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This Review presents an updated view on telomeric chromatin as a dynamic structure with a specialized histone organization and discusses the mechanisms of its regulation by cis-acting subtelomeric elements, as well as their relevance in disease.
Rizzotto et al. discuss the causes and consequences of deregulated mitosis that allow cells arrested in mitosis to escape to the next interphase, where they can initiate inflammatory signalling or undergo cell death, with therapeutic implications.
This Review discusses the effects of three age-associated stressors—loss of proteostasis, oxidative damage and dysregulated nutrient sensing—on global protein synthesis and highlights how altered translation is used by the cell as a stress sensor.
In this Review, Lusk et al. discuss emerging insights into nuclear pore complex variability with regard to composition and dilation state, and propose nuclear mechanics as a key determinant of driving such plasticity and any associated diseases.
In this Review, Andersson et al. discuss emerging insights into ageing of the haematopoietic system and its role in driving organismal ageing, in particular inflammageing and immunosenescence, as well as in rejuvenation of the immune system.
This Review discusses transcription-coupled DNA repair in response to the stalling of RNA polymerase II on different types of DNA lesions and highlights the molecular details for the different steps in the process that have recently emerged.
This Review discusses the intricate relationship between metabolism and embryogenesis, highlighting the orchestration of key developmental processes by metabolites and signalling molecules that provide insights into developmental disorders.
This Review provides an overview of modern mechanistic theories and critically examines two main groups of ageing theories—error and program based—in the context of ageing patterns, genetic manipulations and longevity drugs.
This Review discusses emerging insights into SEL1L–HRD1-mediated endoplasmic reticulum-associated degradation, including the underlying molecular mechanisms, physiological relevance for human disease and potential therapeutic opportunities.
This Review discusses the mechanisms underlying the insertion of α-helical proteins into the mitochondrial outer membrane and highlights the role of convergent evolution in the process by comparing key biogenesis factors across several species.
This Review discusses the diversity of human fibroblasts, including their embryonic origin and precursor populations, and highlights their crucial role in orchestrating organ function and modulating immune responses in healthy and disease contexts.
This Review discusses the role of phosphatidylinositol phosphates and their modifying enzymes in modulating cell motility and adhesion and emphasizes the potential of targeting the associated pathways for therapeutic benefit.
Auwerx and colleagues review recent advances in mitochondrial genetics, proteomics and biochemistry that emphasize the far-reaching impact of mitochondrial genetic variation and the role of mitochondria as finely tuned signalling hubs.
This Review discusses the recent advances in experimental approaches to interrogate the mechanical forces that mediate tissue deformations during development, highlighting the insights afforded at both the cellular and tissue scales.
Cells respond to mitochondrial protein import stress by regenerating clogged import sites and inducing stress responses. Mitochondria are thus tightly integrated into the cellular proteostasis and stress-response network to maintain cell viability.
Recent developments in single-cell technologies have increased our understanding of how the coordinated activities of transcription factors in different quiescent cells and differentiated cells maintain reversible cell cycle arrest.
Narendra and Youle review the current understanding of the role of PINK1–Parkin in the quality control of mitophagy, highlighting the underlying mechanisms and physiological relevance of the pathway, as well as its role in neuroprotection.
Man and Kanneganti discuss how pattern-recognition sensors in innate immune cells recognize and respond to cell-death signatures, and highlight molecular targets for potential therapeutic development.
Gasdermins are a family of proteins that form membrane pores and elicit pyroptosis. This Review discusses recent work highlighting their regulation and emerging biological roles, including in non-lethal pore formation and host defence.
The subcellular localization of numerous mRNAs has been demonstrated. This Review presents the different means of mRNA localization described and discusses how they can account for the widespread occurrence of this phenomenon.
