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DNA circuits hold promise for advancing information-based molecular technologies, yet it is challenging to design and construct them in practice. Thubagereet al. build DNA strand displacement circuits using unpurified strands whose sequences are automatically generated from a user-friendly compiler.

Programming stimulus responsiveness into living systems enables advanced biocomputation. Here, the authors autonomously compile proteins with defined topology that can be site-specifically tethered to and conditionally released from biomaterials and cells following user-specified Boolean logic.

Analysis of a placebo-controlled trial of a BCMA-targeting CAR-T cell therapy in patients with myasthenia gravis shows that CAR-T cell infusion selectively remodels the systemic immune environment, with elimination of BCMA-high plasma cells and activated plasmacytoid dendritic cells and changes in the autoreactive B cell repertoire.

Using a non-human primate model, the authors identified the tissue sites of initial viral rebound after discontinuation of antiretroviral therapy, demonstrating that such rebound preferentially occurs in the gastrointestinal tract-associated lymphoid tissues.

The quantum charge-coupled device architecture is demonstrated, with its various elements integrated into a programmable trapped-ion quantum computer and performing simple quantum operations with state-of-the-art levels of error.

Greenland’s icebergs transport 450 megatonnes of sediment to its fjords each year, representing one-third of the ice sheet’s total sediment export. This ice-rafted debris builds shoals at tidewater glacier margins and provides key nutrients for marine ecosystems.

Photons are essential for quantum information processing, but to date only two-qubit single-photon operations have been realized. Here the authors demonstrate experimentally a three-qubit single-photon linear deterministic quantum gate by exploiting polarization along with spatial-parity symmetry.

Dynamic ionic gradients of counterions in films of metal nanoparticles functionalized with charged organic ligands can be used to create transistors that are capable of a 400-fold modulation of the electrical conductivity and can be used to construct logic gates and half-adder circuits.

A mechanism for coupling the electrons and vibrational motion of a suspended carbon nanotube is now demonstrated. Tailoring the coupling between specific electronic and phononic modes by controlling the position of quantum dots along the resonating tube enables spatial imaging of the mode shape.

The integration of high-κ dielectric materials with 2D semiconductors remains an important challenge for the implementation of post-silicon 2D electronics. Here, the authors report a HfSe₂ plasma oxidation method to integrate HfO₂ dielectric layers on both n- and p-type 2D semiconducting channels, showing the realisation of high-performance complementary electronic devices.

Biocompatible and stretchy organic field-effect transistors can be created using a vulcanized blend film of semiconducting nanofibres and a medical-grade elastomer.

Photonic quantum computation via bulk optical nonlinearities presents challenges, due to the weakness of nonlinearity and the difficulties in doing without feed-forward control. Here, the authors propose an all-unitary approach that is based on a triply-resonant cavity with a time-dependent drive.

The authors report the sweet-spot operation of germanium hole spin qubits, exploring the optimization of the external magnetic field orientation, the g-tensor and its electric tunability, and hyperfine interactions.

A precision nanoassembly technique is used to deterministically create locally tunable, ultralow-disorder electron systems in suspended carbon nanotubes.

Transistors that operate by the passage of electrons through a single-dopant atom achieve the ultimate limit for the miniaturization of electronic devices, but only when multiple transistors are intimately connected can they become useful. Roche et al. demonstrate the equivalent of just this, connecting two such transistors to build a two-atom electron pump.

A unitary protocol for braiding projective non-Abelian Ising anyons in a generalized stabilizer code is implemented on a superconducting processor, allowing for verification of their fusion rules and realization of their exchange statistics.

Debugging a genetic circuit is frustrated by the inability to characterize parts in the context of the circuit. Here the authors use RNA-seq and ribosome profiling to take ‘snapshots’ of a large circuit in different states.

True random number generators are highly demanded for secured data processing, yet it remains challenging to control and reproduce the randomness. Im et al. generate analog random values using a positive feedback transistor and implement it to encrypt and decrypt images, and store encrypted information.

Ferromagnetic nanowires act as conduits for magnetic domain walls which may in principle be used to encode and propagate information. Here, the authors present current-based nanowire domain wall logic prototypes with operational properties required for real devices.

Carbon nanotubes are promising hosts for spin qubits, however existing demonstrations show limited coherence times. Here the authors report quantum states in a carbon-nanotube-based circuit driven solely by cavity photons and exhibiting a coherence time of about 1.3 μs.

Integrating an electronic device with a cavity can cause the electrons to couple to photons strongly enough to form hybrid modes. Now, the cavity effects induced by intrinsic graphite gates are shown to modify the low-energy properties of graphene.

Quantum computers may help to solve classically intractable problems, such as simulating non-equilibrium dissipative quantum systems. The critical dynamics of a dissipative quantum model has now been probed on a trapped-ion quantum computer.

Fault-tolerant quantum computing would require very high accuracy in quantum gate characterisation. Here, the authors introduce an optimal low-depth phase estimation method inspired by quantum signal processing, significantly improving gate calibration accuracy.

The physical realization of a quantum computer requires built-in error-correcting codes that compensate the disruption of quantum information arising from noise. Here, the authors demonstrate a quantum error detection scheme for arbitrary single-qubit errors on a four superconducting qubit lattice.

The Fermi-Hubbard model represents one of the benchmarks for testing quantum computational methods for condensed matter. Here, the authors are able to reproduce qualitative properties of the model on 1 × 8 and 2 × 4 lattices, by running a VQE-based algorithm on a superconducting quantum processor.

Here, the authors use electrostatic gates to trap interlayer excitons (IE) in MoSe₂/WSe₂ heterobilayers. They observe an exponential broadening of the IE emission linewidth that signals the IE ionization threshold.

Luppi et al. identify transcriptomic and connectomic controllers of information integration and its breakdown induced by anaesthesia in humans, macaques, marmosets and mice.

Protein expression vectors in cell-free systems mainly rely on double-stranded DNA and single-stranded RNA. Here, authors use circular single-stranded DNA as a programmable vector for gene regulation in a cell-free expression system by identifying its expression pathways.

Coupling superconductors to mesoscopic systems leads to unusual effects that could be exploited in new devices including topological quantum computers. Here the authors present a double quantum dot with a Yu–Shiba–Rusinov ground state arising from the interplay of Coulomb interactions and superconductivity.

Kim et al. report the oxidation of Sn-based perovskites, previously considered as detrimental, can be exploited to suppress the gate leakage current and enhance transistor performance and stability, enabling low-voltage logic operation using perovskite-IGZO junction field-effect transistors.

As a benchmark for the development of a future quantum computer, sampling from random quantum circuits is suggested as a task that will lead to quantum supremacy—a calculation that cannot be carried out classically.

While most results so far in semiconductor spin-based quantum computation use electron spins, devices based on hole spins may have more favourable properties for quantum applications. Here, the authors demonstrate single-shot readout and coherent control of a qubit made from a single hole spin.

Eliminating wiring in transistors could lead to high integration densities and low power consumption. Here, multiple logic gates are implemented in a microelectromechanical resonator by parametrically mixing binary information channels corresponding to mechanical oscillations of the resonator at different frequencies.

The exchange interaction between spins poses considerable challenges for high-fidelity control of semiconductor spin qubits. Here, the authors use pulse optimization and closed-loop control to achieve a gate fidelity of 99.5% for exchange-based single-qubit gates of two-electron spin qubits in GaAs.

Global Burden of Disease estimates show that between 1990 and 2023, the prevalence and burden of drug use disorders, inclusive of amphetamine, cannabis, cocaine and opioid use, have been increasing in high-income countries, particularly in the USA.

Superconductor–semiconductor hybrid systems can bring together physical properties that are promising for fast and coherent quantum technology. Here, Hendrickx et al. realize such a system in planar germanium heterostructures demonstrating excellent quantum dots and tunable Josephson supercurrents.

Recently, theories have emerged that describe the nonlinear high-energy excitations of one-dimensional electronic fluids. Here, the authors report experimental evidence of their existence and behaviour in tunnelling spectra of short GaAs quantum wires.

Here Plikus and colleagues provide a step-by-step protocol for the isolation and characterization of lipocartilage from mouse ear and the purification of its lipochondrocytes.

This study surveyed key informants across 26 countries on burning plastic for waste management and energy needs. It finds high awareness of this practice, with potential drivers including inadequate waste collection and a lack of affordable fuels.

A photoreactive crosslinker can be used to directly pattern thin films of exfoliated two-dimensional flakes, and the technique can be performed sequentially to create patterned van der Waals heterostructures at wafer scales.

Nitazenes are potent synthetic opioids that are difficult to detect. Here, authors computationally redesign a plant receptor to create sensitive sensors capable of detecting diverse nitazenes and their metabolites in biological samples.

Spin qubits based on hole states in strained germanium could offer the most scalable platform for quantum computation.

Correlated errors coming from leakage out of the computational subspace are an obstacle to fault-tolerant superconducting circuits. Here, the authors use a multi-level reset protocol to improve the performances of a bit-flip error correcting code by reducing the magnitude of correlations.

Charge carriers in graphene can be manipulated, e.g., collimated or focused, as in conventional optics but the efficiency of these processes remains low. Zhang et al. demonstrate interference of electrons in a novel graphene microcavity device and use it to enhance collimation efficiency of the electron flow.

Generative AI has the potential to transform the way chemical and drug safety research is conducted. Here the authors show AnimalGAN, a model developed using Generative Adversarial Networks, which simulates virtual animal experiments to generate multidimensional rat clinical pathology measurements.