Nature Search

James Dewar, 1842–1923: a Friday Evening Lecture to the Members of the Royal Institution, on January 18, 1924

R. A.
Books & Arts12 Jul 1924
Nature

Volume: 114, P: 48
Discovery and development of a new oxazolidinone with reduced toxicity for the treatment of tuberculosis

MK-7762 is a new oxazolidinone antitubercular agent that is structurally similar to linezolid, and demonstrated in vivo efficacy, lesion penetration and limited toxicity compared to linezolid, indicating it could be used in broad tuberculosis regimens.

Brendan M. Crowley
Helena I. Boshoff
David B. Olsen
ResearchOpen Access13 Jan 2026
Nature Medicine

P: 1-8
Natural oligomers of the amyloid-β protein specifically disrupt cognitive function

James P Cleary
Dominic M Walsh
Karen H Ashe
Research19 Dec 2004
Nature Neuroscience

Volume: 8, P: 79-84
Elucidating molecularly stratified single agent, and combination, therapeutic strategies targeting MCL1 for lethal prostate cancer

Despite improving therapeutic options, the prognosis for patients with metastatic castration-resistance prostate cancer (mCRPC) remains poor. Here, the authors identify MCL1 copy number alterations as a prognostic and predictive biomarker, demonstrating its therapeutic potential as a drug target, either alone or in combination, in patients with mCRPC.

Juan M. Jiménez-Vacas
Daniel Westaby
Adam Sharp
ResearchOpen Access08 Oct 2025
Nature Communications

Volume: 16, P: 1-22
A benchmark of expert-level academic questions to assess AI capabilities

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Long Phan
Alice Gatti
Davide Scaramuzza
ResearchOpen Access28 Jan 2026
Nature

Volume: 649, P: 1139-1146
The Liquid–Solid Transition in Helium Near Absolute Zero

F. E. SIMON
C. A. SWENSON
Research27 May 1950
Nature

Volume: 165, P: 829-831
The relative contribution of close-proximity contacts, shared classroom exposure and indoor air quality to respiratory virus transmission in schools

The relative importance of close-proximity interactions, shared space and air quality to the transmission of respiratory viruses is not well understood. Here, the authors investigate this question by collecting longitudinal molecular, physical proximity and environmental data in a school in Switzerland.

Nicolas Banholzer
James Daniel Munday
Lukas Fenner
ResearchOpen Access27 Nov 2025
Nature Communications

Volume: 16, P: 1-15
Vibrio pectenicida strain FHCF-3 is a causative agent of sea star wasting disease

The causative agent of sea star wasting disease has been elusive. This study used genetic datasets and experimental exposures to demonstrate that a strain of the bacterium Vibrio pectenicida caused disease and mortality in sea stars.

Melanie B. Prentice
Grace A. Crandall
Alyssa-Lois M. Gehman
Research04 Aug 2025
Nature Ecology & Evolution

Volume: 9, P: 1739-1751
Prevalence of Alzheimer’s disease pathology in the community

The prevalence of Alzheimer’s disease neuropathological changes is reported based on blood-based biomarkers in a Norwegian population-based cohort.

Dag Aarsland
Anita Lenora Sunde
Nicholas J. Ashton
ResearchOpen Access17 Dec 2025
Nature

P: 1-5
Integration of 12-h time-restricted feeding with exercise training potentiates weight loss and attenuates MASLD in diet-induced obese mice

Guilherme Correia Ferri Antonio
Ana Paula Azevêdo Macêdo
José Rodrigo Pauli
ResearchOpen Access10 Jan 2026
Scientific Reports

Volume: 16, P: 1-19
Large-scale behavioral characterization of oxycodone self-administration in heterogeneous stock rats reveals initial analgesic effects are associated with addiction-like behaviors

Marsida Kallupi
Giordano de Guglielmo
Olivier George
ResearchOpen Access30 Jan 2026
Neuropsychopharmacology

P: 1-10
The British Association at Newcastle Section D

E. W. MACBRIDE
Research12 Oct 1916
Nature

Volume: 98, P: 120-123
Dietary restriction impacts health and lifespan of genetically diverse mice

Health effects of dietary restriction are uncoupled from longevity.

Andrea Di Francesco
Andrew G. Deighan
Gary A. Churchill
ResearchOpen Access09 Oct 2024
Nature

Volume: 634, P: 684-692
DUSP6 mediates resistance to JAK2 inhibition and drives leukemic progression

Oh and colleagues demonstrate that the DUSP6–RSK1 axis is involved in the transformation of myeloproliferative neoplasms to secondary acute myeloid leukemia and that DUSP6 mediates the response to JAK2 inhibition.

Tim Kong
Angelo B. A. Laranjeira
Stephen T. Oh
Research29 Dec 2022
Nature Cancer

Volume: 4, P: 108-127
Vanishing weekly hydropeaking cycles in American and Canadian rivers

Rapid sub-daily and weekly fluctuations in streamflow are known as hydropeaking. Here, the authors apply a new “weekly hydropeaking index” (WHI) to streamflow data from 500 gauges across the USA and Canada and find that the strength of WHI peaked in the mid-20th century and has been declining through the 2010s.

Stephen J. Déry
Marco A. Hernández-Henríquez
Tara J. Troy
ResearchOpen Access09 Dec 2021
Nature Communications

Volume: 12, P: 1-12
Electric vehicles charging stations load forecasting based on hybrid XGBoost-BiLSTM model

Hany S. E. Mansour
Amira S. Mohamed
M. Abdel-Aziz
ResearchOpen Access02 Jan 2026
Scientific Reports

Volume: 16, P: 1-26
Auroral Display

A. E. L. HUDSON
Research19 May 1921
Nature

Volume: 107, P: 359
SuFEx-based antitubercular compound irreversibly inhibits Pks13

A preclinical covalent compound, CMX410, contains a aryl fluorosulfate warhead that targets the acyltransferase domain of Mtb Pks13, an essential enzyme in cell-wall biosynthesis, making it a promising candidate for tuberculosis treatment regimens.

Inna V. Krieger
Paridhi Sukheja
Case W. McNamara
Research30 Jul 2025
Nature

Volume: 645, P: 755-763
Aerobic and resistance exercise-regulated phosphoproteome and acetylproteome modifications in human skeletal muscle

Here, the authors show that post-translational molecular signatures of human skeletal muscle in response to acute or chronic aerobic and resistance exercise are distinct, potentially dictating the differential physiologic adaptations to different exercise modes.

Mark W. Pataky
Carrie J. Heppelmann
K. Sreekumaran Nair
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-19
The striatal indirect pathway mediates hesitation

Hesitation—pausing in the face of uncertainty—is ubiquitous in daily life and disrupted in several psychiatric disorders. Unlike other forms of response inhibition, hesitation is mediated by indirect, but not direct, pathway striatal neurons.

Matthew A. Geramita
Susanne E. Ahmari
Eric A. Yttri
Research05 Dec 2025
Nature Neuroscience

P: 1-6
Prevalence, magnitude and distribution of climate change anxiety in Canada: an interdisciplinary study

Harper et al. used data from a national population-based cross-sectional survey to assess the prevalence, magnitude and distribution of climate change anxiety in Canada.

S. L. Harper
A. Cunsolo
H. L. Bayne
Research21 Oct 2025
Nature Mental Health

Volume: 3, P: 1384-1394
Influence of days of the week on reported food, macronutrient and alcohol intake among an adult population in south western Finland

A Jula
R Seppänen
E Alanen
Research19 Oct 1999
European Journal of Clinical Nutrition

Volume: 53, P: 808-812
Cyber-resilient machine learning framework for accurate individual load forecasting and anomaly detection in smart grids

M. Tayseer
M. Talaat
M. H. Elkholy
ResearchOpen Access18 Dec 2025
Scientific Reports

Volume: 15, P: 1-32
Aurora Borealis

A. BUTCHER
Research18 Aug 1892
Nature

Volume: 46, P: 368
A lactobacilli-based inhaled live biotherapeutic product attenuates pulmonary neutrophilic inflammation

Bronchopulmonary dysplasia and chronic obstructive pulmonary disease are marked by neutrophilic inflammation and microbial changes. Here, the authors show the efficacy of an inhaled live biotherapeutic in reducing inflammation and improving tissue structure across models of respiratory disease.

Teodora Nicola
Nancy Wenger
Charitharth Vivek Lal
ResearchOpen Access19 Aug 2024
Nature Communications

Volume: 15, P: 1-19
A Fast Continuous Electrodialyser for Hydrophilic Colloids, and A Fast Continuous Electrodecanter for Hydrophobic Colloids

A. J. RUTGERS
R. SWYNGEDOUW
Research27 Oct 1951
Nature

Volume: 168, P: 727-728
Drug regimens identified and optimized by output-driven platform markedly reduce tuberculosis treatment time

Current antibiotic therapies for tuberculosis are lengthy and onerous. Here, the authors use an output-driven approach to optimize drug doses for two experimental drug regimens in a mouse model of tuberculosis, leading to improved regimens that reduce treatment time by 75%.

Bai-Yu Lee
Daniel L. Clemens
Marcus A. Horwitz
ResearchOpen Access24 Jan 2017
Nature Communications

Volume: 8, P: 1-11
Microbial metabolite drives ageing-related clonal haematopoiesis via ALPK1

ADP-heptose binds to ALPK1, triggering transcriptional reprogramming and NF-κB activation, endowing pre-leukaemic cells with a competitive advantage due to excessive clonal proliferation.

Puneet Agarwal
Avery Sampson
Daniel T. Starczynowski
ResearchOpen Access23 Apr 2025
Nature

Volume: 642, P: 201-211
Midbrain ghrelin receptor signalling regulates binge drinking in a sex specific manner

Binge drinking is a rising issue in women, yet the underlying neurobiology remains underexplored. Here authors show the Edinger-Westphal (EWcp) peptidergic neurons as a critical regulator of binge drinking in female mice via actions at the ghrelin receptor (GHSR).

Amy J. Pearl
Xavier J. Maddern
Leigh C. Walker
ResearchOpen Access15 Mar 2025
Nature Communications

Volume: 16, P: 1-17
Weakened weekdays: lockdown disrupts the weekly cycle of risk tolerance

Virginia Fedrigo
Benno Guenther
Jet G. Sanders
ResearchOpen Access30 Nov 2023
Scientific Reports

Volume: 13, P: 1-11
“The Friend of Mankind”: A Portrait of Count Rumford

A. H. EWEN
Research06 Feb 1965
Nature

Volume: 205, P: 536-537
Optimizing social media initiatives to promote Neuropsychopharmacology (NPP) publications

Hayley H. A. Thorpe
Leah M Mayo
Briana K. Chen
Research24 Sept 2025
Neuropsychopharmacology

Volume: 50, P: 2072-2078
The temporal dynamics of group interactions in higher-order social networks

The structure and dynamics of many social systems where human interactions involve communities can be described by higher-order networks. The authors propose a hypergraph-based model that describes how individuals form groups and navigate between groups of different sizes.

Iacopo Iacopini
Márton Karsai
Alain Barrat
ResearchOpen Access27 Aug 2024
Nature Communications

Volume: 15, P: 1-11
Multi-jet propulsion organized by clonal development in a colonial siphonophore

Physonect siphonophores are highly mobile jellyfish with complex colonial organization. Here, Costelloet al. show that division of labour among developmental stages controls the direction and propulsion of the colony, with older individuals providing thrust and younger individuals providing torque.

John H. Costello
Sean P. Colin
Kelly R. Sutherland
ResearchOpen Access01 Sept 2015
Nature Communications

Volume: 6, P: 1-6
Weekdays warmer than weekends?

A. H. Gordon
Research27 Jan 1994
Nature

Volume: 367, P: 325-326
Relations Between Moths and Predators

A. D. BLEST
Research16 Mar 1963
Nature

Volume: 197, P: 1046-1047
Explaining Twitter’s inability to effectively moderate content during the COVID-19 pandemic

David A. Broniatowski
Wei Zhong
Lorien C. Abroms
ResearchOpen Access15 Oct 2025
Scientific Reports

Volume: 15, P: 1-17
Medication review improves pain management and quality of life in chronic pain: a pilot randomized controlled study

Nuno Duarte
João Paulo Martins
Marlene Santos
ResearchOpen Access29 Dec 2025
Scientific Reports

Volume: 15, P: 1-12
A Plea for an International Zoological Record

E. A. MINCHIN
Research18 Aug 1892
Nature

Volume: 46, P: 367-368
Allosteric regulation of crocodilian haemoglobin

M. F. Perutz
C. Bauer
K. A. Joysey
Research25 Jun 1981
Nature

Volume: 291, P: 682-684
APOE4 to APOE2 allelic switching in mice improves Alzheimer’s disease-related metabolic signatures, neuropathology and cognition

Using a mouse model enabling an inducible ‘switch’, Golden et al. show that an astrocyte-specific replacement of the Alzheimer’s risk gene APOE4 with protective APOE2 alters metabolism and gene expression, reducing amyloid pathology and gliosis.

Lesley R. Golden
Dahlia S. Siano
Lance A. Johnson
ResearchOpen Access11 Nov 2025
Nature Neuroscience

Volume: 28, P: 2461-2475
Hip adduction and abduction isometric force production in young football players: reliability of different testing protocols

Vincenzo Rago
José M. Oliva-Lozano
Pedro Figueiredo
ResearchOpen Access28 Dec 2025
Scientific Reports

Volume: 16, P: 1-10
The association between internal and external measures of training load in elite rowers during ergometer training

Xinyu Dai
Jihong Yan
Xuecui Bi
ResearchOpen Access29 Dec 2025
Scientific Reports

Volume: 15, P: 1-8
IL-23 secreted by myeloid cells drives castration-resistant prostate cancer

IL-23 produced by myeloid-derived suppressor cells regulates castration resistance in prostate cancer by sustaining androgen receptor signalling.

Arianna Calcinotto
Clarissa Spataro
Andrea Alimonti
Research27 Jun 2018
Nature

Volume: 559, P: 363-369
Reinforcement learning increasingly relates to memory specificity from childhood to adulthood

Making rewarding choices can require either generalization or individuation. Here, the authors show that across contexts, people adapt the specificity with which they represent and, increasingly across development, remember their experiences.

Kate Nussenbaum
Catherine A. Hartley
ResearchOpen Access30 Apr 2025
Nature Communications

Volume: 16, P: 1-20
A novel data-driven model to define physical activity metrics and predict mortality in patients with chronic obstructive pulmonary disease

Qichen Deng
Alex van ’t Hul
Martijn A. Spruit
ResearchOpen Access22 Jul 2025
Scientific Reports

Volume: 15, P: 1-10
Baseline characteristics in the Israel refraction, environment, and devices (iREAD) study

Einat Shneor
Lisa A. Ostrin
Ariela Gordon-Shaag
ResearchOpen Access17 Feb 2023
Scientific Reports

Volume: 13, P: 1-16
Scientific Techniques in Art and Archæology

A. E. WERNER
Research28 May 1960
Nature

Volume: 186, P: 674-677
Sexual Behaviour in Birds

F. H. A. MARSHALL
Research26 Oct 1929
Nature

Volume: 124, P: 655-657
Empirical validation of a touchscreen probabilistic reward task in rats

Brian D. Kangas
Lisa M. Wooldridge
Diego A. Pizzagalli
ResearchOpen Access13 Aug 2020
Translational Psychiatry

Volume: 10, P: 1-11

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