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Molecular precursors containing V, Bi and Zn are thermally transformed into oxide materials. Detailed studies reveal and characterise the formation of amorphous intermediates, a new kinetic polymorph of BiVO₄, and incorporation of Zn dopants.

Synthetic cells mirror fundamental biological behaviors, like growth, metabolism, and mobility, but have lacked genotype-driven selection, which is essential for Darwinian evolution. Here, the authors introduce libraries of short DNA sequences as genotypes into fuel-dependent peptide-RNA-based coacervate droplets, identify sequences that partition on the droplets, and show they differentially affect the droplet phenotype.

Multi-ancestry GWAS meta-analysis identifies risk loci for severe nausea and vomiting of pregnancy. Downstream analyses explore maternal and fetal contributions of these loci and their temporal effects.

Digital distractions are vying for people’s focus, but our underlying capacity to pay attention seems to be undiminished.

Human activities such as dredging and land reclamation have pervasively altered the ways that tides propagate through large estuaries with negative ecological impacts, according to an analysis of recent and historical records.

MoCox6 is an inner mitochondrial membrane regulator of mitophagy in Magnaporthe oryzae, and targeting it with a small molecule, Pan-RAS-IN-1, suppresses fungal virulence and reduces rice blast disease.

Nonlinear optical responses of semiconductors induced by 150-fs and 4.2-MeV electron pulses are investigated. Sub-10-ps bandgap modulations with intensities up to 24.5% are observed near the bandgap and are explained by the band-filling effect and bandgap renormalization.

Singh et al. combine cryo-electron microscopy and functional studies to reveal how a single protein complex selects diverse mRNAs for subcellular localization using a combination of shape, positional sequence information and number of structured RNA elements.

Classical understanding of aromaticity has been challenged by its emergence in rings featuring only metal atoms. Now, diuranium and dithorium inverse sandwich complexes featuring a central cyclo-Bi₃³⁻ unit have been synthesized. These tribismuth rings exhibit exalted diamagnetism and are σ-aromatic, in contrast to the π-aromaticity in analogous tricarbon rings, providing benchmark data for comparisons between organic and inorganic aromaticity.

Thiemann et al. introduce TrajCast, a neural network that bypasses force calculations to directly predict atomic trajectories, enabling time steps up to 30 times longer while accurately reproducing physical properties of molecules and materials.

A monolithic mode-locked semiconductor laser with a continuously and widely tunable repetition rate is achieved by using a microwave driving signal that induces a spatiotemporal gain modulation along the entire laser cavity.

Immune checkpoint inhibitors (ICIs) have shown limited efficacy in recurrent high-grade astrocytoma (rHGA). Here the authors report the results of a Phase 1/randomized Phase 2b trial of laser interstitial thermal therapy followed by anti-PD1 pembrolizumab in patients with rHGA.

The Lap-NET1 phase 1b trial reports that combined netrin1 antibody (NP137) plus modified FOLFIRINOX therapy on patients with locally advanced pancreatic cancer was well tolerated and improved progression-free survival and overall survival via inhibition of epithelial–mesenchymal transition.

Observations and models show decadal ocean temperature regime shifts have increased strongly over the past 150 years due to human warming, linked to abrupt ecological and fishery changes and likely to further intensify without major emission cuts.

Millisecond pulsar PSR J0435+3233, with a spin-down rate that is 100 times higher than those of other millisecond pulsars, occupies a unique position on the P–Ṗ diagram. This pulsar challenges classical recycling models and constrains spin-up theories.

Decapping is a key step in mRNA decay, but how its regulation has diverged across eukaryotes remains unclear. Here, the authors reconstitute the human decapping network, revealing divergent roles for DCP2’s disordered C-terminal region and conserved tetrameric EDC4 scaffolds for DCP2 recruitment.

Cross-ion correlations are crucial to quantitatively explain the appearance of intermediate phases and final product fractions during powder synthesis.

A vaccination strategy using heterologous HIV Env trimers covalently coupled to liposomes for multivalent display generates cross-neutralizing HIV serum antibody responses in non-human primates, mimicking infection-elicited apex-targeting broadly neutralizing antibodies.

Sex and gender influence disease presentation, diagnostic accuracy, treatment response and outcomes across rheumatology, yet remain insufficiently integrated into practice. Integrating sex-aware and gender-aware approaches can improve disease assessment, risk stratification and personalized care, advancing equity and precision in rheumatology.

Assessment of how 16 taxonomic groups in a lowland tropical forest resist and recover from anthropogenic disturbance shows the potential of protecting naturally regenerating secondary forests to reverse biodiversity losses.

A multicountry cohort study found that prediction models combining clinical parameters with either pulse oximetry or the host biomarker sTREM1 more accurately identified febrile children needing referral than standard WHO criteria.

Analysis of 258 ancient genomes from southern Germany reveals a major demographic shift during the late fifth century, yet family structures persisted from Late Roman times, demonstrating cultural continuity despite profound demographic reorganization.

The properties of metal–organic framework glasses can be modulated by additives, but understanding how they modify the glass network is challenging. Now, alkali-modifier sites in MOF glasses have been identified, and the impact of both modifier content and identity on the processing temperatures and hierarchical porosity has been examined.

Trained and validated on data from 2,344 patients with smoldering multiple myeloma, a new algorithm using longitudinal biomarker dynamics provides accurate prediction of risk of disease progression, outperforming established models.

Animal companions can be a lot of work, and are difficult to fit into a busy professional’s life, but they can also enhance well-being.

Time-restricted eating (TRE) and daily calorie restriction both led to significant weight loss in women with polycystic ovary syndrome compared to controls. Thus, TRE is a safe and effective alternative to calorie restriction for weight management in this population.

Microbial activity in glycerol-amended uranium-contaminated mine water promotes reduction of U(VI) to U(V), stabilising it with U(IV), challenging the conventional pathway and providing new insights into uranium remediation in environmental systems.

Age-related cell loss in the retinal pigment epithelium triggers structural and mechanical remodelling that compromises vision-supporting phagocytosis. This study shows that altered mechanical homeostasis alone can drive functional decline in ageing tissue.

Wearable inertial and soft sensors combined with a lightweight learning-based fusion framework achieve long-duration, accurate three-dimensional tracking of shoulder motion with minimal calibration.

Investigating how aging predisposes individuals to a higher metastatic risk, the authors identify that extracellular vesicles secreted by senescent hepatocytes carry miRNAs that enhance metastatic potential in tumor-bearing aged mice, with relevance for older adults with cancer.

The mechanism underlying the formation of ionophore polyethers—polyketide-derived natural products containing tetrahydrofuran and tetrahydropyran rings—has been elusive. Now structural and biochemical analyses reveal that a C₂₆ linear precursor undergoes four successive cyclizations within the single active site of the heterodimeric polyether epoxide hydrolase MonBI·MonBII, in which MonBI promotes MonBII’s folded active conformation.

The genetically encoded voltage indicators JEDI3sub and JEDI3hyp enhance monitoring of subthreshold neuronal activity in the awake mouse brain using a variety of two-photon microscopy techniques.

In this phase 1/2 trial, patients with Ewing sarcoma received trabectedin and low-dose irinotecan at concentrations known to inhibit the activity of the transcription factor EWS::FLI1, leading to encouraging clinical response rates.

A fluorochromic metal–organic framework sensor enables real-time visualization of thorium adsorption and exhibits a higher selectivity than other tetravalent cations.

The TRACS algorithm tracks bacteria, viruses and parasites in metagenomic or population sequencing data, detecting microbial transmission even when multiple strains coexist within a host.

Single-variant and ultrarare variant burden analyses leveraging exome sequencing data from 22 cohorts identify new risk genes for amyotrophic lateral sclerosis and show cumulative effects of several rare variants on disease risk.

Pooled production of recombinant AAV vectors leads to frequent genetic recombination.

Wang, Guo, Zhang and colleagues obtain four cryo-electron microscopy snapshots that show how IscB is kept off by two RNA lids, with a car-pedal-like guide shift activating cleavage after ~11-nt pairing. They also engineer hinge regions that boost flexibility and improve genome editing in cells.

The isomeric state of thorium-229, a candidate for nuclear clocks, can decay through internal conversion and radiative decays. Now experiments suggest indirect evidence for a higher-order decay process through an electronic transition.

Laser-driven neutron sources offer unique advantages for fundamental physics and applications. Here, authors present an experiment at the DRACO PW laser where they achieved for the first time single neutron detection of fast neutrons, establishing LDNSs as a promising, scalable platform for future fast neutron-induced reaction studies.

Methane is a potent greenhouse gas, but can also be used as a source for advanced carbon materials. This work shows a sustainable approach to produce high-value carbon fibres through methane pyrolysis.

The two species of African elephants are facing severe declines. Here, authors assess their continent-wide genomic diversity, identifying differences in their evolutionary histories and highlighting the formative role of gene flow.

Hodgson, Huang, Lang et al. show that TDP-43 limits ribonucleoprotein particle condensation into paraspeckles in a concentration- and polymerization-dependent manner. They also link paraspeckle condensation to stress response and neuroprotection.

This Perspective examines how a systemic, service-oriented framing of nature-based solutions can enhance multifunctionality and long-term resilience within complex social–ecological systems. Aligning adaptive co-management, integrated indicators and governance–finance structures enables nature-based solutions interventions to address interconnected climate, biodiversity and water challenges.

This study introduces genome–host association (GHA), leveraging natural epidemics to map the genetic landscape of host adaptation in the pathogen Zymoseptoria tritici. Applied to 832 wheat fungal strains, GHA identified multiple genes underlying host specialization.

N-desethyl-fluornitrazene is a µ-opioid receptor agonist derived from nitazenes that has supramaximal intrinsic efficacy that produces analgesia with minimal adverse effects in rodent models.

Multiple sclerosis is marked by considerable prognostic uncertainty, and no unified framework currently exists to guide the integration of diverse prognostic factors. To address this gap, a MAGNIMS consortium proposes a multiaxial model, incorporating the overall burden of damage, the topography of injury and the capacity for compensation.

This Perspective highlights the failures of an ageing cell in properly maintaining mRNA health at the various steps of the mRNA life cycle that result in vulnerability to disease, pointing to RNA imbalance as an emerging hallmark of cellular ageing.