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The authors report a catalyst featuring Rh-Zn dual sites in a MoS₂ lattice integrated with TiO₂ for the photocatalytic carbonylation of CH₄ with CO and O₂ to CH₃COOH with a high productivity of 152.0 μmol g_cat.⁻¹ h⁻¹ and selectivity of 96.5%.

Nitriles are key intermediates in production of pharmaceuticals, agrochemicals and organic materials. Here, the authors report a nickel-catalyzed reductive cyanation of organic chlorides with CO₂/NH₃ and urea as cyanation reagents to afford a broad range of organic nitriles.

Lai et al. present a spatially resolved atlas of human atherosclerotic plaques, revealing cellular heterogeneity and identifying lymphoid structures and their potential functions and implications.

Despite decades of research, autonomous robotic manipulation skills remain limited, especially for complex tasks such as insertion or bending of materials. Johannsmeier et al. introduce a taxonomy of manipulation skills that synthesizes tactile behaviours from process specifications, achieving high robustness and performance with minimal learning time.

External stimulus-induced cellular stress response plays a role in the development of esophageal squamous cell carcinoma (ESCC). Here the authors show that stress-induced activation of p38 MAPK leads to ACSL4 phosphorylation and Src myristoylation to promote tumorigenesis in ESCC.

RNase H1 functions as an endonuclease degrading the RNA moiety within RNA–DNA hybrids. Here the authors find that RNase H1 displays 3′-to-5′ exonuclease activity. Moreover, RPA reinforces RNase H1’s 3′-to-5′ nucleolytic rate and processivity and stimulates its 5′-to-3′ exonuclease activity.

Type I-E CRISPR–Cas system is one of the most extensively studied RNA-guided adaptive immune systems in prokaryotes. Here, The authors present structures of the Candidatus Cloacimonetes Cas5-HNH/Cascade, with insights into the assembly and activation of this complex.

N⁶-methyladenosine (m⁶A) RNA modification regulates RNA metabolism, and has been implicated in immune regulation. Here, the authors show that the m⁶A methyltransferase, METTL3, translocates into the cytoplasm to increase viral RNA m⁶A modification, decreases viral ds RNA content, and thereby dampens the RIG/MDA5-induced anti-viral immunity.

Many thrombolytic agents depend on plasminogen, leading to D-dimer accumulation. Here, Tang et al. report a plasminogen-independent thrombolytic enzyme that degrades blood clots and D-dimer without plasminogen.

Integration of mineralogy and biology leads authors to develop the Al4Min-Cr platform to stabilize chromium as chromite in contaminated soils and water for point-to-point remediation and long-term Cr pollution control.

Early-onset lung cancer in young adults remains poorly studied. Here, the authors analyse the clinicopathological, molecular, and immune features of early-onset non-small cell lung cancers in a cohort of 421 patients across ten medical centres in China, identifying potential therapeutic strategies for this subgroup.

CRISPR diagnostics are routinely used for the detecting nucleic acids, but rarely for clinically important proteins. Here, by translating a CRISPR-based DNA test into an ultrasensitive assay for antibodies, the authors achieve antibody detection from serum samples at attomolar concentrations.

Development of efficient upconversion (UC) phosphors that emit under irradiation in the NIR II region is challenging - most UC materials rely on the presence of sensitizers absorbing at shorter wavelengths. Here, authors synthesize Er³⁺ doped ternary sulfides phosphors with visible UC efficiency up to 2.6% and long emission lifetimes under 1532 nm irradiation, via an excited state absorption mechanism.

Protein-protein interactions (PPIs) stabilization with molecular glues plays a crucial role in drug discovery. Here, the authors propose a dual-site approach for the design of clyclin K molecular glues, targeting the PPI region and its dynamic surroundings, and report a dual-site molecular glue for the cyclin-dependent kinase 12 - DNA damage-binding protein 1 complex, resulting in further cyclin K degradation.

This study uncovers a unique broad neutralization mechanism against rotavirus, where antibody 7H13 destabilizes the partial structure of the viral VP4 spike by acting on a critical residue switch located at the interface of multiple VP4 subunits.

Protocadherin-1 (PCDH1) is a critical host factor for hantaviruses that can cause severe cardiopulmonary syndrome. Here, the authors map the binding site of the viral glycoprotein complex within PCDH1 and show that mutations engineered at this site can protect Syrian hamsters from viral challenge.

Complicated associations between multiplexed environmental factors and aging are poorly understood. Here, authors show heterogeneous associations of multiplexed environmental factors with multidimensional aging metrics.

Combined immune checkpoint blockade (ICB) and photodynamic therapies have huge potential but suffer from possible damage of the antibodies. Here, the authors create a ROS-responsive hydrogel that protects the ICB antibodies and allows for sustained co-delivery and demonstrate restrained regrowth of tumours in vivo.

This study reveals the role played by the RNR10-DNR1-auxin module in modulating rice root system architecture and nitrogen uptake, making it a promising target for enhancing nitrogen-use efficiency and grain yield for future sustainable agriculture.

Spur-type of growth is preferred for apple production. Here, the authors employ the trio-based phasing approach to assemble a fully phased Fuji genome and reveal the association of a 167-bp deletion in the promoter region of the MdTCP11 gene with the spur-type varieties.

The role of PHD finger protein 8 (PHF8) in anti-tumour immunity remains to be investigated. Here, the authors suggest PHF8 as an epigenetic checkpoint and show that targeting PHF8 induces a viral mimicry response enhancing anti-tumour immunity in colorectal cancer.

Alternatively activated macrophages have a pivotal role in resolving inflammation but in the tumour microenvironment they are immunosuppressive. Here author show that adoptively transferred engineered macrophages harbouring a heat-inducible genetic switch can resist the polarizing effect of the tumour microenvironment, and do not only remain pro-inflammatory themselves but also re-polarise the endogenous macrophages upon controlled warming with a purpose-made device.

Some features resembling superconductivity at high temperature have been seen under pressure in La₃Ni₂O₇, but a transition to a zero-resistance state has not been observed. Now transport studies demonstrate this transition, along with strange metallicity.

Owing to the nonequilibrium nature, photonic topological phenomena can involve multiple band gaps. Here the authors report on the discovery of a class of hybrid topological photonic crystals that host quantum anomalous Hall and valley Hall phases simultaneously.

The authors propose a matrix plainification strategy to eliminate lattice vacancies in the Cu2Se matrix of the Cu2Se/SnSe composites, resulting in obvious improvement in carrier mobility and power factor, obtaining a high figure of merit of 3.3.

Determining the causal variants at GWAS loci is crucial for understanding genetic disease mechanisms. Here, the authors apply MPRA to perform non-small cell lung cancer (NSCLC) variant-to-function mapping at scale and propose distinct genetic architectures underlying NSCLC susceptibility.

Based on previous research that the Chaoyang virus is an insect-specific flavivirus, only able to replicate in insects and insect cells, authors present this proof-of-concept mosquito-delivered vaccine; they construct a Zika virus focused candidate that can be delivered by mosquito bite, and assess the immune response and protection in mice.

Root-associated microbiota confers benefits to plant in responding to environmental stress. Here, the authors show that wild soybean secretes purines under salt stress, reshapes the microbiota and recruits Pseudomonas.

Through rational engineering of A3A deaminase, Yang and colleagues have designed CBEs termed haA3A-CBEs, which feature a condensed editing window and minimal off-target effects that are independent of defined sequence contexts and methylation status.

Reactivating adult cardiomyocyte proliferation is key to heart regeneration post-injury. Here, authors show that medium from human iPSC-derived primitive macrophages (hiPM-cm) induces adult cardiomyocyte proliferation and promotes heart regeneration.

Here, Zhang et al. identify a metabolic axis by which Lys-producing commensal bacterium Dubosiella newyorkensis mediates a Treg-mediated immunosuppressive microenvironment by activating AhR-IDO1-Kyn metabolic circuitry in dendritic cells.

The biosynthesis of membrane-spanning lipids in archaea is poorly understood. Here, Li et al. identify an archaeal enzyme that forms a C(sp³)–C(sp³) linkage between isoprenoid chains for the synthesis of membrane-spanning GMGT lipids, and show that the corresponding gene is exclusively found in obligate anaerobic archaea and in metagenomes from oxygen-deficient environments.

The SARS-CoV-2 Omicron variant has quickly become the predominant circulating variant, due to the high transmissibility and immune escape. Here, the authors develop a trimeric protein vaccine candidate and show a sustained humoral immune response, and protection from challenge (Omicron and Delta) in various animal models.

High-resolution electron microscopy requires robust and noise-free substrates to support the specimens. Here, the authors present a polymer- and transfer-free direct-etching method for fabrication of graphene grids with ultraclean surfaces and demonstrate cryo-EM at record high resolution.

Synthesizing functionalized polyethylenes via ethylene coordination copolymerization using vinyl polar monomers is challenging. Here, the authors present an approach utilizing binuclear Ni catalysis for ethylene/acrylamide copolymerization to synthesize cyano-functionalized polyethylenes.

Purifying C₂H₂ by removing trace CO₂ is needed but challenging due to their analogous physical properties. Herein, the authors report the pilot-scale production of a commercial resin adsorbent loaded with polyethyleneimine for the selective capture of CO₂ traces and exclusion of C₂H₂.

The authors study transport in the superconducting state of infinite-layer nickelate Nd_0.8Sr_0.2NiO₂ films using a Corbino-disk configuration, finding that the magnetoresistance changes from isotropic to four-fold anisotropic with increasing magnetic field. At even higher field, an additional two-fold component emerges, which coincides with an anomalous upturn of the critical field.

Achieving both high efficiency and narrow emission in organic light-emitting transistors (OLETs) remains a challenge. Here the authors demonstrate laterally integrated OLETs with an intrinsic microcavity that achieve both enhanced efficiency and narrow emission.

Farmland ecosystems are influenced by human interventions. Here, the authors assess the relationship of farmland management to net ecosystem productivity of farmland, finding a positive impact of 17.02% in major grain-producing areas of China.

A natural pathway in rice and in seven other major crop species degrades 57–89% of accumulated methylmercury and releases Hg into the air. The MeHg demethylation within rice mitigates Hg flux into human food webs, diminishing human cognitive damage and generating global economic benefits of US$30.7–84.2 billion.

Dynamic and non-volatile memristors can be used to create hardware-based reservoir and readout layers in artificial neural networks, providing a fully analogue signal processing chain for efficient data classification.

Lymphocyte subsets remain inadequately understood in jawless vertebrates, relative to jawed vertebrates. In this study, the authors combine single-cell RNA and whole-transcriptome sequencing to demonstrate that the lamprey, Lampreta morii, harbours specialised T-like cells that are distinct from those found in jawed vertebrates.