.