|
FET proteins and PARylation-dependent condensates promote replication fork reversal and genome stability
|
|
TRPC4/TRPC5 are critical for neuronal modulation by transcranial focused ultrasound in retrosplenial cortex in male mice
|
|
Probe-based identification of metal-binding sites using deep learning representations
|
|
Discovery of 5’ NAD capped viral RNAs reveals evolutionary divergent 5’ metabolite capping across hepaciviruses
|
|
Cellular replisomes are powered by flex-fuel motors for unwinding DNA
|
|
A primordial synaptotagmin-independent function of complexin in regulated exocytosis
|
|
Karyoptosis mediates cell death and neurodegeneration upon proteotoxic stress
|
|
Mechanistic insights into modulation of productive substrate accessibility for efficient PET depolymerization
|
|
Pseudouridine synthase PUS1 and initiation factor mtIF2 are human mitoribosomal small subunit assembly factors
|
|
Structural mechanism of Necrocide 1 activation of human TRPM4 that triggers necrosis by sodium overload
|
|
Structural basis of nucleosome remodeling by Cockayne syndrome B homologue Komagataella phaffii Rad26
|
|
Investigating the relationship between ATP synthase and the TCA cycle by crosslinking mass spectrometry
|
|
SECmeres outperform extracellular vesicles as potential blood RNA biomarkers for Alzheimer’s disease
|
|
Allostery is a widespread cause of loss-of-function variant pathogenicity
|
|
Structural diversity of heat-sensing channel TRPV3 with Olmsted syndrome mutations
|
|
ATF4 coordinates amino acid and nucleotide synthesis with selective protein translation to ensure proper DNA replication timing in leukemia cells
|
|
Intercellular chemerin-cmklr1 couples epicardial mechanosensing to fibroblasts in pressure overload
|
|
A cyclin-polarity feedback network ensures healthy cell proliferation
|
|
Conformational cycling of the Wntless transporter drives trafficking and secretion of Wnt morphogens
|
|
Conformational landscape and ligand-dependent clustering of the human type 2 IP3 receptor
|
|
PERK orchestrates an endoplasmic reticulum stress alternative splicing program via CLK1/SRSF1
|
|
A Bacillales-specific tubular scaffold essential for NADH dehydrogenase activity
|
|
SplitSeek-Pro: accurate prediction of splittable sites on protein structures
|
|
Pulsed-electron illumination does not reduce beam damage for imaging biological macromolecules
|
|
Mitochondrial protein OPA3 sustains cardiac function by regulating calcium handling in male mice
|
|
Structural basis for LMBD1-dependent trafficking and cobalamin export of ABCD4
|
|
A comprehensive landscape of human organ N-glycoproteome
|
|
SRP orchestrates protein biogenesis beyond initial ER membrane targeting
|
|
Cell polarity control by an unconventional G-protein complex in bacteria
|
|
A minimal chemo-mechanical Markov model for rotary catalysis of F-ATPase
|
|
Retrograde mitochondrial transport is required for mitochondrial biogenesis in zebrafish neurons
|
|
PAR3-mediated coordination of hepatocyte proliferation, maturation, and architecture in liver development and regeneration
|
|
Glycosphingolipids regulate phosphatidylserine transport machinery that operates at ER-PM contact sites
|
|
Nitrate-Sialin2 axis couples ER-mitochondrial calcium signaling with fatty acid metabolism to drive white adipose browning
|
|
Corylin promotes healthy aging via RAGA–mTOR suppression and sex-dependent activation of SIRT3
|
|
SEC14L2 couples chaperone-mediated autophagy to microtubule stability by targeting Stathmin 1
|
|
O-linked glycan-dependent gating of TPC2 controls lysosomal excitability and organelle remodeling
|
|
Structural insights into YheS-mediated release of SecM-arrested ribosome
|
|
Structural basis of insulin receptor antagonism by bivalent site 1-site 2 ligands S961 and Ins-AC-S2
|
|
Cell-to-cell variability and gain of methylation at polycomb CpG islands as a hallmark of aging
|
|
Mapping DNA glycosylase binding across lesion sequence contexts reveals extended sequence and structural recognition logic
|
|
Ameliorating calcium homeostasis improves longevity and healthspan in progeroid and naturally aged mice
|
|
AMC-F1 regulates mitochondria-autophagy crosstalk independent of nutrient stress
|
|
TDP-43 oxidation and PP1 crosstalk at RNA granule-mitochondria contact sites
|
|
Co-enrichment of proteins in extracellular vesicles
|
|
GPI‑anchored protein nanoclusters license migrasome expansion and serve as exocytic platforms for migrasome
|
|
ATP is dispensable for E. coli DNA replication and eukaryotic helicase activity
|
|
Structural dynamics of kappa opioid receptor interactions with β-arrestin 1
|
|
The mannosyltransferase DPM1 regulates the activity of ER-stress sensor IRE1 in colorectal cancer
|
|
Asymmetric attrition and secondary chromosome destabilization after double-strand breaks in human embryonic development
|
|
Targeting hypothalamic SIK3 to promote weight loss and improve glycemic control in mice
|
|
Structural basis for uracil removal from DNA by human SMUG1
|
|
Fmp30p is a mitochondrial phosphatidylinositol hydrolase that modulates CoQ biosynthesis
|
|
CryoWriter: a robotic solution for improved Cryo-EM grid preparation
|
|
Structure-based screening and a conformational biosensor identify a GPR183 inverse agonist and an activation switch
|
|
Improving protein and protein interactions using pseudo-dimers derived from monomeric proteins
|
|
Non-diffusive slow heat dissipation induces high local temperature in living cells
|
|
Deciphering cytokine-driven ADP-ribosylation signaling networks via Af1521-based mass spectrometry analysis of labile Glu/Asp-linkages
|
|
Open-channel block of human TRPV6 by polyamine spermine
|
|
RNAs anchoring replication complex control initiation and firing of DNA replication
|
|
Early hexapod genomes reveal the deep origin of insect gustatory and odorant receptors
|
|
Pathogenic variants in the autophagy-tethering factor EPG5 drive neurodegeneration through mitochondrial dysfunction and innate immune activation
|
|
Small extracellular vesicle signaling and mitochondrial transfer reprogram T helper cell function in human asthma
|
|
A pivotal Wnt antagonist role promoting digit joint specification by constraining Wnt activity
|
|
Measuring morphogen transport over multiple spatial scales in live zebrafish embryos
|
|
De novo design of DNA origami with a generative diffusion model
|
|
Reconstructing calcium conductance in MCUb illuminates its molecular design for tuning the mitochondrial calcium uniporter
|
|
Cryo-EM Structure of the TRPC1/5 Heteromer Enables Design of Antidepressant and Anxiolytic Drug with Reduced Side Effects
|
|
Combined biosynthesis and site-specific incorporation of phenylalanine derivatives from aryl aldehydes or carboxylic acids
|
|
Chaperone-mediated autophagy is required for regulatory T cell function
|
|
A Rahman Syndrome mutation in histone H1.4 disrupts chromatin compaction and phase separation
|
|
Long-term temporal stability of circulating proteins in older adults
|
|
DepoCatalog: mapping diversity of 129 recombinantly produced Klebsiella phage depolymerases
|
|
Amino acid-based biological age clock and its implications for human health and aging
|
|
Structural basis and physiological significance of non-canonical G coupling to the melatonin MT receptor
|
|
N-glycopedia: libraries for native N-glycan structural analysis
|
|
Dynamic regulation of origin firing factors links CDK activity to dormant origin activation
|
|
Blockade of NKp46⁻ CCR6⁻ ILC3 autophagy protects against necrotizing enterocolitis by restoring energy metabolism balance in mice
|
|
DNA-PK-mediated CRTC2 phosphorylation promotes NHEJ and suppresses antitumor immunity via relocation to repair complexes
|
|
Diverse mechanisms of translation arrest by a Clostridia ribosome stalling peptide CliM
|
|
DKC1 promotes colorectal cancer progression and therapy resistance by dysregulating sphingolipid biosynthesis
|
|
EMReady2: improvement of cryo-EM and cryo-ET maps by local quality-aware deep learning with Mamba
|
|
Visualization of the complete preprimosome reveals the structural mechanisms governing DNA replication restart
|
|
PromoterAtlas: decoding regulatory sequences across Gammaproteobacteria using a transformer model
|
|
Perivascular adipose single-cell atlas identifies CD55+ adipose-derived stem cells as vascular remodeling regulators in atherosclerosis
|
|
SIRT6 overexpression counteracts chromatin aging in the male murine liver
|
|
A dual phospholipase system instructs membrane hydrolysis during the final stages of plant autophagy
|
|
TBK1 restricts IRGQ-mediated autophagy
|
|
Mechano-metabolic feedback connects tissue fluidity to mitochondrial DNA–dependent immunity in breast cancer
|
|
Site-specific glycosylation of Sec24D and myoferlin recruit ERGIC to ER exit sites for collagen trafficking
|
|
Structural basis of Ku-mediated activation of WRN exonuclease activity
|
|
Structural basis for prohibitin-mediated regulation of mitochondrial m-AAA protease
|
|
Multiscale machine learning molecular mechanics for mechanism and stereoselectivity of Diels-Alderase catalysis
|
|
A divergent Plasmodium NEK4 acts as a key regulator driving the early events of meiosis
|
|
Identification and quantification of intracellular N-acetylglucosamine modified glycoRNAs
|
|
Intra-mitochondrial glycolysis maintains mitochondrial function and underlies the pathogenesis of retinitis pigmentosa
|
|
Two-dimensional HRS condensates drive the assembly of flat clathrin lattices on endosomes
|
|
Condensin I but not Condensin II is crucial for mitotic chromosome mechanics
|
|
Structural basis for positive allosteric regulation of CB2 receptor
|
|
Subtype-dependent arrestin engagement of the metabotropic glutamate receptors
|
|
Synthesis of sialylated human milk oligosaccharides by automated glycan assembly
|
|
ZO-1 shuttles between apical junctional complexes and podosomes by riding ERK activation waves
|
|
MXene membrane with directionally functionalized channel entrances for enhanced ion selectivity and permeability
|
|
A mutational scar-based genome-wide map of DNA double-strand break repair
|
|
Endosome maturation is orchestrated by inside-out proton signaling through a Na/H exchanger and pH-dependent Rab GTPase cycling
|
|
Glycosite mapping and in situ mass spectrometry imaging of MUC2 glycopeptides via on-slide mucinase digestion
|
|
CCDC120 phase separation contributes to desmosomal integrity and cardiac function
|
|
Evolutionary remodeling of ubiquinone biosynthesis in Toxoplasma gondii reveals an essential bi-functional monooxygenase
|
|
Triose phosphate isomerase 1 remodels mitochondrial cristae ultrastructure to rewire microglial immunometabolism against ischemic stroke
|
|
Mitochondria serve as a holdout compartment for aggregation-prone proteins hindering efficient degradation
|
|
Selective positive allosteric modulation of β2AR using antibody fragments targeting the third intracellular loop
|
|
A single-cell atlas revealing cellular heterogeneity across healthy and diseased human thymus
|
|
Targeting coupling of type H-like vessels and cell fate transition to delay soft tissue aging
|
|
Global mitochondrial connectivity map reveals the landscape of yeast functional assemblies and conserved protein communities
|
|
AAK1-mediated phosphorylation of PDLIM5 and Talin1 promotes focal adhesion disassembly to accelerate cell migration
|
|
Structural basis for transport and inhibition of nucleotide sugar transport in pathogenic fungi
|
|
Single-molecule kinetic exploration of functional sub-states in an evolving phosphotriesterase
|
|
Creating highly active fluoroacetate dehalogenases via gate-based synergetic chain design
|
|
Networked salt-bridges mediate magnesium-dependent conformational dynamics and functional regulation in type IA topoisomerases
|
|
Acetylation of STX17 promotes its autophagosomal translocation
|
|
(-)-Englerin A binding to human TRPC5 exposes an aromatic interaction network in channel activation
|
|
SIRT7 links H3K36ac epigenetic regulation with genome maintenance in the mouse testis
|
|
Proteasome alteration between epithelial and hematopoietic cells facilitates positive selection of CD8 T cells
|
|
Mining of natural diversity enables efficient and expressible peptide asparaginyl ligases
|
|
Sarcopenia promotes tumorigenesis by disrupting NOTCH-SDC2-regulated biogenesis of muscle-derived extracellular vesicles
|
|
Structural basis for phosphorylation and allosteric regulation of bacterial glycogen phosphorylase by histidine phosphocarrier protein
|
|
Probing molecular diversity and ultrastructure of brain cells with fluorescent aptamers
|
|
An atlas of human siglecs integrates expression, affinity, and cis/trans sialoglycan recognition profiles
|
|
Core conformation of arrestin coupling to parathyroid hormone type 1 receptor
|
|
AcuB senses cellular energy charge to coordinate acetyl-CoA synthesis in bacteria
|
|
High-throughput single-vesicle imaging platform for direct extracellular vesicle profiling of human plasma
|
|
Molecular mechanisms of native ligand selectivity in catecholamine G protein-coupled receptors
|
|
Loss of DNA methyltransferase 3a enhances Caspase-8 transcription and promotes cardiomyocyte pyroptosis during myocardial infarction
|
|
An in vitro approach for simulating divergent Golgi O-glycosylation of tumor-associated MUC1 from normal MUC1
|
|
Transplantation of active mitochondria condensed in liquid–liquid phase-separated hydrogels ameliorates myocardial ischemia-reperfusion injury
|
|
Mitochondrial respirasome-like supercomplexes support metabolic flexibility in yeast
|
|
The vault associates with membranes in situ
|
|
Seven complete comparative maps of allosteric mutations in a protein family
|
|
Structural basis of QueC-family protein function in qatABCD anti-phage defense
|
|
DNA deformability in sequence-dependent capture of E. coli gyrase
|
|
Aging-associated decline of phosphatidylcholine synthesis is a malleable trigger of natural mitochondrial aging
|
|
Activation mechanism of the full-length histidine kinase LvrB from pathogenic Leptospira
|
|
Structural basis for protein-free catalysis by ribonuclease P ribozyme
|
|
Shared structural mechanisms of alternating access between the secondary peptide transporter SbmA and ABC transporters
|
|
Loss of TMEM65 in mice causes mitochondrial disease mediated by mitochondrial Ca2+
|
|
High-resolution cryo-EM structures of small protein–ligand complexes near the theoretical size limit
|
|
Phage-assisted evolution of allosteric protein switches
|
|
A pore-forming toxin initiates ABI1 complex switching to promote bacterial cell-to-cell spread
|
|
Structural basis for allosteric regulation of mycobacterial guanosine 5´-monophosphate reductase by ATP and GTP
|
|
Slowed Gompertzian ageing in long-lived results from expansion of decrepitude, not decelerated ageing
|
|
Engineering of genetically encoded programmable calcium channel inhibitory binders
|
|
Adipocytes signal to recruit specific mRNAs from surrounding cells to restore expression deficits
|
|
Agonal cell resuscitation strategy to promote tissue repair
|
|
Combining structural modeling and deep learning to calculate the E. coli protein interactome and functional networks
|
|
PGC-derived migrasomes couple PGC proliferation with migration
|
|
Unveiling alternate pathways for SARS-CoV-2 infection via extracellular vesicle-mediated transfer of ACE2 and TMPRSS2
|
|
Increased WNT10B/FOXO6 signaling promotes cell fate transition in renal tubular cells to aggravate renal inflammation and fibrosis
|
|
Mechanism of lipid-dependent cold sensitivity in a model ion channel
|
|
MARCH2 prevents doxorubicin-induced cardiomyopathy by stabilizing NR1H2 and promoting clearance of apoptotic cardiomyocytes
|
|
Translation in proximity to forming autophagosomes during sustained autophagy
|
|
The integrated stress response suppresses PINK1-dependent mitophagy by preserving mitochondrial import efficiency
|
|
Steric hindrance-mediated extracellular vesicle size fractionation for rapid prehospital diagnosis of intracerebral hemorrhage
|
|
RPS19 and RPL5 haploinsufficient models reveal divergent ribosomal subunit controls of fetal hematopoiesis
|
|
Bacterial extracellular vesicles as recyclable nutrient reservoirs
|
|
Structural basis of GAIN domain autoproteolysis and cleavage-resistance in the adhesion G-protein coupled receptors
|
|
VPS26A retromer complex and SNX27 mediate stress-induced Golgi bypass of membrane proteins
|
|
Circulating extracellular vesicle microRNAs mediate immune modulation of social behavior in male mice
|
|
Dynamic monomer-dimer transition in ligand-induced apelin receptor activation
|
|
A highly limited amino acid library from asteroid Bennu yields wide-ranging protein folds
|
|
ß-adrenergic-like signalling engages CrebB in Drosophila gut to promote female longevity
|
|
Linking multipoint folding and stability with functional regulation in the mitochondrial transmembrane β-barrel Sam50
|
|
Inhibition of adipocyte RUNX1/2 enhances adipose tissue thermogenesis through distinct mechanisms
|
|
Th17 cells require the DNA repair sensor xeroderma pigmentosum complementation Group C to control oxidative DNA damage in a murine model
|
|
Immune-deficient bacteria serve as gateways to genetic exchange and microbial evolution
|
|
Stereoselectivity and functional plasticity of a common ligand-binding pocket in TRPM3
|
|
Interplay of SLC33A1-dependent and -independent Golgi sialic acid -acetylation in CASD1 catalysis
|
|
The genetic architecture of an allosteric hormone receptor
|
|
Sulfatase modifying factors control the timing of zebrafish convergence and extension morphogenesis
|
|
Mapping human pre-rRNA processing and modification at single nucleotide resolution using long read nanopore sequencing
|
|
A pathogenic Tau mutation drives autophagy-lysosome dysfunction that limits Tau degradation in a model of frontotemporal dementia
|
|
Archaeal and eukaryotic MCM rings sequentially melt DNA for replication initiation
|
|
Single-molecule dynamics reveal ATP binding alone powers substrate translocation by an ABC transporter
|
|
Nucleophagy is promoted by two autophagy receptors and inhibited by chromatin-nuclear envelope tethering in fission yeast
|
|
Homoharringtonine exhibits senotherapeutic activity that mitigates diet- and age-associated obesity and insulin resistance and extends lifespan in mice
|
|
Mutant ribosomal protein RPS15 drives B cell malignancy through oxidative stress and genomic instability
|
|
Mad1 facilitates α5 integrin trafficking from the Golgi to promote abscission during cytokinesis
|
|
Deep homology and design of proteasome chaperone proteins in Candidozyma auris
|
|
Lipid turnover and GEF recruitment collectively determine Rab5 recruitment and activation during the first step of early endosome formation
|
|
Dbf4-dependent kinase finetunes Ino80 function at chromosome replication origins
|
|
NorQD AAA+ complex drives metal insertion by a twisting mechanism
|
|
Energetic diversity in retinal ganglion cells is modulated by neuronal activity and correlates with resilience to degeneration
|
|
Structural dynamics of the midnolin-proteasome during ubiquitin-independent substrate turnover
|
|
Aurka-Bhlhe41 axis prevents premature aging-like microglial dysfunction and promotes remyelination
|
|
Formation of S- and Z-twist supramolecular micro-ropes by peptide stereoisomers
|
|
Ceramide disrupts TM9SF2-PGK1 axis to redirect PD-L1 trafficking and enhance antitumor immunity
|
|
Amplifying metabolic profiling of extracellular vesicle dynamics with ACTIVITY
|
|
Atlas of predicted protein complex structures across kingdoms
|
|
Therapeutic potential of dihydronicotinamide riboside (NRH) on obesity and glucose intolerance in mice
|
|
RanBP2-dependent annulate lamellae drive nuclear pore assembly and nuclear expansion
|
|
Substrate-interacting pore loops of two ATPase subunits determine the degradation efficiency of the 26S proteasome
|
|
Structural transitions in the stepwise assembly of proteasome core particles
|
|
GREM1 acts in leptin receptor-expressing skeletal cells to mediate peri-implant fibrosis
|
|
RFC4 drives temozolomide resistance in glioblastoma by activating STK38-BECN1-dependent autophagy
|
|
Functional and structural basis of a negative allostery within GABA hetero-tetramers
|
|
Cooperativity in E. coli aspartate transcarbamoylase is tuned by allosteric breathing
|
|
Structural basis of the cyclin Y/14-3-3 protein-mediated activation of CDK16
|
|
Ultrathin crown ether-based polyamide membrane for ion-ion separations
|
|
Parkinson’s disease-associated PLA2G6 protects IP3R1 protein to control ER-mitochondria tethering and Ca2+ transfer
|
|
Cryo-EM structure of TRPM1 reveals a non-canonical architecture with an inverted transmembrane domain
|
|
StrucGAP: a modular, streamlined and traceable data mining platform for structural and site-specific glycoproteomics
|
|
Functional protein design and enhancement with ontology reinforcement iteration
|
|
Enhancing the performance of Magnets photosensors
|
|
Molecular mechanism of menthol-induced TRPV5 channel inhibition
|
|
Chromatin reorganization drives overexpression of a Btaf1 variant underpinning hematopoietic aging
|
|
Calcium-mediated calreticulin-IRE1α interaction drives dynamic fluctuation of IRE1α activity under chronic endoplasmic reticulum stress
|
|
Structures of respiratory supercomplexes and ATP synthase oligomers in mammalian mitochondrial inner membrane
|
|
Phosphoregulation of the novel hemi-arrestin MAPK scaffold Sms1 prevents untimely mating
|
|
Synchronous activation of striatal cholinergic interneurons induces local serotonin release
|
|
A model for drug transport across two membranes of Gram-negative bacteria by an MFS tripartite assembly
|
|
MFF budding from mitochondria regulates melanosome size and maturation
|
|
Control of lysosome function by the GTPase-activating protein TBC1D9B and its binding partner TMEM55B
|
|
The COP1-ADA2b module mediates light regulation of DNA double-strand break repair in Arabidopsis
|
|
Structural basis and regulation of GSDME pore formation
|
|
Structure of a pH-sensitive pentameric ligand-gated ion channel from the Sarcoptes scabies mite
|
|
Impaired -Synuclein aggregate clearance in neuronal cells drive their spread to microglia through tunneling nanotubes
|
|
Lifestyle change accelerates epigenetic ageing in King penguins
|
|
Molecular insights into the regulation of GNPTαβ by LYSET
|
|
Extracellular vesicle engineering using a small scaffold protein
|
|
Spatial cartography of human thymus enables the geopositioning of lineage transcription factors in rare mimetic thymic epithelial cells
|
|
CF2H: a cell-free two-hybrid platform for rapid protein binder screening
|
|
Unbiased recording and identification of thymic cellular interactomes using synthetic Notch receptors
|
|
Structural and mechanistic insights into the dual-nuclease defense protein Upx as an anti-phage system
|
|
CryoEM structure of mGlu6 captures receptor activation prior to G protein coupling
|
|
Accelerated discovery of highly active enzyme nanohybrids with parallelized Bayesian optimization in hybrid space
|
|
STIM1-Mitofusin2 interactions tether mitochondria and melanosome contacts that promote melanosome maturation
|
|
CPF-CF-terminated snoRNAs shuttle through the cytoplasm via an mRNA guard protein-mediated surveillance mechanism
|
|
Adaptations in tubulin determine distinct microtubule architectures, mechanics and drug susceptibility
|
|
Design-driven optimization of low-cost reagent formulations for reproducible and high-yielding cell-free gene expression
|
|
Swapped and non-swapped TRAAK states co-exist in membranes at a ratio influenced by temperature
|
|
Site-specific profiling of structure and function of Igµ B cell receptor glycans
|
|
Post-catalysis structures of mitochondrial complex I with ubiquinol-10 bound in the active site
|
|
Pharmacological stabilization of hypoxia-inducible factor 1-α dampens the interferon response and promotes glycolysis in Aicardi-Goutières syndrome
|
|
Cross-species gene redesign leveraging ortholog information and generative modeling
|
|
Velocity sensitivity of mechanotransduction in the afferent terminal underlies vibration detection in the Pacinian corpuscle
|
|
TIGAR regulates intestinal mucus barrier integrity by inhibiting lactylation of G6PD/6PGD in ulcerative colitis
|
|
Structural heterogeneity and substrate engagement mechanism of the bacterial proteasome activator Bpa
|
|
Rab14 restricts pathogens by promoting V-ATPase lysosomal delivery to drive lysosomal acidification
|
|
Allosteric activation of the glutamate receptor mGlu2 by the serotonin receptor 5-HT
|
|
A heteromeric TRP channel that functions as a WNT-activated G protein-coupled receptor
|
|
ARK1 regulates spindle formation during atypical mitosis and forms a divergent chromosomal passenger complex
|
|
Identification and engineering of highly functional potyviral proteases in cells using co-evolutionary models
|
|
Decoding the substrate specificity landscape of a promiscuous enzyme through multi-substrate mutational scanning
|
|
Analysis and control of untemplated DNA polymerase activity for guided synthesis of kilobase-scale DNA sequences
|
|
An information theory approach to quantifying the sequence-dependent response of nucleic acid motors with applications to nanopore DNA sequencing
|
|
Harnessing a germ‑free mouse gut bioreactor for directed evolution of probiotics to combat non-alcoholic fatty liver disease
|
|
Villification of the intestinal epithelium is driven by Foxl1 through activation of PDGFRα and BMPs
|
|
DNA-PK-mediated phosphorylation of STAT6 establishes a non-canonical type 2 immunity axis to prevent macrophage senescence
|
|
Engineering LmrR protein for L-proline-based asymmetric aldol biocatalysis
|
|
A protein adaptor mediating Ap4A-dependent control of protein acetylation
|
|
Structural and dynamic insights into agonist recognition and function of the thromboxane A receptor
|
|
Non-hydrolyzable acetyllysine analogs to study protein acetylation in vitro and in cells
|
|
VAMP7-dependent late endosomal secretion of ER and mitochondrial proteins impacts the tumor microenvironment and macrophage engagement
|
|
Mechanism of beta-arrestin 1 mediated Src activation via Src SH3 domain revealed by cryo-electron microscopy
|
|
Epigenetic profiling of hematopoietic stem cells from male mice identifies KDR and PU.1 as regulators of aging transcriptome and caloric restriction response
|
|
From single-sequences to evolutionary trajectories: protein language models capture the evolutionary potential of SARS-CoV-2
|
|
Allosteric and energetic remodeling of a PDZ domain by protein domain extensions
|
|
Molecular insights into fungal inositol phosphorylceramide synthesis and its inhibition by antifungal aureobasidin A
|
|
Conformational biosensors delineate endosomal G protein regulation by GPCRs
|
|
Iron deficiency induces maturation-dependent loss of pancreatic β-cells
|
|
Supercoiled DNA recognition and cleavage control in topoisomerase VI
|
|
The clinical missense variant E282K in PPP3CA/calcineurin shifts substrate dephosphorylation by altering active site recruitment
|
|
Ligand-dependent Wnt signaling promotes gastric cancer metastasis through hyaluronan expression in microenvironment
|
|
Dual recruitment of two CCM2 molecules to KRIT1 suppresses KLF4 expression
|
|
Glycocalyx micro- and nanodomains in cell-cell and cell-matrix interactions revealed by enhanced click chemistry
|
|
Lack of MDA5 delays hematopoietic aging by modulating inflammaging and proteostasis in mice
|
|
Bioactive lipid-mediated structural and functional regulation of the essential human potassium channel Kir7.1
|
|
TANGO: Analysis and curation of particles in cryo-electron tomography
|
|
Interpretable and generative deep learning models explicate phase separating intrinsically disordered motifs
|
|
NAPRT-mediated deamidated NAD biosynthesis enhances colon tissue resiliency and suppresses tumorigenesis
|
|
An integrative structural biology approach reveals the dynamic organization of the R2SP quaternary chaperone complex
|
|
An equivariant pretrained transformer for unified 3D molecular representation learning
|
|
Molecular mechanisms of flotillin complexes in organizing membrane microdomains
|
|
Structural basis of TACO1-mediated efficient mitochondrial translation
|
|
Local PI(4,5)P2 synthesis by septin-associated PIPKIγ isoforms controls centralspindlin association with the midbody during cytokinesis
|
|
Molecular basis of collagen galactosylation by GLT25D1
|
|
FCHo2, not talin, enables inside-out activation of integrin ɑvβ5 in curved adhesions
|
|
Two-step voltage-sensor activation of the human K7.4 channel and effect of a deafness-associated mutation
|
|
Transient protein structure guides surface diffusion pathways for electron transport in membrane supercomplexes
|
|
FGF 13 functions as a regulator of the ERK/aerobic glycolysis axis in the inflammatory state during septic lung injury
|
|
The focal adhesion kinases regulate leptin action and the weight reducing effect of HDAC6 inhibition
|
|
Atomic resolution ensembles of intrinsically disordered proteins with Alphafold
|
|
Cytoplasmic NAD/H synthesis via NRK1 regulates inflammatory capacity and promotes survival of CD4 T cells
|
|
A multivalent adaptor mechanism drives the nuclear import of proteasomes
|
|
Insights into the structure and modulation of human TWIK-2
|
|
TMEM63 proteins act as mechanically activated cholesterol modulated lipid scramblases contributing to membrane mechano-resilience
|
|
Trustworthy prediction of enzyme commission numbers using a hierarchical interpretable transformer
|
|
Cryo-EM structures of human ClpXP reveal mechanisms of assembly and proteolytic activation
|
|
Molecular recognition of thyroglobulin by sortilin
|
|
Combinatory differentiation of human induced pluripotent stem cells generates functional thymic epithelium driving dendritic cell and CD4/CD8 T cell development
|
|
Ultrathin liquid cells for microsecond time-resolved cryo-EM
|
|
Single-cell atlas of human lung aging identifies cell type dyssynchrony and increased transcriptional entropy
|
|
A trans-synaptic IgLON adhesion molecular complex directly contacts and clusters a nicotinic receptor
|
|
Versican expression from lung fibroblasts suppresses pulmonary fibrosis
|
|
Dynamic signature of activity-stability tradeoff in lactamase evolution
|
|
A stochastic mechanism drives fast substrate translocation in the AAA+ machine ClpB
|
|
Protein folding stability estimation with explicit consideration of unfolded states
|
|
Large-scale serum glycomics tracks -glycosylation dynamics in hepatocellular carcinoma progression and enables early diagnosis
|
|
Regulation of AP1 adaptor assembly by the bi-handed chaperone MEA1
|
|
Functional and structural insights into interactions between β-Arrestin 1 and Gαs or Gαi1
|
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Integrative epigenetics and transcriptomics identify aging genes in human blood
|
|
Longitudinal analysis of body weight reveals homeostatic and adaptive traits linked to lifespan in diversity outbred mice
|
|
A small molecule VDAC ligand inhibits ERAD and induces selective cancer cell death via disruption of calcium homeostasis
|
|
Environmental enrichment and physical exercise prevent stress-induced social avoidance and blood-brain barrier alterations via Fgf2
|
|
OCT4 enhances the firing efficiency of late DNA replication origins in mouse embryonic stem cells
|
|
Tmem110 regulates the conformation of TRPML1 to maintain endolysosomal homeostasis and prevent mitochondrial DNA leakage and pathological self-DNA processing
|
|
Inactive ryanodine receptors sustain lysosomal availability for autophagy by promoting ER-lysosomal contact site formation
|
|
Sequence-based generative AI design of versatile tryptophan synthases
|
|
Mechanical rejuvenation of senescent stem cells and aged bone via chromatin remodeling
|
|
A comprehensive -glycoproteome atlas reveals tissue-specific glycan remodeling but non-random structural microheterogeneities
|
|
Reversible lipid-mediated pH-gating of connexin-46/50 by cryo-EM
|
|
Small molecule splicing modulators that disrupt O-GlcNAc homeostasis
|
|
Improved protein binder design using β-pairing targeted RFdiffusion
|
|
Structural basis for late maturation steps of mitochondrial respiratory chain complex IV within the human respirasome
|
|
Molecular mechanism of exchange coupling in CLC chloride/proton antiporters
|
|
A universal polyphosphate kinase powers in vitro transcription
|
|
Noncanonical calcium-independent TRPM4 activation governs intestinal fluid homeostasis
|
|
Time-resolved multiomics profiling reveals chromatin O-GlcNAc modification promotes senescence-associated transcriptional program
|
|
Spatiotemporal regulation of MKK4 dictates switch-like JNK activation and binary cell-fate decisions
|
|
Quantitative optical nanoscopy of mitochondrial-derived vesicles in neurons classifies pre-peroxisomal and clearing organelles
|
|
Structural basis for the subtype-selectivity of KCa2.2 channel activators
|
|
-GlcNAcylation of AMFR stabilizes TSPAN4 to regulate migrasome formation for viral release
|
|
Learning the language of protein-protein interactions
|
|
Stress-trained microalgae robots with probiotics backpack and intestinal brake for inflammatory bowel disease management
|
|
Measuring and locating the changes in protein structure using MELO
|
|
A disulfide redox switch mechanism regulates glycoside hydrolase function
|
|
Capsaicin diet drives gut inflammation and exosomal miR-17-3p elevation in idiopathic short stature
|
|
Structure of the Gq-coupled adhesion receptor ADGRL4
|
|
Geometry-preserving vector field reconstruction of high-dimensional cell-state dynamics using ddHodge
|
|
Comparing cryo-EM methods and molecular dynamics simulation to investigate heterogeneity in ligand-bound TRPV1
|
|
Integrated stress response inhibition prolongs the lifespan of a Pelizaeus-Merzbacher disease mouse model by increasing oligodendrocyte survival
|
|
Subcellular glycan-mannose receptor binding kinetics correlate with myeloid cell function
|
|
SREBP1-mediated lipogenesis promotes dedifferentiation and senescence of vascular smooth muscle cells through epigenetic remodeling
|
|
Stable de novo protein design via joint conformational landscape and sequence optimization
|
|
Leveraging engineered mitochondria through intercellular communication network for accelerated transport and delivery
|
|
Single-cell RNA sequencing reveals a quiescence-senescence continuum and distinct senotypes following chemotherapy
|
|
4EHP and NELF-E regulate physiological ATF4 induction and proteostasis in disease models of Drosophila
|
|
Structural insights into AQP3 channel closure upon pH and redox changes reveal an autoregulatory molecular mechanism
|
|
Endosome-phagophore linking assemblies for the degradation of membrane/extracellular proteins
|
|
Volatile and non-volatile pathogen cues shape host extracellular vesicles production in pre-infection response
|
|
Autophagic extracellular vesicles (AEVs) are distinct from exosomes and play crucial roles in viral infections
|
|
Generalizable and scalable protein stability prediction with rewired protein generative models
|
|
Structural determinants of non-covalent PPARγ inverse agonism and their therapeutic implications
|
|
Directed evolution of a TNA polymerase identifies independent paths to fidelity and catalysis
|
|
A small periplasmic protein governs broad physiological adaptations in Vibrio cholerae via regulation of the DbfRS two-component system
|
|
Molecular insights into ligand recognition and signaling of OXGR1
|
|
Real-time capture of domain movements during copper amine oxidase catalysis by mix-and-inject serial crystallography
|
|
3D-MINFLUX nanoscopy reveals distinct allosteric mechanisms for activation and modulation of PIEZO1 by Yoda1
|
|
TMEM65-dependent Ca2+ extrusion safeguards mitochondrial homeostasis
|
|
PhaseT3M: 3D imaging at 1.6 Å resolution via electron cryo-tomography with nonlinear phase retrieval
|
|
Characterization of the GTPγS release function of a G protein-coupled receptor
|
|
Enantioselective protein affinity selection mass spectrometry (E-ASMS)
|
|
TRIM37–PARP1–TET1 axis maintains stemness and prevents osteoporosis by inhibiting DNMT1 alternative splicing via 5hmC regulation
|
|
Calcium-sensitive synaptotagmin 11-lipid interaction modulates exo-endocytosis
|
|
The ribosome derives the energy to translocate and unwind mRNA from EF-G binding
|
|
An unbiased comparison of 14 epigenetic clocks in relation to 174 incident disease outcomes
|
|
VPS13B recruits lipid vesicles to promote mitochondrial fission and quality control
|
|
Molecular basis of XPF-ERCC1 targeting to SLX4-dependent DNA repair pathways
|
|
Complete structures of the YenTc holotoxin prepore and pore reveal the evolutionary basis for chitinase incorporation into ABC toxins
|
|
Slc22a17 governs postnatal neurogenesis by maintaining the iron homeostasis in hippocampus
|
|
Partial restoration of mitochondrial dysfunction by AAV-Ant1 protects from dilated cardiomyopathy in Ant1-/- plus mtDNA mutant mice
|
|
In silico docking yields small molecule negative allosteric modulators targeting the core of Frizzled 7
|
|
Structural characterisation of the fungal Pmt4 homodimer
|
|
ARMH4 accelerates aging by maintaining a positive-feedback growth signaling circuit
|
|
RHOA regulates mitochondria-ER contact sites through modulation of the VAPB/PTPIP51 tether
|
|
Activation of the RSAD2-YTHDF1 axis in smooth muscle causes inflammatory bowel disease via intercellular mitochondrial transfer
|
|
The microRNA miR-71 suppresses maladaptive UPR signaling through both cell-autonomous and cell-non-autonomous mechanisms
|
|
The non-catalytic DNA polymerase ε subunit is an NPF motif recognition protein
|
|
Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons
|
|
Engineering HLA-G-targeted extracellular vesicles nanoplatform for enhanced cancer therapy through precise cancer drug delivery
|
|
HIV-induced sialoglycans on infected CD4+ T cells promote immune evasion from myeloid cell-mediated killing
|
|
Sodium disrupts mitochondrial energy metabolism to execute NECSO
|
|
Targeting chaperone-mediated autophagy inhibits properties of glioblastoma stem cells and restores anti-tumor immunity
|
|
A novel long-galanin peptide from non-mammalian vertebrates mitigates the inflammatory response in IBD models via the biased GALR2/β-arrestin2 pathway
|
|
De novo sequencing of glycans by ion mobility-mass spectrometry using a self-expanding database
|
|
Cryo-correlative light and electron tomography of dopaminergic axonal varicosities reveals non-synaptic modulation of cortico-striatal synapses
|
|
LRRC59 cooperates with nuclear transporters to restrain the nuclear envelope repair machinery and safeguard genome integrity
|
|
Targeted imaging of specialized plant cell walls by improved cryo-CLEM and cryo-electron tomography
|
|
Structure-based design of macrocyclic peptides to generate functional antibodies against G protein-coupled receptors
|
|
Kap-centric Nsp1-mediated nuclear transport at full amino acid resolution
|
|
Conversion of N2 into oxadiazoles promoted by a multinuclear samarium complex
|
|
Mitochondria are absent from microglial processes performing surveillance, chemotaxis, and phagocytic engulfment
|
|
Collision-induced ribosome degradation driven by ribosome competition and translational perturbations
|
|
GlyContact analyzes glycan 3D structures at scale
|
|
Spatiotemporal coupling of caveolae mechanosensing and RhoA-GEFs regulates cell polarity and directional migration
|
|
Elevated intracellular copper induces CTR1 monomerization and prevents copper uptake
|
|
Revealing the genetic architectures underlying organ-specific aging based on proteomic data
|
|
Mechanistic insights into single-stranded DNA degradation by lysosomal exonucleases PLD3 and PLD4 from structural snapshots
|
|
Ran modulates allosteric crosstalk between importin β surfaces
|
|
Klebsiella ARO112 promotes microbiota recovery, pathobiont clearance and prevents inflammation in IBD mice
|
|
NRF1-mediated innate immune response drives inflammaging
|
|
Chemically-induced degradation of the endoplasmic-reticulum stress sensor IRE1 by a VHL-recruiting chimera
|
|
Multi-faceted roles of β-arrestins in G protein-coupled receptor endocytosis
|
|
Systematic profiling reveals distinct senescence signatures and regulators across human brain cell types
|
|
Tuning CAR-T cells by targeting cancer-associated glycan in pancreatic cancer
|
|
Structural basis of calcium-dependent C1ql1/BAI3 assemblies in synaptic connectivity
|
|
Molecular architecture of the human TRPC1/C5 heteromeric channel
|
|
Pla2g7 regulates bone homeostasis via Alox12/12-HETE/Gpr31 signaling axis
|
|
Reading the immune clock: a machine learning model predicts mouse immune age from cellular patterns
|
|
Ultra-large virtual screening unveils potent agonists of the neuromodulatory orphan receptor GPR139
|
|
Geminin inhibits DNA replication licensing by sterically blocking CDT1-MCM2 interactions
|
|
Dynamic changes in chloride homeostasis coordinate midbrain inhibitory network activity during reward learning
|
|
Efficient cellular transformation via protein delivery through the protrusion-derived extracellular vesicles
|
|
Structural mechanism of mRNA decoding by mammalian GTPase GTPBP1
|
|
Mitochondrial components secretion in extracellular vesicles promotes alveolar epithelial mitochondrial quality control
|
|
Lipid dependence of connexin-32 gap junction channel conformations
|
|
Bone homeostasis regulation by in vivo generation of osteoclast-derived apoptotic bodies using targeted self-assembly
|
|
The genetic and biochemical basis of human leading strand synthesis
|
|
Crystal structures and snapshots along Tpt1-catalyzed phosphate transfer from nucleic acid to NAD+
|
|
Apoptosis-resistant cells drive compensatory proliferation via cell-autonomous and non-autonomous functions of the initiator caspase Dronc
|
|
Molecular insights into species-specific ACE2 recognition of coronavirus HKU5
|
|
Benchmarking all-atom biomolecular structure prediction with FoldBench
|
|
Vacuolar-type H+-ATPase-mediated extra-organellar buffering resolves mitochondrial dysfunction
|
|
Development of a p62 biodegrader for autophagy targeted degradation
|
|
USP16 S-nitrosylation aggravates coronary microembolization-induced myocardial injury via repressing KDM1A-mediated glutathione homeostasis
|
|
Protein Kinase A and assembly of an ABCC4 protein network
|
|
Regulated TRESLIN-MTBP loading governs initiation zones and replication timing in human DNA replication
|
|
Tuneable ion selectivity in vermiculite membranes intercalated with unexchangeable ions
|
|
Understanding interspecies drug response variations between human and rodent P2X7 receptors
|
|
PolySUMOylation of PCNA and Rad52 restricts centromeric recombination in fission yeast
|
|
TMEM145 is a key stereociliary component in the link structures of outer hair cells and mediates the secretion of stereocilin and tubby
|
|
Ei24 deficiency in brown adipocytes induces severe hypothermia under cold stress independent of UCP1 activity
|
|
Computationally-designed aptamers targeting RAD51-BRCA2 interaction impair homologous recombination and induce synthetic lethality
|
|
Rapid estimation of protein folding pathways from sequence alone using AlphaFold2
|
|
GLYCO-BUILD: an enzymatic pipeline for the synthesis of peptides carrying eukaryotic N-glycans
|
|
Structural basis of sodium ion-dependent carnitine transport by OCTN2
|
|
Structure of an LGR dimer, an evolutionary predecessor of glycoprotein hormone receptors
|
|
In-situ cross-linking mass spectrometry reveals compartment-specific proteasomal interactions and structural heterogeneity
|
|
Disruption of the PIKfyve complex unveils an adaptive mechanism to promote lysosomal repair and mitochondrial homeostasis
|
|
Structural basis of menaquinone reduction by succinate dehydrogenase from Chloroflexus aurantiacus
|
|
Visualizing the translation landscape in human cells at high resolution
|
|
Mechanical confinement induces ferroptosis through mitochondrial dysfunction
|
|
ER exit sites mediated by the COPII adaptor sec24D selectively recruit lipid raft-preferring proteins for rapid ER export
|
|
Localized Wnt-signaling promotes asymmetric NuMA-dependent oriented divisions and unequal apportioning of mitochondria
|
|
Antibodies disrupt bacterial adhesion by ligand mimicry and allosteric interference
|
|
Ab-initio amino acid sequence design from protein text description with ProtDAT
|
|
The neuropathy-linked protein TECPR2 is a Rab5 effector that regulates cargo recycling from early endosomes
|
|
Osmotic pressure regulates DNA labelling and transcription with dCas9-SunTag system in live cells
|
|
Investigating the neuronal role of the proteasomal ATPase subunit gene in neurodevelopmental proteasomopathies
|
|
Cyclin CLB2 mRNA localization and protein synthesis link cell cycle progression to bud growth
|
|
Impact of anionic lipids on the energy landscape of conformational transition in anion exchanger 1 (AE1)
|
|
Torsion is a dynamic regulator of DNA replication stalling and reactivation
|
|
Adherent cells sustain membrane tension gradients independently of migration
|
|
Acceleration, simplification and potential parallelization of digital polymers sequencing by coupling tandem mass spectrometry with ion mobility
|
|
Live imaging and functional characterization of the avian hypoblast redefine the mechanisms of primitive streak induction
|
|
The SMC Hinge is a Selective Gate for Obstacle Bypass
|
|
Latent-TGF-β has a domain swapped architecture
|
|
Phosphorylation-coupled autoregulation of TANGO1 and Sec16A maintains functional ER exit sites
|
|
53BP1-RIF1 and DNA-PKcs show distinct genetic interactions with diverse chromosomal break repair outcomes
|
|
Phosphatase specificity influences phosphorylation timing of CDK substrates during the cell cycle
|
|
Drug-bound outward-facing conformation of a heterodimeric ABC exporter suggests a putative mechanism of drug translocation
|
|
Structural basis of lipopolysaccharide assembly by the outer membrane translocon holo-complex
|
|
mRNABERT: advancing mRNA sequence design with a universal language model and comprehensive dataset
|
|
The implications of alternative splicing regulation for maximum lifespan
|
|
GlycoGenius: a streamlined high-throughput glycan composition identification tool
|
|
Live-cell quantitative monitoring reveals distinct, high-affinity Gβγ regulations of GIRK2 and GIRK1/2 channels
|
|
Protein Set Transformer: a protein-based genome language model to power high-diversity viromics
|
|
Disentangling the mechanistic role of loop-C capping in Cys-loop receptor activation
|
|
Topoisomerase IIb binding delineates localized mutational processes and driver mutations in cancer genomes
|
|
The zinc finger of DNA ligase 3α binds to nucleosomes via an arginine anchor
|
|
Spermine modulation of Alzheimer’s Tau and Parkinson’s α-synuclein: implications for biomolecular condensation and neurodegeneration
|
|
Engineered chromatin readers track damaged chromatin dynamics in live cells and animals
|
|
Cryo-electron microscopy reveals sequential binding and activation of Ryanodine Receptors by statin triplets
|
|
Mycobacterium tuberculosis overcomes phosphate starvation by extensively remodelling its lipidome with phosphorus-free lipids
|
|
The dynamic lateral gate of the mitochondrial β-barrel biogenesis machinery is blocked by darobactin A
|
|
Deciphering the timing and impact of life-extending interventions: temporal efficacy profiler distinguishes early, midlife, and senescence phase efficacies
|
|
Enhancing functional proteins through multimodal inverse folding with ABACUS-T
|
|
High-accuracy protein complex structure modeling based on sequence-derived structure complementarity
|
|
Positional programs in early murine facial development and their role in human facial shape variability
|
|
RIOK2 kinase regulates the translocation of the FADD–RIPK1–Caspase-8 complex to the ER and the cleavage of Gasdermin D to drive pyroptosis
|
|
Mechanochemical mechanism underlying intercellular Ca2+ wave propagation and its crucial role in apoptotic cell extrusion
|
|
Fibroblast growth factor signaling induces a chondrocyte-like state of peripheral nerve fibroblast during aging
|
|
A composite motif in calcimembrin/C16orf74 dictates multimeric dephosphorylation by calcineurin
|
|
DAF-16/FOXO and HLH-30/TFEB comprise a cooperative regulatory axis controlling tubular lysosome induction in C. elegans
|
|
GABA-independent activation of GABAB receptor by mechanical forces
|
|
Lysosomal and mTORC1 signaling dysregulation underpin the pathology of spastic paraplegia type 80
|
|
A mitochondria-targeted fluoropolymer nanoparticle with inherent mitophagy-inducing and red fluorescence properties for treatment of atherosclerosis
|
|
Extracellular filaments revealed by affinity capture cryogenic-electron tomography
|
|
Mechanism of Arp2/3 complex branch disassembly by human Coro7
|
|
The locking mechanism of human TRPV6 inhibition by intracellular magnesium
|
|
Structural insights into antagonist recognition by the vasopressin V2 receptor
|
|
Pmt4 recognizes two separate acceptor sites to O-mannosylate in the S/T-rich regions of substrate proteins
|
|
Elevating cytosolic NADPH metabolism in endothelial cells ameliorates vascular aging
|
|
A special latch in yeast mitofusin guarantees mitochondrial fusion by stabilizing self-assembly
|
|
SND3 is the membrane insertase within a distinct SEC61 translocon complex
|
|
Selective silencing of antibiotic-tethered ribosomes as a resistance mechanism against aminoglycosides
|
|
Structure and activation of the Drosophila insulin receptor by three Drosophila insulin-like peptides
|
|
Structural basis of apoptosis induction by the mitochondrial voltage-dependent anion channel
|
|
Super mitochondria-enriched extracellular vesicles enable enhanced mitochondria transfer
|
|
Spatial N-glycan rearrangement on α5β1 integrin nucleates galectin-3 oligomers to determine endocytic fate
|
|
Large transient assemblies of Apaf1 constitute the apoptosome in cells
|
|
Global comparative structural analysis of responses to protein phosphorylation
|
|
Oligomeric HIV-1 integrase structures reveal functional plasticity for intasome assembly and RNA binding
|
|
Engineering unnatural cells with a 21st amino acid as a living epigenetic sensor
|
|
Niche-associated Type IV collagen promotes GLP-1/Notch receptor activation in the C. elegans germline
|
|
Structural mechanisms of assembly, gating, and calmodulin modulation of human olfactory CNG channel
|
|
Correlative voltage imaging and cryo-electron tomography bridge neuronal activity and molecular structure
|
|
Structural mechanism of the agonist binding on human TRPC3 channel
|
|
And-1 coordinates with polymerase δ to regulate nucleotide excision repair and UVB-induced skin tumorigenesis
|
|
Optineurin is an adaptor protein for ubiquitinated substrates in Golgi membrane-associated degradation
|
|
Signal-strapping as a protein-sequence search method for the discovery of metalloproteins
|
|
Cetacean loss of the master adipose tissue regulator β3-adrenergic receptor may underlie their thick blubber and an Oligocene radiation and dispersal
|
|
Visualization of lysosomal membrane proteins by cryo electron tomography
|
|
Structural basis of K11/K48-branched ubiquitin chain recognition by the human 26S proteasome
|
|
Of condensates and coats - reciprocal regulation of clathrin assembly and the growth of protein networks
|
|
The formation of the ‘footprint of death’ as a mechanism for generating large substrate-bound extracellular vesicles that mark the site of cell death
|
|
A basal body microtubule singlet-to-doublet transition in Plasmodium male gametogenesis
|
|
The G1/S transition in mammalian stem cells in vivo is autonomously regulated by cell size
|
|
ALKBH8-mediated codon-specific translation promotes colorectal tumorigenesis
|
|
Munc13-4 mediates tumor immune evasion by regulating the sorting and secretion of PD-L1 via exosomes
|
|
ProFlex as a linguistic bridge for decoding protein dynamics in normal mode analysis
|
|
Dual-ligand engineered exosome regulates WNT signaling activation to promote liver repair and regeneration
|
|
Cardiomyocyte lncRNA Cpat maintains cardiac homeostasis and mitochondria function by targeting citrate synthase acetylation
|
|
Gene expression composite scores of cellular senescence predict aging health outcomes in the Health and Retirement Study
|
|
A model for membrane curvature generation by caveolin discs driven by differential contact interaction
|
|
Quantitative cellular characterization of extracellular mitochondria uptake and delivery
|
|
Molecular bases of the interactions of ATG16L1 with FIP200 and ATG8 family proteins
|
|
LARGE1 processively polymerizes length-controlled matriglycan on prodystroglycan
|
|
Structural insights into the mechanism of activation and inhibition of the prostaglandin D2 receptor 1
|
|
Data-driven fine-grained region discovery in the mouse brain with transformers
|
|
Sensitive, high-throughput, metabolic analysis by molecular sensors on the membrane surface of mother yeast cells
|
|
Investigating whether deep learning models for co-folding learn the physics of protein-ligand interactions
|
|
Template Learning: Deep learning with domain randomization for particle picking in cryo-electron tomography
|
|
Multi-domain O-GlcNAcase structures reveal allosteric regulatory mechanisms
|
|
Dynamic rigidity changes enable rapid cell migration on soft substrates
|
|
Identification of a RAB32-LRMDA-Commander membrane trafficking complex reveals the molecular mechanism of human oculocutaneous albinism type 7
|
|
Stabilized D2R G protein-coupled receptor oligomers identify multi-state β-arrestin complexes
|
|
Bacterial RNA promotes proteostasis through inter-tissue communication in C. elegans
|
|
Self-cleavage of the GAIN domain of adhesion G protein-coupled receptors requires multiple domain-extrinsic factors
|
|
SARST2 high-throughput and resource-efficient protein structure alignment against massive databases
|
|
Design and evolution of artificial enzyme with in-situ biosynthesized non-canonical amino acid
|
|
HSP90 differentially stabilizes plant ABCB-type auxin transporters on the plasma membrane
|
|
MSL10 is a high-sensitivity mechanosensor in the tactile sense of the Venus flytrap
|
|
Calmodulin binding is required for calcium mediated TRPA1 desensitization
|
|
Distal mutations enhance catalysis in designed enzymes by facilitating substrate binding and product release
|
|
A robust platform streamlining aromatic noncanonical amino acid biosynthesis and genetic code expansion in Escherichia coli
|
|
Harnessing indole scaffolds to identify small-molecule IRE1α inhibitors modulating XBP1 mRNA splicing
|
|
EXO1 as a therapeutic target for Fanconi Anaemia, ZRSR2 and BRCA1-A complex deficient cancers
|
|
Mechanical control of cell fate decisions in the skin epidermis
|
|
V-ATPase-dependent induction of selective autophagy
|
|
A domain-swapped CaMKII conformation facilitates linker-mediated allosteric regulation
|
|
MRAP2 modifies the signaling and oligomerization state of the melanocortin-4 receptor
|
|
The shutdown of food digestion due to endoplasmic reticulum homeostasis disruption acts as a protective mechanism in C. elegans
|
|
Structural basis for ligand promiscuity and high signaling activity of Kaposi’s Sarcoma-associated Herpesvirus-encoded GPCR
|
|
Structural remodeling of target-SNARE protein complexes by NSF enables synaptic transmission
|
|
Clinical implications of bone marrow adiposity identified by phenome-wide association and Mendelian randomization in the UK Biobank
|
|
Repeatability of protein structural evolution following convergent gene fusions
|
|
Transient ligand contacts of the intrinsically disordered N-terminus of neuropeptide Y receptor regulate arrestin-3 recruitment
|
|
Structural basis for DNA break sensing by human MRE11-RAD50-NBS1 and its regulation by telomeric factor TRF2
|
|
Temporal control of human DNA replication licensing by CDK4/6-RB signalling and chemical genetics
|
|
The DNA replication machinery transmits dual signals to prevent unscheduled licensing and execution of centrosome duplication
|
|
A reconfigurable piezo-ionotropic polymer membrane for sustainable multi-resonance acoustic sensing
|
|
Human protein synthesis requires aminoacyl-tRNA pivoting during proofreading
|
|
Temporal transcriptional regulation of mitochondrial morphology primes activity-dependent circuit connectivity
|
|
Cardiomyocyte mitochondrial mono-ADP-ribosylation dictates cardiac tolerance to sepsis by configuring bioenergetic reserve in male mice
|
|
Evidence that mitochondria in macrophages are destroyed by microautophagy
|
|
Enhanced enzyme stability at the interphase of water-oil for continuous-flow olefin epoxidation
|
|
Remodeling adipocytes’ lipid metabolism with a polycation loaded enzyme-active framework reverses osteoporotic bone marrow
|
|
Mechanism and function of GPR3 regulated by a negative allosteric modulator
|
|
Heme allocation in eukaryotic cells relies on mitochondrial heme export through FLVCR1b to cytosolic GAPDH
|
|
DeFrND: detergent-free reconstitution into native nanodiscs with designer membrane scaffold peptides
|
|
Epsin1 enforces a condensation-dependent checkpoint for ubiquitylated cargo during clathrin-mediated endocytosis
|
|
Large protein databases reveal structural complementarity and functional locality
|
|
An iPSC-based in vitro model recapitulates human thymic epithelial development and multi-lineage specification
|
|
Fishing out AIEC with FimH capturing microgels for inflammatory bowel disease treatment
|
|
Probiotic acoustic biosensors for noninvasive imaging of gut inflammation
|
|
Ankyrin-B modulates mitochondrial fission in skeletal muscle and is required for optimal endurance exercise capacity
|
|
Modeling of T cell-mediated autoimmune pituitary disease using human induced pluripotent stem cell-originated organoid
|
|
Dual mitotic bookmarking by GAF and H3K27ac orchestrates differential propagation of cell fate memory in neural development
|
|
The cAMP-PKA signaling initiates mitosis by phosphorylating Bora
|
|
A repurposed AMP binding domain reveals mitochondrial protein AMPylation as a regulator of cellular metabolism
|
|
Mechanosensitive channel engineering: A study on the mixing and matching of YnaI and MscS sensor paddles and pores
|
|
Molecular insights of acarbose metabolization catalyzed by acarbose-preferred glucosidase
|
|
Promiscuous and multivalent interactions between Eps15 and partner protein Dab2 generate a complex interaction network
|
|
Control of Golgi- V-ATPase through Sac1-dependent co-regulation of PI(4)P and cholesterol
|
|
Structural basis for the recognition and ubiquitylation of type-2 -degron substrate by PRT1 plant -recognin
|
|
The Escherichia coli replication initiator DnaA is titrated on the chromosome
|
|
Highly scalable prefusion-stabilized RSV F vaccine with enhanced immunogenicity and robust protection
|
|
IWS1 positions downstream DNA to globally stimulate Pol II elongation
|
|
Ca-pumping by PMCA-neuroplastin complexes operates in the kiloHertz-range
|
|
LABind: identifying protein binding ligand-aware sites via learning interactions between ligand and protein
|
|
Noncanonical function of Pannexin1 promotes cellular senescence and renal fibrosis post-acute kidney injury
|
|
Molecular basis of ligand binding and receptor activation at the human A adenosine receptor
|
|
Noncanonical roles of chemokine regions in CCR9 activation revealed by structural modeling and mutational mapping
|
|
Alpha-synuclein interacts with regulators of ATP homeostasis in mitochondria
|
|
A functionally tunable magnetic nanochains platform for N-glycoproteomic analysis of extracellular vesicles from ultratrace biofluids
|
|
A broadly neutralizing antibody recognizes a unique epitope with a signature motif common across coronaviruses
|
|
Conserved nucleocytoplasmic density homeostasis drives cellular organization across eukaryotes
|
|
MacroD1 sustains mitochondrial integrity and oxidative metabolism
|
|
Capturing nematic order on tissue surfaces of arbitrary geometry
|
|
Single extracellular vesicle imaging via rolling circle amplification–expansion microscopy
|
|
Translational fidelity and longevity are genetically linked
|
|
Fbxo42 promotes the degradation of Ataxin-2 granules to trigger terminal Xbp1 signaling
|
|
The topological properties of the protein universe
|
|
Genetic architecture of bone marrow fat fraction implies its involvement in osteoporosis risk
|
|
Lipid interactions and gating hysteresis suggest a physiological role for mechanosensitive channel YnaI
|
|
Structural basis for membrane microdomain formation by a human Stomatin complex
|
|
Complementary cytoskeletal feedback loops control signal transduction excitability and cell polarity
|
|
Mechanistic insights into the versatile stoichiometry and biased signaling of the apelin receptor-arrestin complex
|
|
Conservation of dark CPD photolyase function in blind cavefish
|
|
SLAMseq reveals potential transfer of RNA from liver to kidney in the mouse
|
|
F-actin disassembly by the oxidoreductase MICAL1 promotes mechano-dependent VWF-GPIbα interaction in platelets
|
|
Mitochondrial damage triggers the concerted degradation of negative regulators of neuronal autophagy
|
|
Guanidine aptamers are present in vertebrate RNAs associated with calcium signaling and neuromuscular function
|
|
A covalent organic framework membrane with highly selective and permeable artificial sodium channels via ion recognition
|
|
Glial reactivity and cognitive decline follow chronic heterochromatin loss in neurons
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Lipid-mediated gating of a miniature mechanosensitive MscS channel from
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PABPC1 SUMOylation enhances cell survival by promoting mitophagy through stabilizing U-rich mRNAs within stress granules
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Impaired mitochondria-initiated crosstalk with lysosomes reciprocally aggravates mitochondrial defect through LManVI
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Ribosome biogenesis in plants requires the nuclear envelope and mitochondria localized OPENER complex
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Characterizing and engineering post-translational modifications with high-throughput cell-free expression
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Arp2/3 and type-I myosins control chromosome mobility and end-resection at double-strand breaks in
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Two successive oligomeric Munc13 assemblies scaffold vesicle docking and SNARE assembly to support neurotransmitter release
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A rapid, simple, and economical method for the isolation of ribosomes and translational machinery for structural and functional studies
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Unequal segregation of mitochondria during asymmetric cell division contributes to cell fate divergence in sister cells in vivo
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Synaptotagmin-1 serves as a primary Zn2+ sensor to mediate spontaneous neurotransmitter release under pathological conditions
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Modeling protein conformational ensembles by guiding AlphaFold2 with Double Electron Electron Resonance (DEER) distance distributions
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The EMC acts as a chaperone for membrane proteins
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Development and application of GlycanDIA workflow for glycomic analysis
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A cytokine-based designer enzyme with an abiological multinuclear metal center exhibits intrinsic and extrinsic catalysis
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Mitochondria-derived nuclear ATP surge protects against confinement-induced proliferation defects
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Mapping of endosomal proximity proteomes reveals Retromer as a hub for RAB GTPase regulation
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Senescence-associated lysosomal dysfunction impairs cystine deprivation-induced lipid peroxidation and ferroptosis
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Sequence-based virtual screening using transformers
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A dedicated skin-to-brain circuit for cool sensation in mice
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A controllable photoresponsive potassium transporter
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Biomechanical control of vascular morphogenesis by the surrounding stiffness
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Flower dependent trafficking of lamellar bodies facilitates maturation of the epidermal barrier
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Ancestral sequence reconstruction as a tool for structural analysis of modular polyketide synthases
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Te and Fe nuclear resonance vibrational spectroscopic characterization of intermediate spin state mixed-valent dimers
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Deep-learning structure elucidation from single-mutant deep mutational scanning
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Comprehensive profiling of the catalytic conformations of human Guanylate kinase
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Regulatory interaction between metabolite transporters coordinates glucose and exometabolite fluxes to drive bioenergetics
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Restriction of Ku translocation protects telomere ends
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Age mosaic of gut epithelial cells prevents aging
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Basement membrane perforations guide anterior–posterior axis formation
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The bile acid-sensitive ion channel is gated by Ca-dependent conformational changes in the transmembrane domain
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Structural basis of collagen glucosyltransferase function and its serendipitous role in kojibiose synthesis
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A new paradigm of islet adaptations in human pregnancy: insights from immunohistochemistry and proteomics
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A UFD1 variant encoding a microprotein modulates UFD1f and IPMK ubiquitination to play pivotal roles in anti-stress responses
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Structure of human mitochondrial pyruvate carrier MPC1 and MPC2 complex
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Machine learning-guided evolution of pyrrolysyl-tRNA synthetase for improved incorporation efficiency of diverse noncanonical amino acids
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Engineering glycosyltransferases into glycan binding proteins using a mammalian surface display platform
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Regulation of plant immunity through histone H3 β-hydroxybutyrylation-mediated transcriptional control
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Cellular crosstalk mediated by TGF-β drives epithelial-mesenchymal transition in patient-derived multi-compartment biliary organoids
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LIN-39 is a neuron-specific developmental determinant of longevity in Caenorhabditis elegans with reduced insulin signaling
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Sex difference in BAT thermogenesis depends on PGC-1α–mediated phospholipid synthesis in mice
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Library-based virtual match-between-runs quantification in GlyPep-Quant improves site-specific glycan identification
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Structure-guided engineering of snake toxins for selective modulation of adrenergic and muscarinic receptors
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Highly dynamic mechanical transitions in embryonic cell populations during Drosophila gastrulation
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Endogenous tyrosinase-catalyzed therapeutics
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Structural basis for a nucleoporin exportin complex between RanBP2, SUMO1-RanGAP1, the E2 Ubc9, Crm1 and the Ran GTPase
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Chromatin heterogeneity modulates nuclear condensate dynamics and phase behavior
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Multicolored sequential resonance energy transfer for detection of simultaneous ligand binding at G protein-coupled receptors
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Body temperature regulates glucose metabolism and torpid behavior
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Structural insights into pre-pore intermediates of alpha-hemolysin in the lipidic environment
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Muscle AMP deaminase activity was lower in Neandertals than in modern humans
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Enhancement of enzymatic activity by biomolecular condensates through pH buffering
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A high-performance genetically encoded sensor for cellular imaging of PKC activity in vivo
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Concurrent diffusion of nicotinic acetylcholine receptors and fluorescent cholesterol disclosed by two-colour sub-millisecond MINFLUX-based single-molecule tracking
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Rab27a regulates the transport of influenza virus membrane proteins to the plasma membrane
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The role of gene duplication and paralog specialisation in the evolution of the mammalian PRPS complex
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Gip1 GPCR regulates two sexual-stage differentiation processes in the ascomycete
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EMP1 safeguards hematopoietic stem cells by suppressing sphingolipid metabolism and alleviating endoplasmic reticulum stress
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Mrc1 (MMR, CD206) controls the blood proteome in reducing inflammation, age-associated organ dysfunction and mortality in sepsis
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Orphan receptor GPR153 facilitates vascular damage responses by modulating cAMP levels, YAP/TAZ signaling, and NF-κB activation
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Harnessing protein language model for structure-based discovery of highly efficient and robust PET hydrolases
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DSS1 is required for proper Integrator–PP2A function
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Multiomics and cellular senescence profiling of aging human skeletal muscle uncovers Maraviroc as a senotherapeutic approach for sarcopenia
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A multicellular star-shaped actin network underpins epithelial organization and connectivity
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Foam film vitrification for cryo-EM
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A multi-tiered mechanical mechanism shapes the early neural plate
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The mechanistic basis for interprotomer deglycosylation of antibodies by corynebacterial IgG-specific endoglycosidases
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Discovery of a single-subunit oligosaccharyltransferase that enables glycosylation of full-length IgG antibodies in bacteria
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Structural-functional characterization of the MIRO1-TRAK1 complex
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MIC: A deep learning tool for assigning ions and waters in cryo-EM and crystal structures
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A single main-chain hydrogen bond required to keep GABAA receptors closed
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Engineering of ATP synthase for enhancement of proton-to-ATP ratio
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Nanostructured organic sheets sequestering small extracellular vesicles and reactive species to protect against radiation-induced mucositis
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Evolutionarily divergent Mycobacterium tuberculosis CTP synthase filaments are under selective pressure
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DRAM1 promotes the stability of lysosomal VAMP8 to enhance autolysosome formation and facilitates the extravasation
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Emergence of cellular nematic order is a conserved feature of gastrulation in animal embryos
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Molecular mechanism of Activin receptor inhibition by DLK1
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An O-glycopeptide participates in the formation of distinct Aβ42 fibril structures and attenuates Aβ42 neurotoxicity
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Ghrelin-induced neuronal NPY promotes brain metastasis in lung cancer patients with low BMI
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Transcriptional landscape of the cell cycle in a model thermoacidophilic archaeon reveals similarities to eukaryotes
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A generalized platform for artificial intelligence-powered autonomous enzyme engineering
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Visualizing DNA polymerase ι catalyze Hoogsteen-directed DNA synthesis
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Biomimetic synthesis of vesicular covalent organic frameworks by gemini surfactants for in-situ enzyme cascade immobilization
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Conformational dynamics and membrane insertion mechanism of B4GALNT1 in ganglioside synthesis
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Data-driven protease engineering by DNA-recording and epistasis-aware machine learning
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Ultradeep N-glycoproteome atlas of mouse reveals spatiotemporal signatures of brain aging and neurodegenerative diseases
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Molecular architecture and catalytic mechanism of human glycogen debranching enzyme
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Cooperative and inhibitory ion transport in functionalized angstrom-scale two-dimensional channels
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TUG protein acts through a disordered region to organize the early secretory pathway
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The loss of OPA1 accelerates intervertebral disc degeneration and osteoarthritis in aged mice
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Helix-bundle and C-terminal GPCR domains differentially influence GRK-specific functions and β-arrestin-mediated regulation
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Metabotropic glutamate receptor 4-mediated glutamatergic signaling reshapes the tumor microenvironment by regulating dendritic cell maturation
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Exploitable mechanisms of antibody and CAR mediated macrophage cytotoxicity
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The N-degron pathway governs autophagy to promote thermotolerance in Arabidopsis
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Gut microbiota-derived GlcNAc-MurNAc is a TLR4 agonist that protects the host gut
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Visualizing PIEZO1 localization and activity in hiPSC-derived single cells and organoids with HaloTag technology
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Neurons exploit stochastic growth to rapidly and economically build dense dendritic arbors
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Large-scale predictions of alternative protein conformations by AlphaFold2-based sequence association
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New molecular components of high and low affinity iron import systems in Drosophila
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An adaptive peptide-binding site in ubiquitin receptor hRpn13 revealed by structural studies
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