Medical Biochemistry and Metabolomics articles

Time frame: 1 June 2025 - 30 May 2026

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Count: 1013

Article ‘Count’ for Medical Biochemistry and Metabolomics.

Journal Count
9
Confined Oxidative Catabolism: Organelle-Level Reactive Oxygen Species for Precision Intervention in Metabolic-Associated Fatty Liver Disease
Endolysosomal Impact of Elevated Ceramide Levels Revealed by Optical and Ultrastructural Nanoprobing
Maternal Fine Particulate Matter Exposure Impairs Inguinal White Adipose Tissue Plasticity in Middle-Aged Male Mouse Offspring
Quantitative Mapping of the Lipid Nanoenvironment around Transmembrane Proteins in Living Cells
A Remote-Controlled Nanopump Delivers Oxygen to Boost Energy Production in Osteoarthritis
Amyloid Fibrillation of a Ninjurin-1-Derived α-Helical Peptide: Structural Insights into Conformational Transition
Driving a Stimuli-Responsive Wedge in the Packing of Phospholipid Membranes Using Bolaamphiphile Intercalants
Activating Mitochondrial Complex I by Polyphenol Nanoparticle to Inhibit Hypoxia-Inducible Factor-1 Subunit α for Immunotherapy
Biomimetic Liposomes for G-Protein-Coupled Receptor 120 Exo/Endogenous Coactivation to Reprogram Lipid Metabolism in Obesity-Associated Osteoarthritis
4
Biomechanical adaptation of the thoracic aorta and its perivascular adipose tissue precedes hypertension development in Dahl Salt-Sensitive rats on high-fat diet
Fatty acid albumin conjugates mechanically weaken and disrupt degradation of fibrin networks
A ROS/ultrasound dual-responsive nanocarrier enhances drug penetration for ameliorating metabolic dysfunction-associated steatohepatitis
The phospholipid composition of artificial lipid droplets enhances their deliverability and facilitates a broad Biodistribution in vivo and in vitro
5
Peptide Based Covalent Organic Framework for the Magnetic Resonance Imaging-Mediated Attenuation of Amyloid-β Fibrils
Injectable Tumor-Cell-Mimicking Topology Accelerates the Mechanical Reprogramming of Adipocytes via the Nucleus for Enhanced Metabolic Adaptation to Obesity
Synthetic Nanobiology Actuated Lipometabolic Cell Factory for Autologous Tumor Immunotherapy
Thermo-Responsive Catalytic Hydrogel Enables Oncolytic Enzyme Therapy Through Cascading Plasma Membrane Rupture and Oxidative Stress Amplification
Mitochondrial‐Cytosolic Cascade Metabolic Regulation System: A Robust Strategy to Disrupt Multipath Energy Replenishment in Cancer Therapy
2
ALP-Responsive Luminescent Nanosheets Promote Precise Hepatitis Theragnostic by Co-Targeting NLRP3 and Cholestasis
LDI, A Lipid Droplet Inhibitor, Disrupts Lipid Accumulation and Modulates Hepatic Lipid Profiles in Fatty Liver
25
Dietary fish hydrolysate improves episodic memory in healthy elderly with lower level of memory performance: a double-blind, randomized, placebo-controlled clinical study
Krill oil increase plasma omega-3 fatty acids more than fish oil in healthy adults: a double blind randomized controlled trial
Diabetes modifies the association between magnesium and insomnia, but not depressive symptomatology, in Puerto Rican adults: a prospective cohort study
Magnesium supplementation did not reduce serum calciprotein crystallization and arterial stiffness in individuals with type 2 diabetes: a randomized, double-blind, placebo-controlled trial
Circulating saturated fatty acids and incident chronic kidney disease: a meta-analysis of de-novo prospective cohort investigations
Remission of impaired glucose tolerance by anthocyanin supplementation: a randomized, double-blind, and placebo-controlled trial
Meal fatty acid metabolism is associated with long-term weight gain in women – a retrospective cohort study
Plasma n6 polyunsaturated fatty acid levels and risk for dementia: A prospective observational study from the UK Biobank
Predictive equations commonly used in clinics underestimate resting energy expenditure compared with whole-room indirect calorimetry in colorectal cancer survivors
Biomarkers for dietary fatty acid densities among postmenopausal U.S. females derived using a habitual-diet human feeding study
Comparison of blood lipid responses to high polyunsaturated fatty acid compared with high monounsaturated fatty acid dietary interventions: a systematic review and meta-analysis
Plasma fatty acids and the likelihood of healthy aging: a prospective cohort study
Associations between domestic water hardness and the risk of experiencing fifteen different cardiovascular events: A prospective cohort study of 324,136 UK Biobank participants
High concentrations of polyunsaturated n–3 fatty acids in serum are inversely associated with risk of future incident venous thromboembolism – the HUNT cohort study
Plasma fatty acids, genetic susceptibility, and colorectal cancer risk: results from a large prospective cohort study
New insights into total and resting energy expenditure using state-of-the-art methods in cancer survivors: a cross-sectional study
Association between dietary fat intake and long-term risk of dementia: A prospective cohort study
Associations between serum bile acid profile and mortality in patients with coronary artery disease: a cohort study
The effects of consumption of interesterified fats rich in palmitic acid versus stearic acid on intermediary markers of cardiometabolic disease risk: a randomized controlled trial in healthy adults.
Global, regional, and national burden of high sugar-sweetened beverages consumption, 1990-2021, with projections up to 2050: a systematic analysis for the Global Burden of Disease Study 2021
Circulating Bile Acids, Bile Acids Receptor Polymorphisms, and Risk of Chronic Kidney Disease among Individuals with Newly Diagnosed Type 2 Diabetes: A Prospective Study
Plasma chylomicron-rich lipidomic and fatty acid profile following a meat or analogue meal in healthy males: a randomized controlled trial
Gut microbial community and host intestinal gene expression with combined fish oil and soluble corn fiber compared with corn oil and maltodextrin: A randomized crossover trial in healthy older individuals
Short-Term High Fat Diet Induced Metabolic Endotoxemia in Older Individuals with Obesity: A Randomized Crossover Study
Effects of a Palmitoleic Acid Concentrated Oil on C-Reactive Protein Levels in Adults: A Randomized Double-Blind Placebo Controlled Clinical Trial
1
Elevated lipid levels and altered semen parameters in men of couples seeking fertility care
2
Genetic regulation of fatty acid content in adipose tissue
Genomics-informed drug-repurposing strategy identifies two therapeutic targets for preventing liver disease associated with metabolic dysfunction
7
Resolvin E1 and Maresin 1 Attenuate NLRP3-Associated Inflammation and Invasion in Oral Squamous Cell Carcinoma
Hepatocyte-specific PPARγ Deletion Uncovers Role of an Antagonistic PPARγ–HNF4α Transcriptional Axis in MASLD Progression
Gpat3 Knockout Attenuates Adipose Loss and Steatohepatitis in Agpat2-Deficient Mice
Inactivation of Atp7b copper transporter in intestinal epithelial cells is associated with altered lipid processing and cell growth machinery independent from hepatic copper accumulation and severity of liver histology
Single-cell sequencing has revealed the palmitoylation landscape in lung adenocarcinoma and identified ABHD17C as a novel biomarker
Perilipin 2 mediates progression of lung adenocarcinoma by modulating lipid metabolism
Metabolic dysfunction-associated steatotic liver disease in patients and mouse with Wilson’s disease
53
SQ-KFP: A Framework for Spatially Quantitative Metabolic Flux Analysis Enables Imaging the In Vivo Absolute Metabolic Enzymatic Reaction Rate
Hypoxia-Activated Probe for Targeted Photoacoustic Imaging and Photothermal Modulation of Adipose Tissue in Obesity
Improving Isotope Ratio Accuracy in Metabolic Labeling Using Orbitrap Mass Spectrometry: A Machine Learning Correction Algorithm for Metabolic Flux Analysis
A Dual-Functional Two-Photon PLIM Probe Based on Ruthenium(II) Complex: Sequence Selectivity and Aβ Aggregation Monitoring
Urinary Metabolomics and One-Class Classification To Discover Children Affected by Bile Acid Synthetic Disorders: A Case-Study
Combining Engineered Probe Library with Tiered Screening for the Rational Discovery of Alzheimer’s Diagnostic Probe with an Enhanced Signal-to-Noise Ratio
Rational Design of an Isoform-Specific Fluorogenic Probe for Human UGT2B7: Enabling Functional Analysis and Inhibitor Screening
Comprehensive Profiling of Protein N-Terminal Acetylation Stoichiometry in Extracellular Vesicles
Quantitatively Sensing Lipid Droplets Polarity in Cells and Atherosclerotic Model with a Novel Naphthalimide-Based Fluorescent Probe
Length-Dependent Aβ-Gelsolin Interactions Regulate Amyloid Aggregation in Alzheimer’s Disease
Electrochemistry Reveals the Accelerating Effect of Fluorinated Compounds on Early-Stage Amyloid Fibril Aggregation
Fe-Doped Carbon Dots Functionalized Nanoelectrode for In Situ Monitoring of Metabolism-Associated ROS Changes in Single Microglia
Live-Cell Imaging and Lipidomics of Low-Density Lipoprotein Containing Intrinsically Fluorescent Cholesteryl Esters
Quantification of Ligand–Membrane Interactions Using DNP-NMR Relaxometry
Trifluoromethylphenyl-Induced Specific Acyl Chain Fragmentation in Liquid Chromatography Mass Spectrometry for Free Furan Fatty Acid Screening in Fish Oils
Membrane-Targetable Dual-Responsive Fluorescent Probe for Simultaneous Detection of Polarity and Hypochlorite and Its Application in Apoptosis and Cancer Models
Tracking Metabolic Responses to Citalopram in Colon Cells with Raman Spectroscopy
MS/MS Mass Spectrometry Filtering Tree for Bile Acid Regio- and Stereoisomer Annotation
Dynamic Visualization of Amyloid-β Plaques with a Novel NIR-II Fluorescence Reporter
Revealing Organophosphorus and Carbamate Interactions with Albumin Using 1H NOE Pumping NMR Technique
Characterization of the Lipidome of Neurons in Mouse Brain Nuclei Using Imaging Mass Spectrometry
Amphiphilic Tetraphenylethylene Derivative with Hydrophobic–Hydrophilic Complementarity to Amyloid Oligomers for in Situ Imaging and Modulation of Membrane-Disruptive Neurotoxicity
An Iodinated BODIPY-Based Probe for the Selective Mapping and Disassembly of Amyloid-β Aggregates In Vivo
Integrating Ex Vivo Isotope Labeling with Mass Spectrometry Imaging to Spatially Trace Heterogeneous Metabolic Activity in Rat Kidney Tissue
Discrimination of Formation Processes of Amyloid β Fibrils with Distinct Morphologies Using Rheo-NMR Spectroscopy
Deep-Coverage Ubiquitylomics with Low Starting Materials Reveals Dysregulation of Ubiquitinated FASN as a Key Regulator of MAFLD Pathogenesis
Dual-Mode Chalcone-Based Fluorescent Probe for Distinguishing Amyloid-β Oligomers and Fibrils via Microenvironment Sensitivity
Rational Design of a Dual-Channel Fluorescent Probe for the Simultaneous Imaging of Brain Amyloid-β Plaques and HClO/ClO– in Alzheimer’s Disease
Spatially Mapping Neuropeptide Isomers via MALDI Trapped Ion Mobility MS Imaging
Simultaneous Dual-Channel Tracking Lipid Droplets Dynamic Behaviors and Revealing the Protective Role in Nonalcoholic Fatty Liver in mice
Development of a Novel Hydroxylamine-Based Stable Isotope Labeling Reagent for Profiling Aldehyde Metabolic Biomarkers in Diabetes Using LC-MS/MS and Machine Learning
An Fe(III)-Based Fluorescent Probe for Carbon Monoxide only Senses the “CO Donor” Used, CORM-3, but Not CO
Visual Whole-Process Monitoring Dynamic Phase Separation of Autophagic Lysosomes in Alzheimer’s Disease by a Lysosome-Targeted pH-Activated Fluorescence Probe
Developing Quinacridone-Based Long Fluorescent Lifetime Probes for Cell Membrane Heterogeneity Imaging
Oligomerization Propensity Governs Self-Assembly Morphology: Insights from Steady-State Oligomer Analysis
Simultaneous Monitoring of Intracellular Glucose and Extracellular Lactate in Single Cells to Assess Cell Tumorigenicity
Microfluidic Generation of Oxidized Phospholipid Gradients in Supported Lipid Bilayers to Examine Scavenger Receptor Interactions
Stretchable Sensor-Integrated Microfluidic Chip for Monitoring Fatty Acid-Enhanced Serotonin Release from the Intestinal Epithelium
Tris(2,2′-bipyridyl)ruthenium(II) Electrochemiluminescence of Sugar Alcohols
Deciphering Spatiotemporal Control of Ferroptosis in HCC: A Bifunctional Probe for Lipid Droplet Viscosity Dynamics and Interorganelle Communication
Construction of High-Performance Wash-Free Aβ Probes Based on Amino Group Optimization and Amphiphilic Molecular Engineering Strategies
Ultrafast Autofluorescence of Bilirubin as a Sensor of Albumin Conformation in Blood Serum
Passive Membrane Transport Analysis of Drug Mixtures
Decreased Lysosomal Polarity during Acute Alcoholic Liver Injury Revealed by a Near-Infrared Fluorescent Probe
iIn Vivo/i Identification and Spatial Distribution of Crown Gall Disease Biomarkers in Grapevine
Multilevel Hydrangea-like Heterogeneous Oxides Enabling COVID-19 Progression Surveillance via Metabolic Fingerprints
Near-Infrared Room-Temperature Phosphorescent Organic Nanoparticles for Amyloid-β Targeting and Time-Resolved Imaging
Cascade DNA Logic Strategy for Profiling the MiRNA-210-Targeted Signaling Pathway in the Warburg Effect of Triple-Negative Breast Cancer
Resolving Phospholipid-Molecule Mobility and DNA-Mediated Combinatorial Fusion for a Single Nanoliposome by Plasmonic Imaging
Rapid Determination of Iron in Serum and Plasma Using Micromagnetic Resonance Relaxometry (μMRR)
Real-Time Analysis of the Biomolecular Interaction between C1q and Amyloid-β Protein by Dual Polarization Interferometry
Super-Resolution FLIM Imaging of Intracellular Lipid Microenvironments with a Dual-Responsive Polarity- and pH-Sensitive Fluorescent Probe
Rational Design of Long-Circulating Bright Fluorescent Probe for In Vivo Imaging of Amyloid-β Plaques in Alzheimer’s Disease
1
Efficacy and safety of preemptive magnesium sulfate infusion during pheochromocytoma and paraganglioma resection: a randomized, double-blind, placebo-controlled trial.
16
Computer Vision Enables Monitoring and Kinetic Analysis of Structurally Diverse Carbon Monoxide Surrogates
Oxidative Damage Fine‐Tunes G‐Quadruplex Structures in Human Gene Promoters
A Cathepsin B-Triggered CO-Releasing Molecule with a Non-Toxic Metal Core for Targeted Tumor Delivery
Three‐Segment Protein Labeling Using a Highly Efficient and Cysteine‐Less Split Intein Identified with Computational Prediction of Aggregation Properties
Chiral Discrimination of all Proteinogenic Amino Acid Enantiomers by Nanopore Sensing
Quantitative Reactivity Profiling of Functional Arginine Residues in Human Cancer Cell Line Proteomes
Targeted Detection of Phospholipid Aldehydes in Living Cells by Oxime Ligation
Small Molecule Promoters of Endogenous Lipid Droplet Accumulation Drive Lysophagy
LL‐37 and Its Truncated Fragments Modulate Amyloid‐β Dynamics, Aggregation and Toxicity Through Hetero‐Oligomer and Cluster Formation
A Fluorogenic Hydrazino‐Pictet–Spengler Reaction in Live Cells
Predictable Modulation of a Spontaneous Post‐translational Modification in Living Cells
Location‐Differentiated DNA Hierarchical Cyclic Construction Demarcating Identical Biomolecules Across Cell Membrane Microenvironments
Antiparallel iβ/i‐Sheet as a Key Motif of Amyloid‐iβ/i Inhibitor Designed via Topological Peptide Reprogramming
A Single‐Molecule Liposome Assay for Membrane Permeabilization
Selective Leaflet‐Anchored DNA Nanoprobes for Simultaneous Monitoring of Juxta‐Plasma Membrane Environments
Monitoring Glycolysis by Endogenous sup31/supP CEST Magnetic Resonance Imaging
3
Senescent Cell Clearance Ameliorates Temporal Lobe Epilepsy and Associated Spatial Memory Deficits in Mice
Cross‐Sectional scpFDG/scp in Down Syndrome and Autosomal Dominant Alzheimer's Disease
AAV9-DARS2 Gene Therapy Rescues Phenotype in Leukoencephalopathy with Brainstem and Spinal Cord Involvement and Lactate Elevation Patient Cells and Neuronal Dars2 Deficient Mice
1
Trajectories of Survivors and Non-Survivors Post-burn Injury.
1
Bile acids metabolism in symptomatic hand osteoarthritis
3
The GATA1 N terminus coordinates metabolic reprogramming in erythropoiesis
DHODH as a targetable metabolic Achilles’ heel for chemotherapy-resistant B-ALL
Alpha-ketoglutarate promotes amino acid depletion and suppresses B-cell lymphoma growth and development
3
CRISPR editing of miR-33 restores ApoE lipidation and amyloid-β metabolism in ApoE4 sporadic Alzheimer’s disease
Preclinical and first-in-human evidence of 4-hydroxybenzoic acid for mitochondrial COQ2 deficiency
Compensatory roles of STT3A and ALG5 in glucose metabolism of aged macaque hippocampus
25
NSD1-Mediated PPARγ Methylation Enhances PTEN Activity to Suppress Glycolysis and Tumor Progression in Endometrial Cancer
FASN Inhibition Enhances the Efficacy of Chemotherapy in Colorectal Cancer by Inhibiting the DNA Damage Response
Subcellular Redistribution of Endomembrane GPR15 Promotes NAD+-Mediated Metabolic Reprogramming and Boosts 5-FU Chemosensitivity in Colorectal Cancer
SAICAR Drives T Regulatory Cell Differentiation and FOXP3 Maintenance to Promote Immunotherapy Resistance
ACSL5 Mediates Adaptation to the Palmitic Acid–Enriched Pulmonary Microenvironment to Enhance Metastatic Breast Cancer Cell Survival and Lung Metastasis
IDH1 Reprograms Nucleotide Metabolism by Inducing Chromatin Remodeling and DHODH Transcription to Drive Chemoresistance in Nasopharyngeal Carcinoma
ZNF395 Is a Hypoxia-Responsive Regulator of Mitochondrial Glutaminolysis in Clear Cell Renal Cell Carcinoma
GFER Represents a Target for Dual Disruption of Redox Homeostasis and Reactivation of the Immune Response in Pancreatic Adenocarcinoma
The Microbial Bile Acid Metabolite 3-Oxo-LCA Inhibits Colorectal Cancer Progression
Long-Chain Fatty Acid Redistribution Induced by SLC27A2 Deficiency Facilitates Hypoxic Adaptation and Immunosuppression in Hepatocellular Carcinoma
Nutrient Availability Dictates Cancer Metabolism-Based Therapeutic Responses to Non-oncology Drugs.
A Citrate Synthase Splice Variant Rewires the TCA Cycle to Promote Colorectal Cancer Progression
Targeting the ATM-TGS1-BRCA1 Axis Overcomes Genotoxic Therapy Resistance in Pancreatic Adenocarcinoma.
PTEN Oxidation Promotes Constitutive PI3K Signaling and Inducible Macropinocytosis in Pancreatic Cancer.
PRMT3 Drives IDO1-Dependent Radioresistance and Immunosuppression by Promoting Kynurenine Metabolism in Non-Small Cell Lung Cancer.
Selective Alanine Transporter Utilization Is a Therapeutic Vulnerability in ARID1A-Mutant Ovarian Cancer
PPARδ Orchestrates a Prometastatic Metabolic Response to Microenvironmental Cues in Pancreatic Cancer
tRF-21LeuTAA Promotes Oxidative Stress by Altering Glutathione Metabolic Enzymes to Support Prostate Cancer Progression.
Gut Microbiota-Mediated Bile Acid Metabolism Regulates Colorectal Cancer Liver Metastasis by Altering Neutrophil Recruitment.
Malonyl-CoA Promotes Prostate Cancer Progression and Castration Resistance by Enhancing Lipogenesis and Ran Activation.
PRODH2-Mediated Metabolism in the Bone Microenvironment Promotes Breast Cancer Metastasis.
Tobacco Smoking Rewires Cell Metabolism by Inducing GAPDH Succinylation to Promote Lung Cancer Progression
SCD1 Inhibition Blocks the AKT–NRF2–SLC7A11 Pathway to Induce Lipid Metabolism Remodeling and Ferroptosis Priming in Lung Adenocarcinoma
Ceramide-Induced Metabolic Stress Depletes Fumarate and Drives Mitophagy to Mediate Tumor Suppression.
Blocking the TCA Cycle in Cancer Cells Potentiates CD36+ T-cell–Mediated Antitumor Immunity by Suppressing ER Stress–Associated THBS2 Signaling
8
Predicting competition and substrate preferences for targeted microbiome alteration
Sulfur partitioning from cysteine controls T cell proliferation and effector function
Citrate clearance is a major function of aconitase 2 in the canonical TCA cycle
Pyruvate is a natural suppressor of interferon signaling by inducing STAT1 protein pyruvylation
Tumor-produced ammonia is metabolized by regulatory T cells to further impede anti-tumor immunity
Targeting TFAP2β condensation suppresses the development of esophageal squamous cell carcinoma
Identification of gut microbial bile acid metabolic enzymes via an AI-assisted pipeline
Glucose restriction shapes pre-metastatic innate immune landscapes in the lung through exosomal TRAIL
4
The microbial metabolite imidazole propionate modulates hypothalamic activity and stress-induced behaviors
Gut bacteria metabolize natural and synthetic steroid hormones via the reductive OsrABC pathway
Methylglyoxal is an antibacterial effector produced by macrophages during infection
Bacteroides sphingolipids promote anti-inflammatory responses through the mevalonate pathway
26
Hyocholic acids shape neonatal immune tolerance and microbiota assembly
Adipokine IL-11/IL-11Ra constrains sphingolipid metabolism to limit the thermogenic capacity of beige adipocytes
Mitochondrial metabolism regulates the immunogenic responsiveness of dendritic cells
Psoriasis modulates inflammatory bowel disease risk and intestinal epithelium lipid metabolism via IL-1β-producing macrophages
Targeting microbiota-generated acetaldehyde to prevent progression of metabolic dysfunction-associated steatotic liver disease
Lack of PCK1 in hepatic stellate cells causes liver fibrosis by fueling tricarboxylic acid cycle and increasing glycolysis
Modeling lipid homeostasis using stable isotope tracing and flux analysis
Lipid droplet-induced T cell death sustains autoimmune tissue inflammation
Lipid-induced granules in hepatocytes alleviate liver fibrosis
Digital twins for in vivo metabolic flux estimations in patients with brain cancer
Dual inhibition of ACLY and ACSS2 by EVT0185 reduces steatosis, hepatic stellate cell activation, and fibrosis in mouse models of MASH
Mitochondrial VHL rewires cell metabolism in hypoxia
Bile acids regulate lipid metabolism through selective actions on fatty acid absorption
Nuclear hormone-sensitive lipase regulates adipose tissue mass and adipocyte metabolism
The enedioic acid analog 326E alleviates metabolic dysfunction-associated steatohepatitis via dual targeting at ACLY and PPARα
Adipocyte lipolysis activates epithelial stem cells for hair regeneration through fatty acid metabolic signaling
AMPKα2 signals amino acid insufficiency to inhibit protein synthesis
HEBP2-governed glutamine competition between tumor and macrophages dictates immunotherapy efficacy in triple-negative breast cancer
Homocysitaconate controls inflammation through reshaping methionine metabolism and N-homocysteinylation
Tumor-associated Schwann cell remodeling under metabolic stress via lactate sensing orchestrates pancreatic ductal adenocarcinoma development
Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control
Gut substrate trap of D-lactate from microbiota improves blood glucose and fatty liver disease in obese mice
Xylulose 5-phosphate fosters sustained antitumor activity of progenitor-like exhausted SLC35E2+ CD8+ T effector cells
Microbial riboflavin inhibits ceramide synthase 3 to lower ceramide (d18:1/26:0) and delay colorectal cancer progression
Itaconate promotes inflammatory responses in tissue-resident alveolar macrophages and exacerbates acute lung injury
Derepressing nuclear pyruvate dehydrogenase induces therapeutic cancer cell reprogramming
3
A ketogenesis-ferroptosis axis maintains leukemic stem cell survival and leukemia progression
TCA cycle rewiring underpins histone acetylation sourcing and cell-fate transitions during exit from naive pluripotency
Senolytic-sensitive p16+ fibroblasts in the tumor stroma rewire lung cancer metabolism and plasticity
7
Lipid droplet-targeted photosensitizers: emerging strategies for triggering programmed cell death
Total synthesis of mono-rhamnolipids using organophotoacid-catalyzed glycosylation and their antibacterial activity
Impact of microgravity on the fibrillization kinetics and structure of amyloid beta peptide
Bifunctional nanodisc platforms for studies on self-assembly and amyloid fibrillation
Identification and quantification of human serum albumin from different sources by a fluorescence sensor array
Sizes of amyloid-β oligomers predicted using atomic force microscopy and two-point crosslinked dimers as standards
Importance of the 3′-phosphate group of acetyl-coenzyme A for efficient histone lysine acetyltransferase catalysis
10
Crosslinker nanocarrier-based intratumoral delivery for protein complex mapping in mitochondria of live tumor-bearing mice
Traceless protein semisynthesis in cells using the promiscuous ultra-fast split intein NrdJ-1
Catalytic relevance of a quinol anion in biological energy conversion by respiratory complex I
Thermal-mediated modulation of binary supramolecular self-assembly from phase separation to co-crystallization at the liquid–solid surface
Photoactivatable Ru(ii) polypyridyl complexes as dual action modulators of amyloid-beta peptide aggregation and Cu redox cycling
Ambroxol displaces α-synuclein from the membrane and inhibits the formation of early protein–lipid coaggregates
Engineering ultrapotent trivalent anticoagulants through hybridisation of salivary peptides from multiple haematophagous organisms
Thermal proteome profiling of itaconate interactome in macrophages
A cell-permeable fluorescent probe reveals temporally diverse PI(4,5)P2 dynamics evoked by distinct GPCR agonists in neurons
Probing the ferredoxin:hydrogenase electron transfer complex by infrared difference spectroscopy
3
SREBP1 Transactivation of NHE3 Impairs Cardiac Contraction and Aggravates Heart Failure
HELZ2 Regulates ApoB mRNA Stability to Modulate Fatty Liver Disease and Atherosclerosis.
Association of Smoking Cannabis With Cardiovascular Events Among Veterans With Coronary Artery Disease
3
Magnesium Sulfate to Prevent Perioperative Atrial Fibrillation in Cardiac Surgery: A Randomized Clinical Trial
Association Between Protocolized Magnesium Supplementation and Atrial Fibrillation or Flutter in Critically Ill Patients: A Multicenter Retrospective Cohort Study.
Sex- and Age-Related Differences in Post-Burn Pathophysiology.
2
Altered cortical dynamics and adaptive behavior following early-onset sucrose overconsumption
A simple action reduces high-fat diet intake and obesity in mice
2
Vitamin B6 preserves the stemness-like phenotypes and antitumor ability of CD8+ T cells
A pathological role of O-GlcNAcylation-driven TR11B production and function in lung adenocarcinoma
4
Relationships Between Regional and Ectopic Adiposity and Insulin Sensitivity in Early and Late Pregnancy.
Sleep Extension Improves Sleep Health but Not Insulin Sensitivity in People With Overweight/Obesity Who Maintain Habitual Short Sleep Schedules.
Longitudinal Analysis of Liver Chemistry Trajectories and Risk of Type 2 Diabetes in Children With Metabolic Dysfunction-Associated Steatotic Liver Disease: A Multicenter Cohort Study.
Role of Adipose Tissue Compartments for Cardiovascular Risk in Diabetes Endotypes.
7
Associations between domestic water hardness and incident type 2 diabetes and the mediating role of metabolomics
Associations between Low-Dose Drinking Water Lithium Exposure and Dementia: A Nationwide U.S. Ecological Study
Environmental exposure to bisphenol S suppresses white adipocyte beiging and energy expenditure via CYP2E1 in mice
Short-term ozone exposure and schizophrenia hospitalization risk: temperature modifying effect and greenspace mitigating effect
Polycyclic aromatic hydrocarbon aggravates high-fat diet-induced metabolic dysfunction-associated steatotic liver disease through disturbing hepatocyte sphingolipid metabolism
Chronic exposure to Bisphenol S impairs hepatic mitochondrial dynamics, induces endoplasmic reticulum stress, and worsens metabolism in high-fat diet fed mice
The associations of essential metal elements and their mixture with gallstone disease in Chinese older adults: The mediation role of superoxide dismutase
3
Associations of Concomitant Exposure to Outdoor Light at Night, Air Pollution, and Greenness with Metabolic Syndrome: A Cohort Study in China
Occupational Noise Exposure and ASCVD Risk in Chinese Workers: the Cross-lag Mediating Role of free fatty acids
Disruption of sphingolipid and glycosphingolipid profiles in human bronchial epithelial cells and extracellular vesicles during gradual benzo[a]pyrene-induced epithelial-to-mesenchymal transition
4
Revisiting Quinone-Induced Oxidative Stress via Structure-Related Protein Alkylation
Microcystin-LR Disrupts Bile Acid Homeostasis, Driving Cholestatic Liver Injury and Gallstones via FXR/SHP Antagonism
Photoaged Polystyrene Microplastics Accelerate Aging in Caenorhabditis elegans via Ferroptosis-Linked Insulin Signaling Pathway
Bis(2-Ethylhexyl)-2,3,4,5-Tetrabromophthalate Promotes NASH Progression through Disrupting Endoplasmic Reticulum-Mitochondria Contacts
7
Preservative food additives, hypertension, and cardiovascular diseases: the NutriNet-Santé study
Eicosapentaenoic acid ethyl ester, cardiac metabolomic and lipidomic signatures, and cardioprotection in myocardial infarction
Histamine N-methyltransferase upregulation, cardiac hypertrophy, and heart failure
Oral magnesium and outcomes in US veterans with heart failure
Underweight and cardiovascular risk in Type 2 diabetes: a Korean nationwide study
Taurochenodeoxycholic acid alleviates obesity-induced endothelial dysfunction
Sex-specific body fat distribution predicts cardiovascular ageing
1
Multicenter Prospective Cohort Study on Clinical Outcomes and Fibrosis Patterns in Biopsy-Proven Steatotic Liver Disease Subtypes
1
A brain-specific microRNA, miR-1000, regulates lipid homeostasis via neuropeptide-like precursor 1 in Drosophila melanogaster
15
Tumour-infiltrating adipocyte-derived 12,13-DiHOME subverts CD8+ T cell immunity in pancreatic ductal adenocarcinoma by promoting PPARγ-mediated ferritinophagy and tumour-associated neutrophil ferroptosis
Blocking MOXD1-derived ACOX1 peroxisome trafficking suppresses metabolic dysfunction-associated steatohepatitis
Landscape screening identifies the lactate-modifying enzyme AARS2 as a master regulator and therapeutic target in hepatocellular carcinoma
JOSD1 drives hepatocellular carcinoma malignancy by modulating the ubiquitination-lactylation switch on PGAM1
Dysbiotic microbiota trigger colitis-associated colorectal cancer and imprint a distinctive bile acid profile in a PSC-IBD model
Extrinsic lipids are absorbed and accumulate in colorectal cancer
Parental obesity and risk of metabolic dysfunction associated steatotic liver disease in adult offspring: UK birth cohort study
Oleic acid promotes lung injury in hypertriglyceridaemia-associated acute pancreatitis via the PIEZO1/NR4A1/CPT1A axis impairing endothelial fatty acid oxidation
MTFP1 drives pancreatic cancer liver metastatic colonisation by regulating mitochondrial metabolism reprogramming
Colorectal cancer in metabolic dysfunction-associated steatotic liver disease: an international Delphi consensus statement
Secondary bile acid production by gut bacteria promotes Western diet-associated colorectal cancer
PCK1 deficiency promotes MASH-HCC progression by 12-HETE-induced CD8+ T cell dysfunction
Fibroblast pentose phosphate pathway activation upon decreased circPLCE1 exacerbates intestinal fibrosis in Crohn’s disease
Discovery of a carboxyl fullerene derivative as a new lipid droplet regulator inhibiting MASLD
Targeting Treg–fibroblast interaction to enhance immunotherapy in steatotic liver disease-related hepatocellular carcinoma
11
Statins halt polycystic liver disease by reprogramming metabolism and normalizing mitochondrial bioenergetics in cystic cholangiocytes.
Cardiovascular-Kidney-Metabolic syndrome and the risk of liver fibrosis progression and liver-related events in MASLD.
Glutamine synthetase loss in β-catenin-mutant hepatocellular carcinoma promotes tumor burden through macrophage metabolic reprogramming.
Reclassifying pediatric NAFLD using the steatotic liver disease framework: a multicenter retrospective study from the NASH CRN.
A novel mechanism involving USP53-regulated BSEP trafficking underlies low-GGT intrahepatic cholestasis.
E2F2 transcription factor promotes a cholestatic MASH phenotype by regulating hepatobiliary metabolism through miR-34a-5p.
Pretreatment serum bile acid composition and predictability of subsequent response to odevixibat in patients with bile salt export pump (BSEP) deficiency.
MIF-mediated crosstalk between THRSP+ hepatocytes and CD74+ lipid-associated macrophages in hepatic periportal zone drives MASH.
The OGT-TFF2 axis mediates intrahepatic crosstalk and MASH pathogenesis.
Type 2 Diabetes mellitus as an independent predictor of significant fibrosis in treatment-naïve chronic hepatitis B patients with concurrent hepatic steatosis.
Gut-to-Bile transfer of microbially amidated minor bile acids in patients with hepatopancreatobiliary disorders.
1
Investigating metabolic activity during oocyte and early embryo development through label-free metabolic imaging: a systematic approach for timelapse applications
6
NK cell dysfunction and interferon-γ production underlie autoinflammation in mevalonate kinase deficiency
Metabolic and transcriptional plasticity supports CD8+ T cell resilience and anti-tumor immunity under nutrient stress
Palmitic acid reprograms neutrophils to compromise vascular integrity and promote breast cancer lung metastasis
High-fat diet causes rapid loss of intestinal group 3 innate lymphoid cells through microbiota-driven inflammation and mitochondrial stress
Intra-tumoral hypoxia promotes CD8+ T cell dysfunction via chronic activation of integrated stress response transcription factor ATF4
Inhibition of tumor cell macropinocytosis driver DHODH reverses immunosuppression and overcomes anti-PD1 resistance
5
Ligand-Tuned Mn(I) Complexes with Oxazole, Thiazole, and Selenazole Scaffolds: Synthesis and Mechanistic Insights into Light-Driven CO Release
Pyrene-Based Aggregation-Induced Emissive Manganese Carbonyl Complex for Green Light-Controlled Carbon Monoxide (CO) Release and Theranostic Applications
Low Catalytic Redox Activity of α-N-Pyridylthiosemicarbazone Iron Complexes Suggests an Indirect ROS Generation Mechanism in Their Biological Activity
Catalytic Mechanism of the Bacterial Non-Heme Fe(II) and 2-Oxoglutarate Dependent Enzyme AlkB with Single-Stranded DNA Containing Complex Guanine Adducts
Efficiency of Photodissociation of Carbonyl Ligand in Ruthenium Monocarbonyl Bipyridine Complexes: Effect of Isomeric Structures and Ligands
2
Supplemental Nutrition Assistance Program use and cognitive performance in middle-aged and older adults
The relationship between polyunsaturated fatty acids and inflammation: evidence from cohort and Mendelian randomization analyses
25
Gut microbiota alteration contributes to bone marrow mesenchymal stem cells connexin43 response to high-fat diet induced obesity in mice
Metabolically healthy obesity is independently associated with 20-year incidence of cardiovascular disease: findings from the ATTICA cohort study (2002–2022)
Racial and ethnic disparities in type 2 diabetes: does visceral fat play a role? Evidence from the MESA study
Non-invasive islet β-cell markers track with weight-loss interventions for type 2 diabetes: a prospective cohort study
Risk factors and clinical nomogram for fatty pancreas in adults with obesity: a case-control study
Cold-induced metabolic flexibility explains ethnic disparities among individuals with obesity and insulin resistance
Genetic risk, antiseizure medications, and lifestyle factors in epilepsy-associated obesity and overweight
Genetic evidence for the association between schizophrenia and obesity
Assessment of the elasticity of lipedematous tissue and the examination of the relationship between pain and fibrosis in lipedema
Adipocyte extracellular vesicles (AdEVs) promote a proinflammatory and profibrotic profile in human renal and endothelial cells in vitro
Relationship between the microbiome and obesity-associated cancer risk using Mendelian randomisation
The anti-obesity effect of namodenoson, an A3 adenosine receptor agonist
Elevated serum glucosylsphingosine level in children with obesity: relation to plasma atherogenesis
Brown adipose tissue-derived exosomes ameliorate obesity-related hypertension via HuR-mediated restoration of endothelial function
Metabolic syndrome in Australia: nationwide survey results by remoteness and Indigenous status, 2012–2019
Obesity-induced taste bud loss in mice is only partially remediated long after return to a healthy weight
Deriving sex-specific anthropometric cut-points for obesity and cardiovascular disease risk in Qatari adults
Optimizing adipogenic cocktail composition to enhance beige adipogenesis and evaluate thermogenic potential in primary mouse subcutaneous fat cell cultures
Perirenal fat: a neglected fat depot shaping heterogeneity of obesity along with hepatic fat
Phosphatidylethanolamine/PKA signal axis mediated human milk extracellular vesicles enhance adipose thermogenesis and lipolysis via mitochondrial remodeling
Interleukin-33 promotes lipolysis of adipocytes and protects male mice against obesity via activation of β-adrenergic receptor signaling
Pear-shaped body types linked to lower risk of gout: genetic evidence from Mendelian randomization
Body mass index and infection risks in people with and without type 2 diabetes: A cohort study using electronic health records
Impact of diabetes on proteomic changes in circulating extracellular vesicles in individuals with obesity before and after bariatric surgery
Changes in abdominal subcutaneous adipose tissue thickness associate with disease and anthropometric factors
2
Magnesium Supplementation and Tachyarrhythmias
Adverse Liver Outcomes, Cardiovascular Events, and Mortality in Steatotic Liver Disease
1
Long-Term Cardiometabolic Outcomes in Children With Metabolically Healthy and Unhealthy Obesity
4
Semaglutide and Early-Stage Metabolic Abnormalities in Individuals With Schizophrenia Spectrum Disorders
Semaglutide Treatment of Antipsychotic-Treated Patients With Schizophrenia, Prediabetes, and Obesity
Antipsychotic Drugs and Dysregulated Glucose Homeostasis
Sweetened Beverages and Incident All-Cause Dementia Among Older Adults
71
Lactate-fueled H3K18 lactylation sustains ΔNp63α-dependent self-renewal in limbal epithelial stem cells
Tissue-dependent enzymatic control of N-acetyl-β-alanine by PTER
Arylsulfatase L is a Golgi chondroitin sulfatase regulating skeletal development
Phosphatidylinositol 4-kinase α suppresses glioblastoma progression by inactivating YAP and PI3K/Akt signaling
A functional SNP rs12718466 in APOA1 promoter modulates gene expression via interaction with SOX7
Variants in glycine decarboxylase activate catabolic mechanisms of mitochondrial energy metabolism in the brain
S-acylation and membrane localization of the small GTPase ARL15 are mediated by the Golgi S-acyltransferases ZDHHC7 and ZDHHC3
P4HA3 is dispensable for prolyl 4-hydroxylation of type I collagen during mouse development
Prolyl-3-hydroxylase 1 is a central regulator of collagen post-translational modifications and the collagen biosynthetic network
Fragile histidine triad (FHIT) suppresses gastric cancer via translational regulation of the epigenetic modifier KDM6B
OGG1 increases exercise endurance via elevated skeletal muscle FGF21
Rab5 Nucleotide Binding Promotes Oxidative Metabolism to Fuel Hepatocellular Carcinoma Cell Proliferation
The intrinsically disordered region of the human parathyroid hormone controls functional amyloid properties
Mycobacterium tuberculosis assembles a unique hexameric E2p core of the pyruvate dehydrogenase complex
RNF90 promotes hepatic steatosis by degrading CPT1α to suppress fatty acid oxidation
GPR39 mediated molecular signaling by bile acids
Allosteric targeting with antiviral nucleotide analogs allows fine-tuning of SAMHD1 dNTPase activity
Hypoxia-Inducible Factor 1αa Regulates Lipid Metabolism to Coordinate Adipocyte Hypertrophy and Hyperplasia in Grass Carp
Contribution of organic anion transporting polypeptides to bile acid uptake in the Caco-2 cell monolayer and gastrointestinal tract
Pex6 and ubiquitination regulate topological remodeling of the peroxisomal membrane protein Pex14
In vitro reconstitution in membrane environment reveals critical lipid dependence of substrate S-acylation by protein palmitoyltransferase enzymes
Hepatic management of toxic sterols after acute deletion of Cyp51 from cholesterol synthesis
The amyloidogenic C-Terminal region of TMEM106B modulates lipid membrane biophysical properties: functional and pathological insights
ATGL-catalyzed biosynthesis mediates the upregulation of Fatty Acid Hydroxy Fatty Acids (FAHFA) levels in white adipose tissue with fasting
Time-dependent changes in meibum lipid composition and progression of dry eye following disruption of the fatty acid elongase Elovl1
F2,6BP restores mitochondrial genome integrity in Huntington’s Disease
Myeloid AEG-1/MTDH drives inflammation and hepatocellular dysfunction in diet-induced steatohepatitis
The biochemical dynamics of the glycogen phosphatase laforin directly impact brain metabolism
HDAC6-mediated PFKL deacetylation enhances aerobic glycolysis and promotes VSMC proliferation
Activation of mitophagy antagonizes high uric acid-induced hepatic lipid accumulation
Elevated adipose inflammation, but reduced hepatic triacylglycerol storage in diet-induced obese Plin4−/− mice
Sialoglycans on human T cells attenuate death programs executed through the Fas pathway
The role of acyl cycling in endogenous G protein localization
CircAMOTL1 promotes adipose lipolysis and browning in cancer cachexia through miR-211-5p-mediated TET2 activation
Kallikrein 14 activates the chemoattractant protein chemerin in human skin
Structural and functional consequences of aspartate/asparagine-β-hydroxylase variants causing Traboulsi Syndrome
Neurodevelopmental Disease-causing Variants in Choline Kinase CHKA Gene Couple Phosphatidylcholine Synthesis to Oxidative Stress Damage and Disease Etiology
Metabolic and epigenetic abnormalities cause hepatic fibrogenesis in metabolic dysfunction–associated steatohepatitis model mice
Dynamic acetylation of a conserved lysine impacts glycerol kinase activity and abundance in the haloarchaeon Haloferax volcanii
Transcriptomic plasticity of cholinergic adipose macrophages in the acute thermogenic response
Histone deacetylase HDA-5 regulates lipid metabolism through H4K5 and H4K8 acetylation in Caenorhabditis elegans
Elevated cellular accumulation of endogenous and exogenous CoQ by altered intracellular trafficking
Structures of a lipin/Pah phosphatidic acid phosphatase in distinct catalytic states reveal a signature motif for substrate recognition
YAP-mediated glycolysis promotes pulmonary arterial smooth muscle cells proliferation in pulmonary arterial hypertension
Detection of PIP2 distributions in biological membranes using a peptide-based sensor
RNase P generated tRFSer-GCT promotes fat storage in adipocytes via Adrb2 signaling
A farnesoid X receptor T296I variant disrupts ligand-induced FXR activation and thus bile acid transport in progressive familial intrahepatic cholestasis
The serine protease HTRA1 targets tau fibrils and provides a proteolytic barrier against pathogenic protein conformations
Cysteine redoxome landscape in the liver of male mice fed a high-fat high-sucrose diet
The effects of naturally occurring mutations on functionality of oxylipin metabolizing dehydrogenase reductase nine
The hypoxia-induced chromatin reader ZMYND8 drives HIF-dependent metabolic rewiring in breast cancer
A yeast-based in vivo assay complements in vitro and in silico approaches to characterize sterol-binding by Saccharomyces cerevisiae Lam/Ltc proteins
β-hydroxybutyrate dehydrogenase promotes pancreatic cancer cell proliferation through regulation of the NAD+/NADH balance and mitochondrial acetylation
A biosynthetic pathway for ornithine lipid formation dependent on a GH3 (Gretchen Hagen 3)-like enzyme in planctomycetes
Andrographolide modulates glucose metabolism in visceral adipose tissue in an Alzheimer's disease obese mouse model
Potent antioxidant and mitochondrial-protective effects of ATH434, a moderate affinity iron chaperone
Neddylation inhibitor MLN4924 enhances H3K18 lactylation via binding to LDH and downregulates ITGB4 to block metastasis
TGF-β1-dependent expression of FOXS1 attenuates adipogenic potential and enhances a myofibroblast cellular phenotype
Disulfide bond-mediated stabilization of the oligomers of UDP-glucuronosyltransferase 2B7
O-GlcNAcylation of fatty acid synthase is required for its proper subcellular localization, expression level, and activity
Active site determinants of yeast Pah1 phosphatidate phosphatase activity and cellular functions
The structural characteristics of cellular phospholipid acyl chains required for ABCA1-mediated HDL formation
Structural and functional characterization of CREB-binding protein (CREBBP) as a histone propionyltransferase
Quantification profiles of enzyme activity, secretion, and psychosine levels of Krabbe disease galactosylceramidase missense variants
The ER-associated degradation adaptor SEL1L is dispensable for ER homeostasis and the differentiation of spermatogenic cells
Arylsulfatase B Induces Melanoma Apoptosis by the Ubiquitin Ligase COP1
The sphingosine-1-phosphate receptor 2 S1PR2 mediates chronic glucocorticoid exposure-induced hepatic steatosis and hypertriglyceridemia
The gut microbiota mediates epoxy eicosanoid metabolism in the colon
Biosynthesis of fatty aldehydes and alcohols in the eye and their role in meibogenesis
Characterization of Caenorhabditis elegans sphingomyelin synthases through heterologous expression
Endocytosis of sialic acid Neu5Gc and elevated p53 contributes to preimplantation embryonic arrest during in vitro fertilization
19
Polyploidy reprograms epithelial cells for motility and phagocytosis via stress signaling
Reversible one-way lipid transfer at ER–autophagosome membrane contact sites via Atg2
Cholesterol depletion activates trafficking-coupled sphingolipid synthesis
Surface Morphometrics reveals local membrane thickness variation in organellar subcompartments
NRZ complex facilitates virus infection via enhancing ER–LD contacts
In vivo mapping of peroxisome dynamics and pexophagy using PO-TRG and CA-PO-TRG reporter mice
Systematic membrane thickness variation across cellular organelles revealed by cryo-ET
Lipid packing and local geometry influence septin curvature sensing
Irg1l regulates neuromast size via metabolic reprogramming to promote supporting cell proliferation
PEX14 acts as a molecular link between optineurin and the autophagic machinery to induce pexophagy
PILS-Nir1 is a sensitive phosphatidic acid biosensor that reveals mechanisms of lipid production
Multiple interactions recruit BLTP2 to ER-PM contacts to control plasma membrane dynamics
Protein Kinase C promotes peroxisome biogenesis and peroxisome–endoplasmic reticulum interaction
The p97 ATPase and its adaptor UBXD8 maintain peroxisome pools by preventing pexophagy
Sphingolipid synthesis maintains nuclear membrane integrity and genome stability during cell division
Metabolic adaptations of micrometastases alter EV production to generate invasive microenvironments
Phosphatidic acid drives spatiotemporal distribution of Pex30 at ER-LD contact sites
NEMF-mediated CAT tailing facilitates translocation-associated quality control
ZBTB17/MIZ1 promotes peroxisome biogenesis by transcriptional regulation of PEX13
1
Tracing calcium flows for bulk calcium waste management in China
19
Evaluating the therapeutic impact of tirzepatide in people with partial lipodystrophy
Patients with MASLD exhibit in vivo changes in hepatic response to oral fructose consumption
Bisphenol A decreases peripheral insulin sensitivity in normal weight adults: a double-blind randomized controlled trial
NGF promotes, in an autocrine–paracrine manner, metabolic and anti-inflammatory pathways in human and mouse adipocytes
A Novel POR G88S Mutation Causes Severe PORD and Establishes a Critical Pharmacogenomic Risk Profile
Cold-induced serum short-chain fatty acids act as markers of brown adipose tissue metabolism in humans
Adiposome Lipidomic Shifts Following Bariatric Surgery in Association with Weight Loss and Cardiometabolic Benefit
Insulin sensitivity and associated plasma proteomics during sex hormone therapy
Serum Proteomics of Insulin Resistance Disorders Distinguish MASLD From Lipodystrophy and Insulin Receptor Defects
Reference Values for Serum Leptin Levels in Children, Adolescents, and Adults With Normal Weight, Overweight, and Obesity
Magnesium Depletion, Metabolic Impairment, and Cardiac Alterations: The NAKO-MRI Study with Mendelian Randomization
Effect of Osteocalcin on Insulin Sensitivity, Insulin Secretion, and β-cell Compensation in Mexican Americans
Determinants of Pancreatic Size and Fat Content in the UK Biobank: Influence of Race, Genetic Variants, and Risk Factors
Effects of Acute Iso- and Hypocaloric Carbohydrate Restriction on Liver Fat and Glucose and Lipid Metabolism
Cord Blood DNA Methylation at CHD13 Is Associated with Adiponectin Levels at 10 to 14 Years of Age
Multiomics of Human Obesity and Related Multisystem Diseases
Plasma Sphingolipids in Relation to Glycemia and Glucose Tolerance in People Without Diabetes
Metabolic Dysfunction-associated Steatotic Liver Disease Alters Fatty Acid Profiles in the Liver and Adipose Tissue
The Relationships Between MASLD, Extrahepatic Multimorbidity, and All-Cause Mortality in the UK Biobank Cohort
32
HNF4α controls growth, identity, and KRAS inhibitor response in invasive mucinous adenocarcinoma of the lung
Metabolic dysfunction-associated steatohepatitis exacerbated by Clostridium perfringens-derived ammonia is attenuated by tripeptide DT-109
Hepatic SEC16B regulates lipid homeostasis by coordinating VLDL secretion and lipid droplet expansion
The N-terminus of Apolipoprotein B mediates the interaction of atherogenic lipoproteins with endothelial cells
Redirection of sphingolipid metabolism drives cytoskeletal defects in SPLIS and reveals ROCK inhibition as therapy
The ULK1-NCOA3 axis restrains de novo lipogenesis and prevents diet-induced steatohepatitis and fibrosis in mice
GPR182 is a lipoprotein receptor for dietary fat absorption
L-2-hydroxyglutarate impairs neuronal differentiation through epigenetic activation of MYC expression
Short-term sleep restriction in humans alters diurnal circulating metabolite profiles, including those of microbial origin
α-Ketoglutarate protects against cartilage damage via epigenetically driven metabolic reprogramming in osteoarthritis models
PPARα-NFκB heterodimer mediates obesity-induced diastolic dysfunction through autocrine production of IL-6
Biallelic GLTP mutations cause nonsyndromic epidermal differentiation disorder via disrupted epidermal glucosylceramide transport
Notch1 O-GlcNAcylation drives tumor stemness and mechanoadaptation to a stiff microenvironment and promotes chordoma recurrence
Proanthocyanidins enhance antitumor immunity by promoting ubiquitin-proteasomal PD-L1 degradation via stabilization of LKB1 and SYVN1
EBF2 variant identified in a patient with atypical partial lipodystrophy causes adipose fibrosis and dysfunction
Protectin DX resolves fracture-induced postoperative pain in mice via neuronal signaling and GPR37-activated macrophage efferocytosis
Poly(ADP-ribose) glycohydrolase enforces p21 degradation via dePARylation to promote gastric cancer progression
Mitochondrial complex II orchestrates divergent effects in CD4+ and CD8+ T cells
Nonionotropic action of an acid-sensing ion channel inhibits leukemogenesis in the acidic bone marrow niche
Lamin A/C regulates lipid metabolism and inflammation: insights from models of familial partial lipodystrophy 2
Peroxisomal integrity in demyelination-associated microglia enables cellular debris clearance and myelin renewal in mice
Adipocyte death promotes hepatic infiltration of S100A8+ macrophages and steatotic liver disease progression in mice
GPIHBP1, lipoprotein lipase, and triglyceride-rich lipoproteins in capillaries of the choroid plexus and circumventricular organs
ER stress upregulates S100A11 in steatohepatitis models via epigenetic modifications within the lipotoxicity influenced enhancer
Integrated screening identifies GPR31 as a key driver and druggable target for metabolic dysfunction–associated steatohepatitis
The GLYT1 inhibitor bitopertin mitigates erythroid PPIX production and liver disease in erythroid protoporphyria
SPNS1 variants cause multi-organ disease and implicate lysophospholipid transport as critical for mTOR-regulated lipid homeostasis
Cross-species efficacy of AAV-mediated ARSA replacement for Metachromatic Leukodystrophy
CNS-targeted base editing of the major late-onset Tay-Sachs mutation alleviates disease in mice
Neuraminidase 1 secondary deficiency contributes to CNS pathology in neurological mucopolysaccharidoses via brain proteins hypersialylation
Diet-induced obesity promotes endothelial cell desensitization to VEGF-A and permanent islet vessel dysfunction in mice
Hepatic glycogen directly regulates gluconeogenesis through an AMPK/CRTC2 axis in mice
2
Adipose tissue harbors pathogenic T cells in obesity that exacerbate inflammatory arthritis
Gut dysbiosis from high-salt diet promotes glioma via propionate-mediated TGF-β activation
12
Liver-directed lentiviral gene therapy confers durable hepatic and systemic amelioration of methylmalonic acidemia in mice
Chromatin remodeling in pericentral hepatocytes modulates MASH through CYP450 activity
Activated hepatic stellate cells maintain liver bile acid homeostasis through paracrine FGF10/FGFR2 signaling
Tissue-specific regulation of PNPLA3 promotes lipid remodeling in response to dietary and environmental challenges
AF6 knockout-induced upregulation of bile acid production promotes CXCL14-mediated antitumor immunity in HCC Effect of the BA/Butyrate/CXCL14 axis in HCC
DNAJ-PKAc induces metabolic rewiring and enhanced glutamine flux in fibrolamellar HCC
S1P/S1PR4 Promotes the Differentiation of CD8+ tissue-resident memory T Cells Aggravating Bile Duct Injury in Biliary Atresia
Claudin-1 is a mediator and therapeutic target in primary sclerosing cholangitis
Decreased LONP1 expression exacerbates MASH-induced liver fibrosis via elevated orotic acid levels
Somatic loss-of-function mutations in CIDEB reduce hepatic steatosis by increasing lipolysis and fatty acid oxidation
Phase 1 randomized double-blind study of an RNA interference therapeutic targeting HSD17B13 for metabolic dysfunction–associated steatohepatitis
Bile acids engage the SIPR-STAT3 signaling axis to modulate regulatory T cell responses in fibrosing cholangiopathies
2
BLTP1 is required for survival and normal development and function of the neuromuscular junction in mice
Impact of Elovl5 Deficiency on Cerebellar Excitatory Synaptic Transmission in Mice
10
Obesity, microRNA circulating microRNA signatures reveal core and reversible dysregulations in obesity via machine learning
The endocrine product of renal (preglomerular) contractile pericytes depends on prolyl‐4‐hydroxylases 2 and 3
Low‐dose lithium supplementation promotes musculoskeletal and metabolic health in ovariectomized female mice
Impact of time‐restricted feeding on metabolic health and adipose tissue metabolism in aged female mice with high‐fat diet‐induced obesity
Optimal neuromuscular performance requires motor neuron phosphagen kinases
Hypomagnesaemia‐associated hypokalaemia requires activation of both ENaC and ROMK
Intestinal fructose metabolism triggers a glucagon‐like peptide‐1–β‐cell axis to prevent post‐fructose hyperglycaemia
Harnessing metabolic control for synaptic stability: REST/NRSF links glycolytic inhibition to excitatory neurotransmission
Dihydrosterculic acid induces hepatic PPARα target gene expression in mice
Time‐restricted feeding combined with exercise improves hepatic and glycaemic metabolism in obese mice: A sex‐dependent study
29
Insights into the Debated Lyase Mechanism of Bifunctional DNA Glycosylases from MD and QM/MM MD Simulations: The Case Study of DNA Oxidative Damage Repair by Human 8‑Oxoguanine DNA Glycosylase
Lipid–Substrate Interactions Lead to Bilayer Asymmetry
Covalent Inhibitors of Monoacylglycerol Lipase Induce Conformational Changes and Proteasomal Degradation
Bimodal Cholesterol for Correlative In-Cell DNP Solid-State NMR and Confocal Microscopy of the Plasma Membrane
Tyr39 Phosphorylation of α-Synuclein Accelerates Heterotypic Aggregation and Drives Toxic Amplification
A Scalable COF-Based Sequestrant for Synergistic Bile Acid Modulation in Fatty Liver Disease
Targeting Conformational Flexibility of a Reactive Intermediate to Enhance Selectivity of a GABA Aminotransferase Inactivator
Structural Change of ApoE–Lipid Nanoparticles Alters Receptor-Mediated Endocytosis and Induces Endosomal Disruption
Probing the Conformation of BamC and BamE in Native Bacterial Membranes Using Solid-State NMR Spectroscopy
Secondary Structure-Encoded Control of Lipid Assembly by Radially Amphiphilic Peptides
Discovery of Glycation-Derived Cross-links at Arginine
Heterogeneous Dynamics of the Fuzzy Coat of Full-Length Phospho-Mimetic Tau Fibrils
Structural Insights into Recognition and Translocation of Oxidized Phospholipid by CD36 Using Mass Spectrometry, Molecular Docking, Dynamics, and Metadynamics Simulations
A Structurally Robust Phospholipid Microtube Constructed by Membrane Phase Separation as a Scaffold for On-Tube Characterization of Membrane-Bound Proteins
Bifunctional LYTAC Mediates Hepatocytes-Hepatic Stellate Cells Crosstalk by Regulating 5-HT2A Receptor Degradation and Antagonism to Synergistically Ameliorate Hepatic Fibrosis
Intracellular Peptide N-Myristoylation for Cancer Cell Ferroptosis without Acquired Resistance
Construct Open Lipid Nano-Membranes with Controllable Lateral Behavior
From Transient to Metastable: Generation, Characterization, and Biomimetic Reactivity Studies of Well-Defined Heme Peroxynitrite Model Systems
A Chemical Mechanistic Path Leads the Way to Cellular Argpyrimidine
Dynamic Shape Modulation of Deflated and Adhered Lipid Vesicles
Synthesis of Crystalline Calcium Bicarbonate
Role of Human Mitochondrial Ketosynthase in Long-Chain Fatty Acid Biosynthesis
Structural Heterogeneity of Proteoform-Ligand Complexes in Adenosine Monophosphate-Activated Protein Kinase Uncovered by Integrated Top-Down Mass Spectrometry
The Structure of Human IAPP Fibrils Reflects Membrane and pH Conditions
Strain-Distinct α-Synuclein and Tau Cross-Seeding Uncovered by Correlative Approach with Optical Photothermal Infrared Sub-Micron Imaging
Organic Carbon Monoxide Prodrugs Activated by Endogenous Reactive Oxygen Species for Targeted Delivery
Radical Oxidation of the 2-Deoxyribosyl Moiety of DNA: Characterization of Unique Strand Breaks with 5′-Carboxylate Termini
A Solvatochromic Near Infrared Fluorophore Sensitive to the Full Amyloid Beta Aggregation Pathway
iBis/i-Allylic Deuterated Docosahexaenoic Acid-Esterified Phospholipids Resist In Vivo Peroxidation in Rat Brain
1
Coronary Atherosclerosis in Liver Transplant Recipients and Population Controls
2
Comprehensive Medication Reviews in Medicare Were Not Associated With Reduced Central Nervous System‐Active Polypharmacy in 2021
Comparing Fourteen Behavioral Science Electronic Health Record Deprescribing Tools in Older Adults: NUDGE‐EHR Adaptive Trial
1
Modulation of the APOM/S1PR4 Pathway Reduces Podocyte Lipid Overload in Alport Syndrome via Distinct Autophagy and Efflux Mechanisms
3
Divergent effects of PLA2G7 on prostate cancer biochemical recurrence in European American and African American men
Impact of sodium-glucose cotransporter 2 (SGLT2) inhibitors on hematologic malignancy risk: Insights from Japanese claims data
Adiposity distribution and risks of 12 obesity-related cancers: a Mendelian randomization analysis
17
S-acylation of TDP43 regulates its condensation in amyotrophic lateral sclerosis
Cytoplasmic RNase III Drosha controls lipogenesis by noncanonical regulation of SREBP1
Metabolic profiling reveals pyrimidine synthesis enzyme CAD as a central carbon metabolism signaling node in cancer cell proliferation
Aspartate availability drives differential engagement of the malate-aspartate shuttle
MEDAG functions as an A-kinase-anchoring protein in adipocytes
Functional nutrient-genetic profiling reveals biotin and FBXW7 are essential to bypass glutamine addiction
RAD51 succinylation regulates homologous recombination and contributes to the chemosensitivity in cancer
Mitochondrial glutamine import sustains electron transport chain integrity independently of glutaminolysis in cancer
H4K16 acylations destabilize chromatin architecture and facilitate transcriptional response during metabolic perturbations
HYPK promotes N-terminal protein acetylation through rapid ribosome exchange of NatA
Divergent proteome tolerance against gain and loss of chromosome arms
UDP-GlcUA triggers PKR kinase activity to promote liquid-liquid phase separation of TOP2A and enhances radioimmunotherapy resistance
Rapid remodeling of NTP levels enables immediate translational adaptation to energy stress in yeast
A regulator of amino acid sensing links lipid peroxidation and lipid droplet-dependent antioxidant response
Lactylation of XLF promotes non-homologous end-joining repair and chemoresistance in cancer
Mechanism of cotranslational protein N-myristoylation in human cells
Structural and systems characterization of phosphorylation on metabolic enzymes identifies sex-specific metabolic reprogramming in obesity
1
Perinatal omega-3 sex-selectively mitigates neuropsychiatric impacts of prenatal THC in the cortico-striatal-hippocampal circuit
8
Lipid Composition Determines Hybrid Nanoparticle Selectivity: Beyond Membrane Mimicry in Cancer Targeting
Reconstruction of Molecular Interaction Patterns from Endolysosomes in Ceramide-Depleted Cells
Using DNA Origami to Study Nanoscale Organization of Plasma Membranes
From Shallow to Full Wrapping: Geometry and Deformability Dictate Lipid Vesicle Internalization
Ampholytic Carbon Dots Enable Imaging and Modulation of Amyloid Fibrillation with Reduced Neurotoxicity
Direct Visualization of ATP-Binding Cassette Protein A1 Mediated Nascent High-Density Lipoprotein Biogenesis by High-Speed Atomic Force Microscopy
Hyperbranched Poly(citric acid) Mitigated Iron Overload Damage via Iron Chelation and Antioxidation
Visual Diagnostic Strategy for Assessing the Impact of Aerobic Glycolytic Processes on Tumor Growth and Therapy
29
αKG-mediated carnitine synthesis drives DNA repair via histone acetylation
Mitochondrial -2-hydroxyglutarate is a physiological signalling metabolite
A deep-learning framework reveals whole-body perturbations at cell level
Postprandial lipid metabolism durably enhances T cell immunity
Ubiquitination of glycogen and metabolites in cells and tissues
Proteasome-guided haem signalling axis contributes to T cell exhaustion
CLCC1 governs ER bilayer equilibration to maintain lipid homeostasis
CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly
RYK is a GPNMB receptor that drives MASH
Sleep-dependent clearance of brain lipids by peripheral blood cells
ZFTA–RELA ependymomas make itaconate to epigenetically drive fusion expression
Structure and mechanism of the human bile acid transporter OSTα–OSTβ
Nutrient requirements of organ-specific metastasis in breast cancer
Neutrophils preserve energy storage in sympathetically activated adipocytes
SIGLEC12 mediates plasma membrane rupture during necroptotic cell death
ABCA7 variants impact phosphatidylcholine and mitochondria in neurons
Genetic suppression features as a Barth syndrome therapeutic target
Rewiring of cortical glucose metabolism fuels human brain cancer growth
Quantitative imaging of lipid transport in mammalian cells
Lithium deficiency and the onset of Alzheimer’s disease
ACLY inhibition promotes tumour immunity and suppresses liver cancer
Transient APC/C inactivation by mTOR boosts glycolysis during cell cycle entry
Mitochondrial origins of the pressure to sleep
Selective remodelling of the adipose niche in obesity and weight loss
Coenzyme Q headgroup intermediates can ameliorate a mitochondrial encephalopathy
Interactions between TTYH2 and APOE facilitate endosomal lipid transfer
Allosteric modulation and biased signalling at free fatty acid receptor 2
Glycosaminoglycan-driven lipoprotein uptake protects tumours from ferroptosis
Early life high fructose impairs microglial phagocytosis and neurodevelopment
1
Sustained nitric oxide production by engineered remodels the tumor microenvironment and potentiates immunotherapy
10
Membrane bridges and nanodomain partitioning govern membrane protein targeting to lipid droplets
Palmitoylation-mediated regulation of KAT2A promotes lung metastasis in breast cancer
Tumour acidosis remodels the glycocalyx to control lipid scavenging and ferroptosis
Inhibiting macrophage-derived lactate transport restores cGAS–STING signalling and enhances antitumour immunity in glioblastoma
FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis
Cholesterol sensing by the SCAP–FAM134B complex regulates ER-phagy and STING innate immunity
Remote control of AMPK via extracellular adenosine controls tissue growth
PEX39 facilitates the peroxisomal import of PTS2-containing proteins
The Vps13-like protein BLTP2 regulates phosphatidylethanolamine levels to maintain plasma membrane fluidity and breast cancer aggressiveness
Lactate dehydrogenase B facilitates disulfidptosis and exhaustion of tumour-infiltrating CD8+ T cells
14
Cystine C–S bond cleavage fuels cysteine production under disulfide reductase deficiency
Condensation-independent intramodular translocation mechanism of the trans-AT polyketide synthase assembly line
GCN5–ERK lactylation–phosphorylation loop amplifies lactate-driven cancer progression
Autopalmitoylation of IDH1-R132H regulates its neomorphic activity in cancer cells
Membrane editing with proximity labeling reveals regulators of lipid homeostasis
The membrane transition strongly enhances biopolymer condensation through prewetting
Molecular basis for the regulation of membrane proteins through preferential lipid solvation
Leaflet-specific phospholipid imaging using genetically encoded proximity sensors
An unbiased proteomic platform for ATE1-based arginylation profiling
α-Ketoglutarate dictates AMPK protein synthesis for energy sensing in human cancers
Intracrine FFA4 signaling controls lipolysis at lipid droplets
A genetically encoded selection for amyloid-β oligomer binders
Lipoyl deglutarylation by ABHD11 regulates mitochondrial and T cell metabolism
Unraveling Alzheimer’s complexity with a distinct Aβ42 fibril type and specific AV-45 binding
2
Discovery of chirally dependent protein modifications by - and -2-hydroxyglutarates
High-throughput discovery of fluoroprobes that recognize amyloid fibril polymorphs
186
Inference of upstream-mutation and metabolomic-signature causality identifies prognostic biomarkers and therapeutic targets in pancreatic cancer
Breaking the membrane heredity paradox through de novo protocell formation
Metabolic characterization of the tumor microenvironment orchestrates therapeutic strategies and clinical outcomes in pancreatic cancer
An HDAC4-specific PROTAC degrader achieves radiation sensitization by enhancing ferroptosis in lung cancer
Angptl4 integrates dietary and microbial signals to disrupt gut barrier function in MASH
Insulin receptorT1160 phosphorylation mediates renal cortical insulin resistance but not excess gluconeogenesis from glycerol
Macrophage ALDH2 drives immunotherapy resistance by silencing CXCL9 through metabolic-epigenetic crosstalk
Flow-mediated endothelial remodeling and inflammation drive developmental vascular susceptibility in ldlr loss of function
C2orf74 orchestrates germ-Leydig crosstalk to inhibit white adipose tissue browning in male mice
Glucuronidation metabolomic fingerprinting to map host-microbe metabolism
Western diet-induced MASH in PWK/PhJ mice identifies disruptions in amino acid and sphingolipid metabolism contributing to cardiac dysfunction
Membrane lipid poly-unsaturation selectively affects dopamine D2 receptor endocytosis
Oxysterol undersulfation promotes osteoarthritis by fueling chondrocyte lipid accumulation
Gut microbiota-induced perturbation in bile acids alter keratinocyte lipid metabolism via FXR-NQO1 signaling in psoriasis
Pharmabiotics, Phocaeicola dorei, ameliorates cholestatic liver fibrosis by alleviating macrophage efferocytosis of neutrophils
A conserved ER protein prevents lipotoxicity by stimulating the key enzyme in glycerolipid synthesis
The SIRT3-DsbA-L-TFAM axis restrains cGAS-driven metabolic dysfunction-associated steatohepatitis in male mice
Direct observation of ATP-driven ubiquitin chain handling by Cdc48
Lipid bilayers determine allostery but not intrinsic affinity of cAMP to pacemaker channels
Atomic structures of medin and Aβ fibrils reveal polymorphic remodeling in mixed amyloid systems
Enzyme-centric chemoproteomics reveals isomer-specific S-acylation modification networks
EBF2 condensates enable adipose thermogenesis through ZFP423 sequestration and epigenetic remodeling
Transcription factor 19 modulates fatty acid elongation and unfolded protein response to attenuate palmitic acid-induced hepatic dysfunction
Conserved and divergent features of human mRNA decapping revealed by biochemical reconstitution
SPNS2 exports sphingosine-1-phosphate and imports glucose
Adipose single cell epigenome and transcriptome localize genetic risk for cardiometabolic disease and accelerated aging
White adipose atrophy exacerbates cold stress and accelerates aging in male mice
ATP synthase is a promising target for identifying activated and non-activated adipose tissues
SpiR is a gut microbial enzyme that drives cholesterol conversion
Sphingosine-1-Phosphate-derived 2-Hexadecenal is a central mediator of ocular neovascularization by inhibiting Sphingosine-1-Phosphate receptor 5
Selective membrane wetting of phase-separated giant unilamellar vesicles by coacervate droplets
Adipocyte small extracellular vesicle-derived microRNA-30a-3p exacerbates hepatic steatosis in high fat diet-fed male mice
An immunobiliary single-cell atlas resolves crosstalk between type 2 conventional dendritic cells and γδ T cells in cholangitis
Leucine catabolic enzyme AUH regulates BAT thermogenesis via PPARγ HMGylation and RNA-binding function in male mice
Primary cilia in the hypothalamic AgRP neurons mediate metabolic effects of butyrate
Inhibition of circulating glycocholic acid-regulated signaling potentiates immune checkpoint therapy in colorectal cancer
YY1/Asprosin/PFKP axis regulates glycolytic metabolic and exacerbates pathological cardiac hypertrophy
Structural and functional dissection of a higher-order oligomerization interface in yeast ceramide synthase
The ribosome-associated N-terminal acetyltransferase B coordinates global proteostasis and autophagy in plants by creating Ac/N-degrons
Fluorescence-based mapping of condensate dielectric permittivity uncovers hydrophobicity-driven membrane interactions
Lactylation at lysine 145 fosters KAT8-TIP60 complex formation to promote p53 acetylation at lysine 120 and its pro-apoptotic function
SLIT3 fragments orchestrate neurovascular expansion and thermogenesis in brown adipose tissue
Regulation of physical activity and energy expenditure through Phf6 in the medial preoptic area
Pentose phosphate pathway fuels cGAS-STING signalling to boost function of intratumoral conventional dendritic cells
Structural mechanism of substrate binding and inhibition of human taurine transporter
Engineering synthetic cells with intramembrane domains possessing distinct bilayer asymmetries
FGF1 orchestrates circadian hepatic triglyceride secretion
NANP targeting radiosensitizes glioblastoma through TNFR1 sialylation-driven mesenchymal shift
INSIG1/2 succination mediated by the moonlighting function of ADSL promotes lipogenesis and liver tumorigenesis
Hepatocyte SLCO4C1 is a cAMP uptake transporter for inhibiting lipogenesis and a therapeutic target for MASLD
Butyrate extends health and lifespan in mice with mitochondrial deficiency
Enterocytes rely on purine biosynthesis/salvage pathway to facilitate dietary fat absorption
NAA40 and NAC cooperate in co-translational histone acetylation in humans
Targeting tRNA-dependent tyrosine usage unveils a metabolic vulnerability in hepatocellular carcinoma
Native chromatome profiling reveals hundreds of metabolic enzymes in the nucleus across tissues
GPR146 in adipose tissue drives adipose-liver crosstalk and promotes hepatic steatosis in mice
Embryo metabolite analysis and implantation potential prediction using chemiluminescent microfluidic chips with dielectric wetting valves
Dynamic subcellular proteomics identifies regulators of adipocyte insulin action
Clinically distinct metabotypes of pediatric MASLD identified through unsupervised clustering of NASH CRN data
Diverse regulation of functional dimerization of a sugar transporter by different interfacial lipids
-nitrosoglutathione reductase GSNOR drives age-related obesity by promoting adipose tissue whitening through de-nitrosation of Beclin-1
Investigation of bile salt hydrolase activity in human gut bacteria reveals production of conjugated secondary bile acids
Phosphoglycerate dehydrogenase-mediated serine reprogramming aggravates macrophage hyperinflammation in murine pneumonia
Structural defects in amyloid-β fibrils drive secondary nucleation
Arginase 1 promotes hepatic lipogenesis by regulating ERK2/PPARγ signaling in a non-canonical manner
TGFβ-activated PDHB promotes mitochondrial pyruvate metabolism and contributes to human endoderm differentiation via ATP-dependent BRG1
GCN5 drives MASLD progression through LXRα/SREBP1c signaling pathway–mediated de novo lipogenesis
MG53 mediates skeletal muscle-liver cross-talk and enhances alcohol metabolism in alcoholic liver disease
Exploiting human fucosyltransferase 8 allostery with a covalent inhibitor for core fucosylation suppression
Interleukin-10 expressing B lineage cells in visceral adipose tissue protect against aging-related insulin resistance and extend lifespan
Atypical protein kinase C activation drives intestinal glucose excretion in diabetes mellitus
Structural basis and pathological implications of the dimeric OS9-SEL1L-HRD1 ERAD Core Complex
Ether lipids influence cancer cell fate by modulating iron uptake
1,3-and 1,4-linked polysaccharides uptake in intestinal cells relies on clathrin/dynamin 1/Rab5-dependent endocytosis
Discovery of NIRF theranostic probes targeting amyloid-β and cholinesterases in Alzheimer’s disease models
NatA engages in multi-factor complexes at the ribosomal polypeptide tunnel exit
Sugar rationing during the first 1000 days of life and lifelong risk of heart failure
Spatiotemporal regulation of energetic charge dictates T cell function
The UFL1-AKT positive feedback loop promotes breast cancer progression by enhancing lipid synthesis
NCOA1 is a gatekeeper of the sexually dimorphic thermogenic activity of white adipose tissue
Modeling tissue-specific metabolism identifies high sugar diet-induced metabolic dysregulation in muscle at reaction and pathway levels
Palmitic acid-triggered B7H3 palmitoylation promotes immune escape
Endothelial FUNDC1 regulates metabolic reprogramming and the obesity-diabetes transition through the SIRT3/GATA2/endothelin-1 axis
Epoxy-oxylipins direct monocyte fate in inflammatory resolution in humans
Improving erectile function in diabetic male mice by rescuing depalmitoylated FBP1 to reduce cavernosal lactate
Adipocytic sclerostin loop3-LRP4 interaction required by sclerostin to impair whole-body lipid and glucose metabolism
6-Phosphogluconate dehydrogenase promotes mitochondrial fusion and immune suppression in tumor-associated monocytic suppressor cells
K48-ubiquitin-dependent proteases cut-up post-ER proteins
Lipedema World Alliance Delphi Consensus-Based Position Paper on the Definition and Management of Lipedema: Results from the 2023 Lipedema World Congress in Potsdam
Amyloid-ID: photocatalytic profiling of amyloid deposits in Alzheimer’s disease tissue
Sulfatide deficiency-induced astrogliosis and myelin lipid dyshomeostasis are independent of TREM2-mediated microglial activation
The dorsal aortic compartment is a developmental source of brown adipose tissue in mice
CUL4A-DDB1-DCAF10 is an N-recognin for N-terminally acetylated Src kinases
Adaptation to cystine limitation stress confers a targetable lipid metabolism vulnerability in pancreatic ductal adenocarcinoma
BATF2 is a glutamine-responsive tumour suppressor required for type-I interferon-dependent anti-tumour immunity
Systemic engineering and global regulation enabling high-level bilirubin biosynthesis
AI-guided transition path sampling of lipid flip-flop and membrane nanoporation
TMEM120A maintains adipose tissue lipid homeostasis through ER CoA channeling
Cryo-EM structure of TMEM164 reveals distinct phospholipid remodeling mechanisms with anti-ferroptotic potential
Lactate mitochondrial oxidation drives stemness potential in metastatic breast cancer
Multi-layered transcriptional control of glycogen metabolism coordinates thermogenic remodeling of white adipocytes in male mice
Compression-induced NF-κB activation sustains tumor cell survival in confinement by detoxifying aldehydes and promotes metastasis
Sequestration of the phagocyte metabolite itaconate by Pseudomonas aeruginosa RpoN promotes successful pulmonary infection
Effects of an anti-lipogenic low-carbohydrate high polyunsaturated fat diet or a healthy Nordic diet versus usual care on liver fat and cardiometabolic disorders in type 2 diabetes or prediabetes: a randomized controlled trial (NAFLDiet)
Structural insights into GM4951 as a lipid droplet GTPase regulating hepatic lipid metabolism
AGPAT2 acts at the crossroads of lipid biosynthesis and DRP1-mediated ER morphogenesis
Hyperglycemia exacerbates osteoarthritis by impairing macrophage efferocytosis through modulation of CD11b lactylation
Diet-induced RKIP downregulation disrupts PC/PE-ER homeostasis to drive MASLD
Structure of Trypanosoma peroxisomal import complex unveils conformational heterogeneity
Schisantherin A interacts with gut bacteria to stimulate adipose tissue thermogenesis in obese mice via a TGR5‒p-CREB‒STAT6 signaling pathway
Inhibition of adipocyte lipolysis by vaspin impairs thermoregulation in vivo
Multimodal mass spectrometry imaging for plaque- and region-specific neurolipidomics in Alzheimer’s disease mouse models
Implementing N-terminomics and machine learning to probe Nt-arginylation
Worldwide trends in metabolic syndrome from 2000 to 2023: a systematic review and modelling analysis
Cytochrome c oxidase dependent respiration is essential for T cell activation, proliferation and memory formation
Defective vascular smooth muscle cell tafazzin impairs mitochondrial function and promotes atherosclerosis in preclinical models
Plasma membrane transbilayer asymmetry of PI(4,5)P2 drives unconventional secretion of Fibroblast Growth Factor 2
Avian GCGR-mediated continuous fat utilization offers perspectives for obesity treatment
Plasma lipopolysaccharide levels predict mortality in acutely ill children in Low- and Middle-Income Countries
TOR and heat shock response pathways regulate peroxisome biogenesis during proteotoxic stress
The luminal domain region of Seipin/Fld1 is dispensable for establishing functional ER sites for lipid droplet biogenesis
Acetyl-CoA carboxylase maintains energetic balance for functional oogenesis
Itaconate transport across the plasma membrane and Salmonella-containing vacuole via MCT1/4 modulates macrophage antibacterial activity
Sec14L6 is a phosphoinositide transporter that regulates phosphoinositide homeostasis and biogenesis of lipid droplets
Very long-chain fatty acids drive 1-deoxySphingolipid toxicity
Desat1-mediated lipid homeostasis mitigates 20E-induced lipotoxicity in blood-fed mosquitoes
Multi-omic analysis reveals lipid dysregulation associated with mitochondrial dysfunction in parkinson’s disease brain
The E3 ligase tripartite motif 7 drives the progression of non-alcoholic fatty liver disease by targeting DUSP10 degradation in male mice
Fructose and follistatin potentiate acute MASLD during complete hepatic insulin resistance
The S-depalmitoylase ABHD10 is essential for sperm mitochondrial sheath formation and male fertility
Effect of metformin on insulin resistance in adults with type 1 diabetes: a 26-week randomized double-blind clinical trial
Desaturase-dependent secretory functions of hepatocyte-like cells control systemic lipid metabolism during starvation in Drosophila
Atomic structure and in situ visualization of native PMEL lamellae in melanosomes
MRAP mediated adipocyte differentiation by thymic mesenchymal stromal cells contributes to thymic involution
A UBH-UBX module amplifies p97/VCP’s unfolding power to facilitate protein extraction and degradation
A preserved TGFβ cytostatic response through DLD-mediated metabolic modulation undermines anti-TGFβ therapy in gastric cancer
Alterations in peroxisome-mitochondria interplay in skeletal muscle accelerate muscle dysfunction
Tumour sampling conditions perturb the metabolic landscape of clear cell renal cell carcinoma
The integral membrane protein smim4 modulates redox balance via malate compartmentalization in pancreatic cancer
Integrative brain omics approach highlights sn-1 lysophosphatidylethanolamine in Alzheimer’s dementia
Structural basis for amyloid fibril assembly by the master cell-signaling regulator receptor-interacting protein kinase 1
Physics-based evolution of transmembrane helices reveals mechanisms of cholesterol attraction
Autophagy acts as a brake on obesity-related fibrosis by controlling purine nucleoside signalling
Microglia-specific regulation of lipid metabolism in Alzheimer’s disease revealed by microglial depletion in 5xFAD Mice
UBE2J2 sensitizes the ERAD ubiquitination cascade to changes in membrane lipid saturation
Demethylation of methylguanidine by a stepwise dioxygenase and lyase reaction
Non-canonical dihydrolipoyl transacetylase promotes chemotherapy resistance via mitochondrial tetrahydrofolate signaling
Cells adapt to extracellular acidic pH through TM9SF3-mediated PI(4,5)P flop
Anle138b binds predominantly to the central cavity in lipidic Aβ₄₀ fibrils and modulates fibril formation
MTCH2 modulates CPT1 activity to regulate lipid metabolism of adipocytes
Inhibition of formyl peptide receptor-1-mediated cell death as a therapy for lethal cutaneous drug reactions in preclinical models
Cardiolipin dynamics promote membrane remodeling by mitochondrial OPA1
Uncovering the prevalence, key biogenesis enzymes, and biological significance of archaeal lipoproteins
Identification of Neuritin 1 as a local metabolic regulator of brown adipose tissue
Targeting phagocytosis for amyloid-β clearance: implications of morphology remodeling and microglia activation probed by bifunctional chimaeras
Structural basis of VCP-VCPIP1-p47 ternary complex in Golgi maintenance
Microglial replacement in a Sandhoff disease mouse model reveals myeloid-derived β-hexosaminidase is necessary for neuronal health
Helicobacter hepaticus promotes hepatic steatosis through CdtB-induced mitochondrial stress and lipid metabolism reprogramming
Spatial isotope deep tracing deciphers inter-tissue metabolic crosstalk
Dysregulation of GTPase-activating protein-binding protein1 in the pathogenesis of metabolic dysfunction-associated steatotic liver disease
Dual-targeted siRubicon delivery strategy triggers hepatocellular lipophagy for mitigating liver steatosis
Molecular basis of human taurine transporter uptake and inhibition
Adipocyte RNA-binding protein CELF1 promotes beiging of white fat through stabilizing mRNA
Nucleus-translocated glucokinase functions as a protein kinase to phosphorylate TAZ and promote tumour growth
Defective Olfactomedin-2 connects adipocyte dysfunction to obesity
12,13-diHOME protects against the age-related decline in cardiovascular function via attenuation of CaMKII
Cholesterol modulates membrane elasticity via unified biophysical laws
Inhibition of HDAC6 alters fumarate hydratase activity and mitochondrial structure
A genetically encoded biosensor for point-of-care and live-cell detection of -2-hydroxyglutarate
PFKM phosphorylates histone H3 and promotes mitotic progression by sensing the levels of citrate
PNPLA7 mediates Parkin-mitochondrial recruitment in adipose tissue for mitophagy and inhibits browning
β-Hydroxybutyrate promotes cancer metastasis through β-hydroxybutyrylation-dependent stabilization of Snail
Adipose tissue-derived PRXL2A suppresses hepatic lipogenesis in a study with male mice
Human glycogenins maintain glucose homeostasis by regulating glycogen metabolism
Gut microbial bile and amino acid metabolism associate with peanut oral immunotherapy failure
Tetrandrine regulates NAADP-mediated calcium signaling through a LIMP-2-dependent and sphingosine-mediated mechanism
Dimerization and substrate recognition of human taurine transporter
Spatial patterns of hepatocyte glucose flux revealed by stable isotope tracing and multi-scale microscopy
Cryo-EM of wild-type and mutant PMEL amyloid cores reveals structural mechanism of pigment dispersion syndrome
Lipoic acid functions in Paneth cells to prevent human intestinal stem cell aging
Histone serotonylation promotes pancreatic cancer development via lipid metabolism remodeling
Commitment of adipose-resident c-kit+ progenitors to brown adipocytes contributes to adipose tissue homeostasis and remodeling
Non-canonical nuclear function of glutaminase cooperates with Wnt signaling to drive EMT during neural crest development
The molecular basis for acetylhistidine synthesis by HisAT/NAT16
Aging and diet alter the protein ubiquitylation landscape in the mouse brain
Increased antioxidative defense and reduced advanced glycation end-product formation by metabolic adaptation in non-small-cell-lung-cancer patients
3
p53 inactivation drives breast cancer metastasis to the brain through SCD1 upregulation and increased fatty acid metabolism
Cytidine diphosphate diacylglycerol synthase 2 is a synthetic lethal target in mesenchymal-like cancers
KDM4C inhibition blocks tumor growth in basal breast cancer by promoting cathepsin L-mediated histone H3 cleavage
10
Metabolic quiescence of naive-like memory T cells precedes and maintains antigen-specific T cell memory
SIRT2-mediated deacetylation of LCK governs the magnitude of T cell receptor signaling
Cell cycle arrest enhances CD8+ T cell effector function by potentiating glucose metabolism and IL-2 signaling
Metabolic adaptations rewire CD4+ T cells in a subset-specific manner in human critical illness with and without sepsis
Active aldehydes accelerate CD8+ T cell exhaustion by metabolic alteration in the tumor microenvironment
Early methionine availability attenuates T cell exhaustion
LARP4-mediated hypertranslation drives T cell dysfunction in tumors
Mitochondrial respiration is necessary for CD8 T cell proliferation and cell fate
The prostacyclin receptor PTGIR is a NRF2-dependent regulator of CD8+ T cell exhaustion
Targeting lactylation reinforces NK cell cytotoxicity within the tumor microenvironment
3
Obesity due to MC4R deficiency is associated with reduced cholesterol, triglycerides and cardiovascular disease risk
Dual-vector rAAVrh8 gene therapy for GM2 gangliosidosis: a phase 1/2 trial
Modulation of metabolic, inflammatory and fibrotic pathways by semaglutide in metabolic dysfunction-associated steatohepatitis
2
Microglial mitochondria transfer to astrocytes via GPNMB-enriched extracellular vesicles alleviates cognitive deficits in tauopathy mice
Amyloid-β-driven glymphatic dysfunction in Alzheimer’s disease model mice is driven by Ca-mediated increases in astrocytic cholesterol
6
Redox-driven ADAR1 activation promotes Okazaki fragment maturation and DNA replication integrity
TMEM170 proteins are lipid scramblases associated with bridge-type lipid transporters BLTP1/Csf1
ATG2A-mediated DAG transfer recruits DGAT2 for lipid droplet growth
Hydrophilic metformin and hydrophobic biguanides inhibit mitochondrial complex I by distinct mechanisms
PEX14 condensates recruit receptor and cargo pairs for peroxisomal protein import
ACAD10 and ACAD11 enable mammalian 4-hydroxy acid lipid catabolism
6
Hyperexcitable VTA-mPFC dopaminergic circuit disrupts sleep spindle and mediates sleep fragmentation after chronic social defeat stress
Hepatic expression of APOE3 Christchurch mitigates APOE4-related Alzheimer’s disease pathologies in mice
Glucose hypometabolism and hyperphosphorylated Tau synergistically drive neuronal necroptosis
Lysosomal salvage of neuronal lipids enables glial infiltration of synaptic regions
Aberrant nuclear pore complex degradation contributes to neurodegeneration in VCP disease
Reversal of diet-induced obesity by central insulin sensitizer FSTL1
2
Amidation of Phosphonoacetate-Modified Oligonucleotides and Evaluation of the Properties of the Synthesized Oligonucleotides
Peptide-Compatible Photoredox-Catalyzed Mutagenesis of Dehydroalanine to Aspartic Acid
7
The non-vesicular cholesterol transporter GRAMD1C is a pan-coronavirus antiviral target
USP7 facilitates brain tumor survival upon glucose deprivation by regulating phosphofructokinase muscle-type nuclear translocation in mice
Gpc3 selectively suppresses subcutaneous adipogenesis in diet-induced obesity
The blood–brain barrier regulates brain tumor growth through the SLC36 amino acid transporter Pathetic in Drosophila
The mTORC2 subunit RICTOR drives breast cancer progression by promoting ganglioside biosynthesis through transcriptional and epigenetic mechanisms
Hexokinase 2 is an RNA-binding protein that regulates mRNA translation independently of glycolysis and induces melanoma cell proliferation.
Alterations in ether lipid metabolism in obesity revealed by systems genomics of multi-omics datasets.
8
Tumour-driven lipid accumulation in oenocytes reflects systemic lipid alterations
Sleep rescues age-associated loss of glial engulfment
Huntington’s disease-associated ankyrin repeat palmitoyl transferases are rate-limiting factors in lysosome formation and fusion
A distal enhancer of Pparα regulates thermogenesis and mitochondrial function in brown fat
Individual lipid alterations at the origin of neuronal Ceramide Synthase defects.
Metabolic coupling of ROS generation and antioxidant synthesis by the GABA shunt pathway in myeloid-like blood progenitor cells of Drosophila
Dynamic phosphorylation of Hcm1 promotes fitness in chronic stress
Functional analysis of CYP4B1 enzymes from apes and humans uncovers evolutionary hot spots for adaptations of the catalytical function.
1
Cardiovascular–kidney–metabolic syndrome and all-cause and cardiovascular mortality: A retrospective cohort study
59
Akkermansia muciniphila–derived L-norleucine modulates FABP1-dependent fatty acid transport
Selective targeting of kinesin on lipid droplets in the liver reduces plasma lipids
Lactylated NAT10 contributes to elesclomol-triggered cuproptosis via the NAT10/ac4C-DLAT-mRNA/DLAT positive feedback loop in CRC
Visualization of the interaction between sphingomyelin and cholesterol in lipid bilayer membranes
Cellular Feimin promotes cold-induced thermogenesis
Lipid metabolism in adipocytes modulates tumor growth at a distance through Nplp2-mediated Wnt5 signal
Structural studies of an antinecroptosis viral:human functional heteroamyloid M45:RIPK3 using SSNMR
The temperature dependence of amyloid β solubility reveals the hydrophobic effect as the main driving force for fibril formation
Reconstruction of human metabolic models with large language models
Loss of FoxO in skeletal muscle leads to disrupted muscle metabolism and exacerbates starvation-induced hepatic steatosis
Mining cancer genomes for copy number alterations identifies glycosylation enzymes as oncogenic drivers
PHGDH phosphorylation mediated by WNK1 serves as a dual marker of metabolic vulnerability and responsiveness to oxaliplatin treatment
Tau catalyzes amyloid-β aggregation and toxicity in a polymorph-dependent manner
Elucidation of a potent pro-resolving mediator of inflammation resolution via human neutrophil–vascular endothelial cell interactions
Phase separation of DDHD2 remodels lipid metabolism to dictate treatment sensitivity in luminal breast cancer
Sleep deprivation exhibits an age-dependent effect on infraslow global brain activity
D-amino acid aminotransferase1 regulates grain chalkiness in rice by modulating endoplasmic reticulum stress response
Evolutionary remodeling of a remnant GET pathway factor into PEX38, an essential peroxin
Nonoxidative pentose phosphate pathway regulates CD8+ T cell immunity by maintaining NADPH homeostasis
Mfsd2a is important for maintaining epidermal homeostasis
T-cadherin, a major adiponectin binding partner, suppresses ERK signaling in metabolic tissues
Structural and mechanistic diversity of glycogen phosphorylases from gut bacteria
Functional integrity of the SEL1L–HRD1 complex is critical for endoplasmic reticulum–associated degradation and organismal viability
Apical and basolateral plasma membranes in epithelial cells have distinct lipidomes and biophysical properties
Selective peroxynitrite-mediated protein nitration catalyzed by glyoxalase domain containing protein 4
A structural model of toxic amyloid oligomers involved in type 2 diabetes
The molecular mechanism of lipid uptake by membrane-anchored bridge-like lipid transfer proteins
Sleep loss induces cholesterol-associated myelin dysfunction
Blood-borne sphingosine 1-phosphate maintains vascular resistance, blood pressure, and cardiac function in mice
Cholesterol-containing lipid crystals can directly stiffen the rat steatotic liver before fibrosis
Exploring the interplay between protein conformational changes and phosphorylation in a pancreatic cancer cell and stellate cell coculture system
A neutralizing APOA5 monoclonal antibody reduces amounts of lipoprotein lipase in capillaries and triggers hypertriglyceridemia
NFE2L1/Nrf1 forms a coactivator complex post-peptide:N-glycanase-mediated sequence editing and mitigates proteasome dysfunction
Aducanumab binding to Aβ1-42 fibrils alters dynamics of the N-terminal tail while preserving the fibril core
Competition between Der1 and ERAD-M substrates controls Hrd1 complex function
ATG2 is a triglyceride transfer protein
Neuroplastin-55 is a receptor of Manf and protects against diet-induced obesity by promoting adipose browning
Longitudinal transformation of mitochondrial metabolism during neurogenesis
Ribonuclease RNase Z is an evolutionarily conserved deAMPylase
DDHD2 possesses both lipase and transacylase capacities that remodel triglyceride acyl chains
Amyloid-beta glycation induces neuronal mitochondrial dysfunction and Alzheimer’s pathogenesis via VDAC1-dependent mtDNA efflux
Long-chain unsaturated free fatty acids control gut motility via nitrergic ganglia of the enteric nervous system
A viral Cyclin D homolog protein hijacks the metabolic stress sensor SESN2 to promote primary effusion lymphoma growth
A cell-based scrambling assay reveals the phospholipid headgroup preference of TMEM16F on the plasma membrane
Metabolic adaptation of glucose-deprived macrophages involves partial gluconeogenesis
FibrilPaint to determine the length of Tau amyloids in fluids
A mouse model of MEPAN demonstrates a role for mitochondrial fatty acid synthesis in iron–sulfur cluster and supercomplex formation
Drosophila Ahcy is a redox sensor that modulates gene expression to protect against light stress–induced retinal degeneration
Intercellular propagation of RIPK1/RIPK3 amyloid fibrils
Adrenal lipoma formation via PI(3,4,5)P3/AKT-dependent transdifferentiation of adrenocortical cells into adipocytes
CHP1 promotes lipid droplet growth and regulates the localization of key enzymes for triacylglycerol synthesis
Global profiling of N-terminal cysteine–dependent degradation mechanisms
Engineering a highly selective, hemoprotein-based scavenger as a carbon monoxide poisoning antidote with no hypertensive effect
Micro magnetic resonance spectroscopy for noninvasive metabolic screening of mammalian embryos and oocytes
OGG1 augments the transcriptional activation of Foxp3 to promote iTreg differentiation for IBD alleviation
Amyloid-β modulates the phase separation and aggregation of α-synuclein
An aminosterol breaks the autocatalytic cycle of Aβ42 aggregation and protects cell membranes from its soluble aggregates
PI(4)P recruits CIDE proteins to promote the formation of unilocular lipid droplets during adipogenesis and hepatic steatosis
UFMylation: A supervisor of the HIF1α pathway and a potential therapeutic target for anti-PD-1 combination therapy in hypoxic tumors
2
J-Editing Proton MR Spectroscopy for Brain Signal Separation in Methylmalonic Acidemia: A Pediatric Case-Control Study.
Association of Body Fat Distribution Patterns at MRI with Brain Structure, Cognition, and Neurologic Diseases.
11
Mitochondrial metabolism and signaling direct dendritic cell function in antitumor immunity
Ablation of Prdm16 and beige fat identity causes vascular remodeling and elevated blood pressure
Nucleotide metabolic rewiring enables NLRP3 inflammasome hyperactivation in obesity
Mitochondrial control of fuel switching via carnitine biosynthesis
Adipogenin promotes the development of lipid droplets by binding a dodecameric seipin complex
The origin of hepatocellular carcinoma depends on metabolic zonation
Acidosis orchestrates adaptations of energy metabolism in tumors
Septal LYVE1+ macrophages control adipocyte stem cell adipogenic potential
LYVAC/PDZD8 is a lysosomal vacuolator
ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox
Is taurine an aging biomarker?
48
Metabolic rewiring driven by phosphoglycolate phosphatase deletion inhibits ferroptosis
Noncanonical PI(4,5)P2 coordinates lysosome positioning through cholesterol trafficking
PPT1 selectively depalmitoylates GAP43 to regulate neuronal excitability and cognitive function
Integrated analysis of insulin resistance reveals metabolic remodeling following diet switch–triggered calorie reduction
PARP2 deficiency impairs pancreatic cancer progression by promoting genomic instability and antitumor immunity
LIPT1 loss confers replication stress and PARP inhibitor sensitivity through PrimPol-mediated ssDNA gaps
d-amino acids restrain macrophage IL-1β release through gasdermin D acetylation
Adissp activates insulin-independent glucose disposal and energy expenditure in white fat to treat diabetes and cardiometabolic disease
SLC13A2-transported citrate remodels transcriptional regulation through protein acetylation to suppress tumor growth
Constitutive AMPK activation prevents hepatocellular carcinoma development through inhibition of HNF4α activity
Intracellular enzymatic reducing systems control receptor tyrosine kinase signaling via PTP1B
Posttranscriptional reprogramming controls MASLD progression through chronic ER stress adaptation
Clinically relevant stereochemistry reprograms amyloid proteome for aggregation cross-talk–conferred neuroprotection
The Plasmodium falciparum PPCS is a unique heteromeric complex with prokaryote-like activity and is a target of pantothenate analogs
Ampk alpha2 T172 activation dictates exercise performance and energy transduction in skeletal muscle
Hemizygous loss of helicases promotes genomic instability and cancer development
Elovl6 inhibits colorectal cancer progression through stearic acid–mediated mitochondrial fusion and metabolic reprogramming
A near-complete map of human cytosolic degrons and their relevance for disease
Lactate derived from cancer-associated fibroblasts promotes alternative splicing and castration resistance in prostate cancer
Crotonate suppresses breast cancer metastasis and promotes immunotherapy response by inducing ACSS2-mediated EZH2-K348 crotonylation
ERα activates NAMPT/IL-33 signaling to enhance beige thermogenesis and metabolic fitness
RIPK1 inhibition reduces biliary injury and fibrosis in primary sclerosing cholangitis
The extracellular matrix drives guanylate production and protects pancreatic cancer cells from oxaliplatin-induced DNA damage
Visualizing dynamics of membrane rafts on live cells
Chaperone-mediated autophagy controls brown adipose tissue thermogenic activity
Leptin as a key driver for organ fibrogenesis
ITCH regulates Golgi integrity and proteotoxicity in neurodegeneration
Targeting the ATM-TRMT10A-BRCA1 axis confers synthetic lethality to PARP inhibition in metastatic castration-resistant prostate cancer
How does Mycoplasma pneumoniae scavenge lipids from its host membranes?
Nanomedicine targeting PPAR in adipose tissue macrophages improves lipid metabolism and obesity-induced metabolic dysfunction
Steric repulsion counteracts ER–to–lipid droplet protein movement
Targeted inhibition of hepatic de novo ceramide synthesis ameliorates MASH
Structural basis of Pseudomonas biofilm-forming functional amyloid FapC formation
Linear ubiquitination prevents lipodystrophy and obesity-associated metabolic syndrome
Gangliosides modulate the secretion of extracellular vesicles and their misfolded protein cargo
A noncanonical role of glycolytic metabolites controlling the timing of mouse embryo segmentation
Amyloid-β oligomers, curvilinear and annular assemblies, imaged by cryo-ET, cryo-EM, and AFM
Mechanism and cellular actions of the potent AMPK inhibitor BAY-3827
Complex II assembly drives metabolic adaptation to OXPHOS dysfunction
ACSS2 coupled with KAT7 regulates histone β-hydroxybutyrylation to enhance transcription
Cryogenic electron tomography reveals helical organization of lipoprotein lipase in storage vesicles
Low-dose metformin requires brain Rap1 for its antidiabetic action
Role of d-serine in intestinal ROS accumulation after sleep deprivation
FAF2 is a bifunctional regulator of peroxisomal homeostasis and saturated lipid responses
The lipid bilayer strengthens the cooperative network of membrane proteins
The RNA demethylase FTO promotes glutamine metabolism in clear cell renal cell carcinoma through the regulation of SLC1A5
Molecular basis of the hepatobiliary tropism of typhoid toxin promoting Salmonella pathogenicity
The metabolite itaconate is a transcriptional and posttranslational modulator of plant metabolism, development, and stress response
7
Lactylation fuels nucleotide biosynthesis and facilitates deuterium metabolic imaging of tumor proliferation in preclinical models of H3K27M-mutant gliomas
SREBP-1 increases glucose uptake to promote tumor resistance to lysosome inhibition
Metabolism-programming mRNA-lipid nanoparticles remodel the immune microenvironment to improve immunotherapy against MAFLD
HIVEP1 aggravates NASH by reprogramming polyamine metabolism in TH17 cells
Retinal polyunsaturated fatty acid supplementation reverses aging-related vision decline in mice
FXR adapts hepatic mitochondrial function to increased substrate oxidation in patients with obesity
AGPAT4 targeted covalent inhibitor potentiates targeted therapy to overcome cancer cell plasticity in hepatocellular carcinoma mouse models
2
Time trends in newly recorded diagnoses of 19 long term conditions before, during, and after the covid-19 pandemic: population based cohort study in England using OpenSAFELY
Exposure to sugar rationing in first 1000 days after conception and long term cardiovascular outcomes: natural experiment study
15
Mitochondrial NADH-redox inflexibility constrains genomic and epigenetic stability in pluripotent stem cells
Peroxisome-derived ether lipids regulate lysosomal exocytosis
Tissue-selective COPII modulator SEC16B aggravates cardiovascular disease by promoting lipid export
Global stabilization of the transcriptome in mitotic cells
The coordinated action of UFMylation and the RQC pathways clears arrested polypeptides at the ER
Lipopolysaccharide confinement in the bacterial outer membrane is governed by interactions within the conserved Lipid A anchor
C-reactive protein is a broad-spectrum capsule-binding receptor for hepatic capture of blood-borne bacteria
Genetic variance in the murine defensin locus modulates glucose homeostasis.
NRAC controls CD36-mediated fatty acid uptake in adipocytes and lipid clearance in vivo.
Hepatic ASPG-mediated lysophosphatidylinositol catabolism impairs insulin signal transduction.
NAC couples protein synthesis with nascent polypeptide myristoylation on the ribosome.
Lysine myristoylation mediates long-term potentiation via membrane enrichment of synaptic plasticity effectors
Sphingosine simultaneously inhibits nuclear import and activates PP2A by binding importins and PPP2R1A
Altering metabolism programs cell identity via NAD+-dependent deacetylation
YTHDC1 promotes postnatal brown adipose tissue development and thermogenesis by stabilizing PPARγ
2
Pyrin inflammasome activation triggers an IL-18–driven IFN-γ response in mevalonate kinase deficiency
CARMIL2 deficiency disrupts activation-induced metabolic reprogramming in T cells, and is partially rescued by glutamine supplementation
12
Disorder in Order-Related Membrane Biophysical Parameters: An In-Depth Analysis of Di-4-ANEPPDHQ Generalized Polarization
Amyloid-β “Co-assembles” with Coatomer Subunit Delta (δ-COP)
Logarithmic Binding and Stretched-Exponential Kinetics in Peripheral Protein Interactions with Lipid Membrane Surfaces
Membrane Composition Reshapes the Folding Landscape of a pH-Responsive Peptide
In Situ Probing the Effects of Lipid Packing Density and Concentration of CPPs on the Transmembrane Process at the Air–Water Interface
Insights into Substrate Protonation and Solvent Accessibility in the Active Site of Fatty Acid Photodecarboxylase
Contrary Effects of Cholesterol on Single-Component and Synaptic Vesicle Mimicking Lipid Bilayers
Distinct Structural Responses of Lipid Bilayers to Horizontal and Vertical Electric Fields
Membrane Interactions Drive Hydrogen-Bond Dynamics in the pH-Low Insertion Peptide (pHLIP)
Steric Control of Copper(II) Coordination by Carnosine: Role of the β-Alanyl Methylene Spacer
Enzymatic Reactions Dictated by the 2D Membrane Environment
Interaction of Metal Ion Stabilized Oligomeric Dipeptide with Lipid Membrane: Concurrent Observations of Supported Lipid Membrane, Wetting, and Uptake
4
Disparities in diabetes treatment and monitoring for people with and without mental disorders: a systematic review and meta-analysis
Metformin for overweight and obese children and adolescents with bipolar spectrum and related mood disorders treated with second-generation antipsychotics: a randomised, pragmatic trial
Mortality from respiratory diseases in individuals with severe mental illness: a large-scale systematic review and meta-analysis of pooled and specific diagnoses
Weight trajectories and access to weight management services in individuals with severe mental illness in the UK: a population-based, matched cohort study
3
AAV9 Gene Therapy in Type II GM1 Gangliosidosis — A Phase 1–2 Trial
An Intravenous Brain-Penetrant Enzyme Therapy for Mucopolysaccharidosis II
Fish-Oil Supplementation and Cardiovascular Events in Patients Receiving Hemodialysis

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