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DeepAdaptor can remove different sources of unwanted variations simultaneously from large-scale transcriptomic datasets, revealing biological signals.

Genetic diversity causes heterogeneity in multi-population GWAS data. Here, the authors propose MR-EILLS, a Mendelian randomization method using environment-invariant linear least squares to detect population-invariant causal effects.

Here the authors report a low-cost method to fabricate flexible Ag2Se thermoelectric films with high performance and durability, enabling efficient energy harvesting and cooling in wearable and portable thermoelectric devices.

While they resemble antiferromagnets in terms of vanishing magnetization, altermagnets also have a nonrelativistic spin-splitting bandstructure arising from the combination of crystal symmetry and magnetic ordering. Here, Zhang et al demonstrate the effective manipulation of spin-splitting torque based on the control of Néel vector in altermagnets.

A fibre-structured bandage converts the temperature gradient between the wound and dressing into an electric stimulus to generate an electric field that accelerates wound healing.

The authors find that electric-field gating-controlled lithium intercalation can switch FeSe reversibly between a nonmagnetic superconducting state and a high-temperature superconducting ferromagnetic state. Further, scanning-SQUID magnetometry reveals that the ferromagnetic domains survive deep in the Meissner state and coexist spatially.

The Cement market drives massive GHG emissions, spurring low-carbon material innovation. Here, authors propose a prehydration strategy to convert steel slag into high-performance cementitious material. Crucially, its carbon footprint is just 34–40% of cement’s, offering a positive climate solution.

Here the authors identify the granin hormone SCG2 as a ligand for the inhibitory receptor LILRB4. They show that SCG2 released from tumors can suppress antitumor immune responses via this interaction, indicating possible therapeutic strategies.

The powdery mildew resistance of the MLIW170/PM26 locus, which originated from wild emmer wheat, is determined by a genetically linked atypical NLR gene pair, TdCNL1 and TdCNL5, with TdCNL1 encoding an atypical nucleotide-binding leucine-rich repeat protein integrating a potassium-dependent sodium-calcium exchanger domain.

Ionizable lipids containing albumin-binding motifs are used in lipid-nanoparticle-based mRNA vaccines, facilitating lymph node enrichment and dendritic cell internalization to potentiate their efficacy and avoiding liver accumulation.

A fuzzy sequencer can exceed the current limit of information efficiency of DNA sequencers for resequencing applications.

Here, the authors identify EZH2-mediated DDX1 K234 methylation as a driver of MATR3 mis-splicing, leading to senescence and apoptosis of NP cells, and propose lipid nanoparticle-based delivery of full-length MATR3 as a potential therapy for IVDD.

Preliminary results from an investigator-initiated clinical trial showed that an AAV-OTOF gene therapy was safe and led to hearing improvements in ten patients with congenital deafness with 6–12 months of follow-up, including in a teenager and a young adult, expanding the age range from previous trials.

The authors realize high dielectric energy storage properties at high temperatures in the polymer nanocomposites via the combined approach of adding high-entropy ferroelectric nanofillers and constructing a bilayer structure.

CIGS is a high-resolution dataset comprising chemical perturbation-induced 319,045,108 gene expression events.

Investigating the inner structure of baryons is important to further our understanding of the strong interaction. Here, the BESIII Collaboration extracts the absolute value of the ratio of the electric to magnetic form factors and its relative phase for e + e − → J/ψ → ΛΣ decays, enhancing the signal thanks to the vacuum polarisation effect at the J/ψ peak.

Criegee intermediates are transient carbonyl oxides produced during the ozonolysis of alkenes and play a key role in atmospheric chemistry. Here the authors achieve direct observation of CH₂OO by cavity ringdown spectroscopy in a flow cell reactor.

Understanding precise structures of two-/three- dimensional covalent organic polymers through single-crystal X-ray diffraction analysis is interesting however, to grow high-quality single crystals of these materials is challenging. Here, the authors incorporate tellurium into the backbones covalent organic polymers as a concise and fast method to grow large single crystals.

Siltartoxatug, a first-in-class recombinant monoclonal antibody for tetanus prophylaxis, was shown to be safe and superior to plasma-derived human tetanus immunoglobulin in achieving anti-tetanus neutralizing antibody titers 12 hours after administration.

An asymmetric self-assembled monolayer improves the efficiency of perovskite/silicon tandem solar cells compared with symmetric self-assembled monolayers, resulting in a certified power conversion efficiency of up to 34.58%.

Gasdermin E (GSDME) is abundantly expressed, but its physiological function remains unclear. Here, the authors show a non-pyroptotic function of GSDME in limiting renal inflammation during cisplatin nephrotoxicity by regulating O-GlcNAcylation and STAT3-S100A7A-RAGE signaling.

The first outbreaks of mpox outside Africa in 2022 were caused by clade II but cases of a new clade Ib have been increasing in the Democratic Republic of Congo and neighbouring countries since 2024. Here, the authors describe a case report and public health investigation of the first detected case of mpox clade Ib in China.

Mixed-dimensional 1D-2D heterostructures hold promise for catalytic and optoelectronic applications, but the control of their electronic band structure remains challenging. Here, the authors report the fabrication of 1D-graphene nanoribbon/2D-CuSe heterojunctions with tunable band alignment by varying the geometry and phase of the materials.

Agricultural machinery and supporting sectors such as energy, food processing, transportation and storage are quantified, demonstrating a sixfold increase in related health risks over the past 37 years in China, with disproportionately higher impacts on low-income populations.

Worldwide, the number of only-child families is increasing. This research examines how growing up without siblings affects adult brain structure, function and connectivity, cognition, personality and mental health.

Clear cell renal cell carcinoma (ccRCC) usually metastasizes to the lungs. Here, the authors discover that SWI/SNF ATPase subunit SMARCA4 silencing of HLF regulates ccRCC lung metastasis by modulating the integration of collagen's mechanical cues with the actin cytoskeleton through leupaxin.

Diatomic catalysts show promise for the oxygen reduction reaction, but their complex kinetics hinder rational design. Here, the authors synthesize strongly bonded Fe-Co diatomic catalysts where Co acts as the main active site and Fe aids *OH adsorption, revealing a synergistic effect.

A mechanical exfoliation method for producing freestanding metal oxide ultrathin flakes is reported. The flakes can be transferred and integrated with 2D materials, providing a platform to investigate the fundamental properties of ultrathin metal oxides.

Global land cover conversions increased carbon uptake during 1982 to 2019, with newly established forests in the Northern Hemisphere driving gains that counterbalanced emissions from tropical deforestation.

Finite momentum superconducting pairing refers to a class of unconventional superconducting states where Cooper pairs acquire a non-zero momentum. Here the authors report a new superconducting state in bulk 4Hb-TaS₂, where magnetic fields induce finite momentum pairing via magnetoelectric coupling.

The gas diffusion electrode interface can boost chemical reactions, yet its microenvironment properties are largely unexplored. Here, the authors report the spontaneous generation of reactive redox radical species at the interface using Janus hydrophobic/hydrophilic porous carbon papers to feed gas.

The tissue-specific accumulation patterns of pathogenic mtDNA mutations during aging remain incompletely understood. In this study, the researchers developed three mouse models with distinct mitochondrial tRNA mutations, revealing age-dependent accumulation of these mutations in the kidneys, leading to mitochondrial kidney disease.

“Dissolved oxygen (DO) sustains river ecosystems, but the effects of hydrological extremes remain poorly understood. Here it is shown that sudden floods cause abrupt declines in DO, suggesting that increased future flooding may lead to the degradation of aquatic ecosystems.

The primary entry route of vanilloid ligands to the vanilloid-binding site in transient receptor potential vanilloid 1 (TRPV1) is found to be a distinct and targetable hydrophobic pathway at the TRPV1–cell membrane interface rather than through direct membrane penetration.

Adult zebrafish possess the ability to regenerate injured hearts through a complex orchestration of molecular and cellular activities. Here, the authors present a single cell and spatially-resolved atlas of the regenerating zebrafish heart, which serves as a valuable resource for research on heart regeneration.

A universal, high-resolution printing technology for metal oxide thin-film transistors is still lacking. A plasmonic printing technology is reported to fabricate high-performance, solution-processed all-metal oxide thin-film electronics under room temperature and ambient conditions.

Non-Abelian topological charges and edge states in a PT-symmetric transmission line network are experimentally observed, and a non-Abelian quotient relation for the bulk–edge correspondence is found.

Tong et al. chemically trapped the structure of the E4 enzyme Ufd2, which mediates K48 branched ubiquitination on K29diUb and K29triUb, identifying Ufd2’s core region as a K29diUb binding domain and a dimeric conformation for distal ubiquitin stabilization.

Vaccination is a potential prophylactic treatment for atherosclerosis, but vaccine formulation and regime remain to be optimized. Here the authors show, in preclinical mouse models, that vaccination with nanovaccine containing the antigen, p210, and the adjuvant, CpG, conjugated on distinct carriers reaches better efficacy than co-conjugation.

Traditional solution- and vacuum-deposition may leave pinholes on film surface or suffer from low throughput, respectively. Here, authors vacuum-deposit a 2D capping perovskite layer on solution deposited 3D bulk film, realizing pinhole-free solar submodules with certified efficiency close to 22%.