Medical Biochemistry and Metabolomics articles for United States of America (USA)

Time frame: 1 June 2025 - 30 May 2026

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Count: 459

Article ‘Count’ for Medical Biochemistry and Metabolomics.

Journal Count Share
2 0.30
Quantitative Mapping of the Lipid Nanoenvironment around Transmembrane Proteins in Living Cells 0.08
Driving a Stimuli-Responsive Wedge in the Packing of Phospholipid Membranes Using Bolaamphiphile Intercalants 0.21
2 1.85
Biomechanical adaptation of the thoracic aorta and its perivascular adipose tissue precedes hypertension development in Dahl Salt-Sensitive rats on high-fat diet 1.00
Fatty acid albumin conjugates mechanically weaken and disrupt degradation of fibrin networks 0.85
14 8.45
Diabetes modifies the association between magnesium and insomnia, but not depressive symptomatology, in Puerto Rican adults: a prospective cohort study 0.81
Circulating saturated fatty acids and incident chronic kidney disease: a meta-analysis of de-novo prospective cohort investigations 0.32
Plasma n6 polyunsaturated fatty acid levels and risk for dementia: A prospective observational study from the UK Biobank 0.92
Meal fatty acid metabolism is associated with long-term weight gain in women – a retrospective cohort study 0.67
Predictive equations commonly used in clinics underestimate resting energy expenditure compared with whole-room indirect calorimetry in colorectal cancer survivors 0.13
Biomarkers for dietary fatty acid densities among postmenopausal U.S. females derived using a habitual-diet human feeding study 1.00
Comparison of blood lipid responses to high polyunsaturated fatty acid compared with high monounsaturated fatty acid dietary interventions: a systematic review and meta-analysis 1.00
New insights into total and resting energy expenditure using state-of-the-art methods in cancer survivors: a cross-sectional study 0.17
Association between dietary fat intake and long-term risk of dementia: A prospective cohort study 0.17
Associations between serum bile acid profile and mortality in patients with coronary artery disease: a cohort study 0.11
Global, regional, and national burden of high sugar-sweetened beverages consumption, 1990-2021, with projections up to 2050: a systematic analysis for the Global Burden of Disease Study 2021 0.17
Gut microbial community and host intestinal gene expression with combined fish oil and soluble corn fiber compared with corn oil and maltodextrin: A randomized crossover trial in healthy older individuals 1.00
Short-Term High Fat Diet Induced Metabolic Endotoxemia in Older Individuals with Obesity: A Randomized Crossover Study 1.00
Effects of a Palmitoleic Acid Concentrated Oil on C-Reactive Protein Levels in Adults: A Randomized Double-Blind Placebo Controlled Clinical Trial 1.00
1 0.86
Elevated lipid levels and altered semen parameters in men of couples seeking fertility care 0.86
1 0.93
Genomics-informed drug-repurposing strategy identifies two therapeutic targets for preventing liver disease associated with metabolic dysfunction 0.93
4 2.76
Resolvin E1 and Maresin 1 Attenuate NLRP3-Associated Inflammation and Invasion in Oral Squamous Cell Carcinoma 0.80
Hepatocyte-specific PPARγ Deletion Uncovers Role of an Antagonistic PPARγ–HNF4α Transcriptional Axis in MASLD Progression 1.00
Gpat3 Knockout Attenuates Adipose Loss and Steatohepatitis in Agpat2-Deficient Mice 0.14
Inactivation of Atp7b copper transporter in intestinal epithelial cells is associated with altered lipid processing and cell growth machinery independent from hepatic copper accumulation and severity of liver histology 0.82
9 7.15
Improving Isotope Ratio Accuracy in Metabolic Labeling Using Orbitrap Mass Spectrometry: A Machine Learning Correction Algorithm for Metabolic Flux Analysis 1.00
Comprehensive Profiling of Protein N-Terminal Acetylation Stoichiometry in Extracellular Vesicles 1.00
Live-Cell Imaging and Lipidomics of Low-Density Lipoprotein Containing Intrinsically Fluorescent Cholesteryl Esters 0.18
Quantification of Ligand–Membrane Interactions Using DNP-NMR Relaxometry 1.00
MS/MS Mass Spectrometry Filtering Tree for Bile Acid Regio- and Stereoisomer Annotation 0.93
Spatially Mapping Neuropeptide Isomers via MALDI Trapped Ion Mobility MS Imaging 1.00
An Fe(III)-Based Fluorescent Probe for Carbon Monoxide only Senses the “CO Donor” Used, CORM-3, but Not CO 1.00
Microfluidic Generation of Oxidized Phospholipid Gradients in Supported Lipid Bilayers to Examine Scavenger Receptor Interactions 1.00
Rapid Determination of Iron in Serum and Plasma Using Micromagnetic Resonance Relaxometry (μMRR) 0.04
4 2.06
Targeted Detection of Phospholipid Aldehydes in Living Cells by Oxime Ligation 0.67
LL‐37 and Its Truncated Fragments Modulate Amyloid‐β Dynamics, Aggregation and Toxicity Through Hetero‐Oligomer and Cluster Formation 0.11
Predictable Modulation of a Spontaneous Post‐translational Modification in Living Cells 1.00
Antiparallel iβ/i‐Sheet as a Key Motif of Amyloid‐iβ/i Inhibitor Designed via Topological Peptide Reprogramming 0.28
3 2.76
Senescent Cell Clearance Ameliorates Temporal Lobe Epilepsy and Associated Spatial Memory Deficits in Mice 1.00
Cross‐Sectional scpFDG/scp in Down Syndrome and Autosomal Dominant Alzheimer's Disease 0.76
AAV9-DARS2 Gene Therapy Rescues Phenotype in Leukoencephalopathy with Brainstem and Spinal Cord Involvement and Lactate Elevation Patient Cells and Neuronal Dars2 Deficient Mice 1.00
1 0.05
Bile acids metabolism in symptomatic hand osteoarthritis 0.05
3 2.91
The GATA1 N terminus coordinates metabolic reprogramming in erythropoiesis 1.00
DHODH as a targetable metabolic Achilles’ heel for chemotherapy-resistant B-ALL 0.91
Alpha-ketoglutarate promotes amino acid depletion and suppresses B-cell lymphoma growth and development 1.00
1 0.06
Compensatory roles of STT3A and ALG5 in glucose metabolism of aged macaque hippocampus 0.06
11 8.29
FASN Inhibition Enhances the Efficacy of Chemotherapy in Colorectal Cancer by Inhibiting the DNA Damage Response 1.00
ACSL5 Mediates Adaptation to the Palmitic Acid–Enriched Pulmonary Microenvironment to Enhance Metastatic Breast Cancer Cell Survival and Lung Metastasis 0.07
ZNF395 Is a Hypoxia-Responsive Regulator of Mitochondrial Glutaminolysis in Clear Cell Renal Cell Carcinoma 0.24
GFER Represents a Target for Dual Disruption of Redox Homeostasis and Reactivation of the Immune Response in Pancreatic Adenocarcinoma 1.00
The Microbial Bile Acid Metabolite 3-Oxo-LCA Inhibits Colorectal Cancer Progression 0.80
Targeting the ATM-TGS1-BRCA1 Axis Overcomes Genotoxic Therapy Resistance in Pancreatic Adenocarcinoma. 0.23
PTEN Oxidation Promotes Constitutive PI3K Signaling and Inducible Macropinocytosis in Pancreatic Cancer. 1.00
Selective Alanine Transporter Utilization Is a Therapeutic Vulnerability in ARID1A-Mutant Ovarian Cancer 1.00
SCD1 Inhibition Blocks the AKT–NRF2–SLC7A11 Pathway to Induce Lipid Metabolism Remodeling and Ferroptosis Priming in Lung Adenocarcinoma 1.00
Ceramide-Induced Metabolic Stress Depletes Fumarate and Drives Mitophagy to Mediate Tumor Suppression. 0.95
Blocking the TCA Cycle in Cancer Cells Potentiates CD36+ T-cell–Mediated Antitumor Immunity by Suppressing ER Stress–Associated THBS2 Signaling 1.00
3 2.97
Predicting competition and substrate preferences for targeted microbiome alteration 1.00
Sulfur partitioning from cysteine controls T cell proliferation and effector function 0.97
Citrate clearance is a major function of aconitase 2 in the canonical TCA cycle 1.00
4 4.00
The microbial metabolite imidazole propionate modulates hypothalamic activity and stress-induced behaviors 1.00
Gut bacteria metabolize natural and synthetic steroid hormones via the reductive OsrABC pathway 1.00
Methylglyoxal is an antibacterial effector produced by macrophages during infection 1.00
Bacteroides sphingolipids promote anti-inflammatory responses through the mevalonate pathway 1.00
15 7.08
Adipokine IL-11/IL-11Ra constrains sphingolipid metabolism to limit the thermogenic capacity of beige adipocytes 0.10
Mitochondrial metabolism regulates the immunogenic responsiveness of dendritic cells 0.06
Psoriasis modulates inflammatory bowel disease risk and intestinal epithelium lipid metabolism via IL-1β-producing macrophages 0.06
Lack of PCK1 in hepatic stellate cells causes liver fibrosis by fueling tricarboxylic acid cycle and increasing glycolysis 0.06
Modeling lipid homeostasis using stable isotope tracing and flux analysis 1.00
Lipid droplet-induced T cell death sustains autoimmune tissue inflammation 1.00
Dual inhibition of ACLY and ACSS2 by EVT0185 reduces steatosis, hepatic stellate cell activation, and fibrosis in mouse models of MASH 0.26
Digital twins for in vivo metabolic flux estimations in patients with brain cancer 1.00
Mitochondrial VHL rewires cell metabolism in hypoxia 0.09
Bile acids regulate lipid metabolism through selective actions on fatty acid absorption 1.00
Adipocyte lipolysis activates epithelial stem cells for hair regeneration through fatty acid metabolic signaling 0.07
Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control 0.95
Microbial riboflavin inhibits ceramide synthase 3 to lower ceramide (d18:1/26:0) and delay colorectal cancer progression 0.15
Itaconate promotes inflammatory responses in tissue-resident alveolar macrophages and exacerbates acute lung injury 0.28
Derepressing nuclear pyruvate dehydrogenase induces therapeutic cancer cell reprogramming 1.00
1 0.98
Senolytic-sensitive p16+ fibroblasts in the tumor stroma rewire lung cancer metabolism and plasticity 0.98
1 0.50
Bifunctional nanodisc platforms for studies on self-assembly and amyloid fibrillation 0.50
2 1.43
Traceless protein semisynthesis in cells using the promiscuous ultra-fast split intein NrdJ-1 1.00
Photoactivatable Ru(ii) polypyridyl complexes as dual action modulators of amyloid-beta peptide aggregation and Cu redox cycling 0.43
3 1.95
SREBP1 Transactivation of NHE3 Impairs Cardiac Contraction and Aggravates Heart Failure 0.05
HELZ2 Regulates ApoB mRNA Stability to Modulate Fatty Liver Disease and Atherosclerosis. 1.00
Association of Smoking Cannabis With Cardiovascular Events Among Veterans With Coronary Artery Disease 0.90
1 0.80
A simple action reduces high-fat diet intake and obesity in mice 0.80
1 0.11
A pathological role of O-GlcNAcylation-driven TR11B production and function in lung adenocarcinoma 0.11
3 3.00
Relationships Between Regional and Ectopic Adiposity and Insulin Sensitivity in Early and Late Pregnancy. 1.00
Sleep Extension Improves Sleep Health but Not Insulin Sensitivity in People With Overweight/Obesity Who Maintain Habitual Short Sleep Schedules. 1.00
Longitudinal Analysis of Liver Chemistry Trajectories and Risk of Type 2 Diabetes in Children With Metabolic Dysfunction-Associated Steatotic Liver Disease: A Multicenter Cohort Study. 1.00
2 1.04
Associations between Low-Dose Drinking Water Lithium Exposure and Dementia: A Nationwide U.S. Ecological Study 1.00
Polycyclic aromatic hydrocarbon aggravates high-fat diet-induced metabolic dysfunction-associated steatotic liver disease through disturbing hepatocyte sphingolipid metabolism 0.04
1 1.00
Oral magnesium and outcomes in US veterans with heart failure 1.00
1 1.00
A brain-specific microRNA, miR-1000, regulates lipid homeostasis via neuropeptide-like precursor 1 in Drosophila melanogaster 1.00
5 2.27
Dysbiotic microbiota trigger colitis-associated colorectal cancer and imprint a distinctive bile acid profile in a PSC-IBD model 1.00
Parental obesity and risk of metabolic dysfunction associated steatotic liver disease in adult offspring: UK birth cohort study 1.00
Colorectal cancer in metabolic dysfunction-associated steatotic liver disease: an international Delphi consensus statement 0.11
Secondary bile acid production by gut bacteria promotes Western diet-associated colorectal cancer 0.07
Fibroblast pentose phosphate pathway activation upon decreased circPLCE1 exacerbates intestinal fibrosis in Crohn’s disease 0.09
7 3.56
Cardiovascular-Kidney-Metabolic syndrome and the risk of liver fibrosis progression and liver-related events in MASLD. 0.07
Glutamine synthetase loss in β-catenin-mutant hepatocellular carcinoma promotes tumor burden through macrophage metabolic reprogramming. 1.00
Reclassifying pediatric NAFLD using the steatotic liver disease framework: a multicenter retrospective study from the NASH CRN. 1.00
E2F2 transcription factor promotes a cholestatic MASH phenotype by regulating hepatobiliary metabolism through miR-34a-5p. 0.02
Pretreatment serum bile acid composition and predictability of subsequent response to odevixibat in patients with bile salt export pump (BSEP) deficiency. 0.29
The OGT-TFF2 axis mediates intrahepatic crosstalk and MASH pathogenesis. 1.00
Type 2 Diabetes mellitus as an independent predictor of significant fibrosis in treatment-naïve chronic hepatitis B patients with concurrent hepatic steatosis. 0.19
4 2.80
NK cell dysfunction and interferon-γ production underlie autoinflammation in mevalonate kinase deficiency 0.09
Metabolic and transcriptional plasticity supports CD8+ T cell resilience and anti-tumor immunity under nutrient stress 0.85
High-fat diet causes rapid loss of intestinal group 3 innate lymphoid cells through microbiota-driven inflammation and mitochondrial stress 0.87
Intra-tumoral hypoxia promotes CD8+ T cell dysfunction via chronic activation of integrated stress response transcription factor ATF4 1.00
1 0.89
Catalytic Mechanism of the Bacterial Non-Heme Fe(II) and 2-Oxoglutarate Dependent Enzyme AlkB with Single-Stranded DNA Containing Complex Guanine Adducts 0.89
1 1.00
Supplemental Nutrition Assistance Program use and cognitive performance in middle-aged and older adults 1.00
7 5.28
Non-invasive islet β-cell markers track with weight-loss interventions for type 2 diabetes: a prospective cohort study 1.00
Racial and ethnic disparities in type 2 diabetes: does visceral fat play a role? Evidence from the MESA study 0.91
Genetic evidence for the association between schizophrenia and obesity 0.17
Obesity-induced taste bud loss in mice is only partially remediated long after return to a healthy weight 1.00
Deriving sex-specific anthropometric cut-points for obesity and cardiovascular disease risk in Qatari adults 0.83
Optimizing adipogenic cocktail composition to enhance beige adipogenesis and evaluate thermogenic potential in primary mouse subcutaneous fat cell cultures 1.00
Changes in abdominal subcutaneous adipose tissue thickness associate with disease and anthropometric factors 0.38
1 1.00
Adverse Liver Outcomes, Cardiovascular Events, and Mortality in Steatotic Liver Disease 1.00
3 1.23
Semaglutide and Early-Stage Metabolic Abnormalities in Individuals With Schizophrenia Spectrum Disorders 0.03
Antipsychotic Drugs and Dysregulated Glucose Homeostasis 0.48
Sweetened Beverages and Incident All-Cause Dementia Among Older Adults 0.73
34 25.51
Tissue-dependent enzymatic control of N-acetyl-β-alanine by PTER 1.00
Variants in glycine decarboxylase activate catabolic mechanisms of mitochondrial energy metabolism in the brain 0.80
Prolyl-3-hydroxylase 1 is a central regulator of collagen post-translational modifications and the collagen biosynthetic network 0.32
OGG1 increases exercise endurance via elevated skeletal muscle FGF21 1.00
Rab5 Nucleotide Binding Promotes Oxidative Metabolism to Fuel Hepatocellular Carcinoma Cell Proliferation 1.00
Mycobacterium tuberculosis assembles a unique hexameric E2p core of the pyruvate dehydrogenase complex 1.00
In vitro reconstitution in membrane environment reveals critical lipid dependence of substrate S-acylation by protein palmitoyltransferase enzymes 1.00
ATGL-catalyzed biosynthesis mediates the upregulation of Fatty Acid Hydroxy Fatty Acids (FAHFA) levels in white adipose tissue with fasting 1.00
F2,6BP restores mitochondrial genome integrity in Huntington’s Disease 0.86
Myeloid AEG-1/MTDH drives inflammation and hepatocellular dysfunction in diet-induced steatohepatitis 1.00
The biochemical dynamics of the glycogen phosphatase laforin directly impact brain metabolism 0.88
The role of acyl cycling in endogenous G protein localization 0.67
Sialoglycans on human T cells attenuate death programs executed through the Fas pathway 0.30
Kallikrein 14 activates the chemoattractant protein chemerin in human skin 0.13
Dynamic acetylation of a conserved lysine impacts glycerol kinase activity and abundance in the haloarchaeon Haloferax volcanii 1.00
Transcriptomic plasticity of cholinergic adipose macrophages in the acute thermogenic response 1.00
Structures of a lipin/Pah phosphatidic acid phosphatase in distinct catalytic states reveal a signature motif for substrate recognition 1.00
Detection of PIP2 distributions in biological membranes using a peptide-based sensor 0.79
The effects of naturally occurring mutations on functionality of oxylipin metabolizing dehydrogenase reductase nine 1.00
A biosynthetic pathway for ornithine lipid formation dependent on a GH3 (Gretchen Hagen 3)-like enzyme in planctomycetes 0.10
Andrographolide modulates glucose metabolism in visceral adipose tissue in an Alzheimer's disease obese mouse model 0.11
Potent antioxidant and mitochondrial-protective effects of ATH434, a moderate affinity iron chaperone 0.80
TGF-β1-dependent expression of FOXS1 attenuates adipogenic potential and enhances a myofibroblast cellular phenotype 1.00
O-GlcNAcylation of fatty acid synthase is required for its proper subcellular localization, expression level, and activity 0.08
Active site determinants of yeast Pah1 phosphatidate phosphatase activity and cellular functions 1.00
Structural and functional characterization of CREB-binding protein (CREBBP) as a histone propionyltransferase 0.15
Quantification profiles of enzyme activity, secretion, and psychosine levels of Krabbe disease galactosylceramidase missense variants 0.86
The ER-associated degradation adaptor SEL1L is dispensable for ER homeostasis and the differentiation of spermatogenic cells 1.00
Arylsulfatase B Induces Melanoma Apoptosis by the Ubiquitin Ligase COP1 1.00
The sphingosine-1-phosphate receptor 2 S1PR2 mediates chronic glucocorticoid exposure-induced hepatic steatosis and hypertriglyceridemia 1.00
The gut microbiota mediates epoxy eicosanoid metabolism in the colon 1.00
Characterization of Caenorhabditis elegans sphingomyelin synthases through heterologous expression 0.60
Biosynthesis of fatty aldehydes and alcohols in the eye and their role in meibogenesis 1.00
Endocytosis of sialic acid Neu5Gc and elevated p53 contributes to preimplantation embryonic arrest during in vitro fertilization 0.06
11 9.52
Polyploidy reprograms epithelial cells for motility and phagocytosis via stress signaling 0.79
Cholesterol depletion activates trafficking-coupled sphingolipid synthesis 1.00
Surface Morphometrics reveals local membrane thickness variation in organellar subcompartments 1.00
Lipid packing and local geometry influence septin curvature sensing 1.00
PILS-Nir1 is a sensitive phosphatidic acid biosensor that reveals mechanisms of lipid production 1.00
Multiple interactions recruit BLTP2 to ER-PM contacts to control plasma membrane dynamics 1.00
Protein Kinase C promotes peroxisome biogenesis and peroxisome–endoplasmic reticulum interaction 0.10
The p97 ATPase and its adaptor UBXD8 maintain peroxisome pools by preventing pexophagy 1.00
Sphingolipid synthesis maintains nuclear membrane integrity and genome stability during cell division 0.64
Phosphatidic acid drives spatiotemporal distribution of Pex30 at ER-LD contact sites 1.00
NEMF-mediated CAT tailing facilitates translocation-associated quality control 1.00
13 9.49
Patients with MASLD exhibit in vivo changes in hepatic response to oral fructose consumption 1.00
Bisphenol A decreases peripheral insulin sensitivity in normal weight adults: a double-blind randomized controlled trial 1.00
Adiposome Lipidomic Shifts Following Bariatric Surgery in Association with Weight Loss and Cardiometabolic Benefit 0.96
Insulin sensitivity and associated plasma proteomics during sex hormone therapy 0.41
Serum Proteomics of Insulin Resistance Disorders Distinguish MASLD From Lipodystrophy and Insulin Receptor Defects 0.92
Reference Values for Serum Leptin Levels in Children, Adolescents, and Adults With Normal Weight, Overweight, and Obesity 0.04
Effect of Osteocalcin on Insulin Sensitivity, Insulin Secretion, and β-cell Compensation in Mexican Americans 1.00
Determinants of Pancreatic Size and Fat Content in the UK Biobank: Influence of Race, Genetic Variants, and Risk Factors 1.00
Cord Blood DNA Methylation at CHD13 Is Associated with Adiponectin Levels at 10 to 14 Years of Age 0.94
Multiomics of Human Obesity and Related Multisystem Diseases 0.97
Plasma Sphingolipids in Relation to Glycemia and Glucose Tolerance in People Without Diabetes 1.00
Metabolic Dysfunction-associated Steatotic Liver Disease Alters Fatty Acid Profiles in the Liver and Adipose Tissue 0.08
The Relationships Between MASLD, Extrahepatic Multimorbidity, and All-Cause Mortality in the UK Biobank Cohort 0.17
25 19.89
HNF4α controls growth, identity, and KRAS inhibitor response in invasive mucinous adenocarcinoma of the lung 1.00
Metabolic dysfunction-associated steatohepatitis exacerbated by Clostridium perfringens-derived ammonia is attenuated by tripeptide DT-109 0.18
Hepatic SEC16B regulates lipid homeostasis by coordinating VLDL secretion and lipid droplet expansion 1.00
The N-terminus of Apolipoprotein B mediates the interaction of atherogenic lipoproteins with endothelial cells 0.85
Redirection of sphingolipid metabolism drives cytoskeletal defects in SPLIS and reveals ROCK inhibition as therapy 0.33
The ULK1-NCOA3 axis restrains de novo lipogenesis and prevents diet-induced steatohepatitis and fibrosis in mice 1.00
GPR182 is a lipoprotein receptor for dietary fat absorption 1.00
L-2-hydroxyglutarate impairs neuronal differentiation through epigenetic activation of MYC expression 0.96
Short-term sleep restriction in humans alters diurnal circulating metabolite profiles, including those of microbial origin 1.00
PPARα-NFκB heterodimer mediates obesity-induced diastolic dysfunction through autocrine production of IL-6 0.90
EBF2 variant identified in a patient with atypical partial lipodystrophy causes adipose fibrosis and dysfunction 0.97
Protectin DX resolves fracture-induced postoperative pain in mice via neuronal signaling and GPR37-activated macrophage efferocytosis 1.00
Poly(ADP-ribose) glycohydrolase enforces p21 degradation via dePARylation to promote gastric cancer progression 0.13
Mitochondrial complex II orchestrates divergent effects in CD4+ and CD8+ T cells 0.95
Lamin A/C regulates lipid metabolism and inflammation: insights from models of familial partial lipodystrophy 2 0.93
Peroxisomal integrity in demyelination-associated microglia enables cellular debris clearance and myelin renewal in mice 1.00
Adipocyte death promotes hepatic infiltration of S100A8+ macrophages and steatotic liver disease progression in mice 0.75
GPIHBP1, lipoprotein lipase, and triglyceride-rich lipoproteins in capillaries of the choroid plexus and circumventricular organs 0.81
ER stress upregulates S100A11 in steatohepatitis models via epigenetic modifications within the lipotoxicity influenced enhancer 1.00
The GLYT1 inhibitor bitopertin mitigates erythroid PPIX production and liver disease in erythroid protoporphyria 1.00
SPNS1 variants cause multi-organ disease and implicate lysophospholipid transport as critical for mTOR-regulated lipid homeostasis 0.06
Cross-species efficacy of AAV-mediated ARSA replacement for Metachromatic Leukodystrophy 1.00
Neuraminidase 1 secondary deficiency contributes to CNS pathology in neurological mucopolysaccharidoses via brain proteins hypersialylation 0.08
CNS-targeted base editing of the major late-onset Tay-Sachs mutation alleviates disease in mice 1.00
Hepatic glycogen directly regulates gluconeogenesis through an AMPK/CRTC2 axis in mice 1.00
1 1.00
Adipose tissue harbors pathogenic T cells in obesity that exacerbate inflammatory arthritis 1.00
7 4.83
Liver-directed lentiviral gene therapy confers durable hepatic and systemic amelioration of methylmalonic acidemia in mice 0.16
Tissue-specific regulation of PNPLA3 promotes lipid remodeling in response to dietary and environmental challenges 1.00
DNAJ-PKAc induces metabolic rewiring and enhanced glutamine flux in fibrolamellar HCC 1.00
Claudin-1 is a mediator and therapeutic target in primary sclerosing cholangitis 0.06
Somatic loss-of-function mutations in CIDEB reduce hepatic steatosis by increasing lipolysis and fatty acid oxidation 0.72
Phase 1 randomized double-blind study of an RNA interference therapeutic targeting HSD17B13 for metabolic dysfunction–associated steatohepatitis 0.90
Bile acids engage the SIPR-STAT3 signaling axis to modulate regulatory T cell responses in fibrosing cholangiopathies 1.00
2 1.17
BLTP1 is required for survival and normal development and function of the neuromuscular junction in mice 1.00
Impact of Elovl5 Deficiency on Cerebellar Excitatory Synaptic Transmission in Mice 0.17
5 3.90
Impact of time‐restricted feeding on metabolic health and adipose tissue metabolism in aged female mice with high‐fat diet‐induced obesity 1.00
Optimal neuromuscular performance requires motor neuron phosphagen kinases 1.00
Hypomagnesaemia‐associated hypokalaemia requires activation of both ENaC and ROMK 0.82
Dihydrosterculic acid induces hepatic PPARα target gene expression in mice 1.00
Time‐restricted feeding combined with exercise improves hepatic and glycaemic metabolism in obese mice: A sex‐dependent study 0.08
13 11.89
Lipid–Substrate Interactions Lead to Bilayer Asymmetry 1.00
Targeting Conformational Flexibility of a Reactive Intermediate to Enhance Selectivity of a GABA Aminotransferase Inactivator 1.00
Discovery of Glycation-Derived Cross-links at Arginine 1.00
Heterogeneous Dynamics of the Fuzzy Coat of Full-Length Phospho-Mimetic Tau Fibrils 1.00
Structural Insights into Recognition and Translocation of Oxidized Phospholipid by CD36 Using Mass Spectrometry, Molecular Docking, Dynamics, and Metadynamics Simulations 1.00
Intracellular Peptide N-Myristoylation for Cancer Cell Ferroptosis without Acquired Resistance 1.00
From Transient to Metastable: Generation, Characterization, and Biomimetic Reactivity Studies of Well-Defined Heme Peroxynitrite Model Systems 1.00
A Chemical Mechanistic Path Leads the Way to Cellular Argpyrimidine 1.00
Dynamic Shape Modulation of Deflated and Adhered Lipid Vesicles 0.11
Role of Human Mitochondrial Ketosynthase in Long-Chain Fatty Acid Biosynthesis 1.00
Structural Heterogeneity of Proteoform-Ligand Complexes in Adenosine Monophosphate-Activated Protein Kinase Uncovered by Integrated Top-Down Mass Spectrometry 0.87
iBis/i-Allylic Deuterated Docosahexaenoic Acid-Esterified Phospholipids Resist In Vivo Peroxidation in Rat Brain 0.92
A Solvatochromic Near Infrared Fluorophore Sensitive to the Full Amyloid Beta Aggregation Pathway 1.00
2 1.98
Comprehensive Medication Reviews in Medicare Were Not Associated With Reduced Central Nervous System‐Active Polypharmacy in 2021 1.00
Comparing Fourteen Behavioral Science Electronic Health Record Deprescribing Tools in Older Adults: NUDGE‐EHR Adaptive Trial 0.98
1 0.93
Modulation of the APOM/S1PR4 Pathway Reduces Podocyte Lipid Overload in Alport Syndrome via Distinct Autophagy and Efflux Mechanisms 0.93
2 1.14
Divergent effects of PLA2G7 on prostate cancer biochemical recurrence in European American and African American men 1.00
Adiposity distribution and risks of 12 obesity-related cancers: a Mendelian randomization analysis 0.14
11 5.89
Cytoplasmic RNase III Drosha controls lipogenesis by noncanonical regulation of SREBP1 0.08
Metabolic profiling reveals pyrimidine synthesis enzyme CAD as a central carbon metabolism signaling node in cancer cell proliferation 1.00
Aspartate availability drives differential engagement of the malate-aspartate shuttle 1.00
Functional nutrient-genetic profiling reveals biotin and FBXW7 are essential to bypass glutamine addiction 0.29
MEDAG functions as an A-kinase-anchoring protein in adipocytes 0.10
RAD51 succinylation regulates homologous recombination and contributes to the chemosensitivity in cancer 0.06
H4K16 acylations destabilize chromatin architecture and facilitate transcriptional response during metabolic perturbations 0.40
HYPK promotes N-terminal protein acetylation through rapid ribosome exchange of NatA 0.71
Divergent proteome tolerance against gain and loss of chromosome arms 1.00
Mechanism of cotranslational protein N-myristoylation in human cells 0.27
Structural and systems characterization of phosphorylation on metabolic enzymes identifies sex-specific metabolic reprogramming in obesity 0.98
2 0.27
Lipid Composition Determines Hybrid Nanoparticle Selectivity: Beyond Membrane Mimicry in Cancer Targeting 0.14
Using DNA Origami to Study Nanoscale Organization of Plasma Membranes 0.13
21 16.40
αKG-mediated carnitine synthesis drives DNA repair via histone acetylation 0.99
A deep-learning framework reveals whole-body perturbations at cell level 0.05
Mitochondrial -2-hydroxyglutarate is a physiological signalling metabolite 1.00
Postprandial lipid metabolism durably enhances T cell immunity 1.00
Proteasome-guided haem signalling axis contributes to T cell exhaustion 0.06
CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly 0.96
Sleep-dependent clearance of brain lipids by peripheral blood cells 1.00
ZFTA–RELA ependymomas make itaconate to epigenetically drive fusion expression 0.98
Nutrient requirements of organ-specific metastasis in breast cancer 0.93
Neutrophils preserve energy storage in sympathetically activated adipocytes 1.00
SIGLEC12 mediates plasma membrane rupture during necroptotic cell death 1.00
ABCA7 variants impact phosphatidylcholine and mitochondria in neurons 0.96
Genetic suppression features as a Barth syndrome therapeutic target 0.12
Rewiring of cortical glucose metabolism fuels human brain cancer growth 1.00
Lithium deficiency and the onset of Alzheimer’s disease 1.00
Transient APC/C inactivation by mTOR boosts glycolysis during cell cycle entry 1.00
ACLY inhibition promotes tumour immunity and suppresses liver cancer 0.27
Coenzyme Q headgroup intermediates can ameliorate a mitochondrial encephalopathy 1.00
Allosteric modulation and biased signalling at free fatty acid receptor 2 0.18
Glycosaminoglycan-driven lipoprotein uptake protects tumours from ferroptosis 0.93
Early life high fructose impairs microglial phagocytosis and neurodevelopment 0.96
6 2.42
Membrane bridges and nanodomain partitioning govern membrane protein targeting to lipid droplets 0.57
Tumour acidosis remodels the glycocalyx to control lipid scavenging and ferroptosis 0.04
Inhibiting macrophage-derived lactate transport restores cGAS–STING signalling and enhances antitumour immunity in glioblastoma 0.21
FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis 0.69
PEX39 facilitates the peroxisomal import of PTS2-containing proteins 0.15
The Vps13-like protein BLTP2 regulates phosphatidylethanolamine levels to maintain plasma membrane fluidity and breast cancer aggressiveness 0.75
10 7.53
Cystine C–S bond cleavage fuels cysteine production under disulfide reductase deficiency 0.53
Autopalmitoylation of IDH1-R132H regulates its neomorphic activity in cancer cells 0.62
GCN5–ERK lactylation–phosphorylation loop amplifies lactate-driven cancer progression 0.13
Membrane editing with proximity labeling reveals regulators of lipid homeostasis 1.00
The membrane transition strongly enhances biopolymer condensation through prewetting 1.00
Molecular basis for the regulation of membrane proteins through preferential lipid solvation 1.00
Leaflet-specific phospholipid imaging using genetically encoded proximity sensors 1.00
An unbiased proteomic platform for ATE1-based arginylation profiling 1.00
A genetically encoded selection for amyloid-β oligomer binders 1.00
Lipoyl deglutarylation by ABHD11 regulates mitochondrial and T cell metabolism 0.25
2 1.70
Discovery of chirally dependent protein modifications by - and -2-hydroxyglutarates 0.92
High-throughput discovery of fluoroprobes that recognize amyloid fibril polymorphs 0.78
69 43.29
Breaking the membrane heredity paradox through de novo protocell formation 1.00
Insulin receptorT1160 phosphorylation mediates renal cortical insulin resistance but not excess gluconeogenesis from glycerol 1.00
Flow-mediated endothelial remodeling and inflammation drive developmental vascular susceptibility in ldlr loss of function 0.96
Glucuronidation metabolomic fingerprinting to map host-microbe metabolism 1.00
Western diet-induced MASH in PWK/PhJ mice identifies disruptions in amino acid and sphingolipid metabolism contributing to cardiac dysfunction 0.22
The SIRT3-DsbA-L-TFAM axis restrains cGAS-driven metabolic dysfunction-associated steatohepatitis in male mice 0.46
Lipid bilayers determine allostery but not intrinsic affinity of cAMP to pacemaker channels 1.00
Conserved and divergent features of human mRNA decapping revealed by biochemical reconstitution 0.80
Adipose single cell epigenome and transcriptome localize genetic risk for cardiometabolic disease and accelerated aging 0.44
SPNS2 exports sphingosine-1-phosphate and imports glucose 0.88
SpiR is a gut microbial enzyme that drives cholesterol conversion 1.00
Inhibition of circulating glycocholic acid-regulated signaling potentiates immune checkpoint therapy in colorectal cancer 0.07
SLIT3 fragments orchestrate neurovascular expansion and thermogenesis in brown adipose tissue 0.75
FGF1 orchestrates circadian hepatic triglyceride secretion 0.89
NANP targeting radiosensitizes glioblastoma through TNFR1 sialylation-driven mesenchymal shift 0.93
Butyrate extends health and lifespan in mice with mitochondrial deficiency 0.07
Hepatocyte SLCO4C1 is a cAMP uptake transporter for inhibiting lipogenesis and a therapeutic target for MASLD 0.03
Enterocytes rely on purine biosynthesis/salvage pathway to facilitate dietary fat absorption 1.00
GPR146 in adipose tissue drives adipose-liver crosstalk and promotes hepatic steatosis in mice 0.38
Clinically distinct metabotypes of pediatric MASLD identified through unsupervised clustering of NASH CRN data 1.00
Diverse regulation of functional dimerization of a sugar transporter by different interfacial lipids 0.11
Investigation of bile salt hydrolase activity in human gut bacteria reveals production of conjugated secondary bile acids 1.00
Structural defects in amyloid-β fibrils drive secondary nucleation 0.05
MG53 mediates skeletal muscle-liver cross-talk and enhances alcohol metabolism in alcoholic liver disease 0.21
Atypical protein kinase C activation drives intestinal glucose excretion in diabetes mellitus 0.04
Structural basis and pathological implications of the dimeric OS9-SEL1L-HRD1 ERAD Core Complex 1.00
Ether lipids influence cancer cell fate by modulating iron uptake 0.81
Modeling tissue-specific metabolism identifies high sugar diet-induced metabolic dysregulation in muscle at reaction and pathway levels 1.00
Epoxy-oxylipins direct monocyte fate in inflammatory resolution in humans 0.18
Endothelial FUNDC1 regulates metabolic reprogramming and the obesity-diabetes transition through the SIRT3/GATA2/endothelin-1 axis 0.80
6-Phosphogluconate dehydrogenase promotes mitochondrial fusion and immune suppression in tumor-associated monocytic suppressor cells 0.93
K48-ubiquitin-dependent proteases cut-up post-ER proteins 1.00
Lipedema World Alliance Delphi Consensus-Based Position Paper on the Definition and Management of Lipedema: Results from the 2023 Lipedema World Congress in Potsdam 0.17
Sulfatide deficiency-induced astrogliosis and myelin lipid dyshomeostasis are independent of TREM2-mediated microglial activation 1.00
Adaptation to cystine limitation stress confers a targetable lipid metabolism vulnerability in pancreatic ductal adenocarcinoma 0.54
BATF2 is a glutamine-responsive tumour suppressor required for type-I interferon-dependent anti-tumour immunity 0.97
Systemic engineering and global regulation enabling high-level bilirubin biosynthesis 0.13
TMEM120A maintains adipose tissue lipid homeostasis through ER CoA channeling 0.11
Multi-layered transcriptional control of glycogen metabolism coordinates thermogenic remodeling of white adipocytes in male mice 1.00
Sequestration of the phagocyte metabolite itaconate by Pseudomonas aeruginosa RpoN promotes successful pulmonary infection 0.65
AGPAT2 acts at the crossroads of lipid biosynthesis and DRP1-mediated ER morphogenesis 1.00
Structural insights into GM4951 as a lipid droplet GTPase regulating hepatic lipid metabolism 0.71
Schisantherin A interacts with gut bacteria to stimulate adipose tissue thermogenesis in obese mice via a TGR5‒p-CREB‒STAT6 signaling pathway 0.14
Multimodal mass spectrometry imaging for plaque- and region-specific neurolipidomics in Alzheimer’s disease mouse models 1.00
Worldwide trends in metabolic syndrome from 2000 to 2023: a systematic review and modelling analysis 0.09
Cytochrome c oxidase dependent respiration is essential for T cell activation, proliferation and memory formation 0.88
TOR and heat shock response pathways regulate peroxisome biogenesis during proteotoxic stress 1.00
Plasma lipopolysaccharide levels predict mortality in acutely ill children in Low- and Middle-Income Countries 0.08
Very long-chain fatty acids drive 1-deoxySphingolipid toxicity 0.14
Fructose and follistatin potentiate acute MASLD during complete hepatic insulin resistance 0.86
Desaturase-dependent secretory functions of hepatocyte-like cells control systemic lipid metabolism during starvation in Drosophila 0.50
MRAP mediated adipocyte differentiation by thymic mesenchymal stromal cells contributes to thymic involution 0.50
Integrative brain omics approach highlights sn-1 lysophosphatidylethanolamine in Alzheimer’s dementia 1.00
Physics-based evolution of transmembrane helices reveals mechanisms of cholesterol attraction 0.05
Autophagy acts as a brake on obesity-related fibrosis by controlling purine nucleoside signalling 0.03
Microglia-specific regulation of lipid metabolism in Alzheimer’s disease revealed by microglial depletion in 5xFAD Mice 1.00
Non-canonical dihydrolipoyl transacetylase promotes chemotherapy resistance via mitochondrial tetrahydrofolate signaling 1.00
Cardiolipin dynamics promote membrane remodeling by mitochondrial OPA1 0.70
Uncovering the prevalence, key biogenesis enzymes, and biological significance of archaeal lipoproteins 0.86
Identification of Neuritin 1 as a local metabolic regulator of brown adipose tissue 0.02
Structural basis of VCP-VCPIP1-p47 ternary complex in Golgi maintenance 1.00
Microglial replacement in a Sandhoff disease mouse model reveals myeloid-derived β-hexosaminidase is necessary for neuronal health 1.00
Dysregulation of GTPase-activating protein-binding protein1 in the pathogenesis of metabolic dysfunction-associated steatotic liver disease 0.14
Defective Olfactomedin-2 connects adipocyte dysfunction to obesity 0.07
12,13-diHOME protects against the age-related decline in cardiovascular function via attenuation of CaMKII 0.99
Cholesterol modulates membrane elasticity via unified biophysical laws 0.92
Inhibition of HDAC6 alters fumarate hydratase activity and mitochondrial structure 0.06
Gut microbial bile and amino acid metabolism associate with peanut oral immunotherapy failure 1.00
Spatial patterns of hepatocyte glucose flux revealed by stable isotope tracing and multi-scale microscopy 1.00
2 0.99
p53 inactivation drives breast cancer metastasis to the brain through SCD1 upregulation and increased fatty acid metabolism 0.07
KDM4C inhibition blocks tumor growth in basal breast cancer by promoting cathepsin L-mediated histone H3 cleavage 0.92
5 4.78
SIRT2-mediated deacetylation of LCK governs the magnitude of T cell receptor signaling 0.90
Metabolic adaptations rewire CD4+ T cells in a subset-specific manner in human critical illness with and without sepsis 1.00
Early methionine availability attenuates T cell exhaustion 0.97
Mitochondrial respiration is necessary for CD8 T cell proliferation and cell fate 0.91
The prostacyclin receptor PTGIR is a NRF2-dependent regulator of CD8+ T cell exhaustion 1.00
2 1.05
Dual-vector rAAVrh8 gene therapy for GM2 gangliosidosis: a phase 1/2 trial 1.00
Modulation of metabolic, inflammatory and fibrotic pathways by semaglutide in metabolic dysfunction-associated steatohepatitis 0.05
4 2.12
Redox-driven ADAR1 activation promotes Okazaki fragment maturation and DNA replication integrity 0.88
ATG2A-mediated DAG transfer recruits DGAT2 for lipid droplet growth 0.22
Hydrophilic metformin and hydrophobic biguanides inhibit mitochondrial complex I by distinct mechanisms 0.13
ACAD10 and ACAD11 enable mammalian 4-hydroxy acid lipid catabolism 0.89
2 1.77
Lysosomal salvage of neuronal lipids enables glial infiltration of synaptic regions 0.77
Aberrant nuclear pore complex degradation contributes to neurodegeneration in VCP disease 1.00
1 0.11
Alterations in ether lipid metabolism in obesity revealed by systems genomics of multi-omics datasets. 0.11
4 2.46
Sleep rescues age-associated loss of glial engulfment 1.00
Dynamic phosphorylation of Hcm1 promotes fitness in chronic stress 1.00
Metabolic coupling of ROS generation and antioxidant synthesis by the GABA shunt pathway in myeloid-like blood progenitor cells of Drosophila 0.39
Functional analysis of CYP4B1 enzymes from apes and humans uncovers evolutionary hot spots for adaptations of the catalytical function. 0.07
28 20.87
Visualization of the interaction between sphingomyelin and cholesterol in lipid bilayer membranes 1.00
Structural studies of an antinecroptosis viral:human functional heteroamyloid M45:RIPK3 using SSNMR 0.18
Reconstruction of human metabolic models with large language models 0.14
Elucidation of a potent pro-resolving mediator of inflammation resolution via human neutrophil–vascular endothelial cell interactions 1.00
Sleep deprivation exhibits an age-dependent effect on infraslow global brain activity 1.00
Functional integrity of the SEL1L–HRD1 complex is critical for endoplasmic reticulum–associated degradation and organismal viability 1.00
Apical and basolateral plasma membranes in epithelial cells have distinct lipidomes and biophysical properties 1.00
Selective peroxynitrite-mediated protein nitration catalyzed by glyoxalase domain containing protein 4 1.00
A structural model of toxic amyloid oligomers involved in type 2 diabetes 1.00
Blood-borne sphingosine 1-phosphate maintains vascular resistance, blood pressure, and cardiac function in mice 0.12
Cholesterol-containing lipid crystals can directly stiffen the rat steatotic liver before fibrosis 0.83
Exploring the interplay between protein conformational changes and phosphorylation in a pancreatic cancer cell and stellate cell coculture system 1.00
A neutralizing APOA5 monoclonal antibody reduces amounts of lipoprotein lipase in capillaries and triggers hypertriglyceridemia 0.96
Aducanumab binding to Aβ1-42 fibrils alters dynamics of the N-terminal tail while preserving the fibril core 0.78
Competition between Der1 and ERAD-M substrates controls Hrd1 complex function 1.00
ATG2 is a triglyceride transfer protein 0.75
DDHD2 possesses both lipase and transacylase capacities that remodel triglyceride acyl chains 0.75
Ribonuclease RNase Z is an evolutionarily conserved deAMPylase 1.00
Amyloid-beta glycation induces neuronal mitochondrial dysfunction and Alzheimer’s pathogenesis via VDAC1-dependent mtDNA efflux 1.00
A cell-based scrambling assay reveals the phospholipid headgroup preference of TMEM16F on the plasma membrane 1.00
A mouse model of MEPAN demonstrates a role for mitochondrial fatty acid synthesis in iron–sulfur cluster and supercomplex formation 1.00
Drosophila Ahcy is a redox sensor that modulates gene expression to protect against light stress–induced retinal degeneration 1.00
CHP1 promotes lipid droplet growth and regulates the localization of key enzymes for triacylglycerol synthesis 0.15
Engineering a highly selective, hemoprotein-based scavenger as a carbon monoxide poisoning antidote with no hypertensive effect 1.00
Micro magnetic resonance spectroscopy for noninvasive metabolic screening of mammalian embryos and oocytes 0.09
OGG1 augments the transcriptional activation of Foxp3 to promote iTreg differentiation for IBD alleviation 0.06
An aminosterol breaks the autocatalytic cycle of Aβ42 aggregation and protects cell membranes from its soluble aggregates 0.80
PI(4)P recruits CIDE proteins to promote the formation of unilocular lipid droplets during adipogenesis and hepatic steatosis 0.27
9 7.52
Mitochondrial metabolism and signaling direct dendritic cell function in antitumor immunity 1.00
Nucleotide metabolic rewiring enables NLRP3 inflammasome hyperactivation in obesity 0.95
Ablation of Prdm16 and beige fat identity causes vascular remodeling and elevated blood pressure 0.83
Mitochondrial control of fuel switching via carnitine biosynthesis 1.00
The origin of hepatocellular carcinoma depends on metabolic zonation 1.00
Adipogenin promotes the development of lipid droplets by binding a dodecameric seipin complex 0.75
Acidosis orchestrates adaptations of energy metabolism in tumors 0.06
LYVAC/PDZD8 is a lysosomal vacuolator 1.00
Is taurine an aging biomarker? 0.93
23 16.80
Metabolic rewiring driven by phosphoglycolate phosphatase deletion inhibits ferroptosis 0.11
Noncanonical PI(4,5)P2 coordinates lysosome positioning through cholesterol trafficking 1.00
LIPT1 loss confers replication stress and PARP inhibitor sensitivity through PrimPol-mediated ssDNA gaps 1.00
Adissp activates insulin-independent glucose disposal and energy expenditure in white fat to treat diabetes and cardiometabolic disease 0.92
Constitutive AMPK activation prevents hepatocellular carcinoma development through inhibition of HNF4α activity 1.00
Ampk alpha2 T172 activation dictates exercise performance and energy transduction in skeletal muscle 1.00
A near-complete map of human cytosolic degrons and their relevance for disease 0.09
ERα activates NAMPT/IL-33 signaling to enhance beige thermogenesis and metabolic fitness 0.98
The extracellular matrix drives guanylate production and protects pancreatic cancer cells from oxaliplatin-induced DNA damage 0.12
Chaperone-mediated autophagy controls brown adipose tissue thermogenic activity 0.25
Leptin as a key driver for organ fibrogenesis 1.00
ITCH regulates Golgi integrity and proteotoxicity in neurodegeneration 1.00
Targeting the ATM-TRMT10A-BRCA1 axis confers synthetic lethality to PARP inhibition in metastatic castration-resistant prostate cancer 0.25
Structural basis of Pseudomonas biofilm-forming functional amyloid FapC formation 0.65
Nanomedicine targeting PPAR in adipose tissue macrophages improves lipid metabolism and obesity-induced metabolic dysfunction 1.00
ACSS2 coupled with KAT7 regulates histone β-hydroxybutyrylation to enhance transcription 0.14
Cryogenic electron tomography reveals helical organization of lipoprotein lipase in storage vesicles 0.75
Low-dose metformin requires brain Rap1 for its antidiabetic action 0.92
FAF2 is a bifunctional regulator of peroxisomal homeostasis and saturated lipid responses 1.00
The lipid bilayer strengthens the cooperative network of membrane proteins 0.97
The RNA demethylase FTO promotes glutamine metabolism in clear cell renal cell carcinoma through the regulation of SLC1A5 0.93
Molecular basis of the hepatobiliary tropism of typhoid toxin promoting Salmonella pathogenicity 1.00
The metabolite itaconate is a transcriptional and posttranslational modulator of plant metabolism, development, and stress response 0.73
4 2.92
Lactylation fuels nucleotide biosynthesis and facilitates deuterium metabolic imaging of tumor proliferation in preclinical models of H3K27M-mutant gliomas 1.00
SREBP-1 increases glucose uptake to promote tumor resistance to lysosome inhibition 1.00
Retinal polyunsaturated fatty acid supplementation reverses aging-related vision decline in mice 0.82
FXR adapts hepatic mitochondrial function to increased substrate oxidation in patients with obesity 0.10
1 0.05
Exposure to sugar rationing in first 1000 days after conception and long term cardiovascular outcomes: natural experiment study 0.05
4 3.75
Peroxisome-derived ether lipids regulate lysosomal exocytosis 1.00
Global stabilization of the transcriptome in mitotic cells 1.00
NAC couples protein synthesis with nascent polypeptide myristoylation on the ribosome. 1.00
Sphingosine simultaneously inhibits nuclear import and activates PP2A by binding importins and PPP2R1A 0.75
4 3.50
Amyloid-β “Co-assembles” with Coatomer Subunit Delta (δ-COP) 0.50
Logarithmic Binding and Stretched-Exponential Kinetics in Peripheral Protein Interactions with Lipid Membrane Surfaces 1.00
Membrane Composition Reshapes the Folding Landscape of a pH-Responsive Peptide 1.00
Membrane Interactions Drive Hydrogen-Bond Dynamics in the pH-Low Insertion Peptide (pHLIP) 1.00
3 1.04
Disparities in diabetes treatment and monitoring for people with and without mental disorders: a systematic review and meta-analysis 0.03
Metformin for overweight and obese children and adolescents with bipolar spectrum and related mood disorders treated with second-generation antipsychotics: a randomised, pragmatic trial 0.95
Mortality from respiratory diseases in individuals with severe mental illness: a large-scale systematic review and meta-analysis of pooled and specific diagnoses 0.07
3 1.87
AAV9 Gene Therapy in Type II GM1 Gangliosidosis — A Phase 1–2 Trial 1.00
An Intravenous Brain-Penetrant Enzyme Therapy for Mucopolysaccharidosis II 0.81
Fish-Oil Supplementation and Cardiovascular Events in Patients Receiving Hemodialysis 0.06

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