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Showing 1–50 of 60 results

Advanced filters: Author: Yanxia Zhao Clear advanced filters

KCTD10 is a sensor for co-directional transcription–replication conflicts

KCTD10 interacts with the DNA replication machinery and the RNA polymerase complex, inducing ubiquitination and removal of the transcription machinery in the event of co-directional transcription–replication conflicts.

Jake A. Kloeber
Bin Chen
Zhenkun Lou
ResearchOpen Access08 Oct 2025
Nature

P: 1-10
KDM4B modulates ERα signaling pathway to participate in vascular smooth muscle cell calcification

Fei Liu
Yang Lv
Wen Tian
ResearchOpen Access07 Oct 2025
Cell Death Discovery

Volume: 11, P: 1-16
Diabetes mellitus exacerbates cardiovascular remodeling in elderly Chinese by affecting aortic diameter and pulsatile load

Yuqi Jiang
Ziwei Zhao
Wen Tian
ResearchOpen Access02 Sept 2025
Scientific Reports

Volume: 15, P: 1-11
Trade-driven relocation of air pollution and health impacts in China

International and domestic interprovincial trade of China are entangled, but their health impacts have been treated separately in earlier studies. Here Wang. quantify the complex impacts of trade on public health across China within an integrative framework.

Haikun Wang
Yanxu Zhang
Michael B. McElroy
ResearchOpen Access29 Sept 2017
Nature Communications

Volume: 8, P: 1-7
Genomic and transcriptomic alterations associated with drug vulnerabilities and prognosis in adenocarcinoma at the gastroesophageal junction

Adenocarcinoma at the gastroesophageal junction has a dismal prognosis and few drug options. Here, the authors present genomic and transcriptomic features and potential therapeutic targets and prognostic biomarkers of Chinese and Caucasian tumours, and reveal the molecular similarities.

Yuan Lin
Yingying Luo
Dongxin Lin
ResearchOpen Access30 Nov 2020
Nature Communications

Volume: 11, P: 1-14
Author Correction: Programmable RNA editing by recruiting endogenous ADAR using engineered RNAs

Liang Qu
Zongyi Yi
Wensheng Wei
Amendments and Corrections25 Sept 2019
Nature Biotechnology

Volume: 37, P: 1380
De novo pyrimidine biosynthetic complexes support cancer cell proliferation and ferroptosis defence

Yang, Zhao, Wang and colleagues identify and characterize a pyrimidine biosynthetic complex pyrimidinosome that is regulated by AMP-activated protein kinase and facilitates dihydroorotate dehydrogenase-mediated ferroptosis resistance, thereby regulating cancer cell proliferation and survival.

Chuanzhen Yang
Yiliang Zhao
Binghui Li
Research08 Jun 2023
Nature Cell Biology

Volume: 25, P: 836-847
Topological transformation of microbial proteins into iron single-atom sites for selective hydrogen peroxide electrosynthesis

Single-atom catalysts hold great potential for the electrochemical oxygen reduction reaction in hydrogen peroxide production. Here, the authors report Fe single-atom catalysts derived from microbial protein precursors, which enhance both the selectivity and activity for hydrogen peroxide production.

Xiaofeng Xiao
Zechao Zhuang
Feng Zhao
ResearchOpen Access30 Dec 2024
Nature Communications

Volume: 15, P: 1-13
Lycium barbarum glycopeptide mitigates retinal ischemia-reperfusion injury through its anti-inflammatory, anti- senescence, and anti-apoptosis properties

Chunlin Zhao
Xuejing Lu
Wei Shi
ResearchOpen Access30 Jul 2025
Scientific Reports

Volume: 15, P: 1-12
Author Correction: Repopulated microglia are solely derived from the proliferation of residual microglia after acute depletion

Yubin Huang
Zhen Xu
Bo Peng
Amendments and Corrections20 Nov 2020
Nature Neuroscience

Volume: 24, P: 288
Statins improve endothelial function via suppression of epigenetic-driven EndMT

Liu et al. show that statin enhances cardiovascular disease protection through epigenetic modulation of YAP–SOX9 signaling, improving endothelial function and offering new therapeutic strategies.

Chun Liu
Mengcheng Shen
Joseph C. Wu
Research08 May 2023
Nature Cardiovascular Research

Volume: 2, P: 467-485
HPD degradation regulated by the TTC36-STK33-PELI1 signaling axis induces tyrosinemia and neurological damage

Decreased expression of 4-hydroxyphenylpyruvic acid dioxygenase (HPD) has been linked to tyrosinemia, yet the mechanism underlying the regulation of HPD expression is largely unknown. Here the authors demonstrate that molecular chaperone TTC36, which is highly expressed in liver, is associated with HPD and reduces the binding of protein kinase STK33 to HPD, thereby inhibiting STK33-mediated HPD T382 phosphorylation.

Yajun Xie
Xiaoyan Lv
Qin Zhou
ResearchOpen Access19 Sept 2019
Nature Communications

Volume: 10, P: 1-12
Hypoxia-induced downregulation of PGK1 crotonylation promotes tumorigenesis by coordinating glycolysis and the TCA cycle

The functional relevance of lysine crotonylation in cancer remains to be further explored. Here, the authors show that hypoxia-induced downregulation of PGK1 lysine crotonylation promotes glycolysis and suppresses mitochondrial pyruvate metabolism, contributing to breast cancer progression.

Zihao Guo
Yang Zhang
Chuanzhen Yang
ResearchOpen Access12 Aug 2024
Nature Communications

Volume: 15, P: 1-17
Spatial correlations between summer ozone heatwave dual events and residents mental health in China

Rongjun Zeng
Jinhui Zhao
Chao He
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-15
FNA-Tg improves the diagnostic efficacy of FNAC for PTC lateral cervical LN metastasis

Junsong Liu
Rui Wang
Shaoqiang Zhang
ResearchOpen Access23 Apr 2025
Scientific Reports

Volume: 15, P: 1-9
Experimental and real-world evidence supporting the computational repurposing of bumetanide for APOE4-related Alzheimer’s disease

Through computational drug repurposing, Taubes et al. identified bumetanide as a potential drug for APOE4-related Alzheimer’s disease (AD). The effectiveness of bumetanide was validated in AD mouse models and via real-world health record databases.

Alice Taubes
Phil Nova
Yadong Huang
Research11 Oct 2021
Nature Aging

Volume: 1, P: 932-947
Treatment after Progression on Fulvestrant among Metastatic Breast Cancer Patients in Clinical Practice: a Multicenter, Retrospective Study

Yizhao Xie
Yannan Zhao
Biyun Wang
ResearchOpen Access08 Feb 2019
Scientific Reports

Volume: 9, P: 1-7
Estimated Glomerular Filtration Rate, Proteinuria, and Risk of Cardiovascular Diseases and All-cause Mortality in Diabetic Population: a Community-based Cohort Study

Anxin Wang
Guojuan Chen
Xiuhua Guo
ResearchOpen Access20 Dec 2017
Scientific Reports

Volume: 7, P: 1-7
Engineered circular ADAR-recruiting RNAs increase the efficiency and fidelity of RNA editing in vitro and in vivo

Circular ADAR-recruiting RNAs improve RNA editing in vitro and in a mouse disease model.

Zongyi Yi
Liang Qu
Wensheng Wei
Research10 Feb 2022
Nature Biotechnology

Volume: 40, P: 946-955
Dissecting esophageal squamous-cell carcinoma ecosystem by single-cell transcriptomic analysis

Esophageal squamous-cell carcinomas (ESCC) have poor prognosis, and detailed molecular profiles are necessary to identify prognostic markers. Here the authors analyse 60 ESCC patient samples using scRNA-seq, TCR-seq and genomics; they find mucosal immunity markers associated with survival and immunosuppressive microenvironments.

Xiannian Zhang
Linna Peng
Dongxin Lin
ResearchOpen Access06 Sept 2021
Nature Communications

Volume: 12, P: 1-17
Allelic variation of TaWD40-4B.1 contributes to drought tolerance by modulating catalase activity in wheat

Drought stress limits wheat production around the world. Here, the authors report allelic variation of a WD40 encoding gene TaWD40-4B.1 contributes to wheat drought tolerance by interacting with canonical catalases as a chaperone to promote their activities to avoid ROS over accumulation.

Geng Tian
Shubin Wang
Mengcheng Wang
ResearchOpen Access02 Mar 2023
Nature Communications

Volume: 14, P: 1-18
Association between body mass index changes and short- and long-term outcomes of hypertension in a Chinese rural cohort study

Zihui Gao
Yali Wang
Liqiang Zheng
Research30 Oct 2019
Journal of Human Hypertension

Volume: 34, P: 593-601
Neofunctionalization of zona pellucida proteins enhances freeze-prevention in the eggs of Antarctic notothenioids

Despite subzero temperature of their surroundings, eggs of Antarctic notothenioid fishes do not freeze. This study shows the expansion of genes related to freezing temperature in notothenioid which also acquired of ice melting-promoting zona pellucida proteins with specific structural properties.

Lixue Cao
Qiao Huang
Liangbiao Chen
ResearchOpen Access04 Oct 2016
Nature Communications

Volume: 7, P: 1-11
Programmable RNA editing by recruiting endogenous ADAR using engineered RNAs

Cellular RNAs are edited with high specificity using engineered ADAR-recruiting RNAs.

Liang Qu
Zongyi Yi
Wensheng Wei
Research15 Jul 2019
Nature Biotechnology

Volume: 37, P: 1059-1069
Repopulated microglia are solely derived from the proliferation of residual microglia after acute depletion

Microglia show remarkable regenerative capacity after acute depletion, which had been thought to be derived from de novo progenitors. Peng and colleagues demonstrate that the newly formed microglia are actually solely derived from residual microglia.

Yubin Huang
Zhen Xu
Bo Peng
Research22 Feb 2018
Nature Neuroscience

Volume: 21, P: 530-540
Microglial debris is cleared by astrocytes via C4b-facilitated phagocytosis and degraded via RUBICON-dependent noncanonical autophagy in mice

Microglia are professional phagocytes in the CNS. However, which cells scavenge corpses of microglia is largely neglected. Peng and colleagues found that nonprofessional phagocytes (astrocyte) phagocytose the debris of professional phagocytes (microglia).

Tian Zhou
Yuxin Li
Bo Peng
ResearchOpen Access24 Oct 2022
Nature Communications

Volume: 13, P: 1-22
Mechanism of microscopic behind the influence of stress loading on gas adsorption by coal

Zhihui Wen
Shuqian Guo
Jiangang Ren
ResearchOpen Access25 Jan 2025
Scientific Reports

Volume: 15, P: 1-13
BAIAP2L2 facilitates hepatocellular carcinoma progression and immune evasion of via targeting JAK1-mediated pathway and PD-L1 expression

Zhiyue Xie
Yanxia Wu
Liang Zhao
Research17 Mar 2025
Cancer Gene Therapy

Volume: 32, P: 464-474
Assessing the effect of digital platforms on innovation quality: mechanism identification and threshold characteristics

Bing Han
Miaomiao Li
Dongri Han
ResearchOpen Access24 Jul 2024
Humanities and Social Sciences Communications

Volume: 11, P: 1-10
Cumulative Resting Heart Rate Exposure and Risk of All-Cause Mortality: Results from the Kailuan Cohort Study

Quanhui Zhao
Haibin Li
Shouling Wu
ResearchOpen Access09 Jan 2017
Scientific Reports

Volume: 7, P: 1-9
Ice-and-snow tourism in China: trends and influencing factors

Jianping Yang
Yanxia Wang
Guangxi Ding
ResearchOpen Access17 Nov 2023
Humanities and Social Sciences Communications

Volume: 10, P: 1-12
Protein kinase A regulates ferroptosis by controlling GPX4 m⁶A modification through phosphorylation of ALKBH5

Xiaocheng Zhao
Yanxi Sun
Xingwu Wang
Research03 Feb 2025
Cell Death & Differentiation

Volume: 32, P: 1058-1070
Realization of 2D multiferroic with strong magnetoelectric coupling by intercalation: a first-principles high-throughput prediction

Ying Zhao
Yanxia Wang
Xue Jiang
ResearchOpen Access07 Jun 2024
npj Computational Materials

Volume: 10, P: 1-11
Activity-based metaproteomics driven discovery and enzymological characterization of potential α-galactosidases in the mouse gut microbiome

The gut microbiota offers an extensive resource of enzymes, however, many remain uncharacterized. Here, the authors apply an activity-based metaproteomics strategy using an activity-based cyclophellitol aziridine probe specific to α-galactosidases (AGAL), and identify and characterize several gut microbiota enzymes possessing AGAL activities.

Jianbing Jiang
Diana Czuchry
Nan Li
ResearchOpen Access16 Aug 2024
Communications Chemistry

Volume: 7, P: 1-15
A nomogram incorporating linezolid and metabolite concentrations for predicting linezolid induced thrombocytopenia in patients with renal impairment

Hanzhen Zhao
Lian Tang
Jinhui Xu
ResearchOpen Access30 Oct 2024
Scientific Reports

Volume: 14, P: 1-10
Biparatopic antibody BA7208/7125 effectively neutralizes SARS-CoV-2 variants including Omicron BA.1-BA.5

Yanqun Wang
An Yan
Jincun Zhao
ResearchOpen Access07 Jan 2023
Cell Discovery

Volume: 9, P: 1-16
Aryl hydrocarbon receptor activation drives polymorphonuclear myeloid-derived suppressor cell response and efficiently attenuates experimental Sjögren’s syndrome

Yanxia Wei
Na Peng
Liwei Lu
Research11 Nov 2022
Cellular & Molecular Immunology

Volume: 19, P: 1361-1372
Association of obesity with cardiovascular disease in the absence of traditional risk factors

Hui Luo
Yesong Liu
Anxin Wang
Research08 Nov 2023
International Journal of Obesity

Volume: 48, P: 263-270
Integrin α6/Akt/Erk signaling is essential for human breast cancer resistance to radiotherapy

Ting Hu
Rui Zhou
Gang Wu
ResearchOpen Access14 Sept 2016
Scientific Reports

Volume: 6, P: 1-10
Environmental monobutyl phthalate exposure promotes liver cancer via reprogrammed cholesterol metabolism and activation of the IRE1α-XBP1s pathway

Tingting Zhang
Faming Zhao
Xia Sheng
Research15 Jun 2024
Oncogene

Volume: 43, P: 2355-2370
Losartan rewires the tumor-immune microenvironment and suppresses IGF-1 to overcome resistance to chemo-immunotherapy in ovarian cancer

Yao Sun
Zhenzhen Yin
Lei Xu
Research05 Oct 2024
British Journal of Cancer

Volume: 131, P: 1683-1693
Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells

Zhihua Song
Jun Cai
Hongkui Deng
Research08 Sept 2009
Cell Research

Volume: 19, P: 1233-1242
Regulation of Anticancer Styrylpyrone Biosynthesis in the Medicinal Mushroom Inonotus obliquus Requires Thioredoxin Mediated Transnitrosylation of S-nitrosoglutathione Reductase

Yanxia Zhao
Meihong He
Weifa Zheng
ResearchOpen Access21 Nov 2016
Scientific Reports

Volume: 6, P: 1-14
GABPA is a master regulator of luminal identity and restrains aggressive diseases in bladder cancer

Yanxia Guo
Xiaotian Yuan
Dawei Xu
ResearchOpen Access04 Dec 2019
Cell Death & Differentiation

Volume: 27, P: 1862-1877
Rotation with other crops slow down the fungal process in tobacco-growing soil

Ming Liu
Rujun Xue
Yonglei Jiang
ResearchOpen Access19 Jun 2024
Scientific Reports

Volume: 14, P: 1-12
Sintilimab (anti-PD-1 antibody) plus chidamide (histone deacetylase inhibitor) in relapsed or refractory extranodal natural killer T-cell lymphoma (SCENT): a phase Ib/II study

Yan Gao
Haixia He
Huiqiang Huang
ResearchOpen Access17 May 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-9
Evaluating the psychometric properties of the simplified Chinese version of PROMIS-29 version 2.1 in patients with hematologic malignancies

Qianqian Zhang
Jinying Zhao
Wenjun Xie
ResearchOpen Access15 May 2024
Scientific Reports

Volume: 14, P: 1-10
Increased levels of conjugated bile acids are associated with human bile reflux gastritis

Aihua Zhao
Shouli Wang
Wei Jia
ResearchOpen Access14 Jul 2020
Scientific Reports

Volume: 10, P: 1-9
Dual extra-retinal origins of microglia in the model of retinal microglia repopulation

Yubin Huang
Zhen Xu
Bo Peng
ResearchOpen Access27 Feb 2018
Cell Discovery

Volume: 4, P: 1-16
Inhibition of the m⁶A reader IGF2BP2 as a strategy against T-cell acute lymphoblastic leukemia

Panpan Feng
Dawei Chen
Chunyan Ji
ResearchOpen Access01 Aug 2022
Leukemia

Volume: 36, P: 2180-2188

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